Paediatric Respiratory Medicine Second edition remains the first point of reference for those faced with treating acute or chronic respiratory problems. The handbook discusses the approach to clinical problems, specific conditions, supportive care and practical procedures, and includes vital appendices covering specific tests and statistics. Designed as a practical guide, it serves general and specialist paediatricians at both consultant and trainee level. The book is divided into five parts. Part I provides a practical approach to acute and non-acute clinical problems. Part II provides detailed information about common and more rare clinical conditions. Part III provides useful information on supportive care, including for example, use of non-invasive ventilation and the care of a child with a tracheotomy. Part IV gives details on how to perform several practical procedures, such as ciliary brush biopsy, flexible bronchoscopy, and inserting a chest drain. The appendices provide information on lung function testing and tables of age-corrected normal values for several respiratory parameters. Written by three consultants in paediatric respiratory medicine, their expertise in the subject provides all levels of paediatricians with practical guide on a subject that is increasingly relevant in paediatrics.

This issue is the first of a two-part series on Life-Threatening Infections, edited by Dr. Anand Kumar. Article topics include: Meningitis and other non-viral CNS infections, Encephalitis and viral meningitis, Community Acquired Pneumonia, Hospital Acquired Pneumonia/Ventilator Associated Pneumonia, Clostridial gangrene and bacterial myositis, Acute peritonitis and bowel perforations, Post-operative wound and surgical site infections and Fulminant viral hepatitis.

Atrial fibrillation is a heart condition that causes an irregular and often abnormally fast heart rate. It can cause problems including dizziness, shortness of breath and tiredness and a patient may be aware of noticeable heart palpitations, where the heart feels like it is pounding, fluttering or beating irregularly, often for a few seconds or, in some cases, a few minutes (NHS Choices). This comprehensive guide presents clinicians with the latest developments in the diagnosis and management of atrial fibrillation. Divided into seven sections, the book covers clinical spectrum, diagnosis, therapeutic strategies, interventions, and new technologies used in its treatment and prevention. Complete sections are dedicated to other arrhythmias, to cardiac surgery and to future directions in atrial fibrillation. With more than 1000 pages providing in depth coverage of the topic, this manual is further enhanced by clinical photographs, diagrams and tables. Key Points Comprehensive guide to latest developments in diagnosis and treatment of atrial fibrillation More than 1000 pages discuss clinical spectrum, diagnosis, treatment options, interventions, and new technologies Complete sections dedicated to other arrhythmias, cardiac surgery, and future directions Highly illustrated with clinical photographs, diagrams and tables

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Chronischer Beckenbodenschmerz (CPPS) ist ein vorwiegend in der Urologie beheimatetes Krankheitsbild, das aber haufig auch interdisziplinar auftreten kann und dann fachubergreifend diagnostiziert und behandelt werden muss. Walter Merkle betrachtet in diesem UEberblick vor allem die urologischen Erscheinungsformen, arbeitet jedoch die interdisziplinaren Zusammenhange ein. Er pladiert an die AErzteschaft, das Krankheitsbild des CPPS verstarkt zu beachten, da dieses oft unzureichend diagnostiziert und behandelt wird. Essentiell ist dabei, sich von der alleinigen Sichtweise aus dem Fachgebiet der Urologie zu loesen und sich unbedingt interdisziplinar auf Empathie, Psychosomatik und Osteopathie sowie Biofeedbacktherapie einzulassen, um erfolgreich diagnostizieren und behandeln zu koennen. Der Autor: Dr. Walter Merkle war im Fachbereich Urologie der Deutschen Klinik fur Diagnostik GmbH in Wiesbaden tatig.

This issue covers topics central to the management of the patient with a chronic disease by taking a comprehenisve look at: Successful/Innovative Models in Chronic Disease Management, The Patient-Centered Medical Home, Self-Management Education and Support, Major Pharmacologic Issues in Chronic Disease Management, Health Information Technology, Community-Based Partnerships for Improving Chronic Disease Management, and Effective Strategies for Behavioral Change, Diabetes Management, CHF Management, Asthma Management, and Depression Management.

Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder, causing pain, discomfort, and embarrassment to millions. While medically based treatments have demonstrated only limited effectiveness, recent research strongly supports the role of psychosocial factors in both symptom expression and symptom control. This book presents a brief cognitive-behavioral treatment approach that is suitable for use with individuals or groups. Delineating a clear medical rationale, the authors help clinicians both to reduce the stigma associated with IBS and to overcome client resistance to psychological treatment. Effective techniques are outlined for helping clients manage anxiety, anger, and shame; enhance their self-efficacy and stress management skills; and alleviate gastrointestinal distress. Session-by-session guidelines are illuminated by such useful features as sample therapist-client dialogues, lists of important points to cover, troubleshooting tips, and examples of recommended handouts and forms. Also covered in depth are treatment issues specific to women.

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

This issue, guest edited by Alimuddin Zumla and H. Simon Schaaf, focuses on the topic of Tuberculosis. Articles include: Global Burden and Epidemiology of Tuberculosis; Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in the West. Europe and the United States: Epidemiology, Surveillance, and Control; Multidrug- and Extensively Drug-resistant Tuberculosis in Africa and South America: Epidemiology, Diagnosis and Management in Adults and Children; Antiretroviral Therapy for Control of the HIV-associated Tuberculosis Epidemic in Resource-Limited Settings; Novel and Improved Technologies for Tuberculosis Diagnosis: Progress and Challenges; Advances in Imaging Chest Tuberculosis: Blurring of Differences Between Children and Adults; Update on Tuberculosis of the Central Nervous System: Pathogenesis, Diagnosis, and Treatment; Advances in Immunotherapy for Tuberculosis Treatment, and more!

Bristol - 1953 It's Coronation Year. A new beginning in the aftermath of war, but there are still battles to be fought and secrets to be kept. Charlotte Hennessey-White copes with the shortcomings of her marriage and throws herself into helping refugees unwelcome by some and exploited by others. Edna Burbage has three beautiful children and considers herself lucky until the advent of a deadly twentieth century disease makes her think otherwise. Polly Chandler still hopes for a better life, but there are too many obstacles standing in her way. These three women lived through a war, can they now cope with the demands of peace? Praise for Lizzie Lane: 'A gripping saga and a storyline that will keep you hooked' Rosie Goodwin 'The Tobacco Girls is another heartwarming tale of love and friendship and a must-read for all saga fans.' Jean Fullerton 'Lizzie Lane opens the door to a past of factory girls, redolent with life-affirming friendship, drama, and choices that are as relevant today as they were then.' Catrin Collier 'If you want an exciting, authentic historical saga then look no further than Lizzie Lane.' Fenella J Miller

Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain.
*Neurogenic inflammation in historical perspective
*Cardiac protection by nociceptive afferents
*Molecular mechanisms of nociception
*Sensory mechanisms in migraine pathophysiology
*Vagal signalling of visceral inflammation
*Neurogenic mechanisms in arthritis
*Therapeutic implications of vanilloid-type compounds

Dieses Buch gibt Psychologen und AErzten ein diagnostisches Instrument an die Hand, Schmerzen im Sinne einer multimodalen Schmerzdiagnostik und -therapie systematisch zu dokumentieren. MASK-P ermoeglicht einen einfachen Einstieg in die bio-psychosoziale Krankheitsperspektive bei chronischen Schmerzstoerungen: systematisch, umfassend und klinisch-anwendungsbezogen. Mit MASK-P koennen sowohl co-morbide Stoerungen (wie Depressionen oder Angsstoerungen) als auch Schmerzen verhaltensnah und mit konkreten Ansatzpunkten fur die schmerzpsychologische und schmerzmedizinische Behandlung erfasst werden. MASK-P wurde von der Deutschen Schmerzgesellschaft e.V. und der Deutschen Gesellschaft fur psychologische Schmerztherapie und -forschung (DGPSF) entwickelt und ist Bestandteil des Lernzielkatalogs in der Weiterbildung zum Schmerztherapeuten. Damit stellt es fur Psychologen und AErzte ein gut strukturiertes Nachschlagewerk fur den klinischen Alltag dar und ist in der Weiterbildung zum Schmerztherapeuten unerlasslich.

