This ground-breaking book brings together scholars from the humanities and social and physical sciences to address the question of how recent work in the genetics, zoology, and epidemiology of plague's causative organism (Yersinia pestis) can allow a rethinking of the Black Death pandemic and its larger historical significance. This book is available as Open Access.

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.

Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

"The Metabolic Syndrome" is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease.

"The Metabolic Syndrome" has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndromeBariatric surgery for obesityFitnessBrain insulin resistance and appetiteThe nature of the insulin resistance seen in metabolic syndrome.

This brand new edition of "The Metabolic Syndrome" will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

Subcortical Stroke is a new and fully revised edition of Lacunar and Other Subcortical Infarctions (OUP, 1995).

Stroke is one of the most common causes of death and subcortical stroke accounts for 20-30% of all cerebrovascular infarctions. Our understanding of stroke processes in general, and subcortical stroke in particular, has advanced considerably in recent years. Research findings from the fields of neurochemistry, imaging and genetics have provided insight and input to our understanding of this condition, and this new edition provides an opportunity to describe these advances, and to relate the findings to the clinical expression, neural mechanism, prognosis and treatment of subcortical stroke. In addition, new subcortical syndromes such as CADASIL are covered, as is subcortical haemorrhage.

This book presents a comprehensive and authoritative review of the field with contributions from the leading international experts.

Subcortical Stroke is for stroke physicians, neurologists and those researching cerebrovascular diseases.

Infectious disease pandemics are a rising threat in our globalizing world. This agenda-setting collection provides international analysis of the pressing sociological concerns they confront us with, from cross-border coordination of public health governance to geopolitical issues of development and social equity. * Focuses on vital sociological issues raised by resurgent disease pandemics * Detailed analysis of case studies as well as broader, systemic factors * Contributions from North America, Europe and Asia provide international perspective * Bold, agenda-setting treatment of a high-profile topic

Constipation and incontinence are of considerable importance to a great number of patients but many put it under taboo. Both functional disturbances comprise a wide spectrum of pathophysiological findings of neuro-muscular changes of the colon or the pelvic floor, but psychological factors may play an important role as well. In recent years much progress has been made in several disciplines which are important for the understanding and handling of constipation and incontinence. This volume, the proceedings of Falk Symposium No. 95 held in Freiburg, Germany, October 28-30, 1996, concentrates on clinically relevant and open questions rather than trying to cover the whole field in all details.

As the human lifespan increases, New York Times best-selling author Michael Roizen, M.D. offers an inspiring look into the future of longevity--and reveals how to prepare for a longer, healthier future. Believe it or not, living to 100, 120, or even 130 years old will become increasingly common over the next decade--and life past 100 may not be what you think. In this groundbreaking narrative, best-selling author Michael Roizen explains how cutting-edge science and technology will revolutionize your ability to live longer, younger, and better. As evidenced in the global press, today's breakthroughs in longevity research are unprecedented. This provocative yet practical book will help you prepare for the next major social disruptor by making the best decisions for your brain, your body, and your bank account. Dr. Roizen, along with acclaimed economists Peter Linneman and Albert Ratner, unpacks a wide swath of medical phenomena--from reengineering aging cells to DNA manipulation to bionic bodies--and shows how increased longevity will change our lives and our culture. They also provide a concrete action plan for good health, a youthful appearance, mental vigor, and strong finances in this brave new world. The most comprehensive and forward-looking take on aging to date, this indispensable book illuminates the prevention, treatment, and technology that will reshape how we think about old age--and help us plan for an audacious future.

The Gunner Goggles Series is the first exam prep resource written by a high-scoring peer group of medical students, ensuring the most practical and efficient study guidance. It organizes topics around the USMLE and NBME content outlines for the required shelf exams and features state-of-the-art Augmented Reality (AR) mobile application to extend learning beyond the book. This innovative series features AR opportunities throughout the text for an integrated print-mobile experience that maximizes learning and test preparation. The Gunner Goggle function allows you to scan pages for integrated AR links, unlocking animations, visuals, and 3D models that clarify complex anatomy, conditions, and concepts in a remarkably effective and unique manner. Gunner Goggles Series: Medicine is one of seven authoritative exam preparation guides that use cutting-edge AR technology to fully prepare you for the NBME clinical shelf exams, the USMLE Step 2 Clinical Knowledge (CK) exam, and successful clinical rotations. Topics are organized around the USMLE and NBME content outlines for specific shelf exams, and information is presented in a highly templated, concise manner. The Augmented Reality application allows you to efficiently study and learn using an integrated print-mobile approach. In addition to unlocking animations and other visuals, AR app access also includes additional content, links to provide feedback to the authors, community pages, and more. All test topics are covered in just enough detail to help you hone in on key points you must know for exam success. Unique! Every disease is described by its stem clues (buzzwords that appear in question stems) and prophylactic measures (PPx), mechanism (MoD), diagnostic tests (Dx) and treatment/management principles (Tx/Mgmt) - the four "Physician Tasks" that the NBME requires students to know about each disease. You'll also get real-world tips for your clinical rotations from your peers - information that won't show up on the shelf exam but is ideal for maximum impact when on rounds (knowing the prognosis for a specific disease, for example). Plus . effective study techniques, sample study schedules, tips and tricks to better retain information learned from review questions, and methods to self-generate mnemonics. Edited, written, and crowdsourced by high-performing medical students and residents and reviewed by experts in the field to ensure accuracy, relevancy, and accessibility. Titles in the Gunner Goggles series: Family Medicine . Print ISBN: 978-0-323-51034-9 . e-Book ISBN: 978-0-323-52756-9 Medicine . Print ISBN: 978-0-323-51035-6 . e-Book ISBN: 978-0-323-52758-3 Neurology . Print ISBN: 978-0-323-51036-3 . e-Book ISBN: 978-0-323-52760-6 Ob-Gyn . Print ISBN: 978-0-323-51037-0 . e-Book ISBN: 978-0-323-52768-2 Pediatrics . Print ISBN: 978-0-323-51038-7 . e-Book ISBN: 978-0-323-52763-7 Psychiatry . Print ISBN: 978-0-323-51039-4 e-Book ISBN: 978-0-323-52765-1 Surgery . Print ISBN: 978-0-323-51040-0 . e-Book ISBN: 978-0-323-52767-5

