In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.

Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000.

For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.

In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures.

He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.

These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

Die Forschung zu Diagnostik und Behandlung von Dysphagien verschiedenster Stoerungsbilder bei Erwachsenen und Kindern hat in Deutschland in den letzten zwanzig Jahren deutlich an Bedeutung gewonnen. Der Arbeitskreis Dysphagie Ostwestfalen-Lippe in Kooperation mit dem Studiengang der Klinischen Linguistik an der Universitat Bielefeld befasst sich im Rahmen einer zweijahrig stattfindenden Tagung speziell mit aktuellen Fragen dieser Thematik. Der vorliegende Band diskutiert aktuelle Forschungsfragen und Ergebnisse aus Diagnostik und Therapie.

Author of the international bestsellers The Diabetes Code and The Obesity Code Dr. Jason Fung returns with an eye-opening biography of cancer in which he offers a radical new paradigm for understanding cancer—and issues a call to action for reducing risk moving forward. Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline . . . but the “War on Cancer� has hardly been won. In The Cancer Code, Dr. Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease—what it is, how it manifests, and why it is so challenging to treat. In this rousing narrative, Dr. Fung identifies the medical community’s many missteps in cancer research—in particular, its focus on genetics, or what he terms the “seed� of cancer, at the expense of examining the “soil,� or the conditions under which cancer flourishes. Dr. Fung—whose groundbreaking work in the treatment of obesity and diabetes has won him international acclaim—suggests that the primary disease pathway of cancer is caused by the dysregulation of insulin. In fact, obesity and type 2 diabetes significantly increase an individual’s risk of cancer. In this accessible read, Dr. Fung provides a new paradigm for dealing with cancer, with recommendations for what we can do to create a hostile soil for this dangerous seed. One such strategy is intermittent fasting, which reduces blood glucose, lowering insulin levels. Another, eliminating intake of insulin-stimulating foods, such as sugar and refined carbohydrates. For hundreds of years, cancer has been portrayed as a foreign invader we’ve been powerless to stop. By reshaping our view of cancer as an internal uprising of our own healthy cells, we can begin to take back control. The seed of cancer may exist in all of us, but the power to change the soil is in our hands. 

"The Deadly Truth" chronicles the complex interactions between disease and the peoples of America from the pre-Columbian world to the present.

Grob's ultimate lesson is stark but valuable: there can be no final victory over disease. The world in which we live undergoes constant change, which in turn creates novel risks to human health and life. We conquer particular diseases, but others always arise in their stead. In a powerful challenge to our tendency to see disease as unnatural and its virtual elimination as a real possibility, Grob asserts the undeniable biological persistence of disease.

Diseases ranging from malaria to cancer have shaped the social landscape--sometimes through brief, furious outbreaks, and at other times through gradual occurrence, control, and recurrence. Grob integrates statistical data with particular peoples and places while giving us the larger patterns of the ebb and flow of disease over centuries. Throughout, we see how much of our history, culture, and nation-building was determined--in ways we often don't realize--by the environment and the diseases it fostered.

The way in which we live has shaped, and will continue to shape, the diseases from which we get sick and die. By accepting the presence of disease and understanding the way in which it has physically interacted with people and places in past eras, Grob illuminates the extraordinarily complex forces that shape our morbidity and mortality patterns and provides a realistic appreciation of the individual, social, environmental, and biological determinants of human health.

This second edition of the popular advanced student textbook (previously published as "Worms and Disease: A Manual of Medical Helminthology") has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. * An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control * Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.

Now that 5G ultra-wideband technology is here to stay, the harmful effects of electronic pollution are greater than ever. So what can we do to protect ourselves? The hazards of electronic pollution may once have been the stuff of science fiction, but now we know they're all too real. Dr Joseph Mercola, one of the world's foremost authorities on alternative health, has mined the scientific literature to offer a radical new understanding of how electromagnetic fields impact your body and mind. In this first-of-its-kind guide, he reveals: * What EMFs (electromagnetic fields) actually are, where you find them in your daily life and how they affect you * The toll that EMFs have been proven to take on conditions such as cancer, heart disease and neuropsychiatric illnesses * Why you've been largely kept in the dark about this threat to your health * How you can actually repair the damage done by EMFs at a cellular level * Practical strategies to protect yourself and your loved ones from EMFs at home, at work and out in the world The 5G technology is pervasive and powerful. It is also one of the largest public health experiments in history - with no way of opting out. That's why you need to read this book. Now.

Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer's disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens. The book's editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D'Agostino lend their oversight on their respective sections.

An inspiring collection of real-life stories from cancer survivors who followed the ground-breaking programme in NYT bestseller Radical Remission, alongside guidance for anyone starting their own healing journey. Thousands of readers have followed the 9 key factors from Radical Remission by Kelly A. Turner PhD and achieved successful remission - from cancer and more. Radical Hope co-writer Tracy White is one of the many who did so, and together Turner and White explore the real-life application of the Radical Remission principles and the people who have chosen to take this journey. Each chapter shares a survivor's in-depth story and their interpretation of a key factor in the Radical Remission lifestyle. Turner and White provide updated research and new tips for each factor and present a tenth key factor for integration into your healing approach. Male and female, younger and older, these survivors achieved remission by recognizing and committing to the fact that by taking ownership of their approach to healing, they would be giving themselves the best chance for a longer and healthier life. With warmth, realness and a true sense of hope, Turner and White shine the spotlight on the pure strength of our own being and offer steadfast support and guidance for making the unique and individual decisions that are best suited for your own journey of healing.

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Get ready to provide efficient, informed patient care, with the newly updated Professional Guide to Diseases , 11th Edition . This comprehensive guide offers the causes, signs and symptoms for more than 600 disorders, with expert nursing direction on tests, assessments, diagnosis, treatments, and special considerations. Whether you are a student preparing for board certification or are a new or experienced nurse, this is vital support for understanding correct treatment of the common conditions seen almost daily. Build up your ground-floor knowledge of a wide range of common disorders and diseases: NEW full-color figures and illustrations Boxed text on pathophysiology and prevention that helps reinforce difficult concepts Icons that emphasize important concepts: Elderly Tip, Pediatric Tip, Clinical Alert, Life-Threatening Disorder, and Confirming Diagnosis Consistent template that makes information quick and easy to find yet comprehensive enough to offer complete coverage of a group of similar diseases Expert guidance that leads you to targeted, cost-effective testing Chapters offer a thorough grounding in:Disorders found in individual body systems - Cardiovascular; respiratory; neurologic; gastrointestinal; hepatobiliary; musculoskeletal; renal and urologic; immune; hematologic; metabolic and nutritional; endocrine; eye; ear, nose and throat; skin; genetic; obstetric and gynecologic; sexual; and psychiatric Malignant neoplasms - Head, neck and spine; thorax; abdomen and pelvis; male and female genitalia; bone, skin and soft tissue; blood and lymph Infection - Gram-positive cocci, gram-negative cocci, gram-positive bacilli, gram-negative bacilli, spirochetes and mycobacteria, mycoses, respiratory viruses, rash-producing viruses, enteroviruses, arbovirus, miscellaneous viruses, rickettsia, protozoa, helminths Trauma - Head, neck and spine, thorax, abdomen, extremities, whole body Updated information on rare diseases, potential agents of bioterrorism, and complementary and alternative therapies for specific conditions, with additional coverage for more than 50 life-threatening disorders Detailed guidance on hundreds of commonly seen disorders and diseases in easy-to-read language - ideal for both graduate and undergraduate study Offers new nurses the confidence to function fully while building on-the-unit skills and know-how Small enough size to carry with you as a solid resource - informative, concise and organized for easy reference Your book purchase includes a complimentary download of the enhanced eBook for iOS (TM), Android (TM), PC and Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offline Easily convert to audiobook, powering your content with natural language text-to-speech Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks About the Clinical Editor Dr. Laura M. Willis, DNP, APRN-CNP,CMSRN, is a Family Nurse Practitioner at Urbana Family Medicine and Pediatrics in Urbana, Ohio

