Reversibility of Chronic Disease and Hypersensitivity, Volume 4: The Environmental Aspects of Chemical Sensitivity is the fourth of an encyclopedic five-volume set describing the basic physiology, chemical sensitivity, diagnosis, and treatment of chronic degenerative disease studied in a 5x less polluted controlled environment. This text focuses on treatment techniques, strategies, protocols, prescriptions, and technologies. Distinguishing itself from previous works on chemical sensitivity, it explains newly understood mechanisms of chronic disease and hypersensitivity, involving core molecular function. The authors discuss new information on ground regulation system, genetics, the autonomic nervous system, and immune and non-immune functions. The book also includes the latest technology and cutting-edge techniques, numerous figures, and supporting research.

Treatment for the chronically ill has traditionally focused on physical factors and symptoms, despite the fact that chronic illness also affects life in an emotional and spiritual way. The approach toward treatment described in this volume addresses all aspects of a patient's life, including their interpersonal experiences and relationships, presenting family therapists and family physicians as part of the same treatment team. This volume thus provides a foundation for understanding the role illness plays in family systems. The meaning an individual gives to an illness is profoundly influenced by and influences that person's social world. In turn, social culture and social networks both shape and are shaped by the individual's experiences. Exploring how the meaning of chronic illness is defined tells us much about the individual's interpersonal relations and the resultant meaning given to the person's illness. As a consequence, family therapy must be an integral part of the treatment plan for chronically ill patients . Family Therapy and Chronic Illness approaches chronic illness from a leading-edge perspective. This approach enables therapists to listen attentively to complicated narratives. Because these stories, feelings, and emotions are difficult to describe, the clients have demanding "telling" tasks while therapists have demanding "listening" tasks. This book sends an important message not just about the chronically ill, but also about their families, therapists, and doctors, and how they can work together to develop the best treatment plan possible.

This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.

This volume is a first of its kind, addressed principally to the professional reader. While it is not intended to be exhaustive, its aim is to sketch a broad picture of some of the nondrug and nonsurgical treatment strategies with a demonstrated basis in conventional scientific method. Likewise, though it does not include all those who have contributed to the emergence of this exciting new field, it assembles those authors whose seminal work has earned them international reputations.
This volume's declared purpose is to provide a state-of-the-art guide to methods and techniques in the behavioral treatment of epilepsy and to their basis in theory. The editors hope that it will catalyze the evolution of their acceptance as standard elements, where appropriate, in the clinical activities of independent practitioners, clinics, and agencies that service those with convulsive disorders.

This study discusses cultural change among the Ainu, Japan's indigenous people, its specificity and the circumstances which have led to it. The book focuses on strategies in response to change, laying bare the multiple nature of agency that characterizes the interaction between the Ainu, the larger society and the state. The stress is on cultural aspects of Ainu's contemporary activities and how they have been incorporated into the larger society. The Japanese pursue a policy of assimilating the Ainu but this policy has not been successful, resulting in a resurgence among the Ainu. This is characterized by its emphasis on ethnic features, distinguishing them from the majority of the population who do not recognize the existence of ethnic groups but view them instead as social classes or casts. For the Ainu this strategy serves to firmly define their own position in the larger system, challenging the pre-established social and cultural context of Japanese society.

Chronic diseases have become predominant in Western societies and in many developing countries. They affect quality of life and daily activities and require regular medical care. This unique monograph will bring readers up to date with chronic disease research, with a focus on health-related quality of life and patient perception of the impact of the diseases and health intervention, as well as psychological adaptation to the disease. It considers the application of concepts and measures in medical and psychological clinical practice and in public health policies. Informed by theory, philosophy, history and empirical research, chapters will indicate how readers might advance their own thinking, learning, practice and research. The book is intended to be provocative and challenging to enhance discussion about theory as a key component of research and practice. Perceived Health and Adaptation in Chronic Disease will be of interest to researchers and academics alike. It boasts a wide range of contributions from leading international specialists from Australia, Canada, Denmark, France, Germany, the Netherlands, Spain, Sweden, the UK and the USA. This has also allowed the book to provide readers with a multidisciplinary approach.

How do men react to diagnosis of male infertility and how, if at all, are all their lives affected by it? Male infertility is commonplace yet the male experience of it has been woefully neglected. "Male Infertility - Men Talking" explores these issues by gathering together men's stories and seeing what common strands, if any, exist between them. Mary-Claire Mason explores the past and present medical management of male infertility as this forms an essential backdrop to the men's stories but the main emphasis is on how men's lives are affected. In the first half of this book, the discovery of sperm and the man's role in reproduction is considered together with a review of how the past affects the present medical management of male infertility and the problems that bedevil it. The male voice predominates in the second half, speaking of painful events and relationships with families and friends, their feeling of isolation, their medical experiences, the importance of biological fatherhood, and their hopes for the future.

