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Books > Medicine > Clinical & internal medicine > Paediatric medicine > General

Chronic Disorders in Children and Adolescents (Hardcover, 2011): Mark L. Goldstein, Stephen J. Morewitz Chronic Disorders in Children and Adolescents (Hardcover, 2011)
Mark L. Goldstein, Stephen J. Morewitz
R2,904 Discovery Miles 29 040 Ships in 10 - 15 working days

There has been a significant increase in the prevalence of certain chronic disorders among children and adolescents. For example, health experts warn of an epidemic of diabetes mellitus due to an increase in the sedentary life style and poor nutrition of children. There are many questions still to be addressed in the study of chronic disorders among children and adolescents.What are the risk factors associated with chronic diseases in these populations?What are the major complications that contribute to disability and increased health care utilization and costs? What impact do chronic diseases have on the psychosocial development? What are the most effective diagnostic, treatment, and rehabilitation strategies? How can patient education and self-management activities be improved to help children and adolescents improve compliance with treatment regimens? How can parents and other family members become more involved in assessment and management? In what ways can peers, schools, religious institutions, and other organizations help children and adolescent scope with their chronic disease? This book addresses these questions by focusing on how eight chronic disorders affect health care utilization, costs, coping, and health outcomes in children and adolescents.Research studies are used to illustrate wide range of topics from the epidemiology of chronic diseases in children and adolescents, health care utilization and costs, to treatment outcomes, disability, and family processes.Case studies from a clinical psychologist's private practice are used to clarify major psychosocial issues underlying chronic diseases in these populations. Chapter One analyzes the epidemiology of eight chronic conditions in children and adolescents. Data on the prevalence of diseases and associated risk factors are stressed in this chapter. Health care planners can use these analyses to improve primary, secondary, and tertiary prevention through more effective uses of health care resources. Chapter Two examines the latest information on health care utilization and costs for children and adolescents that can point to a more efficient means of reducing the rising health care costs associated with the treatment of chronic diseases.

In the remaining chapters, the eight chronic diseases are evaluated in terms of five major issues. First, the latest trends in complications associated with each chronic condition are explored.Second, the impact of each disease on disability and psychosocial development of children and adolescents are analyzed. Third, recent research findings on diagnosis, treatment, and rehabilitation strategies are discussed. Fourth, new trends in patient education and self-management are presented. Fifth, each chapter will assess the role of family, peers, schools, and other organizations in helping children and adolescents cope with their chronic disorders. Dr. Mark L. Goldstein, a clinical psychologist, reviews the literature and uses composite case studies from his practice to illustrate the impact of these trends on how children and adolescents manage chronic disease.The information in this book will be relevant to a wide range of professionals and students in the fields of pediatrics, medicine, nursing, public health, mental health, social work, education, health administration, health policy, and social sciences."

Disruptive Behavior Disorders (Hardcover, 2013 ed.): Patrick H. Tolan, Bennett L. Leventhal Disruptive Behavior Disorders (Hardcover, 2013 ed.)
Patrick H. Tolan, Bennett L. Leventhal
R3,809 R3,526 Discovery Miles 35 260 Save R283 (7%) Ships in 12 - 19 working days

Aggressive behavior among children and adolescents has confounded parents and perplexed professionals-especially those tasked with its treatment and prevention-for countless years. As baffling as these behaviors are, however, recent advances in neuroscience focusing on brain development have helped to make increasing sense of their complexity.

""

Focusing on their most prevalent forms, Oppositional Defiant Disorder and Conduct Disorder, "Disruptive Behavior Disorders" advances the understanding of DBD on a number of significant fronts. Its neurodevelopmental emphasis within an ecological approach offers links between brain structure and function and critical environmental influences and the development of these specific disorders. The book's findings and theories help to differentiate DBD within the contexts of normal development, non-pathological misbehavior and non-DBD forms of pathology. Throughout these chapters are myriad implications for accurate identification, effective intervention and future cross-disciplinary study.

Key issues covered include:

Gene-environment interaction models.Neurobiological processes and brain functions.Callous-unemotional traits and developmental pathways.Relationships between gender and DBD.Multiple pathways of familial transmission.

"Disruptive Behavior Disorders" is a groundbreaking resource for researchers, scientist-practitioners and graduate students in clinical child and school psychology, psychiatry, educational psychology, prevention science, child mental health care, developmental psychology and social work.

