The overall objective of this book is to provide standards for the knowledge, skills, and attitudes expected of all hospitalists and to provide a framework for ongoing professional and curriculum development for learners at all levels. The framework is intended for use by hospital medicine program directors, directors of medical student clerkships, residency programs, fellowships, and continuing medical education, as well as other educators involved in curriculum development. The competencies do not focus on specific content, but rather general learning objectives within the skills, knowledge, and attitudes related to each topic. Attaining competency in the areas defined in these chapters is expected to require post-residency training. This training is most likely to be obtained through a combination of work experience, local mentorship, and engagement in specific educational programs or fellowship. Hospitalists, directors, and educators can create specific instructional activities and methods chosen to reflect the characteristics of the intended learners and context of the practice environment.

Within each section, individual chapters on focused topics provide competencies in three domains of educational outcomes: the Cognitive Domain (Knowledge), the Psychomotor Domain (Skills), and the Affective Domain (Attitudes). To reflect the emphasis of hospital medicine practice on improving healthcare systems, a fourth section entitled Systems Organization and Improvement is also included. An attempt has been made to make the objectives timeless, allowing for creation of curriculum that can be nimble and reactive to new discoveries.

Although the entire document can be a resource for comprehensive program development, each chapter is intended to stand-alone and thus support curriculum development specific to the needs of individual programs.

This book contains selected contributions to the 16th European Conference on Psychosomatic Research, held in Athens from September 6 to 11, 1986. The t of psychosomatic medicine was one of the two basic topics of the meeting. We thought that, since this topic has a touch of history in it, it would be appropriate for a conference held in Greece. It is really amazing how advanced the psychosomatic conceptions of the ancient Greek philosophers and physicians were. It was the basic psychosomatic ideology that Socrates was expressing when he taught: "S"lOTT :: P O

The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.

Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.

This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

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This volume contains contributions by well-known scientists and clinicians in the fields of microbiology, infectious diseases, physiology, internal medicine, surgery, anaesthesiology, and intensive care medicine. It provides an up-to-date overview of the mediators and pathophysology of sepsis and septic shock as well as the latest therapeutic approaches.

Jaundice ofnewbom infants was described by several authors in the 17th century. The condition, however, was usually thought of as being similar to adult jaundice and due ro occlusion of the bile ducts by 'glutinous humours'. On the other hand, some writers reported on the fact that more than one consecutive baby was often affected, and there is a classic example of the disease in twins written by Louyse Bourgeois, the midwife of Marie de Medici, in 1609. It was not until early in the 20th century that it was realised that the common link between these familial cases was anaemia, and later still that this was of the haemolytic type. The breakthrough, in terms of an idea, came in 1938, when Darrow postulated that the baby's red cells were destroyed by an immune reaction on the part of the mother, the result of immunisation by paternal factors in the fetus. Shortly afterwards Wiener discovered an entirely new blood group system, 'Rh', and it was found that it was in compatibility within this system that was responsible for the vast majority of cases of haemolytic disease of the newborn."

In this work, leading physicians; hepatologists; pharmacologists; pathologists; and transplant surgeons discuss the most recent advances in the field of liver disease and its treatment. Attention is focused on epidemiology; the diagnosis of disease (clinical chemistry, histopathology, medical imaging analysis); prognosis; prediction; and clinical management. Pathogenesis of diseases such as liver cirrhosis following viral disease or alcohol abuse are discussed at length, and special attention is dedicated to high risk patients (children, fulminant hepatitis). The other major topics include terminal liver failure, for which transplantation is now routine. The latter is discussed in depth, starting from the organ donor management; organ evaluation and preservation; new surgical techniques; post-transplant patient follow-up including side effects of immunosuppression; and reports of the latest drugs used to prevent rejection.

