Advanced techniques in eye care has significantly influenced how diseases and conditions are treated and diagnosed. While many strides have been made, there is still continuous research in the ophthalmology field. Ophthalmology: Breakthroughs in Research and Practice is an innovative reference source for the latest academic material on the identification, treatment, and management methodologies of eye diseases and disorders. Highlighting a range of topics, such as retinal prosthesis, ocular diseases, and ophthalmoscopy, this publication is ideally designed for researchers, graduate-level students, and professionals in the medical field.

Sjoegren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know. The Oxford Textbook of Sjoegren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

When Joel Soukup was diagnosed with osteosarcoma at the age of sixteen, the diagnosis changed him and his family forever. This family traveled down an unknown path and emerged from their journey in a way they never expected. Read how this young patient and his family handled the devastating diagnosis with strength, love, and faith in God.

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease.

From Michael Greger, M.D., the author of the New York Times bestseller How Not to Die, comes a full-color, fully illustrated cookbook that shares the science of long-term weight-loss success.

Greger offers readers delicious yet healthy options that allow them to ditch the idea of 'dieting' altogether. As outlined in his book How Not to Diet, Greger believes that identifying the twenty-one weight-loss accelerators in our bodies and incorporating new, cutting-edge medical discoveries are integral in putting an end to the all-consuming activity of counting calories and getting involved in expensive juice cleanses and Weight Watchers schemes.

The How Not to Diet Cookbook is a revolutionary addition to the cookbook industry: incredibly effective and designed for everyone looking to make changes to their dietary habits to improve their quality of life.

All recipes in this cookbook have been fully anglicized.

A long, healthy, happy life is possible after a diagnosis of multiple sclerosis. Around the world, thousands of people are living active and fulfilling lives on the Overcoming Multiple Sclerosis Program.The Overcoming Multiple Sclerosis Handbook explains what MS is, and outlines the scientifically credible and evidence-based 7 step self-management program originally devised by Professor George Jelinek. It covers all aspects of living on the program, from first diagnosis to later life, with chapters from medical specialists and other experts on choosing your healthcare team, improving resilience, work, pregnancy and progressive MS. The book taps into the wealth of knowledge and experience in the community of people following the Overcoming Multiple Sclerosis Program, with personal stories from across the world.If you have recently been diagnosed with MS, if you have been living with MS for years, or if you have a family member with MS, the Overcoming Multiple Sclerosis Handbook is your best companion. It is also an invaluable resource for doctors treating people with MS.'If you or someone that you love is impacted by MS this book is a must-read.' - Dr Aaron Boster, The Boster Center for Multiple Sclerosis, Columbus, Ohio'This highly recommended book highlights the importance of a holistic approach to MS management.' - Professor Richard Nicholas, Imperial College London'Overcoming MS is now the essential mainstay of MS management, before or alongside drug therapy, offering the best chance of a full and healthy life for people with MS.' - Dr Peter Silbert, Clinical Professor of Neurology, University of Western Australia Medical School

For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.

This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field.

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

"Rare Diseases and Orphan Drugs" shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases.

Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease.

This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common.
Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseasesStresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathologyDiscusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchersOffers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.