Facilitating Pathways - Care, Treatment and Prevention in Child and Adolescent Mental Health (Hardcover, 2004 ed.): Helmut... Facilitating Pathways - Care, Treatment and Prevention in Child and Adolescent Mental Health (Hardcover, 2004 ed.)
Helmut Remschmidt, Myron Belfer, Paul Goodyer
R3,077 Discovery Miles 30 770 Ships in 10 - 15 working days

Multidisciplinary and trans-cultural ...

This book provides an up-to-date review of the current state of care, treatment and prevention in child and adolescent mental health from multidisciplinary and trans-cultural perspectives. Systems of care, services and interventions in selected parts of the world are described by leading experts with a focus on

the current status of services in the respective parts of the world

the major needs and deficits in identifying mental health problems in children and adolescents (awareness and diagnosis)

the major needs in treatment, care and prevention

realistic proposals on how to improve the situation of children and adolescents who suffer from, or are at risk for, mental health problems.

In addition, the major principles and strategies of treatment and intervention are described, on an empirical basis, using a selected number of treatment approaches and treatment settings as examples.

Finally, the possibilities, strategies and limitations of early detection and prevention are reviewed with the aim of improving the living conditions of children and families in need of mental health support.

... a valuable resource for mental health workers all over the world

Theory and Research in Behavioural Paediatrics, v. 5 (Hardcover, New): Hiram E. Fitzgerald, Etc Theory and Research in Behavioural Paediatrics, v. 5 (Hardcover, New)
Hiram E. Fitzgerald, Etc
R2,591 Discovery Miles 25 910 Ships in 12 - 19 working days

Maternal Cocaine Use: Neonatal Outcome (I.J. chasnoff et al.). Psychosocial Influences in the Etiology, Diagnosis, and Prognosis of Nonorganic FailuretoThrive (D. Drotar et al.). A Developmental Approach to Understanding and Controlling Violence (F. Earls). The Role of the School in Prosocial Development (V. Battistich et al.). The Human Infant in Studies of Lateralization of Function: An Historical Perspective (L.J. Harris). Organization of Lateralized Behavior during Infancy (H.E. Fitzgerald et al.). Clinical Application of Asymmetrical Behavioral Communication in ParentInfant Interaction (P. de Chateau). Author Index. Subject Index.

Tongue-Tied - How a Tiny String Under the Tongue Impacts Nursing, Speech, Feeding, and More (Hardcover): DMD Richard Baxter Tongue-Tied - How a Tiny String Under the Tongue Impacts Nursing, Speech, Feeding, and More (Hardcover)
DMD Richard Baxter; Contributions by Ma CCC-Slp Megan Musso, CCC-Slp Lauren Hughes
R728 R655 Discovery Miles 6 550 Save R73 (10%) Ships in 10 - 15 working days
Solving Children's Soiling Problems - A Handbook for Health Professionals (Paperback, 1st ed): Jackie Bracey Solving Children's Soiling Problems - A Handbook for Health Professionals (Paperback, 1st ed)
Jackie Bracey
R936 Discovery Miles 9 360 Ships in 12 - 19 working days

This excellent new title is set to become the first point of reference for all practitioners dealing with children's soiling problems. The author produced this book with the intention of helping the inexperienced practitioner to become more confident in dealing with these clients. The book is aimed at School nurses, health visitors, child branch nursing students, paediatricians and GP's and is designed to be a book can be read front to back, but can also be 'dipped into' when help on a particular aspect of management is required.Easy straight forward approach Written by a nurse for nurses To provide information to the inexperienced nurse, and to assist the more experienced nurse for reference

Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy... Molecular Markers of Brain Tumor Cells - Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy (Hardcover, 2004 ed.)
Bela Bodey, Stuart E Siegel, Hans E. Kaiser
R4,418 Discovery Miles 44 180 Ships in 10 - 15 working days

Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

On Masturbation and Hysteria in Young Children (Hardcover): A (Abraham) 1830-1919 Jacobi On Masturbation and Hysteria in Young Children (Hardcover)
A (Abraham) 1830-1919 Jacobi
R716 Discovery Miles 7 160 Ships in 10 - 15 working days
Complementary Therapies for Pregnancy and Childbirth (Paperback, 2nd edition): Denise Tiran, Sue Mack Complementary Therapies for Pregnancy and Childbirth (Paperback, 2nd edition)
Denise Tiran, Sue Mack
R1,075 Discovery Miles 10 750 Ships in 12 - 19 working days