This book provides multifaceted strategies necessary to treat hyperlipidemia, as well as tips for incorporating techniques into clinical practice. In addition to discussing pharmacologic treatment, the book includes a review of popular diets and therapeutic foods, herbs, and vitamins. A section on evidence-based recommendations for treating special populations discusses approaches for elderly patients, women, elite athletes, and other populations with unique medical needs. Case studies illustrate the principles introduced in the book. The text is complete with screening tools for real world risk assessment.

In the informal language of letters to public officials, Efraim Racker argues in favor of basic research as the most effective path to the treatment of disease. He contends that knowledge of the fundamentals of biological and biochemical processes is essential if we are to gain an understanding of disease processes. He then shows how this understanding is necessary for a rational approach to the prevention and cure of disease. Originally published in 1979. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Consultants and nurses in palliative medicine who do not have a background in oncology need to know about the different types of cancer to be able to deal with palliation in these patients. The new edition of this popular book continues to provide comprehensive coverage of cancer management aimed at palliative care professionals. To aid understanding in the specialty, the format of the book has been thoroughly revised to include numerous tables, figures, algorithms, case histories and key points to ensure that it will prove an invaluable, practical guide to oncology for all health care professionals involved in the care of patients with malignant disease.

The book provides a comprehensive overview of the management of malignant disease from the perspective of palliative medicine. The pathology, diagnosis and management of individual tumour sites are described with an emphasis on the symptoms produced in advanced disease and the place of oncological treatment in their management. Introductory chapters present the principles of oncological management and later chapters address specific symptoms from the viewpoint of their pathophysiology and management. Each chapter is enhanced by typical case histories and patient journeys.

This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences.

The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.

In this book, an international group of investigators from a broad array of clinical and basic disciplines present the ideas and concepts in the foreground of cerebrovascular disease. Included in their discussion are perspectives on topics that continue to guide current investigations, such as white matter injury, newer imaging approaches, delayed neuronal death, and recovery after stroke, as well as continuing disagreements on the value of heparin or MRI endpoints in the management of stroke patients. Further topics include a proposal for a major multicenter re-study of the utility of extracranial-intracranial bypass surgery in light of additional diagnostic information available through PET scanning; examination of how processes such as apoptosis, inflammation, free radicals, poly (ADP-ribose) polymerase activation, and alterations in glutamate receptor function contribute to the pathogenesis of ischemic brain injury; and finally an exploration of how estrogens or cholesterol-lowering agents might be used therapeutically.

Die Viszeralchirurgie ist eine der wichtigsten chirurgischen Subdisziplinen. Ihre Anwendung erfordert spezielle sonographische Kenntnisse, die uber das in der Weiterbildungsordnung geforderte Grundwissen weit hinausgehen. Das Buch bietet Facharzten und Assistenten topaktuelles Standardwissen fur die klinische Praxis und Weiterbildung. Umfassend und praxisorientiert: o Die gesamte Sonographie des Abdomens aus viszeralchirurgischer Sicht ist erfasst. o Das Standardwissen wird erganzt durch die laparoskopische, 3D- und Duplexsonographie. o Pra- und postoperative Befunde sind berucksichtigt. UEbersichtlich und lerngerecht: o Alle Kapitel sind einheitlich strukturiert und damit besonders benutzerfreundlich. o Die klare Didaktik erleichtert das schnelle Erfassen und gezielte Nachlesen. o Mit neuer Technik fur die optimale Wissensvermittlung: sonographische Originalabbildungen werden nach EDV-gestutzter Aufbereitung interessierender Areale korrespondierend zueinander dargestellt. Der ideale Praxis-Leitfaden fur die qualifizierte sonographische Ausbildung und die sichere Anwendung der Sonographie im viszeralchirurgischen Klinikalltag.

HIV und AIDS (3. Auflage) Das Ziel der Herausgeber und Autoren dieser Loseblattsammlung war es, eine ubersichtliche, individuell strukturierbare und einfach zu aktualisierende Arbeitshilfe fur AErzte, Helfer und Betroffene zu erstellen. Dieses Ringbuch enthalt die fur den taglichen Bedarf wichtigen Informationen, vorwiegend in Form von Tabellen. Jeder Benutzer kann zudem seine persoenlichen Erfahrungen und Erganzungen notieren. Durch fortschreitende Forschung und Erfahrung ist eine Korrektur und Erganzung dieses Leitfadens standig notwendig. Daher die Publikation in Form einer Loseblattsammlung.