Ulcerative colitis is a chronic condition that has a number of long-term complications and creates certain short-term problems for the sufferer. Michael Kelly, himself a sufferer, describes the experience of ulcerative colitis from the perspective of men and women who have had the disease and examines the social and psychological issues surrounding the condition. This book should be of interest to professionals in training and practice in the fields of medicine, nursing, medical sociology and social medicine.

For many women breast cancer is one of the most distressing of all diseases. This guide focuses on experiences of the disease from the woman's perspective. Drawing on 1000 in-depth interviews, the book makes extensive use of verbatim accounts by women of their own experiences during different stages - from the discovery of the lump, through to diagnosis, treatment, and possible recurrence and death. These extracts illustrate the meaning that a diagnosis of breast cancer and its treatment has for different women. A practical, introductory chapter fully describes the medical aspects of the disease. The women's perceptions and insights are interspersed with relevant findings and theories from recent scientific literature. The authors are well-known for their contributions to cancer research and especially for their work on the psychosocial aspects of breast cancer and their effect on the quality of life.

Following the boom in population databases in recent years there has been sustained and intense international debate about political processes and legal and ethical issues surrounding the protection and use of genetic data. As a result, several national and international organizations and committees have published widely differing guidelines and statements concerning genetic databases and biobanks. Ethical Issues of Human Genetic Databases compares the new area of biobanking with the tradition of ethically accepted classical research and highlights the distinctive features of existing databases and guidelines. The volume identifies areas of consensus and controversy while investigating the challenges posed to classical health research ethics by the existence of genetic databases, analyzing the reasons for such varying guidelines. The book will be essential to academics, biobankers, policy-makers and researchers in the field of medical ethics.

Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics.

This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Laboratory evaluation plays a very important role in the diagnosis of mitochondrial diseases, in addition to clinical assessment. This includes analysis of plasma/mitochondrial coenzyme Q10 content, mitochondrial respiratory chain function and oxidative phosphorylation in isolated mitochondria and biopsy material, and nuclear magnetic resonance methods.

In addition to standard medical therapy to treat cardiac, CNS, and other involvements in the mitochondrial disease patients, adjunctive nutritional therapy is indicated primarily to improve mitochondrial function. Therapy include coenzyme Q10, a -lipoic acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized light.

Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q10 in 1957, and to the Celebration of 50th year of Coenzyme Q10discovery.

This book is intended for general medical practitioners, for specialists specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.

If you had a trillion dollars and a year to spend it for the good of the world and the advancement of science, what would you do? It's an unimaginably large sum, yet it's only around one per cent of world GDP, and about the valuation of Google, Microsoft or Amazon. It's a much smaller sum than the world found to bail out its banks in 2008 or deal with Covid-19. But what could you achieve with $1 trillion? You could solve the problem of the pandemic, for one, and eradicate malaria, and maybe cure all disease. You could end global poverty. You could settle on the Moon and explore the solar system. You could build a massive particle collider to probe the nature of reality like never before. You could build quantum computers, develop artificial intelligence, or increase human lifespan. You could even create a new life form. Or how about transitioning the world to clean energy? Or preserving the rainforests, or saving all endangered species? Maybe you could refreeze the melting Arctic, launch a new sustainable agricultural revolution, and reverse climate change? How to Spend a Trillion Dollars is the ultimate thought experiment but it is also a call to arms: these are all things we could do, if we put our minds to it - and our money.

When this title was first published in 1971, there were about 300, 000 people with epilepsy in England and Wales. Nearly one-third of them were children. This book is an integrated review of how epileptic children behaved, and of how they were regarded by parents, teachers and peers at the time. Written by a sociologist with a training in psychology, human biology and education, the book draws on several disciplines - sociology, psychology, biology - in seeking to understand the complex determinants of deviant behaviour in children with epilepsy. The author considers in detail the lives of 118 epileptic children, bringing together and analysing a wide range of measurements of behaviour, social relations and abnormalities of brain function. He discusses how the children fare in school, and how epilepsy affects both the teacher's perception of the child and the child's scholastic performance. The dearth of medical centres which could diagnose and treat epilepsy at the time is examined, and hospital use according to parents' social class is analysed. The author looks at the role of parents of epileptic children and shows that their attitude to epilepsy is of major importance for the child's adjustment. The prejudice to which epileptic children and adolescents were subjected by the world at large is chronicled in detail. Finally the author considers how his empirical material makes a contribution to the theoretical problem of integrating sociology, psychology and biology into a single discipline concerned with the explanation of human social behaviour.