'Billy Connolly says he's no idea who Parkinson was and just wishes he'd kept his disease to himself. He should read this book.' Jeremy Paxman Parkinson's disease is one of the most common forms of dementia, with 10,000 new cases each year in the UK alone, and yet few know anything about the man the disease is named after. In 1817 - exactly 200 years ago - James Parkinson (1755-1824) defined the disease so precisely that we still diagnose it today by recognising the symptoms he identified. The story of this remarkable man's contributions to the Age of the Enlightenment is told through his three passions - medicine, politics and fossils. As a political radical Parkinson was interrogated over a plot to kill King George III and revealed as the author of anti-government pamphlets, a crime for which many were transported to Australia; while helping Edward Jenner set up smallpox vaccination stations across London, he wrote the first scientific study of fossils in English, which led to fossil-hunting becoming the nation's latest craze - just a glimpse of his many achievements. Cherry Lewis restores this neglected pioneer to his rightful place in history, while creating a vivid and pungent portrait of life as an 'apothecary surgeon' in Georgian London.

Fever has long been recognized as a symptom of disease. Until the past century it was considered a healthy sign; since then this view has changed and the use of drugs to reduce fever has grown quite common. Acting on the revival of interest as to whether the effects of fever are beneficial or harmful, Matthew Kluger and other physiologists began a series of experiments designed to resolve this question. This book synthesizes their research, making a case not only for the beneficial function of fever but also for the re-evaluation of current clinical practices regarding fever. Originally published in 1979. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

The two parts of this volume feature seventeen and six extended conference abstracts corresponding to selected talks given by participants at "Joint CRM-Imperial College Workshop in Complex Systems" and "Emergence, Spread and Control of Infectious Diseases" respectively, both held at the Centre de Recerca Matematica in Barcelona in spring 2013. Most of them are short articles giving preliminary presentations of new results not yet published in regular research journals. The articles are the result from a direct collaboration among active researchers in the area after working in a dynamic and productive atmosphere.Almost everything that is interesting and important for society is complex; here, examples scattered across science are presented in order to illustrate the cross-disciplinary richness of state-of-the-art complex systems research: fracture avalanches and rain showers that mimic earthquakes; highly organized graphs that account for processes in neural networks, metabolic networks, food webs, or language; models for DNA dynamics; or statistical methods to test complexity in the form of structure along many different scales. The mathematics is put to work for the modeling of the real system, and the models are kept at a minimum level to allow the understanding of the essentials of the real system. The book is intended for established researchers, as well as for PhD and postdoc students who wish to learn more about the latest advances in these active areas of research."

Originally published in 1915, this book gathers together a collection of papers on tuberculosis by the renowned British epidemiologist Arthur Ransome (1834 1922). The papers approach the subject from a number of different viewpoints, encompassing both scientific and public health perspectives, and draw on Ransome's experience of more than fifty years fighting tuberculosis. Illustrative figures and notes are also incorporated within the text. This book will be of value to anyone with an interest in tuberculosis and the history of medicine."

This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments. "

In this groundbreaking book, psychologist Daniel Lobel offers essential skills based in dialectical behavior therapy (DBT) and cognitive behavioral therapy (CBT) to help you understand your daughter's disorder, define appropriate boundaries, put an end to daily emergencies, and rebuild the family's structure from the ground up. If you have a daughter with borderline personality disorder (BPD), you may feel frustration, shame, and your family may be at the breaking point dealing with angry outbursts, threats, and constant emergencies. You may even feel guilty for not enjoying spending time with your child--but how can you when her behavior is abusive toward you and the rest of your family? You need solid skills you can use now to help your daughter and hold your family together. In this important guide, you'll learn real solutions and strategies based in proven-effective DBT and CBT to help you weather the storm of BPD and restore a sense of normalcy and balance in your life. You'll find an overview of BPD so you can better understand the driving forces behind your daughter's difficult behavior. You'll discover how you can help your daughter get the help she needs while also setting boundaries that foster respect and self-care for you and others in your family. And, most importantly, you'll learn "emergency parenting techniques" to help you put a stop to abusive patterns and restore peace.