Why do racial and ethnic controversies become attached, as they often do, to discussions of modern genetics? How do theories about genetic difference become entangled with political debates about cultural and group differences in America? Such issues are a conspicuous part of the histories of three hereditary diseases: Tay-Sachs, commonly identified with Jewish Americans; cystic fibrosis, often labeled a "Caucasian" disease; and sickle cell disease, widely associated with African Americans.

In this captivating account, historians Keith Wailoo and Stephen Pemberton reveal how these diseases -- fraught with ethnic and racial meanings for many Americans -- became objects of biological fascination and crucibles of social debate. Peering behind the headlines of breakthrough treatments and coming cures, they tell a complex story: about different kinds of suffering and faith, about unequal access to the promises and perils of modern medicine, and about how Americans consume innovation and how they come to believe in, or resist, the notion of imminent medical breakthroughs.

With Tay-Sachs, cystic fibrosis, and sickle cell disease as a powerful backdrop, the authors provide a glimpse into a diverse America where racial ideologies, cultural politics, and conflicting beliefs about the power of genetics shape disparate health care expectations and experiences.

ABC of Multimorbidity is the first title to provide primary care practitioners with a practical approach to the complex issues of treating and managing patients with more than one morbidity. Ageing populations and earlier diagnosis of chronic conditions mean more people are living longer with multimorbidity. However, treatment guidelines are often designed for treatment in isolation of other morbidities. Multimorbidity management therefore requires a more patient centred approach and greater knowledge and coordination of existing services. Effective multimorbidity management both improves overall patient well-being and reduces the overall demand on health services. ABC of Multimorbidity examines how multimorbidities can be addressed within primary care, from the GP and family physician consultation through to the effective use of a range of health care services. It addresses complex issues such as polypharmacy, mental health, patient safety, patient involvement in self-management, and the role of the practitioner. It then provides guidance on how multimorbidities can be best treated and managed within primary care through specific interventions to improve outcomes. From an international, primary care editor and contributor team, ABC of Multimorbidity is a practical resource for general practitioners, family physicians, practice and specialist nurses, and others caring for multimorbid patients. It is also relevant for junior doctors, medical trainees and students.

Consultants and nurses in palliative medicine who do not have a background in oncology need to know about the different types of cancer to be able to deal with palliation in these patients. The new edition of this popular book continues to provide comprehensive coverage of cancer management aimed at palliative care professionals. To aid understanding in the specialty, the format of the book has been thoroughly revised to include numerous tables, figures, algorithms, case histories and key points to ensure that it will prove an invaluable, practical guide to oncology for all health care professionals involved in the care of patients with malignant disease.

The book provides a comprehensive overview of the management of malignant disease from the perspective of palliative medicine. The pathology, diagnosis and management of individual tumour sites are described with an emphasis on the symptoms produced in advanced disease and the place of oncological treatment in their management. Introductory chapters present the principles of oncological management and later chapters address specific symptoms from the viewpoint of their pathophysiology and management. Each chapter is enhanced by typical case histories and patient journeys.

This ground-breaking book brings together scholars from the humanities and social and physical sciences to address the question of how recent work in the genetics, zoology, and epidemiology of plague's causative organism (Yersinia pestis) can allow a rethinking of the Black Death pandemic and its larger historical significance. This book is available as Open Access.

"The Metabolic Syndrome" is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease.

"The Metabolic Syndrome" has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndromeBariatric surgery for obesityFitnessBrain insulin resistance and appetiteThe nature of the insulin resistance seen in metabolic syndrome.

This brand new edition of "The Metabolic Syndrome" will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

This chart shows the location of glands on the body and illustrates the thyroid, parathyroid, thymus, adrenal, pineal, and pituitary glands. The heart, kidney, stomach, duodenum, jejunum, pancreas, ovary, and testes are also shown. The chart also lists the hormones found in each organ and gland.

This title includes proceedings of the 3rd European Congress on Obesity, Nice, France, 1991.

In our new Key Questions Answered series which complements the Oxford Core Texts, Clinical medicine KQA has been written to cover the breadth of clinical medicine for the medical undergraduate. Most students buy a selection of multiple choice questions across the specialties to help them revise for exams, etc. This book has been designed to provide a starting point - using just this one book the students can assess their knowledge and understanding of the different specialties, and build their confidence for their exams. The book has been written to complement the Oxford Handbook of Clinical Medicine.

