For undergraduates taking introduction courses in communication sciences and disorders. This leading introductory book on communication disorders uses student-friendly content to explore current research, central theories, and the nuts and bolts of clinical therapy. Updated with the most current research and information, the newly revised eighth edition of Human Communication Disorders continues to cover a broad range of topics including speech and language development, genetics, the biology and physics of communication, and an overview of cultural and linguistic diversity. With an emphasis on evidence-based practice, experts in speech-language pathology and audiology place communication processes and communication disorders in perspective, define basic theories of causation, introduce identifying characteristics, and present an overview of procedures for evaluation and treatment - while at the same time focusing on the real people who both have communication disorders and the real people who study them. The new eighth edition has been rewritten with a more contemporary, student-friendly approach and style that makes the content more engaging and easier to process.

An account of the use of the gastrointestinal hormone glucagon in different clinical emergencies. An international group of experts from different fields of medicine cover a wide range of situations within acute medicine: cardiology; internal medicine; endocrinology; diabetology; clinical toxicology; surgery; paediatrics; gastroenterology; hepatology; and radiology. Based on an International Workshop held in Barcelona in October 1992, this volume contributes to the growing interest in the importance of glucagon both as a diagnostic tool and as a therapeutic agent in acute medicine. It should be of value to physicians and emergency and critical care specialists as well as to researchers interested in this hormone.

1) Mechanism of Fe(II) Oxidation and Core Formation in Ferritin.- 2) Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin.- 3) Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins.- 4) The Transferrin Receptor and the Release of Iron from Transferrin.- 5) The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages.- 6) Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition.- 7) Mechanism of Production of the Serum Transferrin Receptor.- 8) Iron Absorption and Cellular Uptake of Iron.- 9) Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.- 10) Cellular Responses to Iron and Iron Compounds.- 11) The Structure and Function of Iron Regulatory Factor.- 12) Structure and Function of IREs, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase.- 13) Translational Control by Iron-Responsive Elements.- 14) The Role of Cytokines in the Regulation of Ferritin Expression.- 15) Stimulation of IRE-BP Activity of IREF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase.- 16) Reciprocal Modulation of Aconitase Activity and RNA-binding Activity of Iron Regulatory Factor by Nitric Oxide.- 17) A New Look at Ferritin Metabolism.- 18) Bacterioferritin: A Hemoprotein Member of the Ferritin Family.- 19) Intracellular Iron.- 20) Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation.- 21) Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells.- 22) Differential Effects of Iron and Iron Carrier on Hematopoietic Cell Differentiation and Human ADA Gene Transfer.- 23) A Hemin-Inducible Enhancer Lies 4. 5 Kb Upstream of the Mouse Ferritin H Subunit Gene.- 24) Iron Deficiency: The Global Perspective.- 25) Iron Regulation in the Brain at the Cell and Molecular Level.- 26) Pathophysiology of Iron Toxicity.- 27) Morphologic Observations in Iron Overload: An Update.- 28) Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells.- 29) Iron Overload and the Biliary Route.- 30) Changing Concepts of Haemochromatosis.- 31) Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis.- 32) The Morbidity of Hemochromatosis Among Clinically Unselected Homozygotes: Preliminary Report.- 33) Genetics of Haemochromatosis.- 34) Localization of Seven New Genes Around the HLA-A Locus.- 35) Searching for the Hemochromatosis Grail.- 36) Iron Chelator Design.- 37) Results from a Phase I Clinical Trial of HBED.- 38) Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds.- 39) Iron Chelation Therapy for Malaria.- 40) The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells.

"Diseases and Diagnoses" discusses why such social problems as addiction, sexually transmitted diseases, racial predisposition for illness, surgery and beauty, and electrotherapy, all of which concerned thinkers a hundred years ago, are reappearing at a staggering rate and in diverse national contexts. In the twentieth century such problems were viewed as only historical concerns. Yet in the twenty-first century, we once again find ourselves confronting their implications.

In this fascinating volume, Gilman looks at historical and contemporary debates about the stigma associated with biologically transmitted diseases. He shows that there is no indisputable way to measure when a disease or therapy will reappear, or how it may be perceived at any given moment in time. Consequently, Gilman focuses on the socio-cultural and political implications that the reappearance of such diseases has had on contemporary society. His approach is to show how culture (embedded in cultural objects) both feeds and is fed by the claims of medical science-as for example, the reappearance of "race" as a cultural as well as a medical category.

If the twentieth century was the "age of physics," in the latter part of the past century and certainly in the twenty-first century biological concerns are recapturing central stage. Achievements of the biological sciences are changing the public's sense of what constitutes cutting-edge science and medicine. None has captured the public imagination more effectively than the mapping of the human genome and the promise of genetic manipulation, which fuel what Gilman calls a "second age of biology." Although not without controversy, the role of genetics appears to be key. Gilman puts contemporary debates in historical context, showing how they feed social and cultural concerns as well as medical possibilities.

Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents.

