This book explains how studies in brain development and epigenetics-the inextricable interplay of genes and environments-have led to breakthroughs in the understanding of children's psychological disturbances and serve to discredit the scientifically unsupported "chemical imbalance theory" of mental illness. Intended for mental health practitioners, concerned parents, and child advocates alike, this book presents a powerful new paradigm for understanding the causes of children's psychological disturbances-and as a result, the proper treatment of these symptoms. Based in cutting-edge research on the developing brain and epigenetics, this important volume serves to inform readers about the latest scientific conclusions and clinical practices that need to supplant pervasive and often dangerous drug prescriptions to millions of children. Sharna Olfman, PhD, and contributors including leading researchers, clinicians, and childhood advocates present their research findings and explain the implications for treatment of a range of symptoms, including autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), concussion syndromes, and mood disorders. The book definitively lays to rest the "chemical imbalance theory" of mental illness, a theory that has been roundly discredited by the scientific community but kept alive by the pharmaceutical industry. Chapters focus on the real science of epigenetics and the sensitivity of the developing brain to environmental influences such as trauma and chemical toxins-legitimate research findings that are largely ignored by mental health practitioners and rarely influence practice. Presents a new paradigm for understanding the cause and treatment of children's psychological disturbances based in cutting edge research on the developing brain and epigenetics Addresses the latest groundbreaking research on the treatment of concussion syndromes as well as on the cause and treatment of autism spectrum disorders Offers strategies that promote healthy brain development and protect against childhood psychological disturbances Explains how 21st-century parents' excessive use of cell phones and other mobile devices undermines the quality of attachment and places children at risk for compromised brain development and psychological disturbance

Handbook of Pediatric Surgical Patient Care focuses on the decision-making process in the overall management of the pediatric surgical patient and provides guidelines for diagnosis. The book covers topics ranging from a wide spectrum of neonatal conditions and surgical critical care to other childhood afflictions, pediatric cancer and the injured child. It also focuses on the current management of common childhood conditions including appendicitis, pyloric stenosis and hernias. Algorithms are employed in an effort to streamline surgical care. The purpose of this handbook is to provide a brief, easily accessible, rapid source of contemporary information to students, residents and practitioners caring for infants and children with surgical disorders.

The most comprehensive and practical guide available for caregivers of children who have seizures and epilepsy, now completely updated. For more than 30 years, parents, caregivers, and health care providers have trusted Seizures and Epilepsy in Children to provide comprehensive, science-based information and practical answers to the most common questions about these conditions. In this new edition, completely revised and updated, a team of experts from Johns Hopkins Medicine offers guidance on: * diagnostic testing and the latest treatments * recommendations for the best devices, apps, and websites * driving, health insurance, and playing sports * navigating school and other environments * mental health issues and counseling * coping with disability * side effects from medications This new edition also features dedicated chapters on diet, complementary and alternative medicine, and rescue medicines. Seizures and Epilepsy in Children is the go-to resource for caregivers and families with children who have epilepsy and seizures.

In collaboration with Consulting Editor, Dr. Bonita Stanton, Guest Editor Dr. Nelson L. Turcios has created a comprehensive issue on the multiple pulmonary symptoms associated with pediatric disease. In this issue of Pediatric Clinics of North America, expert authors have contributed clinical review articles that are current and timely. Articles are devoted to the following topics: Pulmonary Manifestations of Genetic Disorders in Children; Pulmonary Manifestations of Congenital Heart Disease in Children; Pulmonary Manifestations of Gastrointestinal, Pancreatic & Liver Diseases in Children; Pulmonary Manifestations of Hematologic and Oncologic Diseases in Children; Pulmonary Manifestations of Endocrine and Metabolic Diseases in Children; Pulmonary Manifestations of Immunosuppressive Diseases Other than HIV in Children; Pulmonary Manifestations of Human Immunodeficiency Virus (HIV) Infection in Children; Pulmonary Manifestations of Rheumatoid Diseases in Children; Pulmonary Manifestations of Systemic Vasculitis in Children; Pulmonary Manifestations of Neuromuscular Diseases in Children; Pulmonary Manifestations of Renal Disorders in Children; Pulmonary Manifestations of Parasitic Diseases in Children; Pulmonary Manifestations of Skin Disorders in Children; Adverse Environmental Exposure and Childhood Respiratory Health in Children; Functional Respiratory Disorders in Children; and Healthcare Inequalities in Pediatric Respiratory Diseases in Children. Pediatricians will come away with the clinical information they need to treat pulmonary conditions and manage outcomes in children with pediatric diseases.