The investigation and management of infertility has progressed radically since the advent of in vitro fertilization. It has ceased to be the province of the gynecologist alone, and often requires the co-operation of gynecologists, andrologists, endocrinologists, embryologists, geneticists, general scientists, psychologists, radiologists, nurses, ultrasonographers, social workers, medical administrators, and lawyers. Many of these do not have a medical background and fewer still have knowledge of the gynecological terms which are still in predominant use. Furthermore, scientific advances have led to the introduction of techniques and terms unfamiliar to the non-scientist, including the gynecologist. This dictionary of reproductive medicine, the first of its kind, has been conceived to address the concerns of all of these groups.

A succinct, single-authored text and atlas of bone marrow pathology, this book is based on over 10,000 bone marrow biopsies. Divided into seven sections, it covers indications and techniques for biopsy, normal findings, and bone marrow alterations in specific neoplastic and non-neoplastic disorders and other diseases. The author approaches the practical problems and pitfalls in making particular types of diagnoses. The volume is lavishly illustrated with over 300 full-color photographs. The emphasis has been placed on the histologic interpretation of the bone marrow core biopsy, but the histopathologic findings have been integrated with clinical and laboratory features, as well as with peripheral blood and bone marrow aspiration morphology.
Morphology is, in fact, accorded special attention in this book, since it remains the "gold standard" for many hematologic diagnoses and is the appropriate point of departure for more complex diagnostic investigations. More advanced immunologic and molecular techniques are not overlooked, however, and a discussion of these newer techniques is incorporated in the analysis throughout the text. Written as an introduction and guide to the interpretation of the bone marrow biopsy, this volume is intended primarily for pathologists and pathologists-in-training, but may also be used successfully by hematologists and oncologist who perform bone marrow biopsies.

This revelatory book charts and explains the impact and consequences of successive pandemics, plagues and epidemics on the course of world history - all through the lens of today's ongoing global experience of COVID 19\. Ranging from prehistory to the present day, it first defines what constitutes a pandemic or epidemic then looks at 20 guilty diseases: including cholera, influenza, bubonic plague, leprosy, measles, smallpox, malaria, AIDS, MERS, SARS, Zika, Ebola and, of course, Covid-19\. Some less well-known, but equally significant and deadly contagions such as Legionnaires' Disease, psittacosis, polio, the Sweat, and dancing plague, are also covered. The book is ordered chronologically. Each chapter features an explanation and description of epidemiology, sources and vectors, morbidity, mortality, governmental response and reaction, societal response and impact as well as psychological issues where known - and the political, legal and scientific consequences it had or has for each locus at a local and international level. In short - the book explains how each of the events both made and influenced subsequent history in its own way, particularly how each shaped future medical and scientific research and vaccine development programmes. It also examines myths about infectious diseases, the role of the media and social media. Perhaps most importantly, Paul Chrystal asks what lessons have been learnt. Will we be better prepared next time? Because, if one thing is sure, there is going to be a 'next time'.

The importance of appropriate and effective management of patient with long term chronic conditions cannot be underestimated, and both the Department of Health and the public are expecting much from the improvements and changes outlined in the recently published review by Lord Darzi.
"Case Management of Long Term Conditions" aims to provide all appropriate practitioners across all the professions (nurses, pharmacists, physiotherapists including social care practitioners) who might be involved in delivery of proactive case management with a practical understanding of how their knowledge and skills can be utilised to improve outcomes for people with Chronic Long Term Conditions. The text contains some broad reflections on care and service delivery based on reviews of evidence and views from clinicians in the use of these skills and competencies to deliver improved outcomes for these clients.

Sacroiliac joint pain is one of the most common painful conditions, as disorders of this joint are often the cause or a contributing factor to back pain. Treatment of sacroiliac joint pain has advanced significantly in the last decade, ranging from minor interventions to major surgical interventions. Written for pain physicians, neurologists, neurosurgeons, and orthopedic surgeons at all levels of training and practice, this book highlights new and innovative approaches to sacroiliac disease so clinicians may incorporate current techniques into practice. The international roster of authors present up to date information on interventional and surgical pain procedures including peripheral nerve stimulation, surgical fusion, and regenerative techniques. In addition to providing well-illustrated, step-by-step guidance on procedural technique, chapters review patient selection, instrumentation, complications management, and outcomes.

