For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.

Two years after his wife, Jane, was diagnosed with Alzheimer's, Robert McAllister began a journal, closely documenting the course of Jane's illness, and all that transpired between them. He wrote faithfully for Jane's sake and for his own, always committed to deepening his understanding of the disease and to talking openly with Jane about what was happening. He promised not only to be her sole caretaker till the end, but always to be at her side to help her sort out Alzheimer's devastating consequences from the "essential Jane" who was the love of his life and complete companion for over fifty years. Robert was 92 at the time of Jane's death and the completion of his journal. His graceful writing, emotional honesty, and ability to convey the transformative power of their love and their abiding faith in God makes this book stand as one of the most powerful additions to the Alzheimer's literature.

"Judy is a wonderful physical therapist, who has energy, enthusiasm and the best 'can do' attitude. She has accurately given a description of the major task of 'in-home care' that most people cannot understand. I applaud her efforts; both the monumental task of care for Dean (who was a super guy) and writing this helpful book. Job well done "

-Joyce Dunlevy Cready, RN, BSN, Rehabilitation

"I want to commend Mrs. Jennings on the work done to put together this book. It will be a valuable resource for patients and caregivers, and provides an honest and thoughtful look at her experiences with LBD. It was an honor to care for Dean and I know that her work with him and in this book will help others who are going through the same difficult life journey."

-Andrew P. Duker, MD, Neurology

"This book is medically appropriate and concise. The information has breadth that is not available in other books. I will recommend it to all my patients with Lewy Body Dementia."

-James P. Simcoe, MD, Family Practice

"What an outstanding caregiver and loving wife to share this most personal knowledge, gained from her heartfelt experience with Lewy Body Dementia."

- Peter A. Towne, PT, FAPTA

Linda L. Towne, PT, MEd,

Orthopedic and Neurological Physical Therapy

Now in paperback - Chris Wark's bestselling guide can help you beat cancer through a toxin-free diet and lifestyle and embark on your own journey towards wellness and healing. Millions of readers have followed Chris Wark's journey on his blog and podcast, and in Chris Beat Cancer, he dives deep into the reasoning and scientific foundation behind the approach and strategies that he used to successfully heal his body from stage III colon cancer. Drawing from the most up-to-date and rigorous research, as well as his deep faith, Chris provides clear guidance and continuous encouragement for his healing strategies, including his Beat Cancer Mindset; radical diet and lifestyle changes; and means for mental, emotional and spiritual healing. Packed with both intense personal insight and extensive healing solutions, this Wall Street Journal bestseller will inspire and guide you on your own journey.

Blindness A world that both horrifies and fascinates. Imagine you find your eyes aren't working quite right one day. You think you need glasses. Instead, over the next few months, while you lose your vision daily, you discover it is caused by a defect in your mitochondrial DNA. It is hereditary. There is no cure and no way to stop your vision loss. There is no way to predict how much sight you will lose. You could be anywhere from visually impaired to total darkness. You are the first one in your family to be effected so you had no idea this could happen. Typically you are a male at your prime -late teens to early 20's. But, you can be any age or any sex. In this collaboration you will meet a skydiver, lawyer, athlete, sailor, world golf champion, musicians, one who defied death 3 times, people desperate to try anything for a cure, and potentially the first and only person in the world ever cured. There is humor, despair, joy, and the spirit of human nature conquering extreme adversity. Even you may have been born with this genetic bomb - so Welcome to our World.

When Joel Soukup was diagnosed with osteosarcoma at the age of sixteen, the diagnosis changed him and his family forever. This family traveled down an unknown path and emerged from their journey in a way they never expected. Read how this young patient and his family handled the devastating diagnosis with strength, love, and faith in God.

By applying data analytics techniques and machine learning algorithms to predict disease, medical practitioners can more accurately diagnose and treat patients. However, researchers face problems in identifying suitable algorithms for pre-processing, transformations, and the integration of clinical data in a single module, as well as seeking different ways to build and evaluate models. The Handbook of Research on Disease Prediction Through Data Analytics and Machine Learning is a pivotal reference source that explores the application of algorithms to making disease predictions through the identification of symptoms and information retrieval from images such as MRIs, ECGs, EEGs, etc. Highlighting a wide range of topics including clinical decision support systems, biomedical image analysis, and prediction models, this book is ideally designed for clinicians, physicians, programmers, computer engineers, IT specialists, data analysts, hospital administrators, researchers, academicians, and graduate and post-graduate students.

