Considering the impact of translational breakthroughs on the early detection, diagnosis, prevention, and treatment of breast cancer, this all-encompassing guide collects cutting-edge research on the most promising strategies and agents likely to impact the management and long-term outcomes of women with breast cancer. This book will provide current information on rapidly evolving translational therapies, as well as improved strategies for the selection of patients for these treatments.

In this issue of Critical Care Clinics, guest editors Drs. Robert M. Kliegman and Brett J. Bordini bring their considerable expertise to the topic of Undiagnosed and Rare Diseases in Critical Care. Top experts in the field cover key topics such as critical genetic arrhythmia disorders, uncommon causes of rhabdomyolysis, status epilepsy syndromes, autoimmune encephalitis, rapid-onset paralysis and weakness, and more. Contains 17 relevant, practice-oriented topics including understanding cognitive diagnostic errors in the ICU; rapid WES/WGS in the ICU; diagnostic time-outs to improve diagnosis; when "sepsis" is not sepsis: MAS, HLH, malignancies and other sepsis mimics; all that wheezes is not asthma or bronchiolitis; and more. Provides in-depth clinical reviews on undiagnosed and rare diseases in critical care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

About the book: Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain. Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology and ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes; analyses the latest scientific advances including the role of functional imaging in patient care; integrates fundamental scientific concepts with a practical clinical approach; and; supplies 250 figures, and more than 16 color photographs. About the editors: P.Jay Pasricha is Chief, Division of Gastroenterology research that includes pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on NIH panels. He holds several patents related to gastrointestinal diagnostics and therapeutics and is a consultant to many companies. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi. William D. Willis is Director, Cecil H. and Ida M. Green Chair, and Chief of the Division of Comparative Neurobiology, Marine Biomedical Institute; Professor and Chairman, Department of Anatomy & Neurosciences; and Professor, Department of Physiology & Biophysics; University of Texas Medical Branch, Galveston. Dr.Willis has been President of the Society for Neuroscience (1984-1985), the Association of Neuroscience Departments and Programs (1982-1983), and the American Pain Society (1982-1983). He has also been on the Executive Committee of the American Association of Anatomists (1982-1986) and the Council of the International Association for the Study of Pain (1984-1990). He received the M.D. degree (196) from the University of Texas Southwestern Medi Gebghart is Head, Department of Pharmacology, University of Iowa, Iowa City. The author or editor of numerous professional publications, he is editor-in-chief of the Journal of Pain and is the recipient of the Purdue Pharma Prize for Pain Research (2004).

Emphasizing new and emerging therapies in each chapter, this reference provides essential information for clinicians to provide accurate diagnoses and select the most appropriate treatment regimens for patients with primary and metastatic brain tumors and neurological complications of cancer. Edited by a leading cast of authorities on the topic-including the Chief and Associate Editors of the Journal of Neuro-oncology-this easily-accessible guide reviews the epidemiology, identification, and management of brain tumors while exploring the latest advances in this increasingly diverse field.

Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

This first reference to comprehensively address both the medical and surgical management of diseases affecting the colon, this source spans the wide array of colorectal disorders including rectal prolapse, irritable bowel syndrome, benign and malignant colonic tumors, fissures and ulcers, and Crohn's colitis, among other ailments. With chapters by world leaders in the field, this guide analyzes diagnostic and imaging techniques for disease evaluation and management including advances in colonoscopy, radiology, and surgery.

This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behcet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behcet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

After half a century of doubt and debate, dyslipidemia has at last been accepted by cardiologists and the medical community at large as a major, treatable cause of atherosclerotic cardiovascular disease. Written by a general practitioner, an epidemiologist, and a lipidologist, this updated second edition provides a broad, cutting-edge perspective of dyslipidemia, presenting the very latest information on lipid disorders from etiology to management. Clear, concise and highly illustrated, this user-friendly work: details normal lipid metabolism; describes the genetic and acquired causes of excessively high cholesterol disorders; reviews the evidence that dyslipidemia is a risk factor for vascular disease; and includes chapters summarising current US, British and European guidelines, the importance of diet and the role of lipid-lowering drugs. A highly practical text providing sound advice on screening, risk assessment and the management of dyslipidaemia, this second edition of Dyslipidemia in Clinical Practice is essential reading for a wide range of specialists who are increasingly dealing with patients with excessively high cholesterol disorders.