Written by internationally renowned contributors, this text includes:

• morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe
• the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents
• alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe
• non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others
• morphological and kinetic differences of the various forms of cell death

Physiology and Metabolism: Genetic Influences on Urinary Calcium Excretion (R.P. Holmes et al.). Oxalate Metabolism and Transport: Vectorial Oxalate Transport across a Monolayer of Renal Epithelial Cells (H. Koul et al.). Physicochemistry, Promoters and Inhibitors: Crystal Growth and Nucleation Rates for Calcium Oxalate in 92% Fresh Urine in a Continuous Crystalliser (J.P. Kavanagh et al.). Crystallization and Proteins: Possible Role of Stone Matrix in Calcium Oxalate Stone Formation (S. Yamaguchi et al.). Stone Composition, Matrix and Membranes: Role of Organic Matrix in Formation and Growth of Calcium Oxalate Urinary Stones (S.R. Khan, R.L. Hackett). Risk Factors and Diet: Urinary Silicate in Calculous Patients (W.C. Thomas). Epidemiology and Infection: Urinary Enzymes (C.H. van Aswegen et al.). ESWL and Lithotropsy: Ultrasound Velocity-A Measure of Stone Strength? (N.P. Cohen et al.). Investigation, Medical and Surgery Management: A New Therapeutic Agent for Cystinuria (T. Koide et al.). 276 additional articles. Index.

Written with a broader perspective and knowledge, Cancer Supportive Care: Advances in Therapeutic Strategies presents state-of-the-art management options for the full range of symptoms, toxicities, and complications experienced by cancer patients. In addition to "bread and butter" topics such as pain control and nausea and vomiting, the book contains unique, ground-breaking discussions of symptom measurement, the role of growth factors, and late effects and cancer survivorship. Written by key opinion leaders in the field, Cancer Supportive Care: Advances in Therapeutic Strategies: assembles and synthesizes state-of-the-art information into one convenient resource, helping busy clinicians learn the most effective supportive care strategies available discusses emerging therapies and approaches covers topics not included in other cancer supportive care books, such as measurement of symptoms, growth factors, thromboembolism, skeletal complications, fatigue, the elderly cancer patient, cancer survivorship, and alternative and integrative therapies

This book provides a concise but comprehensive description of human infectious diseases due to microbial pathogens, from a physician's and a microbiologist's point of view, as well as providing an understanding of the use of microbial pathogens as biological weapons. It is indispensable for students, physicians, medical and nursing staff, and infectious disease specialists. All topics are covered in a concise fashion, which also are useful for self-study and life-long learning (applicable for part-time students).

Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides an authoritative discussion of strategies to effectively implement and interpret the new ASCO/NCCN directives. Standing as the only up-to-date source to readily examine exciting new translational science findings regarding the biology of cancer-associated thrombosis, as well as new clinical recommendations, this guide supplies an authoritative and current discussion of the mechanisms, management, and prevention of cancer-associated thrombosis.

Considering the impact of translational breakthroughs on the early detection, diagnosis, prevention, and treatment of breast cancer, this all-encompassing guide collects cutting-edge research on the most promising strategies and agents likely to impact the management and long-term outcomes of women with breast cancer. This book will provide current information on rapidly evolving translational therapies, as well as improved strategies for the selection of patients for these treatments.

This reference discusses best practices for the management of patients with cancers of the esophagus, stomach, colon, liver, and pancreas. Focusing on a wide variety of GI carcinomas by organ and tumor type, this source provides expert coverage of diagnostic, staging, and treatment procedures by seasoned oncologists and radiologists, and offers in-depth discussions of current research regarding tumor markers, molecular biology, and clinical presentation.

A must for the busy clinician, this source:

• spans the existing evidence from experienced opinion leaders in the field of gastrointestinal oncology
• pairs organ-based chapters so that surgical and non-surgical oncologists provide perspectives on the same condition supplies an up-to-date and relevant summary of the key topics in gastrointestinal oncology, supported by clear scientific evidence
• combines surgical and medical approaches to cancers in specific organs, supplying a rigorous evidence-based approach to the evaluation of various treatments
• addresses critical topics in the area including the management and prevention of cancers around the gastroesophageal junction, rectal cancer, and gastrointestinal stromal tumors
• considers the latest developments in surgical, radiation, and chemotherapeutic management

about the book... Assisting clinicians in the differential diagnosis of the wide range of disorders responsible for fever of unknown origin (FUO), this source stands as the only recent and comprehensive differential diagnosis of these conditions. This guide provides a clear overview of diagnostic approaches and offers expert recommendations that are invaluable to anyone caring for patients with prolonged undiagnosed fever. Written by clinicians for clinicians, this single authoritative source emphasizes the syndromic approach in the diagnosis of FUOs...discusses the etiology and distribution of disorders causing FUOs...and stresses the importance of a focused history, physical examination, and laboratory tests in the differential diagnosis of the FUO patient. about the editor... BURKE A. CUNHA is Chief, Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, and Professor of Medicine, State University of New York School of Medicine, Stony Brook. Dr. Cunha is the author or coauthor of more than 150 abstracts, 100 electronic publications, 1000 articles, and 150 book chapters. He has edited 20 books on various infectious disease topics and is Editor-in-Chief of the journals Infectious Disease Practice and Antibiotics for Clinicians. Dr. Cunha is a Fellow of the Infectious Diseases Society of America. Dr. Cunha is internationally recognized as a teacher-clinician and is the recipient of many teaching awards including the prestigious Aesculapius Award. Dr. Cunha is a Master the American College of Physicians awarded for lifetime achievement as a master clinician and teacher of infectious diseases. Dr. Cunha received the M.D. degree from Pennsylvania State UniversityCollege of Medicine, Hershey.