Drawing from many disciplinary areas, this edited volume explores how the Coronavirus pandemic has disproportionately harmed vulnerable and marginalized people in the U.S. Chapters address harm to people of color that exacerbated structural racism and harm to low-wage workers that highlighted existing inequalities. In addition, the volume provides strategies that have been successful in mitigating these harms and recommendations for a postpandemic more peaceful and just future.

Thousands of people from more than eighty countries have traveled to China since 2001 to undergo fetal cell transplantation. Galvanized by the potential of stem and fetal cells to regenerate damaged neurons and restore lost bodily functions, people grappling with paralysis and neurodegenerative disorders have ignored the warnings of doctors and scientists back home in order to stake their futures on a Chinese experiment. Biomedical Odysseys looks at why and how these individuals have entrusted their lives to Chinese neurosurgeons operating on the forefront of experimental medicine, in a world where technologies and risks move faster than laws can keep pace. Priscilla Song shows how cutting-edge medicine is not just about the latest advances in biomedical science but also encompasses transformations in online patient activism, surgical intervention, and borderline experiments in health care bureaucracy. Bringing together a decade of ethnographic research in hospital wards, laboratories, and online patient discussion forums, Song opens up important theoretical and methodological horizons in the anthropology of science, technology, and medicine. She illuminates how poignant journeys in search of fetal cell cures become tangled in complex webs of digital mediation, the entrepreneurial logics of postsocialist medicine, and fraught debates about the ethics of clinical experimentation. Using innovative methods to track the border-crossing quests of Chinese clinicians and their patients from around the world, Biomedical Odysseys is the first book to map the transnational life of fetal cell therapies.

Francois Delaporte's Chagas Disease chronicles Brazilian medicine's encounter with a disease, an insect, and a history of discovery. Between 1909 and 1911, Carlos Chagas described an infection (pathogenic trypanosome), its intermediate host, and the illness that he believed it caused, parasitic thyroiditis. Chagas's work did not lack significance: the disease that came to share his name would be one of Latin America's most serious endemic diseases. However, the clinical identification of the disease through "Romana's sign" (a palpebral edema or swelling of the eyelid) some decades later marked a transformation in the general medical knowledge of the disease and its basis altogether. Not only was the disease entity that Chagas had described shown to be a nosological illusion, but twenty-five years of scientific controversy turned out to have been based on a misunderstanding. The continued use of the term "Chagas's Disease" even after Cecilio Romana's discovery thus refers to a fundamental ambiguity. Delaporte dispels this ambiguity by re-examining the various discoveries, dead ends, controversies, and major epistemological transformations that marked the history of the disease--a history that begins with the creation of the Oswaldo Cruz Institute in Rio de Janeiro and ends in the forests of Santa Fe in northern Argentina. Delaporte's study shows how an epistemological focus can add depth to the history of medicine and complexity to accounts of scientific discovery.

Sir Francis Avery Jones 149 Harley Street, London, WlN 2DE, U.K. This first international symposium on Mucus in Health and Disease brought together medical scientists, physiologists, pharmacologists, physicians, surgeons, gynaecologists, ophthalmologists, anatomists, biologists, medical engineers and biochemists - a spectrum which indicates the wide field of interest in mucus both in health and in disease. The idea for the meeting came from Dr. S. Gottfried whose researches led to the development of carbenoxolone, a substance which stimulates mucus production and in this way favours the healing of peptic ulcers. The idea was enthusiastically welcomed by Professor Dennis Parke and he, and Mr. Max Elstein, have been the dynamo behind the meeting. The opening keynote address by Professor Clamp set the scene for the Symposium, painting a broad canvas and highlighting the main features. We cannot do without mucus, irritating though it may be if there is too much or too little, and in so many systems of the body it plays a vital role. For the first time the specialists in different systems of the body have had the opportunity of coming together and discussing their special problems - a cross-fertilisation which proved to be most valuable, not only for one another but also for the medical scientists who had been closely concerned with the chemistry and physical properties of mucus.

