This User's Guide advises readers on the many beneficial supplements for reducing pain. These pain-relieving supplements include fish oils, B vitamins, glucosamine, MSM and more traditional homeopathic remedies. The authors also describe how life's stresses can exacerbate pain, and offer simple pain-reducing exercises and stretches.

Pain is the number-one reason American visit their doctors, Back pain, muscle aches, arthritis affect millions of people daily, limiting their activities and costing billions in medical care. Much of this suffering is unnecessary. Where It Hurts and Why can help readers take charge of their pain and become proactive in their own recovery. Individual chapters provide detailed recommendations for specific areas of the body, and also instructions for immediate treatment of acute pain.

In the Age of Sail scurvy was responsible for more deaths at sea than piracy, shipwreck and all other illnesses, and its cure ranks among the greatest of military successes - yet its impact on history has mostly been ignored. Stephen Bown searches back to the earliest recorded appearance of scurvy in the sixteenth century, to the eighteenth century when the disease was at its gum-shredding, bone-snapping worst, and to the early nineteenth century, when the preventative was finally put into service. Bown introduces us to James Lind, the navy surgeon and medical detective, whose research on the disease spawned the implementation of the cure; Captain James Cook, who successfully avoided scurvy on his epic voyages; and Gilbert Blane, whose social status and charisma won over the British Navy. Scurvy is a lively recounting of how three determined individuals overcame the constraints of eighteenth-century thinking to solve the greatest medical mystery of their era.

355 articles arranged under the following sections: B and T Cells of the Mucosal Immune System: Trafficking and Cytokine Regulation. Nonlymphoid Cells of the Mucosal Immune System: Epithelial Cells, APC, and Other Cell Types. Development of Mucosal Immunity: Reproductive Tract, Ontogeny, Phylogeny, and Immunodeficiency. Gnotobiology, Environmental, Nutritional, and Intrinsic Factors in Mucosal Immunology. Structure, Proteolysis, and Function of Mucosal Immunoglobulins: Cellular Receptors. Clinical Immunology, Immunopathology, Immunodeficiency, and Allergology. Microbial, Parasite, and HIV Mucosal Infections. Immunology of the Liver. Oral Immunology and Immunopathology. Autoimmunity, Oral Tolerance, and Aging. Chronic Inflammation, Inflammatory Bowel Diseases and Celiac Disease. Induction of Mucosal Immune Responses and Vaccine Delivery Systems. Index.

Molecular diagnosis and gene therapy are of increasing interest and importance in clinical medicine. The increasing understanding of the pathogenesis of human diseases at the molecular level opens new perspectives for their diagnosis, prevention and therapy. The first part of this book, the proceedings of Falk Symposium No. 88 'Molecular Diagnosis and Gene Therapy', held in Basel, Switzerland, October 22-23, 1995, is aimed at an in-depth understanding of the methodology of molecular diagnosis by hybridization analysis, polymerase chain reaction and others. Further, the applications and limitations of these technologies in clinical medicine for the detection of genetic, malignant and infectious diseases are reviewed. In the second part of the book, the basic strategies of gene therapy are presented, including gene transfer and targeting. Further, experimental and clinical applications of gene therapy strategies for the prevention and treatment of hepatic and other diseases are presented. Molecular diagnosis and gene therapy are clearly going to be key elements of clinical medicine after the year 2000. In this sense, the book should allow basic scientists as well as clinicians to be informed about the state-of-the-art of molecular diagnosis and gene therapy and should provide a perspective for future developments in molecular medicine.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

This book synthesizes the flourishing field of anthropology of infectious disease in a critical, biocultural framework. Leading medical anthropologist Merrill Singer holistically unites the behaviors of microorganisms and the activities of complex social systems, showing how we exist with pathogenic agents of disease in a complex process of co-evolution. He also connects human diseases to larger ecosystems and various other species that are future sources of new human infections. Anthropology of Infectious Disease integrates and advances research in this growing, multifaceted area and offers an ideal supplement to courses in anthropology, public health, development studies, and related fields.

th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The #1 guide to behavioral issues in medicine delivering thorough, practical discussion of the full scope of the physician-patient relationship "This is an extraordinarily thorough, useful book. It manages to summarize numerous topics, many of which are not a part of a traditional medical curriculum, in concise, relevant chapters."--Doody's Review Service - 5 stars, reviewing an earlier edition The goal of Behavioral Medicine is to help practitioners and students understand the interplay between psychological, physical, social and cultural issues of patients. Within its pages readers will find real-world coverage of behavioral and interactional issues that occur between provider and patient in everyday clinical practice. Readers will learn how to deliver bad news, how to conduct an effective patient interview, how to care for patients at the end of life, how to clinically manage common mental and behavioral issues in medical patients, the principles of medical professionalism, motivating behavior change, and much more. As the leading text on the subject, this trusted classic delivers the most definitive, practical overview of the behavioral, clinical, and social contexts of the physician-patient relationship. The book is case based to reinforce learning through real-world examples, focusing on issues that commonly arise in everyday medical practice and training. One of the significant elements of Behavioral Medicine is the recognition that the wellbeing of physicians and other health professionals is critically important to caring for patients.

