For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.

This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field.

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

"Rare Diseases and Orphan Drugs" shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases.

Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease.

This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common.
Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseasesStresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathologyDiscusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchersOffers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.

Two years after his wife, Jane, was diagnosed with Alzheimer's, Robert McAllister began a journal, closely documenting the course of Jane's illness, and all that transpired between them. He wrote faithfully for Jane's sake and for his own, always committed to deepening his understanding of the disease and to talking openly with Jane about what was happening. He promised not only to be her sole caretaker till the end, but always to be at her side to help her sort out Alzheimer's devastating consequences from the "essential Jane" who was the love of his life and complete companion for over fifty years. Robert was 92 at the time of Jane's death and the completion of his journal. His graceful writing, emotional honesty, and ability to convey the transformative power of their love and their abiding faith in God makes this book stand as one of the most powerful additions to the Alzheimer's literature.

"Judy is a wonderful physical therapist, who has energy, enthusiasm and the best 'can do' attitude. She has accurately given a description of the major task of 'in-home care' that most people cannot understand. I applaud her efforts; both the monumental task of care for Dean (who was a super guy) and writing this helpful book. Job well done "

-Joyce Dunlevy Cready, RN, BSN, Rehabilitation

"I want to commend Mrs. Jennings on the work done to put together this book. It will be a valuable resource for patients and caregivers, and provides an honest and thoughtful look at her experiences with LBD. It was an honor to care for Dean and I know that her work with him and in this book will help others who are going through the same difficult life journey."

-Andrew P. Duker, MD, Neurology

"This book is medically appropriate and concise. The information has breadth that is not available in other books. I will recommend it to all my patients with Lewy Body Dementia."

-James P. Simcoe, MD, Family Practice

"What an outstanding caregiver and loving wife to share this most personal knowledge, gained from her heartfelt experience with Lewy Body Dementia."

- Peter A. Towne, PT, FAPTA

Linda L. Towne, PT, MEd,

Orthopedic and Neurological Physical Therapy

This book is the one I wish I'd come across when I joined the fraternity or soon thereafter. It takes a hard look at some of the non-medical issues you may not have thought about. If it has succeeded, you'll recognize them when they turn up in your life. You'll learn how some other men have dealt with them and get ideas about how you might manage them in your own way. Not least, you'll discover some new ways to think about your situation.

What this book is not about is treating prostate cancer. There are countless volumes on that topic. It's about dealing and living with prostate cancer; about handling unfamiliar situations that are going to arise; about regaining a sense of control; about living productively, well and yes, happily to the outerlimits of possibilities.

Blindness A world that both horrifies and fascinates. Imagine you find your eyes aren't working quite right one day. You think you need glasses. Instead, over the next few months, while you lose your vision daily, you discover it is caused by a defect in your mitochondrial DNA. It is hereditary. There is no cure and no way to stop your vision loss. There is no way to predict how much sight you will lose. You could be anywhere from visually impaired to total darkness. You are the first one in your family to be effected so you had no idea this could happen. Typically you are a male at your prime -late teens to early 20's. But, you can be any age or any sex. In this collaboration you will meet a skydiver, lawyer, athlete, sailor, world golf champion, musicians, one who defied death 3 times, people desperate to try anything for a cure, and potentially the first and only person in the world ever cured. There is humor, despair, joy, and the spirit of human nature conquering extreme adversity. Even you may have been born with this genetic bomb - so Welcome to our World.

