Raising a child with a neuromuscular disorder can be a overwhelming experience for even the strongest parent or grandparent. Dr. Charlotte Thompson, a leading authority in pediatric neuromuscular disorders, draws on her 38 years of experience treating children with muscular dystrophy, spinal atrophy, congenital and mitochondrial myopathies, Charchot-Marie-Tooth, and all the childhood neuromuscular disorders. Her book provides not only medical facts but much practical advice on how to cope with the many challenges of day-to-day parenting a child with neuromuscular disease. Dr. Thompson discusses how to cope with the initial diagnosis of a neuromuscular disorder and then suggests ways to get beyond the shock, numbness, and anger that may occur. She describes each of the principal diseases giving the history, signs and symptoms, the usual course, outcome, genetics, and any possible treatments. Subsequent chapters offer advice on when to ask for a second opinion about the diagnosis, how to navigate the medical maze and work with a child's medical team. Tips on finding the most appropriate school placement and developing an individual education program (IEP) are invaluable. Dr. Thompson stresses the importance of taking one day at a time and insists that parents must care for themselves. She offers suggestions for developing family closeness and even how to make time for fun. Wise advice from parents of children with neuromuscular disease is inserted in boxes throughout the chapters. A large appendix gives resources state by state and country by country. There is no training that prepares you to be the parent of a child with a disability, but Raising a Child with a Neuromuscular Disorder should be a great help to parents, grandparents, and anyone who cares for a child or young person.

Peroxisomal disorders constitute a major research front in clinical genetics, paediatrics and cell biology. Since 1983, the metabolic defect in some 20 different peroxisomal disorders has been described. The best known conditions include Zellweger syndrome, rhizomelic chondrodysplasia punctata and X-linked adrenoleukodystrophy and, in the most recent edition of The Metabolic and Molecular Basis Inherited Disease, edited by Scriver and colleagues, more than 100 pages are now devoted to the subject. Progress in our understanding of these conditions, and their diagnosis, results from the application of a variety of laboratory investigations. These include microscopic studies, analysis of metabolites (very long-chain fatty acids, bile acids, and plasmalogens), enzyme studies (peroxisomal beta-oxidation pathway and dihydroxyacetone phosphate acyltransferase), immunodetection of peroxisomal (membrane) proteins and molecular analysis of mutant DNA. In order to encourage a greater awareness in this field and the diagnostic protocols required, an international course was organised in Gent, Belgium, in May 1994, on the clinical and biochemical diagnosis of peroxisomal disorders. A number of international experts in the field who provided intensive hands-on experience over 3.5 days, have now collected their course work and reviews together in this Handbook. The volume is introduced by Sidney Goldfischer, who in 1973 was the first to recognise the absence of peroxisomes in Zellweger syndrome, but whose observations were not fully appreciated for a further decade. This handbook provides the most comprehensive and detailed account of laboratory methods for the diagnosis of peroxisomal disorders. The methods are clearly presented and well illustrated, and should allow laboratories to introduce these methods into their repertoire. Audience: Paediatricians, neurologists, clinical biochemists, pathologists, genetic counsellors, obstetricians, and GPs interested in the recognition, diagnosis and prenatal prevention of peroxisomal disorders.

Adhesions can cause a wide range of problems, complaints and hazards, even after simple abdominal procedures, such as appendectomy, with complications ranging from recurrent discomfort and pain to intestinal obstruction. Postsurgical adhesions increase the risk of following operations of the abdominal and thoracic cavity. They impair peritoneal dialysis and chemotherapy and play a crucial part in laparoscopic procedures. Adhesion-related problems account for a large amount of clinical work and have a significant socioeconomic impact. This book presents the current knowledge on the aetiopathogenesis of adhesion formation as well as the available methods for their prevention and control. Experts in the field contribute to clinical standards for preventive measures to control the formation of postoperative adhesions