This book presents the proceedings of the meeting on "Lipid Storage Disorders" which took place in Toulouse, France, in September 14-18, 1987 and which was set up as a joint NATO Advanced Research Workshop and INSERM International Symposium. The meeting probably was the first truly international symposium devoted entirely to basic as well as applied aspects of lipid metabolism as related to the lipid storage disorders. Participants came from Europe, USA, Israel and Japan, and presented data on research in molecular biology and genetics, enzymology, cell biology as well as medical and epidemiological aspects of normal and pathological lipid metabolism. In the latter case, special attention was directed to the lysosomal B-glucosidase in relation to Gaucher disease and to sphin gomyelinase in relation to Niemann-Pick disease, and "two round" table discussions were devoted to the two respective items. But research on many other lipidoses was presented, as lectures or posters and avidly discussed. Other topics presented in special sessions were drug induced lipidoses and peroxisomal disorders. The meeting ended with a session devoted to medical aspects of disorders of lipid metabolism. The symposium which included about 50 lectures and close to 70 posters had an intense scientific character superimposed on a most pleasant and collegial atmosphere. Ample time was provided to personal discussions; lodging of the participants in the students' residence located near the meeting place, permitted further contacts between them."

Since the dawn of the industrial age, we have unleashed a bewildering number of potentially harmful chemicals. But out of this vast array, how do we identify the actual threats? What does it take to prove that a certain chemical causes cancer? How do we translate academic knowledge of the toxic effects of particular substances into understanding real-world health consequences? The science that answers these questions is toxicology. In The Alchemy of Disease, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases. Balancing clear accounts of groundbreaking science with human drama and public-policy relevance, Whysner describes key moments in the development of toxicology and their thorny social and political implications. The book features discussions of toxicological problems past and present, including DDT, cigarettes and other carcinogens, lead poisoning, fossil fuels, chemical warfare, pharmaceuticals-including opioids-and the efficacy of animal testing. Offering valuable insight into the science and politics of crucial public-health concerns, The Alchemy of Disease shows that toxicology's task-pinpointing the chemical cause of an illness-is as compelling as any detective story.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

This book discusses how human beings cope with serious physical ill ness and injury. A conceptual model for understanding the process of coping with the crisis of illness is provided, and basic adaptive tasks and types of coping skills are identified. The major portion of the book is organized around various types of physical illness. These physical illnesses, which almost all people face either in themselves or their family members, raise common relevant coping issues. The last few sections cover "the crisis of treatment," emphasizing the importance of unusual hospital environments and radical new medical treatments, of stresses on professional staff, and of issues related to death and the fear of dying. The material highlights the fact that people can successfully cope with life crises such as major ill ness and inj ury, rather than the fact that severe symptoms and/or breakdowns sometimes occur. The importance of support from professional care-givers, such as physicians, nurses, and social workers, and from family, friends, and other sources of help in the community, is emphasized. Many of the selections include case examples which serve to illustrate the material. Coping with Physical Illness has been broadly conceived to meet the needs of a diverse audience. There is substantial information about how human beings cope with illness and physical disability, but this material has never been collected in one place.

If you've been diagnosed with OCD, you already understand how your obsessive thoughts, compulsive behavior, and need for rituals can interfere with everyday life. Maybe you've already undergone therapy or are in the midst of working with a therapist. It's important for you to know that life doesn't end with an OCD diagnosis. In fact, it is possible to not only live with the disorder, but also live joyfully. This practical and accessible guide will show you how. In Everyday Mindfulness for OCD, you will discover how you can stay one step ahead of your OCD. You'll learn about the world of mindfulness, and how living in the present moment non-judgmentally is so important when you have OCD. You'll also explore the concept of self-compassion; what it is, what it isn't how to use it, and why people with OCD benefit from it. Finally, you'll discover daily games, tips, and tricks for outsmarting your OCD, meditations and mindfulness exercises, and much, much more. Living with OCD is challenging; but it doesn't have to define you. If you are tired of focusing on how you are living with OCD is and are looking for fun ways to make the most of your unique self, this book will be a breath of fresh air.

