Research into metabolic bone disease has made remarkable progress over the last 20 years, with the identification of numerous new molecules and pathways regulating bone cells as well as their plasma milieu. Their activities are largely regulated by the physiological status of the body incorporating the biochemical, physical and mechanical functions of bone, kidney and intestinal tissues. The Physiological Basis of Metabolic Bone Disease integrates the knowledge derived from molecular techniques with the fundamental principles of the physiology of these organs. The book places particular emphasis on bone cell activities and the regulation of plasma calcium, phosphate homeostasis, and whole body nutrition. It reviews the nutritional requirements for calcium and vitamin D for the prevention of osteoporosis. It covers vitamin D, calcium and phosphate absorption; calcium sensing receptors; the role of parathyroid hormone; physiological actions of calcitonin; and the diagnosis and significance of osteoporosis. Reviewing the physiological significance of advances in the molecular biology of metabolic bone disease, this book provides a valuable reference for researchers as well as practicing clinicians.

Anthocyanins, polyphenolic compounds abundant in certain foods, are responsible for the orange-red to blue-violet hues evident in many fruits, vegetables, cereal grains, and flowers. Interest in these pigments has intensified due to their potential health-promoting properties as dietary antioxidants, as well as their use as natural dyes in a variety of products. Mechanistic studies from in vitro experiments as well as in vivo clinical trials demonstrate wide-ranging efficacy and biological activity of anthocyanins. Anthocyanins in Health and Disease presents the first comprehensive review of modern-day research on the relationship of anthocyanins to human health and disease. Written by an interdisciplinary group of distinguished scientists, this book examines the bioavailability, chemistry, metabolism, and efficacy of anthocyanins, as well as their role in protecting the body from several age- and obesity-related chronic diseases. Chapters cover the absorption, digestion, metabolism, and excretion of anthocyanins; current methodology for the assessment of anthocyanins in the blood, plasma, urine, and tissues; and anthocyanins as potent antioxidants. The book discusses health-related topics such as anthocyanins and protection against disease, including cardiovascular disease, metabolic syndrome, type-2 diabetes, and cancers of the gastrointestinal tract. It also addresses health-promoting effects of anthocyanins, namely, maintenance of normal vision and prevention of ocular pathologies, protective effects against skin aging, and their role in innate immunity and exercise. Covering a wide array of specialized knowledge, this book provides an authoritative source of information on the role of anthocyanins in health and disease, an important step toward advancing research and enhancing communication on these functional ingredients.

The Understanding GERD chart presents a detailed overview of the symptoms and causes of Gastroesophageal Reflux Disease (GERD). Several views show normal esophagus and stomach anatomy, as well as GERD, esophagitis and Barrett's esophagus. Heavy cover stock with protective varnish for durability.

First Published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

What causes chronic and persistent fatigue in so many people? How is it best prevented and treated? What can patients and physicians do to better understand this common medical issue? Fatigue is an extremely common component of many physical and mental disorders, from anxiety and depression to heart disease and hypertension. Many patients even find themselves suffering from persistent fatigue with little understanding of how to safely and effectively treat the issue, especially if their symptoms don’t qualify for diagnosis as Chronic Fatigue Syndrome, which can make them “fall through the cracks� of the medical system.   But now, with Fatigue and Dysautonomia: Chronic or Persistent, What’s the Difference?, physicians Joseph Colombo and Nicholas L. DePace aim to close those cracks, offering a simplified analysis and discussion focusing on this common patient complaint and how best to treat it. Topics covered include: ​ Parasympathetic and Sympathetic (P&S) causes of both chronic and “persistent� fatigue Natural therapies to help relieve fatigue and promote wellness.  Concepts of fatigue, the six-pronged Mind-Body Wellness Program, and the P&S nervous systems.  Causal relationships between fatigue and P&S dysfunction (a more specific description of autonomic dysfunction or dysautonomia) How to treat fatigue with supplements and lifestyle modifications that have been documented to work without the added side-effects of most pharmaceutical therapies.  Presenting discussions with patients and doctors side-by-side to help physicians see how to present information to their patients and patients to learn what physicians need to know to tailor therapy to their individual needs, Fatigue and Dysautonomia is an essential resource for anyone concerned with fatigue, from medical professionals to patients to family and friends.