Cryptorchidism remains a common but poorly understood anomaly affecting 2%-5% of children. Major controversies exist over the timing and type of treat ment (i. e. surgical vs hormonal therapy) and whether intervention prevents sub sequent infertility and testicular cancer. Part of the dilemma is caused by lack of understanding of the normal process of descent, despite intensive research and study since the eighteenth century, when Hunter and von Haller first described the gubernaculum (caudal genito-inguinal ligament) and processus vaginalis (Williams and Hutson 1991a). More needs to be known, not only of the normal mechanism, but also of the ways that it can be deranged to produce undescended testes. This review describes the recent results of studies on normal descent, with emphasis on our studies of the different stages of descent. As the reader will appreciate, the ever-more complex models proposed to account for normal tes ticular descent predict that undescended testes will be caused by a multitude of anomalies affecting different stages of the process. A description is given of current hypotheses of the aetiology of cryptorchidism, correlating these with studies of cryptorchid animal models. For a more detailed description of the numerous ideas about the mechanism, the reader is referred to Heyns and Hutson (1995) and other monographs (Fonkalsrud and Mengel 1981; Abney and Keel 1989)."

'Billy Connolly says he's no idea who Parkinson was and just wishes he'd kept his disease to himself. He should read this book.' Jeremy Paxman Parkinson's disease is one of the most common forms of dementia, with 10,000 new cases each year in the UK alone, and yet few know anything about the man the disease is named after. In 1817 - exactly 200 years ago - James Parkinson (1755-1824) defined the disease so precisely that we still diagnose it today by recognising the symptoms he identified. The story of this remarkable man's contributions to the Age of the Enlightenment is told through his three passions - medicine, politics and fossils. As a political radical Parkinson was interrogated over a plot to kill King George III and revealed as the author of anti-government pamphlets, a crime for which many were transported to Australia; while helping Edward Jenner set up smallpox vaccination stations across London, he wrote the first scientific study of fossils in English, which led to fossil-hunting becoming the nation's latest craze - just a glimpse of his many achievements. Cherry Lewis restores this neglected pioneer to his rightful place in history, while creating a vivid and pungent portrait of life as an 'apothecary surgeon' in Georgian London.

The articles in Issue 4 of JOURNAL OF INHERITED METABOLIC DISEASE, Volume 16 (1993) contain the main lectures presented at the 30th Annual Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM), Leuven, Belgium, 1992, which was dedicated to Inherited Metabolic Diseases and the Brain'. Topics discussed included: Inborn errors and brain fluids, neurotransmitter disorders, inborn errors and demyelination, and recent developments. Participants from many countries provided a state-of-the-art review which will be of interest to clinicians and research workers alike in many different disciplines.

On the subject of stomach and gastric diseases, current cli- nical, morphological, pharmacological, biochemical as well as cellular and molecularbiological aspects will be presen- ted. The articles of the first part of this book will discuss the normal functions of the stomach (such as motility, secre- tion, tissue regeneration etc.). The second part deals with pathophysiological aspects (such as inflammation, ulceration and tumor formation) and modern possibilities of treatment. The authors aim at gaining a deeper knowledge of the sto- mach, its physiology and pathophysiology in order to use this knowledge for the better of their patients.

An experienced pathologist, radiologist and clinician combine forces to review the recent literature on coloproctology and give a precis of the results. Their Highlights in Coloproctology are the ideal source for a clinician or researcher who wants a quick overview of the subject. The book highlights the papers that have had an impact on developments in the field and brings the reader up to date with modern references.

The anastomotic technique plays a predominant role in gastrointestinal surgery. A feared complication is leakage due to the sutures. Such leakage cannot be detected early; consequently, infection spreads locally and systemically. An anastomotic method is generally evaluated according to its rate of leakage, related to the localization, bur real scientific comparisons, i.e., controlled studies, are almost totally lack ing. The criteria of evaluation include the type of suture, the localization, the auxiliary technical tools, practicability, the different forms of wound healing, angiogenesis, and vascularization, among others. The postoperative criteria are complications shortly after surgery, such as bleeding, ruptures, and stenoses of the anastomosis. A standard comparison is made difficult by the variety of cytophysiological and biochemical factors that influence wound healing. In the comparison of larger series one must always take into account differences of auxiliary tools, strategies, and inhomogeneity of patients. A change of one auxiliary tool or of one strategy implies the modification of various target criteria. Often enough, however, one does not sufficiently consider the surgeon's most. important role."