There has been a rapid increase in the interest of safe complementary and alternative approaches to healthcare in pregnancy and childbirth. For those working in maternity care who seek the evidence base for therapeutic approaches, this book offers a comprehensive guide to the principles and practice of complementary therapies, and their application to expectant andnew mothers and their babies.History and background are given for each therapy, using a specifically midwifery perspective Contraindications and appropriate conditions to treat are specified Up-to-date research is included, as more research is available than ever before and so the midwife has to be able to make accurate assessments based on evidence. Legislative and professional conduct issues are covered ,putting the information into a clear midwifery context and giving guidelines to enable the midwife to deal confidently with new therapeutic approachesComprehensively updated with new research studies where available New chapters on chiropractic, hypnotherapy, Bach flower remedies, Alexander technique

Paediatric Intensive Care Nursing (Hardcover): Carol Williams, Julie Asquith Paediatric Intensive Care Nursing (Hardcover)
Carol Williams, Julie Asquith
R1,835 Discovery Miles 18 350 Ships in 12 - 19 working days

A comprehensive textbook on caring for the infant and child in intensive care. The text includes specific illness / disorders with related A & P, medical management and nursing care and a complete guide to the problems and solutions of working in the PICU.

Pediatric Injury Biomechanics - Archive & Textbook (Hardcover, 2013 ed.): Jeff R. Crandall, Barry S. Myers, David F. Meaney,... Pediatric Injury Biomechanics - Archive & Textbook (Hardcover, 2013 ed.)
Jeff R. Crandall, Barry S. Myers, David F. Meaney, Salena Zellers Schmidtke
R4,398 Discovery Miles 43 980 Ships in 10 - 15 working days

Pediatric Injury Biomechanics: Archive and Textbook consolidates and describes the current state of the art in pediatric injury biomechanics research in the automotive crash environment. Written by the most respected scientists in the field, the objective of this ground-breaking project is to provide a comprehensive archive and analysis of pediatric injury biomechanics research; to be the go-to reference for the epidemiology of motor vehicle related childhood injury data, pediatric anthropometry, pediatric biomechanical properties, tissue tolerance, and computational models. This book provides essential information needed by researchers working in the field of pediatric injury including those involved in rulemaking activities, injury criteria development, child dummy development, and child injury interventions development. In addition to the text, a companion archive will include valuable information and tools to assist in the identification of gaps in research and future research directions.This living document will be regularly updated with current research and advancements in pediatric injury biomechanics.

Assessing Attention-Deficit/Hyperactivity Disorder (Hardcover, 2001 ed.): Arthur D. Anastopoulos, Terri L. Shelton Assessing Attention-Deficit/Hyperactivity Disorder (Hardcover, 2001 ed.)
Arthur D. Anastopoulos, Terri L. Shelton
R3,181 Discovery Miles 31 810 Ships in 10 - 15 working days

Over the past two decades, the assessment of Attention-Deficit/Hyperactivity Disorder (AD/HD) has evolved into a sophisticated balance of science and clinical judgement essential for arriving at reliable and valid diagnostic de- sions. Because of the precarious mix of clinical and empirical skill needed to evaluate children with this disorder, diagnostic practice in this area has been found wanting by many critics. In fact, a 1998 National Institutes of Health consensus panel concluded that "existing diagnostic treatment practices ... point to the need for improved awareness by the health service sector conce- ing an appropriate assessment, treatment, and follow-up. A more consistent set of diagnostic procedures and practice guidelines is of utmost importance" (p. 21). Drs. Arthur D. Anastopoulos and Terri L. Shelton have designed a book that addresses this need. A number of themes are highlighted throughout the text. Perhaps the most important is that the assessment guidelines set forth in this book represent a balance between science and practice. The authors account for the realities of clinical practice in an age of managed care while challenging clinicians to heed the lessons of empirical research. Although the use of empirically based asse- ment procedures may at times fly in the face of cost constraints (e. g. , systematic evaluation of medication effects), the authors present a strong argument for them. Further, they call upon their vast clinical experience to provide concrete suggestions for translating research findings into effective evaluations.