An award-winning memoir and instant "New York Times" bestseller that goes far beyond its riveting medical mystery, "Brain on Fire" is the powerful account of one woman's struggle to recapture her identity.
When twenty-four-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she'd gotten there. Days earlier, she had been on the threshold of a new, adult life: at the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?
In a swift and breathtaking narrative, Susannah tells the astonishing true story of her descent into madness, her family's inspiring faith in her, and the lifesaving diagnosis that nearly didn't happen. "A fascinating look at the disease that . . . could have cost this vibrant, vital young woman her life" ("People"), "Brain on Fire" is an unforgettable exploration of memory and identity, faith and love, and a profoundly compelling tale of survival and perseverance that is destined to become a classic.

Whilst the body has recently assumed greater sociological significance, there has been less engagement in social work and social care on the bodily experience of health, illness and disease. This innovative volume redresses the balance by exploring chronic illness and social work, through the specific lens of autoimmunity, engaging in wider debates around vulnerability, resistance and the lived experience of ongoing ill-health. Moving beyond existing conceptualisations of vulnerability as an issue of mental distress, ageing, child protection and poverty, Price and Walker demonstrate the role that society has to play in actively engaging the physical body, rather than working around and through it. The book focuses on auto-immune conditions such as lupus, multiple sclerosis, rheumatoid arthritis and scleroderma. Conditions like these allow for an exploration of the materiality of illness which exacerbates social and economic vulnerability and may precipitate personal and social crises, requiring a variety of interventions and support. The risks and challenges associated with chronic illness include disruptions to a sense of self and identity, altered relationships and the renegotiation of roles and responsibilities in a variety of relationships in addition to an economic impact, with the potential for disruption to employment status and financial insecurity. This text opens up a range of debates around some of the central concerns of the social work profession, including vulnerability, ill-health, and independence. It will be of interest to scholars and students of social work, nursing, disability studies, medicine and the social sciences.

There are common midlife events that account for the special narcissistic vulnerabilities of this period of life, and Eda Goldstein ably reviews these events and the theoretical perspectives commonly brought to bear on them. In When the Bubble Bursts, however, Goldstein's special concern is those individuals who come to midlife with heightened narcissistic vulnerabilities that make the navigation of this stage of life more difficult still. In understanding the latter such patients and devising a treatment approach appropriate to their "self" issues, Goldstein adopts a broadly self-psychological frame of reference. It is a matter, she finds again and again, of understanding how current stressors frustrate healthy self needs and trigger narcissistic vulnerabilities. Self-psychologically informed treatment, which, in Goldstein's pragmatic purview, embraces modalities that are, to varying degrees, supportive, psychodynamic, and psychoanalytic, reworks and strengthens self structures in helping patients find new ways of affirming their sense of self. Her substantive case studies, which accompany the reader through all the chapters in her study, draw on personal and supervisory experiences to illustrate crucial foci of the treatment process with a range of midlife patients in psychotherapy. Eda Goldstein presents a study that comprises an admirable blend of theoretical astuteness, clinical wisdom, and personal honesty. Her clinical study of midlife narcissistic pathology is bracketed by her balanced discussion of theoretical perspectives on adult development and her concluding consideration of the countertransference issues elicited by midlife patients in midlife therapists. When the Bubble Bursts is an edifying contribution to the literatures of psychodynamic psychotherapy, self psychology, and adult development.