First published in 1931, this book is the first of three volumes that describe the circumstances of medical work in several European countries at that time. Together, the three books look at public administration, local and national, in relation to the prevention of disease. This first volume focuses on the Dutch, Scandinavian and German speaking countries, as well as Switzerland. It shows that many of these countries have gone beyond most other countries in their in the socialization of medicine in several ways.

First published in 1931, this book is the third of a three volume set which focuses on medical work, and in particular, public administration in relation to the prevention of disease. This volume provides the most in depth account of the countries it surveys: England and Wales, Scotland, and Ireland.

First published in 1931, this book is the second of a three volume set which focuses on medical work, and in particular, public administration in relation to the prevention of disease. This volume focuses on the medical circumstances of Belgium, France, Italy, Jugo-Slavia, Hungary, Poland and Czecho-Slovakia. It shows that many of these countries have gone beyond most other countries in their in the socialization of medicine in several ways.

This book synthesizes the flourishing field of anthropology of infectious disease in a critical, biocultural framework. Leading medical anthropologist Merrill Singer holistically unites the behaviors of microorganisms and the activities of complex social systems, showing how we exist with pathogenic agents of disease in a complex process of co-evolution. He also connects human diseases to larger ecosystems and various other species that are future sources of new human infections. Anthropology of Infectious Disease integrates and advances research in this growing, multifaceted area and offers an ideal supplement to courses in anthropology, public health, development studies, and related fields.

Defects in Secretion of Cystic Fibrosis presents an overview on current research from leading experts in North America and Europe. This update on cystic fibrosis provides in depth original work as well as review material on many of the relevant physiological and molecular topics in the field. Subjects covered include the interplay of the various epithelial ion channels, the underlying intracellular signal transduction, mucus secretion, and novel approaches to develop drugs against cystic fibrosis. This book brings together physicians, physiologists, and other scientists involved in basic research, from molecular biology to drug design and introduces novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and related diseases.

This book will be of interest to Molecular biologists, physiologists, scientists working in pharmaceutical research and drug developement, physicians and researchers in Cystic fibrosis and related diseases.

Encyclopedic in scope, Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 2: The Effects of Environmental Pollutants on the Organ System draws deeply from clinical histories of thousands of patients. It focuses on clinical syndromes within the musculoskeletal, gastrointestinal, and respiratory systems. The book explores mechanisms of chemical sensitivity and chronic degenerative disease as well as the triggering agents of musculoskeletal, gastrointestinal, and sino-respiratory diseases. It then discusses triggering agents such as natural gas, pesticides, solvents, and micotoxins. The authors include new data for indoor and outdoor air pollution that harms the chemically sensitive and chronic degenerative diseased patient as well as new data for breath analysis. They also describe the physiology of chemical sensitivity and chronic degenerative diseases, their manifestations, diagnosis, and approaches to reverse dysfunction. The second volume of a five-volume set, the book provides an essential resource for health care providers diagnosing and treating chemical sensitivity and chronic degenerative disease.

This next volume in Research in the Sociology of Health Care covers a variety of important social factors and their relationship to health and health care inequities both in the United States and the rest of the world. The authors of this volume explore issues related to infectious diseases and various chronic health problems. One section focuses on Covid 19 and issues of kidney disease, face masks and social values, pandemic experiences in rural parts of the United States, and in urban India. Other topics that are discussed focus on issues outside the United States such as in Nepal, Ecuador, and broader cross-national comparisons. Several papers focus on health care system issues within the United States including micro hospitals in Texas, evidence-based medicine, and trends in health disparities in the Latina population in the United States. Written from a sociological and broader social science approach, the papers provide important information both about broad trends in the US and other countries and some specific considerations of issues from a social perspective as linked to Covid 19.

The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

• Cardio-Pulmonary Disease
• Oncology
• Endocrinology
• Infectious Disease
• Allergy/Rheumatology
• Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.

An award-winning memoir and instant "New York Times" bestseller that goes far beyond its riveting medical mystery, "Brain on Fire" is the powerful account of one woman's struggle to recapture her identity.
When twenty-four-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she'd gotten there. Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?
In a swift and breathtaking narrative, Susannah tells the astonishing true story of her descent into madness, her family's inspiring faith in her, and the lifesaving diagnosis that nearly didn't happen. "A fascinating look at the disease that . . . could have cost this vibrant, vital young woman her life" ("People"), "Brain on Fire" is an unforgettable exploration of memory and identity, faith and love, and a profoundly compelling tale of survival and perseverance that is destined to become a classic.