"Updates in Colo-Proctology" covers the proceedings of the Anglo-Swiss Colo-Proctology Meeting held in St Moritz in 1990. The book contains the papers which were presented and dis cussed there by physicians of the various specialties concerned with the care of patients with diseases of the colon, rectum and anus. The authors, each distinguished in a particular field, have contributed across a wide range of subjects and different dis ciplines. The topics covered include surgical and investigative techniques, cancer, inflammatory bowel disease and specific infections. Being familiar with the previous literature, it is clear that little was really new among the themes presented in St Moritz, but few will deny that many of the techniques and methods of treatment described in this book are truly modern. Some contribute an entirely new dimension to the approach to well known colo-proctological conditions, while others may open up new paths for future research. In addition, in colo-proctology as in other disciplines, advances in treatment almost always bring new problems in the complications which attend them. These are the subject of some of the papers. Although it would be invidious to pick out individual contributions when there is so much that is new to talk about and so much that is old to be looked at in a new light, we should like to record how much we have enjoyed reading and collating these chapters. We hope that others will share our enthusiasm and pleasure.

Corneal topography has become essentially a pattern recognition trade, best learned by viewing multiple images of representative patterns. In spite of this, currently available topography books focus only on the technology behind topography, or a particular application of topography, as opposed to presenting a comprehensive collection of topographic patterns that provide quick, consistent pattern recognition and identification. Drs. Wang and Kugler, along with Drs. Morgan and Boerman, look to fill this void with Atlas and Clinical Reference Guide for Corneal Topography. Atlas and Clinical Reference Guide for Corneal Topography is the first corneal topography book that lends itself to efficient image search and reference for busy clinicians at chair side. Organised into both map-based and disease-based sections, the book allows for quick reference in busy clinical situations. Images come from the commonly used topographers, the Zeiss Atlas and the Oculus Pentacam, but the principles of pattern recognition can be applied to any topographer. Due to the text's large collection of topographic images and corresponding corneal conditions, Atlas and Clinical Reference Guide for Corneal Topography can be used side by side with the topographer. Designed as both a learning tool for students and a reference for clinicians to use when faced with a challenging topography interpretation, Atlas and Clinical Reference Guide for Corneal Topography will be appreciated by a wide spectrum of eye care professionals. General ophthalmologists, cataract and refractive surgeons, corneal specialists, optometrists, and ophthalmology residents and students will benefit from this invaluable atlas for corneal topography.

This book synthesizes the flourishing field of anthropology of infectious disease in a critical, biocultural framework. Leading medical anthropologist Merrill Singer holistically unites the behaviors of microorganisms and the activities of complex social systems, showing how we exist with pathogenic agents of disease in a complex process of co-evolution. He also connects human diseases to larger ecosystems and various other species that are future sources of new human infections. Anthropology of Infectious Disease integrates and advances research in this growing, multifaceted area and offers an ideal supplement to courses in anthropology, public health, development studies, and related fields.

Notfalle erfordern adaquates chirurgisches Vorgehen, da ansonsten lebensbedrohliche Komplikationen im postoperativen Verlauf auftreten koennen. Jeder Arzt muss deshalb die Massnahmen der Notfallmedizin und der chirurgischen Erstversorgung beherrschen. Die "Definitive chirurgische Erstversorgung" - ein etablierter Klassiker in neuer Auflage - von G.H. Willital und A. Holzgreve soll jedem chirurgisch tatigen Arzt eine wertvolle Orientierungshilfe sein. Alle Erkrankungen und Unfalle, die eine chirurgische Erstversorgung notwendig machen, werden aufgefuhrt. Die chirurgische Erstversorgung aller Falle wird einheitlich systematisch gegliedert und klar und pragnant dargestellt. das erfolgreiche Werk (65.000 Exemplare und 5 Auflagen bei Urban & Schwarzenberg) erscheint jetzt in der 6. Auflage bei Walter de Gruyter alle Erkrankungen und Unfalle, die eine chirurgische Erstversorgung notwendig machen, sind sorgfaltig aktualisiert einheitlich systematisch gegliedert in Leitsymptome, Diagnostik und Therapie Kitteltasche-Format fur schnelles Nachschlagen

Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a summary of underlying principles for human health and disease studies from a microbiome point-of-view. From birth to old age, microbiomes in fecal, oral/nasal, vaginal, and skin samples contain important information that can predict disease risks in the future. Tissue samples also contain microbes that are relevant for diseases. The microbiome connects genetic and environmental factors and is poised to greatly facilitate precision medicine, including prevention, diagnosis and effective treatment of many complex diseases. Based in traditional microbiology and adding a more wholistic view of the advent of high-throughput sequencing, this reference poses the key questions of the total number of microbial cells and their distribution in the human body while also considering concepts from macroecology and from causal reasoning. An entire chapter is dedicated to methods, providing hands-on information for important considerations when collecting samples for metagenomic studies.

Medically unexplained symptoms and somatisation are the fifth most common reason for visits to doctors in the USA, and form one of the most expensive diagnostic categories in Europe. The range of disorders involved includes irritable bowel syndrome, chronic widespread pain and chronic fatigue syndrome. This book reviews the current literature, clarifies and disseminates clear information about the size and scope of the problem, and discusses current and future national and international guidelines. It also identifies barriers to progress and makes evidence-based recommendations for the management of medically unexplained symptoms and somatisation. Written and edited by leading experts in the field, this authoritative text defines international best practice and is an important resource for psychiatrists, clinical psychologists, primary care doctors and those responsible for establishing health policy.

Environmental, genetic, psychological, and societal factors interact to produce obesity, a chronic condition of epidemic proportions. The Handbook of Obesity Intervention for the Lifespan guides professionals in meeting this complex challenge with a multidisciplinary palette of evidence-based interventions that can be tailored to men and women across the lifespan, regardless of background. This unique reference combines salient research data and hands-on clinical applications for use with overweight patients, from the very young to the very old, and includes a "treatment resources" section with extra materials to bolster therapy-all geared toward respectful, encouraging treatment and lasting weight-loss results.

A complete guide to the side-effects and treatments - both conventional and alternative - for endometriosis, from a respected name in the field who also suffers from endometriosis.

Endometriosis is a debilitating reproductive and immunological disease that affects 7-10 million American women each year. The disease occurs when the same kind of tissue that lines the walls of the uterus grows outside the uterus in the pelvic cavity or some other area of the body, usually significantly affecting the woman's fertility and often causing pelvic pain. And as with any condition that affects fertility, the results are often emotional and psychological as well as physical.

As someone who suffers from endometriosis, and who has connections to a wide network of healthcare professionals, Morris is the perfect person to guide sufferers through diagnosis, treatment and living well with the condition. Like the previous titles in our successful Living Well series, this book will offer a holistic approach to living with the disease. The author will offer strategies for coping with the psychological aspects of endometriosis, including how best to tell others about the condition; treatment options including alternative and complementary treatment plans; dealing with infertility; and weighing the hysterectomy option. The author will draw on her relationship with fellow sufferers as well as medical professionals to help readers, making this the most comprehensive guide to endometriosis available.

Kerry-Ann Morris was diagnosed with endometriosis in 1999. Since then she has become one of the most active members of the endometriosis community, and has started an outreach website for the disease.She has relationships with many fellow sufferers and experts in the medical community, making her the perfect author for a book on holistic treatment.