The importance of appropriate and effective management of patient with long term chronic conditions cannot be underestimated, and both the Department of Health and the public are expecting much from the improvements and changes outlined in the recently published review by Lord Darzi.
"Case Management of Long Term Conditions" aims to provide all appropriate practitioners across all the professions (nurses, pharmacists, physiotherapists including social care practitioners) who might be involved in delivery of proactive case management with a practical understanding of how their knowledge and skills can be utilised to improve outcomes for people with Chronic Long Term Conditions. The text contains some broad reflections on care and service delivery based on reviews of evidence and views from clinicians in the use of these skills and competencies to deliver improved outcomes for these clients.

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Obesity is an increasing problem in the UK, affecting a large proportion of men, women and children. The ABC of Obesity is a new guide which will aid its effective management, addressing issues such as dieting, exercise, self esteem, drug treatment and surgery. Recent evidence is used to highlight frequent problems, successful treatment options, and the most common causes. This is an indispensable guide for all general practitioners, junior doctors, nurses, and other healthcare professionals who are involved in the treatment of this common condition. Obesity is a hugely expensive and increasing problem worldwide, leading to disability, reproductive problems, depression and accelerated metabolic and vascular diseases in a large proportion of men, women and children. The ABC of Obesity is a new guide which will aid its effective management, addressing issues such as dieting, exercise, self esteem, drug treatment and surgery. Recent evidence is used to highlight frequent problems, successful treatment options, and the most common causes. Written by leading experts, this is a widely accessible text and an indispensable guide for all general practitioners, junior doctors, nurses, and other healthcare professionals who are involved in the treatment and research of this common condition.

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain. Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context. By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

Cough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. "Cough: Causes, Mechanisms and Therapy" is the most comprehensive, up-to-date account of the subject.It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital respiratory units, and will also be of use to interested general practitioners.

Disease-related malnutrition is a global public health problem. The consequences of disease-related malnutrition are numerous, and include shorter survival rates, lower functional capacity, longer hospital stays, greater complication rates, and higher prescription rates. Nutritional support, in the form of oral nutritional supplements or tube feeding, has proven to lead to an improvement in patient outcome. This book is unique in that it draws together the results of numerous different studies that demonstrate the benefits of nutritional support and provides an evidence base for it. It also discusses the causes, consequences, and prevalence of disease-related malnutrition, and provides insights into the best possible use of enteral nutritional support.

Intensivmedizin zum Nachschlagen und Lernen fur die Zusatzbezeichnung "Intensivmedizin". Das Repetitorium Intensivmedizin stellt das Fach der Intensivmedizin kompakt und fundiert dar und gehoert in die Reihe der Repetitorien, die sich hervorragend zur Prufungsvorbereitung oder Beantwortung von Fragen im Klinikalltag eignen. Alle Inhalte sind systematisch und ubersichtlich dargestellt und klar und pragnant in den Aussagen. Zahlreiche Schemazeichnungen und Tabellen erleichtern das Verstandnis und bundeln Informationen. Das Werk erscheint bereits in der 5. Auflage. Dieses ist komplett aktualisiert und erscheint in neuem Layout. Das Werk richtet sich an alle auf einer Intensivstation tatigen AErzte.