Expanding Receptive and Expressive Skills Through Stories (Express) - Language Formulation in Children with Selective Mutism... Expanding Receptive and Expressive Skills Through Stories (Express) - Language Formulation in Children with Selective Mutism and Other Communication Needs (Paperback)
Evelyn R. Klein, Donna Kennedy
R1,503 Discovery Miles 15 030 Ships in 12 - 19 working days

Expanding Receptive and Expressive Skills through Stories (EXPRESS): Language Formulation in Children with Selective Mutism and Other Communication Needs is a resource that provides a specific treatment approach for professional speech-language pathologists working with children with selective mutism and other language delays or disorders including language learning disabilities, autism spectrum disorders, or for children learning English as a second language. It is a program for expanding receptive and expressive language skills at varying stages of language development, with five levels of communication to allow the clinician to start at the appropriate level for each child, and progress through the levels.The "EXPRESS" approach includes activity modules corresponding to classic children's stories. Children's literature is used as a tool for presenting activities designed to help children learn specific language skills, and supports the Common Core State Standards. Each of the modules requires the corresponding storybook that can be obtained individually or found within "The 20th Century Children's Book Treasury", a compendium that includes all the stories.Using "EXPRESS", children listen to the stories and through the activities presented acquire key concepts, ideas, and details about the material. Vocabulary is enhanced through drawing, describing, and demonstration. Children also have an opportunity to make inferences from the textual material through the question-answer routines developed for each story. Creativity and imagination are fostered using sentence formulation and story generation. "EXPRESS" also includes forms to help the clinician monitor progress and a PluralPlus companion website with video links to the stories and downloadable items from the book such as activity cards and scoring sheets.

Pediatric Cancer in Africa - A Case-Based Guide to Diagnosis and Management (Hardcover, 1st ed. 2017): Daniela Cristina Stefan,... Pediatric Cancer in Africa - A Case-Based Guide to Diagnosis and Management (Hardcover, 1st ed. 2017)
Daniela Cristina Stefan, Mhamed Harif
R3,760 Discovery Miles 37 600 Ships in 12 - 19 working days

This text is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries. Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. This book includes simplified therapy protocols, pain therapy and palliation, as well as ward procedures such as bone marrow aspiration/biopsies, intravenous therapy and chemotherapy drugs mixing. It provides an overview of pediatric cancer epidemiology, cancer registration and organizing support networks and features the management of cancers with associated pathology like AIDS, malnutrition, malaria and tuberculosis.

Pediatric Neuropsychology Case Studies - From the Exceptional to the Commonplace (Hardcover, 2008 ed.): Jennifer Niskala Apps,... Pediatric Neuropsychology Case Studies - From the Exceptional to the Commonplace (Hardcover, 2008 ed.)
Jennifer Niskala Apps, Robert F. Newby, Laura Weiss Roberts
R5,692 Discovery Miles 56 920 Ships in 12 - 19 working days

In the recent literature, the most influential case study books in neuropsychology are in the adult realm. Pediatric neuropsychology is a rapidly developing field with increasingly greater influence in the assessment, diagnosis, early identification, and treatment of childhood illnesses. This book will provide the first centralized, comprehensive resource for case studies in pediatric neuropsychology. Not only will this supply a valuable compilation for the growing numbers of professionals in this field, but will also serve as an innovative and appealing resource for therapists, teachers, and others interested in child development.

This book will be structured in such a way that readers can easily access individual cases of interest, as well as related areas of dysfunction. Section breakdowns will be provided in order to highlight the combined focus of case presentations in acquired neuropsychological dysfunction as well as developmental disorders. Each section will begin with an introductory chapter, highlighting the salient feature of the concept and providing brief, up to date reviews of the current research and theories. Within each global section, individual case studies will serve as stand-alone chapters. Contributing authors will be provided extensive guidance and coaching with regards to the standard format and information to be included in each chapter.

The first section of this book will present cases involving neurological disorders. The intention of this section is to provide not only classic examples of neurological dysfunction in children, but also to provide interesting cases of unique or remarkable presentations. The second section will present an accumulation of cases representing both common and progressive conceptualizations of developmental disabilities. Section three has been designed to highlight cases which often present complex issues to neuropsychologists. The case examples in this section will highlight the use of alternative treatments, pathologies that are often a source of inquiry, and situations that lack the more rigorous scientific data often utilized in other diagnostic procedures. Additionally, this section may include chapters on common differential diagnosis dilemmas in clinical practice. Often multifaceted and even contradictory evidence can arise during evaluations, resulting in complex or problematic situations for the clinician. Such examples are difficult, by their nature, to forecast, but rather would be added during the book s development, as they occur."