Drawing from many disciplinary areas, this edited volume explores how the Coronavirus pandemic has disproportionately harmed vulnerable and marginalized people in the U.S. Chapters address harm to people of color that exacerbated structural racism and harm to low-wage workers that highlighted existing inequalities. In addition, the volume provides strategies that have been successful in mitigating these harms and recommendations for a postpandemic more peaceful and just future.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Do you suffer from ongoing pain or other chronic medical symptoms such as fatigue, lower back pain, arthritis, acid indigestion, insomnia, or migraines? Do you feel as though your symptoms are taking over your life?

Thirty percent of the population suffers from chronic debilitating illnesses and pain that respond only partially to conventional medicine, but this doesn't mean that there is no relief in sight. Dr. Arthur Barsky, psychiatrist and pioneer in the field of mind-body medicine, has found that changing the way you think about your illness can have a remarkable effect on how you experience your symptoms. The groundbreaking program he offers in "Stop Being Your Symptoms and Start Being Yourself" teaches patients to master the five psychological factors that make chronic symptoms persist through hundreds of exercises, worksheets, and patient examples.

You may not be able to completely eliminate your medical symptoms, but it is possible to control your symptoms rather than letting them control you--and this book shows you how.

Now in paperback, the bestselling exploration of the effects of the mind-body connection on stress and disease

Can a person literally die of loneliness? Is there such a thing as a ""cancer personality""? Drawing on scientific research and the author's decades of experience as a practicing physician, this book provides answers to these and other important questions about the effect of the mind-body link on illness and health and the role that stress and one's individual emotional makeup play in an array of common diseases.Explores the role of the mind-body link in conditions and diseases such as arthritis, cancer, diabetes, heart disease, IBS, and multiple sclerosisDraws on medical research and the author's clinical experience as a family physicianIncludes The Seven A's of Healing-principles of healing and the prevention of illness from hidden stress

Shares dozens of enlightening case studies and stories, including those of people such as Lou Gehrig (ALS), Betty Ford (breast cancer), Ronald Reagan (Alzheimer's), Gilda Radner (ovarian cancer), and Lance Armstrong (testicular cancer)

An international bestseller translated into fifteen languages, "When the Body Says No" promotes learning and healing, providing transformative insights into how disease can be the body's way of saying no to what the mind cannot or will not acknowledge.

The increased incidence of pancreatic cancer in the Western world and its grave prognosis has resulted in an urgency for research in this area. Until now the available data on toxicology of the pancreas has been few and fragmentary, scattered throughout the literature. A benchmark volume, Toxicology of the Pancreas pulls together information in this neglected area of toxicological research and highlights fundamental research performed in the last ten years. Leaders in the field discuss important structures, the detoxification and toxification process at the cellular and sub-cellular level, the distribution of phase 1 and phase 2 drug-metabolizing enzymes and their role in pancreatic disease, and the role of diet and toxicants on pancreatic disease. The book also covers the role of altered genes in the integrity of the pancreas and explores comparative toxicology in humans and in the lab species used in testing. Illustrated with histological, electron microscopical, and immunohistochemical formats, this book provides a comprehensive and novel presentation of biological and toxicological data. It stands alone as a reliable resource of information easily accessible to professionals in different disciplines.

This book describes and discusses the assessment and treatment techniques applied by Occupational Therapists (OTs) to sufferers from Multiple Sclerosis (MS). The text begins with basic information about MS and follows this with suggestions for assessment and treatment. Then the specific issues of work, fatigue, leisure, mobility and the home are considered in detail. The needs of people who reach the later stages of the disease are discussed, as are the needs and concerns specific to carers of those with MS. Contact details are provided for many of the services and agencies mentioned in the text. Insight into the impact of MS on peoplea s lives is provided by individuals with MS.