Encyclopedic in scope, Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 3: Environmental Manifestations of the Neurocardiovascular Systems draws deeply from clinical histories of thousands of patients. It focuses on clinical syndromes within the musculoskeletal, neurological, and cardiovascular systems with a special focus on vascular dysfunction and heart failure treatment. The book explores mechanisms of chemical sensitivity and chronic degenerative disease, their manifestations, diagnosis, and approaches to reverse dysfunction. It covers a wide variety of topics including environmental sensitivity due to external pollutants, environmental control for reducing total body load, pollutant damage to vascular perfusion, altered blood volume, fluctuations of oxygen extraction, effects of endocrine on the vascular system, effects of pollutants on myocardial cells, and mechanisms in vascular damage. The book also discusses in detail a wide variety of clinical manifestations including vasculitis, cardiac arrhythmias, cardiac metabolic syndrome, myocarditis, atherosclerosis, heart failure, urticaria, and anaphylaxis. Treatment for heart failure is also discussed. The third volume of a five-volume set, the book provides an essential resource for health care providers diagnosing and treating chemical sensitivity and chronic degenerative disease.

Liver disease is the leading cause of death after heart, cancer, stroke and respiratory disease, and kills more people than diabetes and road deaths combined. But, there is hope. The liver is a uniquely regenerative organ, and some European countries have dramatically cut liver disease in recent years. This book looks at lifestyle factors and medical interventions that can help.

There are 7,000 rare diseases affecting 6%-8% of the global population. That's 3.5 million people in the UK alone. Yet only 200 rare diseases have approved treatments. In recent years, there has been a surge of interest from business and social entrepreneurs in the field of health - including looking at ways to treat rare disease patients better and faster. This book presents some of the latest developments in the world of rare disease entrepreneurship from a global group of experts. It examines the topic from the business angle, considering the drug development process and providing case studies of successful orphan drug enterprises. It also looks at rare diseases from the perspective of the patient, analysing the growing rare disease patient movement, a successful patient group that uses social enterprise techniques, and chapters on key requirements for helping patients with rare diseases through registries and centres of excellence. The book will be an essential toolkit for social and business entrepreneurs who are interested in the world of rare/orphan diseases. It has the rigour of an academic publication, along with the clarity of a lay publication. An original and timely book, Rare Diseases will help to add knowledge and awareness to a vastly under-published subject.

Patients suffering from psychosomatic disorders represent a formidable challenge. Psychosomatic disorders are common, and account for substantial personal discomfort, unnecessary medical expenditures, socioeconomic loss, and disability. They are challenging to diagnose, treat, and are rarely completely cured. Furthermore, they often provoke strong negative reactions from family, friends, and caregivers, who are unable to fathom their inconsistencies. Currently, little is known as to how they develop or why their symptoms tend to transform over time. In Pathologies of the Mind/Body Interface, Richard Kradin, a medical internist, pulmonologist, and psychoanalyst at a large Harvard hospital, examines the historical, philosophical, cultural, psychological, and neurobiological factors that contribute to the development of psychosomatic disorders. He focuses on the role that developmental stress and attachment disorders appear to play in increasing the risk of developing psychosomatic symptoms, and advises medical practitioners and psychologists on how to diagnose and treat them. Dr. Kradin suggests areas of importance for future medical and psychological research into the causes and treatments of these debilitating disorders.

Patients suffering from psychosomatic disorders represent a formidable challenge. Psychosomatic disorders are common, and account for substantial personal discomfort, unnecessary medical expenditures, socioeconomic loss, and disability. They are challenging to diagnose, treat, and are rarely completely cured. Furthermore, they often provoke strong negative reactions from family, friends, and caregivers, who are unable to fathom their inconsistencies. Currently, little is known as to how they develop or why their symptoms tend to transform over time. In Pathologies of the Mind/Body Interface, Richard Kradin, a medical internist, pulmonologist, and psychoanalyst at a large Harvard hospital, examines the historical, philosophical, cultural, psychological, and neurobiological factors that contribute to the development of psychosomatic disorders. He focuses on the role that developmental stress and attachment disorders appear to play in increasing the risk of developing psychosomatic symptoms, and advises medical practitioners and psychologists on how to diagnose and treat them. Dr. Kradin suggests areas of importance for future medical and psychological research into the causes and treatments of these debilitating disorders.