Pediatric PET Imaging (Hardcover, 2006 ed.): Martin Charron Pediatric PET Imaging (Hardcover, 2006 ed.)
Martin Charron
R4,545 Discovery Miles 45 450 Ships in 10 - 15 working days

Positron emission tomography (PET) has been at the forefront of fu- tional and molecular imaging for a number of years. The future of di- nostic imaging depends upon the ability to change from imaging anatomy to examining the processes at work in the body. The fact that there are now monographs examining particular aspects of PET, such as this book on the examination of children, speaks to the newly won maturity of PET. The authors are to be congratulated for the timely appearance of this volume. In recent years, PET has transformed the contributions of nuclear medicine to the diagnosis, staging, and follow-up of patients with cancer. Children with cancer deserve the very best and most comp- sionate care that society can provide. Ultimately the greatest comp- sion we can offer as physicians is to provide the best possible care. Those charged with creating public policy in the context of diagnostic medicine must make common cause with physicians and other sci- tists to ensure that that best possible care is realized at the bedside. All of the evidence suggests that PET is central to such optimal cancer care. In addition to the distinguished cast of physicians and researchers who contributed to this book, I welcome the contributions from te- nologists who are a key part of the interaction between the diagnostic process and the sick or potentially sick child. Good care is contingent upon putting parents and child at ease, and the technologist has a lead role in this.

Against-Medical-Advice Discharges from the Hospital - Optimizing Prevention and Management to Promote High Quality,... Against-Medical-Advice Discharges from the Hospital - Optimizing Prevention and Management to Promote High Quality, Patient-Centered Care (Hardcover, 1st ed. 2018)
David Alfandre
R3,621 Discovery Miles 36 210 Ships in 12 - 19 working days

This first-of-its-kind text provides a multidisciplinary overview of a significant problem in hospital-based healthcare: patients who decline inpatient medical care and leave the hospital against medical advice (AMA). Compared to standard hospital discharges, AMA discharges are associated with worse health and health services outcomes. Patients discharged AMA have been found to have disproportionately higher rates of substance use, psychiatric illness, and report stigmatization and reduced access to care. By providing a far reaching examination of AMA discharges for a wide academic and clinical audience, the book serves as a reference for clinical care, research, and the development of professional guidelines and institutional policy. The book provides both a broad overview of AMA discharges with chapters on the epidemiology, ethical and legal aspects, as well as social science perspectives. For clinicians in the disciplines of hospital medicine, pediatrics, emergency medicine, nursing, and psychiatry, the book also provides a patient-centered analysis of the problem, case-based discussions, and a discussion of best practices. This comprehensive review of AMA discharges and health care quality will interest physicians and other health care professionals, social workers, hospital administrators, quality and risk managers, clinician-educators, and health services researchers.

Pediatric Drug Doses (Paperback, 4th Revised edition): G.L. Chattri Pediatric Drug Doses (Paperback, 4th Revised edition)
G.L. Chattri
R609 Discovery Miles 6 090 Ships in 12 - 19 working days
Tuberous Sclerosis Complex - From Basic Science to  Clinical Phenotypes International Review of Child  Neurology Series... Tuberous Sclerosis Complex - From Basic Science to Clinical Phenotypes International Review of Child Neurology Series (Hardcover)
P Curatolo
R1,845 Discovery Miles 18 450 Ships in 10 - 15 working days

"This is clearly the most authoritative and contemporary statement of current knowledge yet published."
from the Foreword by H. Sarnat

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.

This book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.

Paediatricians and child neurologists will find this book uniquely useful.

Respiratory Outcomes in Preterm Infants - From Infancy through Adulthood (Hardcover, 1st ed. 2017): Anna Maria Hibbs, Marianne... Respiratory Outcomes in Preterm Infants - From Infancy through Adulthood (Hardcover, 1st ed. 2017)
Anna Maria Hibbs, Marianne S. Muhlebach
R3,154 Discovery Miles 31 540 Ships in 10 - 15 working days

This book presents pulmonary outcomes of prematurity, from their emergence in infancy through to their consequences in adulthood. With an increasing number of preterm births and more infants surviving, there is now a larger population of adults with lung disease originating in infancy requiring specialized care. Looking at the whole group of preterm infants, not just those with bronchopulmonary dysplasia, this text covers a wide spectrum of pulmonary outcomes, including: pulmonary hypertension, wheezing, and alterations in sleep. The chapter authors focus on critically appraising what is and is not known about each outcome and suggest key questions that still need to be answered. Respiratory Outcomes in Preterm Infants: Sequelae from Infancy through Adulthood is an ideal reference for the multidisciplinary group that cares for these preterm infants and the adults they become, including: neonatologists, pediatric pulmonologists, pediatricians, adult pulmonologists, primary care physicians, nurses, and fellows.