Recently, there has been a significant and healthy shift to establish the effectiveness of clinical practice, widely referred to as evidence-based medicine. This book fills a major gap in the practice literature for healthcare professionals engaged in providing psychosocial care for their patients suffering from chronic pain or illness. Oxford University, a leader in evidence-based medicine, now has a master's program in evidence-based social work, the only one of its kind. Much of the practice of medicine is evidence based; however, much of the psychosocial care provided to patients is not. This is not due to the absence of such evidence; rather, practice has traditionally relied on clinical evidence, common sense, and practitioner wisdom. However, given the demand for results from governments, from insurance companies, and, most importantly, from patients, psychosocial care must move in the direction of evidence-based practice, for which a great deal of research is available. This book will (1) provide empirically derived support and understanding of psychosocial problems encountered by patients and (2) explore the efficacy of the interventions available for patient care. Chapter 1 will take a historical view of the development of evidence-based practice in medicine and psychology. Chapter 2 will examine the concept of empirically supported evidence, ie, the extent to which the impact of psychosocial problems on health has been measured. The remaining eight chapters will explore a range of psychosocial issues through case illustration and examine both the problems and their management from an evidence-based approach. This book is a departure from reports on evidence-basedpractice to the extent that the empirical bases of the problems reported, and not just their treatment, are subjected to scrutiny.

Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain.
*Neurogenic inflammation in historical perspective
*Cardiac protection by nociceptive afferents
*Molecular mechanisms of nociception
*Sensory mechanisms in migraine pathophysiology
*Vagal signalling of visceral inflammation
*Neurogenic mechanisms in arthritis
*Therapeutic implications of vanilloid-type compounds

Simulation facilities are invaluable for training in medicine and clinical education, biomedical engineering and life sciences. They allow the practice of prevention, containment, treatment, and procedure in a risk-free setting.
This book is a practical guide and reference to the latest technology, operations and opportunities presented by clinical simulation. It shows how to develop and make efficient use of resources, and provides hands-on information to those tasked with setting up and delivering simulation facilities for medical, clinical and related purposes, and the development and delivery of simulation-based education programs.
- A step-by-step manual to developing successful simulation programs
- Shows how to design, construct, outfit and run simulation facilities for clinical education and research.
- The Residency Review Committee of the US Accreditation Council on Graduate Medical Education has begun requiring residency programs to have simulation as an integral part of their training programs.

As medical technology advances and the number of users across different mediums increases, how do we continually shape medical education and practice to meet the needs of these users? Clinical Solutions and Medical Progress through User-Driven Healthcare provides comprehensive coverage and understanding of clinical problem solving in healthcare. The term "user" includes health professionals, as well as patients and anyone who uses the web with a user name. These "users" generate an information flow that "drives" the system's workflow (hence, the choice of the term "driven"). "User-driven healthcare" aims at improved healthcare through clinical problem solving utilizing concerted experiential learning in conversations between multiple users and stakeholders, primarily patients, health professionals, and other actors in a care giving collaborative network across a web interface. Serving as a valuable source for information, this title is perfect for healthcare professionals, researchers, academic instructors, and students alike.

By applying data analytics techniques and machine learning algorithms to predict disease, medical practitioners can more accurately diagnose and treat patients. However, researchers face problems in identifying suitable algorithms for pre-processing, transformations, and the integration of clinical data in a single module, as well as seeking different ways to build and evaluate models. The Handbook of Research on Disease Prediction Through Data Analytics and Machine Learning is a pivotal reference source that explores the application of algorithms to making disease predictions through the identification of symptoms and information retrieval from images such as MRIs, ECGs, EEGs, etc. Highlighting a wide range of topics including clinical decision support systems, biomedical image analysis, and prediction models, this book is ideally designed for clinicians, physicians, programmers, computer engineers, IT specialists, data analysts, hospital administrators, researchers, academicians, and graduate and post-graduate students.

Written by a team of experts in the field, this unique book is a practical guide for the care of cystic fibrosis patients based on day-to-day experience and scientific evidence. Chapters cover every aspect of care from basic daily respiratory and gastroenterology management to the more common complications in cystic fibrosis and includes problem solving more complex issues. Covering all areas of clinical and psychosocial care for the cystic fibrosis patient, Cystic Fibrosis Care is designed to allow quick access to relevant information and is an invaluable guide for physiotherapists, GPs, paediatricians, nurses and dieticians. Quick access to relevant information Boxes throughout the text to reinforce important messages Chapters to cover every aspect of care from basic daily respiratory and gastroenterology management, the more common complications in CF, to problem solving more complex issues