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand receptor and ligand enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.

Depression is one of the most common forms of psychological distress and can have devastating consequences for individuals and their loved ones. Decades of research have shown that there are many possible causes of depression, and one of those causes involves problems with self-regulation. Self-regulation involves setting and pursuing important personal goals - put simply, the process of trying to be the kind of person you want to be. Self-System Therapy for Depression: Therapist Guide provides a thorough description of Self-System Therapy (SST)-a motivational approach to treating depression that helps decrease feelings of disappointment and failure and increase feelings of pride and accomplishment, by improving the process of self-regulation. Clinical studies have shown that SST is effective in reducing depression and anxiety. The treatment program is structured within a 16-session plan, and strategies and techniques for each phase of treatment are presented in detail, along with case vignettes and examples. The core strategies of SST focus on identifying appropriate and reasonable personal goals and standards (including coping with perfectionistic standards), evaluating and improving the effectiveness of goal pursuit strategies, and adjusting goals in order to improve opportunities for positive emotions. The accompanying Client Workbook explains the basics of self-regulation in simple terms and provides worksheets to help illustrate and implement these strategies.

A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena. Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, Analysis of Complex Diseases: A Mathematical Perspective presents a holistic approach for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. Using mathematics to identify patterns of deviation from normality, or the healthy state-spanning multiple levels from molecules to the organism-the author identifies a range of dynamical behaviors that correspond to either cellular physiology or pathology. He uses the information from multiple levels in order to develop a unified theory, which includes the discovery that certain diseases may stem from well-evolved, useful mechanisms activated in the wrong context. This book is divided into three parts. Part I focuses on the organismal level to describe normal physiology and how the body as a whole meets its functional requirements. Part II addresses the subcellular, molecular level to elucidate the organizing principles of cellular biomolecules to meet the demands of the organism. Part III examines complex diseases by combining information from the organismal level and the molecular level, offering a paradigm that can be extended to the study of other categories of diseases.

This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimer’s disease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer. Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.

This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity and conclusive remarks and areas for future research. The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis and lead to the unraveling of their mechanisms of diseases and to novel treatments.

Since the dawn of the industrial age, we have unleashed a bewildering number of potentially harmful chemicals. But out of this vast array, how do we identify the actual threats? What does it take to prove that a certain chemical causes cancer? How do we translate academic knowledge of the toxic effects of particular substances into understanding real-world health consequences? The science that answers these questions is toxicology. In The Alchemy of Disease, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases. Balancing clear accounts of groundbreaking science with human drama and public-policy relevance, Whysner describes key moments in the development of toxicology and their thorny social and political implications. The book features discussions of toxicological problems past and present, including DDT, cigarettes and other carcinogens, lead poisoning, fossil fuels, chemical warfare, pharmaceuticals-including opioids-and the efficacy of animal testing. Offering valuable insight into the science and politics of crucial public-health concerns, The Alchemy of Disease shows that toxicology's task-pinpointing the chemical cause of an illness-is as compelling as any detective story.

Rabies is the deadliest zoonotic disease that threatens humans and animals on all continents except Antarctica. Asia and Africa are worst affected as more than 95 per cent of rabies associated human deaths occur in these regions. India alone bears about 36 per cent of the global human rabies burden. Dogs are the main transmitters of rabies that potentially threaten over 3 billion people in Asia and Africa. Many developed nations have been able to successfully control dog rabies but continue to face the risk from wildlife including bats. Bat rabies is responsible for most human rabies deaths in the United States of America and Canada but has emerged as a public health threat in Australia, Latin America and Western Europe as well. Despite being vaccine preventable, rabies continues to haunt the mankind. Poor resources is a major constraint but the factors like low priority attributed to rabies, misconceptions in the community about the disease and unsystematic approach for its prevention and control are also responsible for the grim situation. Targets have been set for elimination of human and dog rabies in all Latin American countries by 2015 and of human rabies transmitted by dogs in South-East Asia by 2020. However, the myths prevailing among the people together with inadequate knowledge of the health professionals, veterinarians, and the civic body staff about the rabies prevention and control strategies might make the task very difficult. This book comprising eight chapters elaborates the causation of rabies in man and animals, its global epidemiology, risk analysis and effective strategies for the management of exposures. Proven methods of rabies prevention and control have been discussed in length along with the challenges and ways to overcome the constraints through intersectoral coordination. The inclusion of 200 frequently asked questions is a unique feature of the book which may help not only the common people and pet lovers in clearing their doubts about rabies in man and animals also be equally instrumental in updating the knowledge and skills of the public health personnel, veterinarians and other professionals. Apt illustrations and simple language make the contents of the book easily comprehensible and a reading pleasure.

Parkinson’s Disease (PD) is a progressive neurodegenerative disease with a prevalence of 0.1% of the global population, and 5-10% patients are under 40 years of age. Several text books have been published on various aspects of PD to date, including research and clinical aspects. However these do not emphasize the inflammatory pathways and pathways of neurodegeneration in PD. Inflammation in Parkinson’s Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.