Autoimmune Diseases in Pediatric Gastroenterology (Hardcover, 2002 ed.): F. Hadziselimovic Autoimmune Diseases in Pediatric Gastroenterology (Hardcover, 2002 ed.)
F. Hadziselimovic
R4,386 Discovery Miles 43 860 Ships in 10 - 15 working days

This book is the proceedings of the Falk Symposium No. 127 on Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response.

Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules.

Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC.
In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response.

Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.

Melanoma (Hardcover, 1st ed. 2016): Howard L Kaufman, Janice M Mehnert Melanoma (Hardcover, 1st ed. 2016)
Howard L Kaufman, Janice M Mehnert
R4,325 R3,756 Discovery Miles 37 560 Save R569 (13%) Ships in 12 - 19 working days

Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.

New Directions In Language Development And Disorders (Hardcover, 2000 ed.): Michael Perkins, Sara Howard New Directions In Language Development And Disorders (Hardcover, 2000 ed.)
Michael Perkins, Sara Howard
R4,617 Discovery Miles 46 170 Ships in 10 - 15 working days

Research into child language development is being conducted more extensively, by more people, and in more countries throughout the world than at any point in the past. We now know more than we ever did before about the linguistic, cognitive, neurobio logical, and social capacities that children bring to their language learning task, as well as the ways in which these capacities interact with a whole range of factors present in the child's environment throughout the learning process, not least the particular character istics of the language or languages to which the child is exposed. Far from inducing a sense of complacency, this new knowledge seems instead to create an even stronger impetus to know more. This is partly because of the new and unforeseen questions it raises and partly because of competition between different theories to provide the best explanation of the phenomenon, and which in turn engender different methods of enquiry. This volume addresses many of the key issues which are currently exercising the minds of child language researchers, and which are likely to motivate research for some years to come. The chapters included here-all previously unpublished-present a great deal of new data and address a range of theoretical issues from a variety of perspectives."

Reoperative Pediatric Surgery (Hardcover, 2008 ed.): Steven Teich, Donna A. Caniano Reoperative Pediatric Surgery (Hardcover, 2008 ed.)
Steven Teich, Donna A. Caniano
R5,739 Discovery Miles 57 390 Ships in 10 - 15 working days

Reoperative surgery is a problem that is confronted by every surgeon and this book offers up-to-date information and techniques for critical cases in all of the pediatric surgical specialties. The book is comprehensive, covering the full spectrum of pediatric reoperation, and it addresses the complications of common pediatric surgeries. This book is an essential resource for both surgeons and non-surgeons involved in the care of pediatric patients.

Pediatric Pain Management (Hardcover, 1999 ed.): Lynnda M. Dahlquist Pediatric Pain Management (Hardcover, 1999 ed.)
Lynnda M. Dahlquist
R2,983 Discovery Miles 29 830 Ships in 10 - 15 working days

Pain is a complex, multidimensional phenomenon, with physiological, behav ioral, emotional, cognitive, and developmental aspects (Zeltzer, Barr, McGrath, & Schechter, 1992). To effectively evaluate and manage pain in children, the clini cian must be able to assess the unique ways these complex dimensions interact for the individual child and integrate these dimensions into a treatment plan. This can be a daunting task. The purpose of this book is to provide a framework for conceptualizing pain problems in children that can guide the practitioner in developing an evaluation and treatment plan that is optimal for the individual child. This book is not in tended to be a comprehensive, exhaustive review of the literature on pain manage ment in children. There are several excellent books of this nature (e.g., Bush & Harkins, 1991: McGrath, 1990; Ross & Ross, 1988). Instead, this book is an at tempt to outline an hypothesis testing process of case conceptualizing and treat ment planning that can help structure the task of sorting through the complex interrelationships that determine children's pain."

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