Part of the "What Do I Do Now?: Palliative Care" series, Pain uses thought-provoking, real-world cases to illustrate concepts, approaches to therapy, and potential barriers to optimal care presented by a diverse panel of interdisciplinary authors. Pain is a frequent and distressing symptom encountered by those with serious or life-limiting illness and may present in a multitude of fashions and from a wide array of etiologies. This book intertwines pharmacologic, nonpharmacologic, and ethical principles of pain control within case-based discussions, allowing readers to expect: * Unique perspectives of pain control, from numerous essential members of the healthcare team; * An engaging collection of cases that illustrate the most current approaches to the most commonly encountered pain syndromes in palliative care; * Chapters that begin with cases and that utilize a conversational tone throughout, like a "curb-side" consult with a seasoned colleague. Consisting of 46 chapters that cover everything from antidepressants to cannabis, cultural competency to bone pain, this volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"

Although acute inflammation is a healthy physiological response indicative of wound healing, chronic inflammation has been directly implicated in a wide range of degenerative human health disorders encompassing almost all present day non-communicable diseases including autoimmune diseases, obesity, diabetes and atherosclerosis. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions provides an exposition of the process of chronic inflammation in three parts:

1. Systems Biology of Inflammation and Regulatory Mechanisms describes the process of chronic inflammation including initiation, progression, and resolution.
   
2. Pathologies Associated with Inflammation gives a rigorous and critical treatment of specific human health disorders where chronic inflammation plays a major role.
   
3. Nutrition & Therapeutics for Inflammatory Diseases details the protective abilities of structurally diverse antioxidants, phytochemicals, anti-inflammatory diets, omega-3 fatty acids, NSAIDs, disease modifying anti-rheumatic drugs, and novel regimens.

Designed for scientists as well as clinicians, Chronic Inflammation provides critical understanding of the key checkpoints that regulate chronic inflammation. Going beyond the epidemiology of chronic inflammation, the text covers regulatory mechanisms controlling inflammation initiation, progression, and resolution. The authors address pathologies associated with inflammation and provide various nutritional and therapeutic interventions for inflammatory diseases.

It is now widely accepted that there are important links between inactivity and lifestyle-related chronic diseases, and that exercise can bring tangible therapeutic benefits to people with long-term chronic conditions. Exercise and Chronic Disease: An Evidence-Based Approach offers the most up-to-date survey currently available of the scientific and clinical evidence underlying the effects of exercise in relation to functional outcomes, disease-specific health-related outcomes and quality of life in patients with chronic disease conditions.

Drawing on data from randomized controlled trials and observational evidence, and written by a team of leading international researchers and medical and health practitioners, the book explores the evidence across a wide range of chronic diseases, including:

• cancer
• heart disease
• stroke
• diabetes
• parkinson's disease
• multiple sclerosis
• asthma.

Each chapter addresses the frequency, intensity, duration and modality of exercise that might be employed as an intervention for each condition and, importantly, assesses the impact of exercise interventions in relation to outcomes that reflect tangible benefits to patients. No other book on this subject places the patient and the evidence directly at the heart of the study, and therefore this book will be essential reading for all exercise scientists, health scientists and medical professionals looking to develop their knowledge and professional practice.

It is now widely accepted that there are important links between inactivity and lifestyle-related chronic diseases, and that exercise can bring tangible therapeutic benefits to people with long-term chronic conditions. Exercise and Chronic Disease: An Evidence-Based Approach offers the most up-to-date survey currently available of the scientific and clinical evidence underlying the effects of exercise in relation to functional outcomes, disease-specific health-related outcomes and quality of life in patients with chronic disease conditions. Drawing on data from randomized controlled trials and observational evidence, and written by a team of leading international researchers and medical and health practitioners, the book explores the evidence across a wide range of chronic diseases, including: cancer heart disease stroke diabetes parkinson's disease multiple sclerosis asthma. Each chapter addresses the frequency, intensity, duration and modality of exercise that might be employed as an intervention for each condition and, importantly, assesses the impact of exercise interventions in relation to outcomes that reflect tangible benefits to patients. No other book on this subject places the patient and the evidence directly at the heart of the study, and therefore this book will be essential reading for all exercise scientists, health scientists and medical professionals looking to develop their knowledge and professional practice.

Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis: Modern Insights into Disease from Molecules to Man covers apoptosis from A to Z. Comprehensive in scope, it explores a wide range of topics including various cancers, asthma, and multiple sclerosis as well as alcohol induced liver disease, chronic back pain, and cardiovascular health. With 40 chapters written by highly respected authorities, this single source reference provides researchers and scientists with the foundation they need.

The Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poor diet. Ongoing attention to this issue led to an International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases bringing together the top experts in that area. With the belief that the recognition of the occurrence of risk factors and their identification are important to overcoming lifestyle-related diseases, three of those experts invited prominent participants at the symposium to contribute to a book. Molecular Interventions in Lifestyle-Related Diseases is the result of that effort. This book is divided into three main sections: Free Radicals, Lifestyle-Related Diseases, and Their Protection Free Radicals, Brain Diseases, and Their Protection Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions When bad lifestyle choices cause oxidants and free radicals to have a negative influence on cell signaling and gene expression, lifestyle-related diseases are set into motion, which in turn lead to further oxidative stress. Molecular Interventions in Lifestyle-Related Diseases addresses the molecular basis of free radicals and lifestyle-related diseases and preventive/therapeutic approaches including the use of nutraceuticals, functional foods, and pharmacological interventions. Each section contains several chapters addressing critical molecular mechanisms, therapeutic interventions, and other issues of relevance to human health that will be of interest to students and researchers in the health professions including nutritional and environmental scientists, molecular and cell biologi

From an acclaimed author in the field, this is a compelling study of the origins and history of the disease commonly seen as afflicting young unmarried girls. Understanding of the condition turned puberty and virginity into medical conditions, and Helen King stresses the continuity of this disease through history, depsite enormous shifts in medical understanding and technonologies, and drawing parallels with the modern illness of anorexia. Examining its roots in the classical tradition all the way through to its extraordinary survival into the 1920s, this study asks a number of questions about the nature of the disease itself and the relationship between illness, body images and what we should call'normal' behaviour. This is a fascinating and clear account which will prove invaluable not just to students of classical studies, but will be of interest to medical professionals also

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice.

Written by experts in the field and combining information that is unable to be found in a single source volume, Pharmacogenetics of Breast Cancer

• combines a complete overview of pharmacogenetics and how it relates to breast oncology for diagnosis, treatment, and the recovery of patients using an individualized therapy model
• is the first single source reference demonstrating the application of pharmacogenetics in the care of breast cancer patients
• enables physicians a coherent interpretation of the emerging science of pharmacogenetics, aiding them to incorporate individual therapies in their own practice
• gives practical guidance on various forms of specimen collection, tissue selection, and handling procedures

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: Challenges and Opportunities in Translation is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: Challenges and Opportunities in Translation: Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Multiple myeloma is the second most prevalent hematological malignancy, with over 55,000 new cases diagnosed each year. This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular pathogenesis, biology, and prognostic factors on the diagnosis, prognosis, and individualization of treatment and the development of novel therapeutic options for patients with myeloma. Moving from the bench to the bedside to the forefront of therapeutic development, this source: helps clinicians and researchers effectively deploy therapeutic strategies into clinical practice reflects trends in the use of agents which target both the tumor cell and its bone marrow microenvironment to overcome resistance to conventional therapies considers the critical role of the bone marrow microenvironment in the regulation of growth, survival, and homing of multiple myeloma discusses novel therapies in phase I and phase II trials, focusing specifically on therapeutic options for patients with newly diagnosed or relapsed/refractory multiple myeloma addresses novel therapies for other plasma cell disorders, and provides the framework for the design of next generation agents and combination therapies covers the entire scope of translational work in multiple myeloma, from advances in molecular pathogenesis, to prognostic factors, immunotherapy, and new options for newly diagnosed and relapsed multiple myeloma patients

The Understanding IBS chart presents an overall view of the symptoms and causes of Irritable Bowel Syndrome. The main image features the large intestine, with cut-away views showing a spasm and inflammation. Heavy cover stock with protective varnish for durability.