Get ready to provide efficient, informed patient care, with the newly updated Professional Guide to Diseases , 11th Edition . This comprehensive guide offers the causes, signs and symptoms for more than 600 disorders, with expert nursing direction on tests, assessments, diagnosis, treatments, and special considerations. Whether you are a student preparing for board certification or are a new or experienced nurse, this is vital support for understanding correct treatment of the common conditions seen almost daily. Build up your ground-floor knowledge of a wide range of common disorders and diseases: NEW full-color figures and illustrations Boxed text on pathophysiology and prevention that helps reinforce difficult concepts Icons that emphasize important concepts: Elderly Tip, Pediatric Tip, Clinical Alert, Life-Threatening Disorder, and Confirming Diagnosis Consistent template that makes information quick and easy to find yet comprehensive enough to offer complete coverage of a group of similar diseases Expert guidance that leads you to targeted, cost-effective testing Chapters offer a thorough grounding in:Disorders found in individual body systems - Cardiovascular; respiratory; neurologic; gastrointestinal; hepatobiliary; musculoskeletal; renal and urologic; immune; hematologic; metabolic and nutritional; endocrine; eye; ear, nose and throat; skin; genetic; obstetric and gynecologic; sexual; and psychiatric Malignant neoplasms - Head, neck and spine; thorax; abdomen and pelvis; male and female genitalia; bone, skin and soft tissue; blood and lymph Infection - Gram-positive cocci, gram-negative cocci, gram-positive bacilli, gram-negative bacilli, spirochetes and mycobacteria, mycoses, respiratory viruses, rash-producing viruses, enteroviruses, arbovirus, miscellaneous viruses, rickettsia, protozoa, helminths Trauma - Head, neck and spine, thorax, abdomen, extremities, whole body Updated information on rare diseases, potential agents of bioterrorism, and complementary and alternative therapies for specific conditions, with additional coverage for more than 50 life-threatening disorders Detailed guidance on hundreds of commonly seen disorders and diseases in easy-to-read language - ideal for both graduate and undergraduate study Offers new nurses the confidence to function fully while building on-the-unit skills and know-how Small enough size to carry with you as a solid resource - informative, concise and organized for easy reference Your book purchase includes a complimentary download of the enhanced eBook for iOS (TM), Android (TM), PC and Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time - providing a seamless reading experience online or offline Easily convert to audiobook, powering your content with natural language text-to-speech Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks About the Clinical Editor Dr. Laura M. Willis, DNP, APRN-CNP,CMSRN, is a Family Nurse Practitioner at Urbana Family Medicine and Pediatrics in Urbana, Ohio

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

"The Deadly Truth" chronicles the complex interactions between disease and the peoples of America from the pre-Columbian world to the present.

Grob's ultimate lesson is stark but valuable: there can be no final victory over disease. The world in which we live undergoes constant change, which in turn creates novel risks to human health and life. We conquer particular diseases, but others always arise in their stead. In a powerful challenge to our tendency to see disease as unnatural and its virtual elimination as a real possibility, Grob asserts the undeniable biological persistence of disease.

Diseases ranging from malaria to cancer have shaped the social landscape--sometimes through brief, furious outbreaks, and at other times through gradual occurrence, control, and recurrence. Grob integrates statistical data with particular peoples and places while giving us the larger patterns of the ebb and flow of disease over centuries. Throughout, we see how much of our history, culture, and nation-building was determined--in ways we often don't realize--by the environment and the diseases it fostered.

The way in which we live has shaped, and will continue to shape, the diseases from which we get sick and die. By accepting the presence of disease and understanding the way in which it has physically interacted with people and places in past eras, Grob illuminates the extraordinarily complex forces that shape our morbidity and mortality patterns and provides a realistic appreciation of the individual, social, environmental, and biological determinants of human health.

"The Body Multiple" is an extraordinary ethnography of an ordinary disease. Drawing on fieldwork in a Dutch university hospital, Annemarie Mol looks at the day-to-day diagnosis and treatment of atherosclerosis. A patient information leaflet might describe atherosclerosis as the gradual obstruction of the arteries, but in hospital practice this one medical condition appears to be many other things. From one moment, place, apparatus, specialty, or treatment, to the next, a slightly different "atherosclerosis" is being discussed, measured, observed, or stripped away. This multiplicity does not imply fragmentation; instead, the disease is made to cohere through a range of tactics including transporting forms and files, making images, holding case conferences, and conducting doctor-patient conversations.

"The Body Multiple" juxtaposes two distinct texts. Alongside Mol's analysis of her ethnographic material--interviews with doctors and patients and observations of medical examinations, consultations, and operations--runs a parallel text in which she reflects on the relevant literature. Mol draws on medical anthropology, sociology, feminist theory, philosophy, and science and technology studies to reframe such issues as the disease-illness distinction, subject-object relations, boundaries, difference, situatedness, and ontology. In dialogue with one another, Mol's two texts meditate on the multiplicity of reality-in-practice.

Presenting philosophical reflections on the body and medical practice through vivid storytelling, "The Body Multiple" will be important to those in medical anthropology, philosophy, and the social study of science, technology, and medicine.

This second edition of the popular advanced student textbook (previously published as "Worms and Disease: A Manual of Medical Helminthology") has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. * An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control * Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.