This revelatory book charts and explains the impact and consequences of successive pandemics, plagues and epidemics on the course of world history - all through the lens of today's ongoing global experience of COVID 19\. Ranging from prehistory to the present day, it first defines what constitutes a pandemic or epidemic then looks at 20 guilty diseases: including cholera, influenza, bubonic plague, leprosy, measles, smallpox, malaria, AIDS, MERS, SARS, Zika, Ebola and, of course, Covid-19\. Some less well-known, but equally significant and deadly contagions such as Legionnaires' Disease, psittacosis, polio, the Sweat, and dancing plague, are also covered. The book is ordered chronologically. Each chapter features an explanation and description of epidemiology, sources and vectors, morbidity, mortality, governmental response and reaction, societal response and impact as well as psychological issues where known - and the political, legal and scientific consequences it had or has for each locus at a local and international level. In short - the book explains how each of the events both made and influenced subsequent history in its own way, particularly how each shaped future medical and scientific research and vaccine development programmes. It also examines myths about infectious diseases, the role of the media and social media. Perhaps most importantly, Paul Chrystal asks what lessons have been learnt. Will we be better prepared next time? Because, if one thing is sure, there is going to be a 'next time'.

The Understanding IBS chart presents an overall view of the symptoms and causes of Irritable Bowel Syndrome. The main image features the large intestine, with cut-away views showing a spasm and inflammation. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

The fully updated and revised sixth edition of the definitive guide to clinically tested and proven methods for effectively managing all of the symptoms characteristic of MS and MS treatment.

Based on the most up-to-date disease management strategies, medical and research breakthroughs, and latest drug therapies, Dr. Randall T. Schapiro provides the information you need to manage both the disease and symptoms, and make everyday life easier.

"Managing the Symptoms of Multiple Sclerosis" features comprehensive treatment options for: Fatigue Spasticity Weakness Tremor Spasms Pressure Sores Incontinence Stutters Blurry Vision Pain Dizziness Numbness Sexual Difficulties Cognitive Difficulties

Current research on the pathophysiological mechanisms of brain trauma is at the vanguard of neuroscience research. Clinical trials in head trauma are being conducted to determine the potential effectiveness of numerous drugs, with major results projected over the next few years. Unfortunately, no existing book presents the topic of head trauma with both a summary of the science and an extension of these findings into clinical applications. Head Trauma: Basic, Preclinical, and Clinical Directions fills the void in the literature on this subject.

Providing an overview of the major modalities in head trauma therapeutics, this book not only offers a comprehensive presentation of the science in this area but also contains the most up-to-date discussion regarding the basis for experimental and clinical pharmacological treatment of head trauma. Chapters cover basic mechanisms, preclinical targets, clinical aspects with information on efficacy studies, and a straightforward, easy-to-follow presentation of the side effects and potency ratios. In addition, a list of major Web sites of interest and importance to neurotrauma researchers is included.

Additional topics reviewed in Head Trauma: Basic, Preclinical, and Clinical Directions include:

• In vitro models of traumatic brain injury
• Receptor-based mechanisms in head trauma
• Mitochondrial dysfunction following traumatic brain injury
• Epidemiology and economics of head trauma
• Guidelines for medical and surgical management of head trauma patients used throughout the world
• Perspectives on the future of head trauma therapeutics
• And much more

With this book, neurosurgeons, neurologists, neurophysiologists, and neuroscientists now have a definitive reference on the subject of head trauma.

Hepatologie konkret - komplett - kompakt Erfahrene Kliniker fuhren ubersichtlich, zusammenfassend und gewichtet durch das Gebiet der Leber- und Gallenwegserkrankungen. Komplexe Inhalte werden anschaulich, klar und gut verstandlich dargestellt. Differenzierte Diagnostik und Therapie: Was - Wann - Warum Neueste diagnostische und therapeutische Konzepte Rasche, prazise Information Konzentration auf krankheitsbezogene klinische Informationen Therapie individuell abgestimmt auf Ihre Patienten Standards Therapie fur multimorbide Patienten Loesungen fur typische und atypische Therapieprobleme Zur sofortigen sicheren Anwendung Entsprechend der neuesten Studien und Leitlinien aller wichtigen deutschen, europaischen und amerikanischen Fachgesellschaften