This first reference to comprehensively address both the medical and surgical management of diseases affecting the colon, this source spans the wide array of colorectal disorders including rectal prolapse, irritable bowel syndrome, benign and malignant colonic tumors, fissures and ulcers, and Crohn's colitis, among other ailments. With chapters by world leaders in the field, this guide analyzes diagnostic and imaging techniques for disease evaluation and management including advances in colonoscopy, radiology, and surgery.

Patients with mental and substance use disorders have shown higher rates of morbidity and mortality from medical illnesses than the general population, and physicians are also increasingly aware of adverse effects of psychiatric medications on metabolic and cardiovascular health. In light of these problems, this book addresses an important unmet need of patients with mental disorders -- namely, the lack of integration of general medical care with psychiatric care and the related problem of barriers to collaboration and communication among health care providers. Managing Metabolic Abnormalities in the Psychiatrically Ill is the first book to provide a current review of the relationships among psychiatric illnesses, metabolic abnormalities, and treatment, focusing on how clinicians can tailor care to those doubly-afflicted patients.

The book integrates research findings into practical clinical guidelines that spell out what psychiatrists need to know when their patients with mental illness suffer from -- or are at risk of developing -- obesity, diabetes, cardiovascular disease, or the metabolic syndrome. The contributors address those risks that need to be considered in the overall context of treatment, background risks of medical illnesses associated with specific psychiatric disorders themselves, and the means of applying these data to treatment recommendations, monitoring, and clinical practice. Among the specific topics addressed are: - Potential effects of psychotropics on appetite, body weight, and metabolic parameters in obese patients, and the potential effects of anti-obesity agents on psychotic, manic, and depressive syndromes- Increased risk of type 2 diabetes among individuals with psychotic and mood disorders due to neurobiological changes and behavioral effects associated with these disorders- Greater risk for cardiovascular disease among the mentally ill, stressing the importance of mental health providers understanding cardiovascular risk classification and modification strategies- An association between dysregulation of glucose and lipid metabolism and the related risk of type 2 diabetes during treatment with any of the eight second-generation antipsychotics currently available in the United States- Guidance in choice of medications and appropriate monitoring strategies for hyperlipidemia, along with recognition of which antipsychotics pose the greatest risk and an understanding of the common dyslipidemia patterns seen with their use

Chapters include key clinical concepts, quick-reference tables, and extensive references, and a final chapter provides an assessment tool for evaluating patients' metabolic risk. Together, the chapters in this book constitute an authoritative clinical guide that enables psychiatrists to better integrate the treatment of patients' mental disorders with their metabolic conditions.

About the book: Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain. Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology and ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes; analyses the latest scientific advances including the role of functional imaging in patient care; integrates fundamental scientific concepts with a practical clinical approach; and; supplies 250 figures, and more than 16 color photographs. About the editors: P.Jay Pasricha is Chief, Division of Gastroenterology research that includes pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on NIH panels. He holds several patents related to gastrointestinal diagnostics and therapeutics and is a consultant to many companies. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi. William D. Willis is Director, Cecil H. and Ida M. Green Chair, and Chief of the Division of Comparative Neurobiology, Marine Biomedical Institute; Professor and Chairman, Department of Anatomy & Neurosciences; and Professor, Department of Physiology & Biophysics; University of Texas Medical Branch, Galveston. Dr.Willis has been President of the Society for Neuroscience (1984-1985), the Association of Neuroscience Departments and Programs (1982-1983), and the American Pain Society (1982-1983). He has also been on the Executive Committee of the American Association of Anatomists (1982-1986) and the Council of the International Association for the Study of Pain (1984-1990). He received the M.D. degree (196) from the University of Texas Southwestern Medi Gebghart is Head, Department of Pharmacology, University of Iowa, Iowa City. The author or editor of numerous professional publications, he is editor-in-chief of the Journal of Pain and is the recipient of the Purdue Pharma Prize for Pain Research (2004).

Providing a detailed coverage that is impossible in broader-based textbooks, "Urogenital Ultrasound, Second Edition", is a comprehensive study of genitourinary ultrasound that has been completely revised to keep up-to-date with this rapidly changing field. Reflecting the obviously visual nature of ultrasound imaging, "Urogenital Ultrasound, Second Edition" contains more than 1,000 images, including those from more technically advanced ultrasound machines than were in the first edition. Aiding the reader in recognizing various disease states and recommending effective therapeutic or surgical measures, this new edition also covers all recent developments, explained in a pragmatic style that is easily read and understood.