Now in its fourteenth edition, Clinical Anatomy is the definitive text offering medical students, postgraduate trainees and junior doctors the anatomical information they need to succeed in a clinical setting. Professor Harold Ellis and Professor Vishy Mahadevan provide an accessible, comprehensive, and detailed exploration of anatomy, specifically designed for students and trainees at all levels. Revised and updated, the fourteenth edition contains more information about the nervous system as well as medical images, diagrams and photographs that are overlaid with anatomical illustrations, revealing detailed surface anatomy. This edition: Puts greater emphasis on clinical relevance and contains more content for non-surgical trainees Offers a variety of illustrative clinical scenario case studies Contains many more medical images and diagrams such as CT and MRI Presents expanded information on the nervous system Includes a companion website that contains digital flashcards of all the illustrations and photographs presented in the book Written for medical students, junior doctors, and those studying for The Royal College of Surgeons examinations, the new edition of Clinical Anatomy continues to be an essential resource for understanding the basics of clinical anatomy.

The current interest in prion diseases has been fueled by the panic that originated from the appearance of a new variant of Creutzfeldt-Jakob disease and the evidence linking it to human exposure to the bovine spongiform encephalopathy (BSE) agent. Peer-reviewed to assure accuracy, this book describes the science, concepts, hypothesis, and mechanisms of prion disease transmission. It covers human and animal prion diseases, their incidence, prevalence, origin, and clinical and neuropathologic characteristics. The author provides scientific facts and a clear explanation of the relevance and implications of the findings for science in general.

What is it about the challenges and stresses of midlife that disrupts equilibrium and promotes a sense of despair, even of crisis? Why does this stage of the life cycle give rise to new mental and physical symptoms that, for some, lead to chronic unhappiness to the point of dysfunction? Of course, there are common midlife events that account for the special narcissistic vulnerabilities of this period of life, and Eda Goldstein ably reviews these events and the theoretical perspectives commonly brought to bear on them. In When the Bubble Bursts, however, Goldstein's special concern is those individuals who come to midlife with heightened narcissistic vulnerabilities that make the navigation of this stage of life more difficult still. In understanding the latter such patients and devising a treatment approach appropriate to their self issues, Goldstein adopts a broadly self-psychological frame of reference. It is a matter, she finds again and again, of understanding how current stressors frustrate healthy self needs and trigger narcissistic vulnerabilities. purview, embraces modalities that are, to varying degrees, supportive, psychodynamic, and psychoanalytic, reworks and strengthens self structures in helping patients find new ways of affirming their sense of self. Her substantive case studies, which accompany the reader through all the chapters in her study, draw on personal and supervisory experiences to illustrate crucial foci of the treatment process with a range of midlife patients in psychotherapy. It is a striking that, amid a voluminous literature on psychodynamic psychotherapy, so little attention has been paid to the narcissistic vulnerabilities of midlife and the manner in which they enter into the psychotherapy of midlife patients. Eda Goldstein remedies this glaring lacuna in the literature with a study that comprises an admirable blend of theoretical astuteness, clinical wisdom, and personal honesty. balanced discussion of theoretical perspectives on adult development and her concluding consideration of the countertransference issues elicited by midlife patient in their midlife therapists, is an edifying and ingratiating contribution to the literatures of psychodynamic psychotherapy, self psychology, and adult development.

A detailed compilation of the latest research and recommendations for the diagnosis and assessment of esophageal disorders, this reference delves into a wide range of applications and technologies currently utilized in the field including radiology, endoscopy, endoscopic ultrasonography, manometry, ambulatory manometry, pH testing, catheter-free pH testing, bilitec monitoring, and impedance plethysmography.

This reference analyzes the cellular and molecular biology and mechanisms of the blood-brain barrier (BBB) and presents the most recent studies on the role of the BBB in the development and initiation of a wide range of physiological and pathological conditions affecting the central nervous system.