Chronic diseases are the leading causes of death and disability worldwide. Within the next few decades, the burden of chronic disease will more than triple, with the greatest rises occurring in developing countries. However, the rapid growth of chronic diseases is not being met with a proportionate increase in global attention, with global health traditionally focusing on infectious disease and maternal and child health.
This book is the first to synthesise the growing evidence-base surrounding the chronic disease, comprehensively addressing the prevention and control of chronic diseases from epidemiologic, economic, prevention/management, and governance perspectives.
Sick Societies is written in five main parts; the first part of the book aims to understand the causes and consequences of chronic diseases on a global level. The second part of the book identifies approaches for preventing and managing chronic diseases while the third part of the book considers the power and politics in global health that have stymied an effective response to chronic disease. In the fourth part of the book the themes from the first three parts come into focus through a series of invited contributions from leading public health experts. The final part of the book sets out a model of pragmatic and imaginative solidarity, wherein the struggles of the rich and poor to survive are united by a common cause and shared goals.

This contributed volume provides a complete overview of Neuro-Behcet's disease (NBD), one of the most serious manifestations of Behcet's disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields.

"A powerfully informative guide for patient and practitioner from a misinformed past toward a future of recovery and health." -David Perlmutter, MD, #1 New York Times best-selling author of Grain Brain and Brain Wash In this important and timely book, Steven Phillips, MD, and his former patient, Sony singer-songwriter Dana Parish, reveal striking evidence that a range of common infections, from COVID-19 to Lyme, cause a variety of autoimmune, psychiatric, and chronic conditions. Chronic explores the science behind what makes them difficult to diagnose and treat, debunks widely held beliefs, and provides solutions that empower sufferers to reclaim their lives. After nearly dying from his own mystery illness, Dr. Phillips experienced firsthand the medical community's ignorance about the pathogens that underlie a deep spectrum of serious conditions-from fibromyalgia, multiple sclerosis, chronic fatigue syndrome, rheumatoid arthritis, and lupus, to depression, anxiety, OCD and neurodegenerative disorders. Parish, too, watched her health spiral after twelve top doctors missed the underlying infections that caused heart failure and other sudden debilitating symptoms. Now, they've come together with a mission: to change the current model of simply treating symptoms and shift the focus to finding and curing root causes of chronic diseases that affect millions around the world.

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

Obesity is an increasing problem in the UK, affecting a large proportion of men, women and children. The ABC of Obesity is a new guide which will aid its effective management, addressing issues such as dieting, exercise, self esteem, drug treatment and surgery. Recent evidence is used to highlight frequent problems, successful treatment options, and the most common causes. This is an indispensable guide for all general practitioners, junior doctors, nurses, and other healthcare professionals who are involved in the treatment of this common condition. Obesity is a hugely expensive and increasing problem worldwide, leading to disability, reproductive problems, depression and accelerated metabolic and vascular diseases in a large proportion of men, women and children. The ABC of Obesity is a new guide which will aid its effective management, addressing issues such as dieting, exercise, self esteem, drug treatment and surgery. Recent evidence is used to highlight frequent problems, successful treatment options, and the most common causes. Written by leading experts, this is a widely accessible text and an indispensable guide for all general practitioners, junior doctors, nurses, and other healthcare professionals who are involved in the treatment and research of this common condition.

Cough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. "Cough: Causes, Mechanisms and Therapy" is the most comprehensive, up-to-date account of the subject.It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital respiratory units, and will also be of use to interested general practitioners.

Disease-related malnutrition is a global public health problem. The consequences of disease-related malnutrition are numerous, and include shorter survival rates, lower functional capacity, longer hospital stays, greater complication rates, and higher prescription rates. Nutritional support, in the form of oral nutritional supplements or tube feeding, has proven to lead to an improvement in patient outcome. This book is unique in that it draws together the results of numerous different studies that demonstrate the benefits of nutritional support and provides an evidence base for it. It also discusses the causes, consequences, and prevalence of disease-related malnutrition, and provides insights into the best possible use of enteral nutritional support.

This new edition of The Handbook of Memory Disorders has been completely rewritten to reflect the huge amount of new research in recent years on both the understanding of memory disorders and the assessment and treatment of patients. Written by a truly international team of experts, it offers an authoritative review of the key areas of research and development in this field.

Highlights of the second edition include:

• a new section on developmental memory disorders

• new chapters on frontal lobe deficits, confabulation and the neuropsychological basis of false memory

• discussion of research on animals and computational modelling

• a new chapter that overviews structural and functional imaging techniques.