Following the core principle of phenomenology as a return "to the things themselves," Body Matters attends to the phenomena of bodily afflictions and examines them from three different standpoints: from society in general that interprets them as "sicknesses," from the medical professions that interpret them as "diseases," and from the patients themselves who interpret them as "illnesses." By drawing on a crucial distinction in German phenomenology between two senses of the body the quantifiable, material body (Korper) and the lived-body(Leib) the authors explore the ways in which sickness, disease, and illness are socially and historically experienced and constructed. To make their case, they draw on examples from a multiplicity of disciplines and cultures as well as a number of cases from Euro-American history. The intent is to unsettle taken-for-granted assumptions that readers may have about body troubles. These are assumptions widely held as well by medical and allied health professionals, in addition to many sociologists and philosophers of health and illness. To this end, Body Matters does not simply deconstruct prejudices of mainstream biomedicine; it also constructively envisions more humane and artful forms of therapy."

Recently, there has been a significant and healthy shift to establish the effectiveness of clinical practice, widely referred to as evidence-based medicine. This book fills a major gap in the practice literature for healthcare professionals engaged in providing psychosocial care for their patients suffering from chronic pain or illness. Oxford University, a leader in evidence-based medicine, now has a master's program in evidence-based social work, the only one of its kind. Much of the practice of medicine is evidence based; however, much of the psychosocial care provided to patients is not. This is not due to the absence of such evidence; rather, practice has traditionally relied on clinical evidence, common sense, and practitioner wisdom. However, given the demand for results from governments, from insurance companies, and, most importantly, from patients, psychosocial care must move in the direction of evidence-based practice, for which a great deal of research is available. This book will (1) provide empirically derived support and understanding of psychosocial problems encountered by patients and (2) explore the efficacy of the interventions available for patient care. Chapter 1 will take a historical view of the development of evidence-based practice in medicine and psychology. Chapter 2 will examine the concept of empirically supported evidence, ie, the extent to which the impact of psychosocial problems on health has been measured. The remaining eight chapters will explore a range of psychosocial issues through case illustration and examine both the problems and their management from an evidence-based approach. This book is a departure from reports on evidence-basedpractice to the extent that the empirical bases of the problems reported, and not just their treatment, are subjected to scrutiny.

Simulation facilities are invaluable for training in medicine and clinical education, biomedical engineering and life sciences. They allow the practice of prevention, containment, treatment, and procedure in a risk-free setting.
This book is a practical guide and reference to the latest technology, operations and opportunities presented by clinical simulation. It shows how to develop and make efficient use of resources, and provides hands-on information to those tasked with setting up and delivering simulation facilities for medical, clinical and related purposes, and the development and delivery of simulation-based education programs.
- A step-by-step manual to developing successful simulation programs
- Shows how to design, construct, outfit and run simulation facilities for clinical education and research.
- The Residency Review Committee of the US Accreditation Council on Graduate Medical Education has begun requiring residency programs to have simulation as an integral part of their training programs.

As medical technology advances and the number of users across different mediums increases, how do we continually shape medical education and practice to meet the needs of these users? Clinical Solutions and Medical Progress through User-Driven Healthcare provides comprehensive coverage and understanding of clinical problem solving in healthcare. The term "user" includes health professionals, as well as patients and anyone who uses the web with a user name. These "users" generate an information flow that "drives" the system's workflow (hence, the choice of the term "driven"). "User-driven healthcare" aims at improved healthcare through clinical problem solving utilizing concerted experiential learning in conversations between multiple users and stakeholders, primarily patients, health professionals, and other actors in a care giving collaborative network across a web interface. Serving as a valuable source for information, this title is perfect for healthcare professionals, researchers, academic instructors, and students alike.

This contributed volume provides a complete overview of Neuro-Behcet's disease (NBD), one of the most serious manifestations of Behcet's disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields.

The author will explain why you need to question the doctor if he doesn't acknowledge the symptoms as a part of the disease. Why it is important to search through research medical journal reviews to discover if other patients have reported your symptoms. To keep up-to-date on diagnosis tools available to confirm your diagnosis. Do not be afraid to ask your health insurance to cover the costs of tests. Get second opinions.