The increased incidence of pancreatic cancer in the Western world and its grave prognosis has resulted in an urgency for research in this area. Until now the available data on toxicology of the pancreas has been few and fragmentary, scattered throughout the literature. A benchmark volume, Toxicology of the Pancreas pulls together information in this neglected area of toxicological research and highlights fundamental research performed in the last ten years. Leaders in the field discuss important structures, the detoxification and toxification process at the cellular and sub-cellular level, the distribution of phase 1 and phase 2 drug-metabolizing enzymes and their role in pancreatic disease, and the role of diet and toxicants on pancreatic disease. The book also covers the role of altered genes in the integrity of the pancreas and explores comparative toxicology in humans and in the lab species used in testing. Illustrated with histological, electron microscopical, and immunohistochemical formats, this book provides a comprehensive and novel presentation of biological and toxicological data. It stands alone as a reliable resource of information easily accessible to professionals in different disciplines.

With a greater emphasis on the basic principles, practical recommendations, and economics of phototherapy, the Third Edition remains the standard source on the UV treatment of skin disease-presenting an expanded number of case studies, clinical solutions, and treatment protocols for a clear understanding of the present and future state of phototherapy, photochemotherapy, and phototesting in the dermatologic arena.

Master the nurse's role in therapeutic nutrition and in teaching dietary health! Nutritional Foundations and Clinical Applications: A Nursing Approach, 8th Edition describes nutritional healing and wellness from the nurse's perspective. It covers dietary guidelines with a humanistic, personal touch, using first-hand accounts to show how nutrition principles apply to patients in real-world practice. This edition is updated with the most current guidelines and the latest research on nutrition. Written by noted educators Michele Grodner, Sylvia Escott-Stump, and Suzie Dorner, this leading nutrition text promotes healthy diets and shows how nutrition may be used in treating and controlling diseases and disorders. Applying Content Knowledge and Critical Thinking: Clinical Applications case studies help you apply nutrition principles to real-world practice situations. Personal Perspective box in each chapter offers a firsthand account of the ways in which nutrition affects patients' lives, demonstrating the personal touch for which this book is known. Teaching Tool boxes include strategies for providing nutrition counseling to patients. The Nursing Approach boxes analyze a realistic nutritional case study according to the nursing process. Social Issue boxes show how ethical, social, and community concerns can influence health and wellness. Health Debate boxes address the nurse's response to differing opinions or controversies about food, nutrition, and health concerns. Cultural Considerations boxes show how to understand and respect the food and health customs of specific ethnic groups. Key terms and a glossary make it easy to learn key vocabulary and concepts. NEW! Nursing Approach sections include Next Generation NCLEX (R) terminology as well as single-episode cases and questions, with answers on the Evolve website.

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.

This reference discusses state-of-the-art methods for the management of children with conditions affecting the nervous system-providing over 80 chapters that outline direct, logical approaches to numerous pediatric neurologic disorders using clear tables, algorithms, and figures for quick reference to key material.

This book summarizes the most current research on the anemia of chronic disease and identifies effective diagnostic strategies for this common clinical condition-covering key topics related to the design and selection of therapeutic options including the treatment of the underlying disease, the biology of erythropoietin and the regulation of erythropoiesis, the disturbance of iron homeostasis, and the complex nature of the systemic inflammatory response.

The Understanding IBS chart presents an overall view of the symptoms and causes of Irritable Bowel Syndrome. The main image features the large intestine, with cut-away views showing a spasm and inflammation. Heavy cover stock with protective varnish for durability.

Parenteral nutrition is the standard of care for patients who are unable to maintain nutritional status via the gastrointestinal tract. New techniques in this therapy are giving patients with intestinal failure the time they need to achieve maximal intestinal rehabilitation and return to a more normal and productive life. Edited and written by an international group of experts in the field, Intestinal Failure and Rehabilitation: A Clinical Guide presents the most current information regarding the prevention, diagnosis, care, and management of patients with intestinal failure. Organized in a logical manner, the book opens with a review of the basic principles and concepts, and progresses into discussions on diagnostic evaluation using a variety of techniques, and treatment plan formulation. The next section addresses dietary modifications, medical management, the use of trophic substances, enteral and parenteral nutrition, surgery, and transplantation. Following a discussion of special considerations, such as pediatrics and enterostomaltherapy, the text concludes with outcomes and future directions for research. This volume is devoted solely to intestinal failure and all of the information is supported by evidence-based medicine. It greatly enhances understanding of this area and aids in the care and rehabilitation of individuals with intestinal insufficiency.

The information in Healthy Solutions can help readers maintain and enhance their own health. Readers will come to understand how natural medicine views health, disease, and healing. Also, how to interpret the body's reaction to illness, and become familiar with self-care remedies for more than 50 health conditions. Explains how to use homopathic tissue salts for treating symptoms, and how to master the therapeutic uses of herbs, spices, and foods.

This book is the result of a "State-of-the-Art-Conference" held at the University of Georgia dedicated to the evidence-based treatment of stuttering. An international group of prominent fluency researchers and clinicians were invited to present and discuss current data and issues related to the treatment of stuttering. The topic was defined to include evidence about stuttering, evidence about stuttering treatment, and discussions of how that evidence should guide the continuing research and practice. The explicit link between empirical evidence and suggestions for clinical practice is the goal of the book. The book begins by addressing the notion of "evidence-based practice" and considers its implications for stuttering treatment. Part II presents the intersection of the nature of stuttering; the theories of stuttering; and the implications of nature, theory, and other knowledge for stuttering treatment decisions. Part III provides two of the many measurement issues facing stuttering treatment followed by Part IV, which is devoted to the quality of treatment research evidence, for specific treatments and in terms of some more general methodological and professional issues. The final part summarizes the clinical recommendations made throughout the book and discusses evidence-based, outcomes-focused clinical decisions for stuttering. These chapters are intended to provide "state-of-the-art" information to researchers, clinicians, and students who are interested in developing, identifying, or using the best possible evidence-based treatments for stuttering.

Learn how a patient's behavior can factor into the prognosis of medically unexplainable illness! The Psychopathology of Functional Somatic Syndromes examines the link between mental illness and physical syndromes that lack organic disease explanations, including chronic fatigue syndrome, fibromyalgia, premenstrual dysphoria, irritable bowel, and Gulf War illness. The author has evaluated the best research work of the past 20 years to determine the association between psychopathology and functional illness, the biological gradient between somatic and psychological symptoms, and the manifestations of dysfunctional coping. The Psychopathology of Functional Somatic Syndromes challenges recent conceptualizations of functional somatic syndromes as brain disorders connected to affective spectrum disorder, serotonin deficiency, cerebral hypoperfusion or abnormal hypothalamic-pituitary-adrenal function and highlights the importance of abnormal illness behavior, sexual victimization, and maladaptive coping for the production and maintenance of these disorders. The Psychopathology of Functional Somatic Syndromes explores observations on the neurobiology and the personality abnormalities of patients made from structured data collected over a period of several years. It describes modern perceptions of functional somatic syndromes and how they have evolved into a tightly knit family of self-standing syndromes with a common core. The book examines the correlation between the burden of psychopathology and the physical features of these illnesses; reviews advances made in the appraisal of the neuroanatomy, neuropsychology, and neurochemistry of functional syndromes; and focuses on the connection between measurable dimensions of personality, coping, and illness behavior and the prognosis of medically unexplainable illnesses. The Psychopathology of Functional Somatic Syndromes examines: psychiatric morbidity brain perfusion post-traumatic stress in Gulf War illness the spectrum of mood disorders the hypothalamatic-pituitary-adrenal axis the sexual victimization of patients and much more! The Psychopathology of Functional Somatic Syndromes is an essential resource for psychiatrists and psychologists working in outpatient practice.

Seizures are frightening events. They frighten the patients who experience them; they frighten those who witness them; they also frighten many physicians who have to deal with them. Most individuals with seizures present to family physicians or to emergency room physicians. However, despite the fact that seizures are among the most common neurological conditions, most general practitioners, family practice specialists, and intemists do not see large numbers of patients with seizures. Given the apoplectic appearance of generalized tonic clonic convulsions, it is not difficult to understand why they arouse such emotional responses in those that experience them, those that witness them, and those whose care is sought for them. Seizures are symptoms of something wrong with the brain. Many different kinds of perturbations in brain anatomy, chemistry, or physiology can produce seizures. For many individuals, seizures occur in the context of an acute illness and will not recur once that illness is treated. These individuals do not have epilepsy. They have transient disturbances in brain function attributable to systemic medical conditions. It is important to recognize these issues, because, first, the seizure may be the initial, or even only, manifestation of the underlying medical problem and this needs to be recognized.