Together with Consulting Editor Dr. Bonita Stanton, Guest Editors Dr. Max Coppes and Leontein Kremer have put together a comprehensive monograph that updates pediatricians on pediatric cancer survivorship. They have selected worldwide experts who have contributed the most current clinical reviews to provide the information you need for care of the pediatric cancer patient. Articles are devoted specifically to the following topics: Stories from survivors and introduction to survivorship; What we know about survivors and how we know this: Early studies, early cohorts, registries and current cohorts of survivors; Radiotherapy and late effects; Guidelines for survivorship care after childhood cancer; Lifestyle, fatigue, social integration in survivors; Psychological & neurocognitive health; Second cancer risk: Risk, exposures, genetics; Cardiovascular (including genetics ) and pulmonary disease; Fertility and reproductive complications; Endocrine health conditions, including thyroid, growth, bone, and metabolic syndrome; Renal and hepatic health after childhood cancer; Hearing and other neurologic problems; and The future of survivorship (future challenges and research) including new agents. Pediatricians will come away with the information they need to improve patient outcomes.

The new edition of Manual of Pediatric Anesthesia, by Drs. Lerman, Cote & Steward, summarizes the principles of pediatric anesthesia and details important management considerations for a wide variety of conditions. Thoroughly updated and expanded, it reflects the latest research on new drugs and techniques to keep you absolutely up to date. Covering everything from chronic and acute pain through the pathophysiology of surgical disease to endoscopic procedures, you'll find exactly what you need to safely and effective administer anesthesia to your pediatric patients. Also, it's handy, pocket size is perfect for quick reference and review. . Discusses anesthetics and procedures outside of the operating room. . Explores the issue of anxiety and the parent/child/anesthesiologist relationship. . Provides more tables and algorithms for at-a-glance guidance. . Presents an index of syndromes and conditions and their implications for the anesthesiologist. . Includes appendices on drug dosages and growth curves. . Uses a consistent format throughout that makes reference easy. . Includes the latest information on recently introduced drugs used in pediatric anesthesia to keep you up to date on dosing and adverse reactions. . Features new chapters on Anesthetic Implications of Syndromes and Unusual Disorders and Cardiopulmonary and Neonatal Resuscitation to help you prepare for the challenges you face. . Presents expanded coverage of complex surgical conditions, including minimally invasive techniques. . Covers today's advances in sedation and intraoperative and postoperative pain management for the latest perspectives on the controversial topic of pediatric pain management.

This book addresses the importance and relevance of interprofessional care coordination for children and youth with autism spectrum disorder (ASD). It covers the role of interprofessional collaborations across various settings for multiple service provision purposes. The volume examines interprofessional collaboration among professionals across such broad issues as screening, evaluation, intervention, and overall care management of ASD. In addition, the book explores more narrowly focused issues, such as providing transition services during early childhood and young adulthood, culturally responsive practice and advocacy issues for individuals with ASD from diverse backgrounds, and providing care for individuals with ASD and co-occurring trauma. Finally, the book concludes with the editors' recommendations for future directions in interprofessional care for pediatric ASD. Topics featured in this book include: Autism screening tools and interdisciplinary coordination of the processes. Dell Children's (S)TAAR Model of Early Autism Assessment. The Early Start Denver Model (ESDM). Transition from early schooling for youth with ASD. Postsecondary and vocational opportunities for youth with autism. Transitioning from pediatric to adult medical systems. International perspectives in coordinated care for individuals with ASD. Psychopharmacology of ASD. Interprofessional Care Coordination for Pediatric Autism Spectrum Disorder is an essential resource for researchers, clinicians and professionals, and graduate students in clinical child and school psychology, social work, behavioral therapy and related disciplines, including clinical medicine, clinical nursing, counseling, speech and language pathology, and special education.

This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.

Together with Consulting Editor, Dr. Bonita Stanton, the Guest editors of this issue, from the University of Colorado School of Medicine, have secured expert authors to provide updated clinical review articles in the area of pediatric cardiology. Specific topics include: Evaluation of Cardiac Murmur and chest pain; Palpitations and Syncope; Update on Management of Kawasaki Disease; Rheumatic Heart Disease; Myocarditis/Pericarditis; Update on Infective Endocarditis; Update on Pediatric Heart Failure; Update on Pediatric Pulmonary Hypertension; Update on Preventative Cardiology; Common Left to Right Shunt Lesions; Outcomes in Hypoplastic Left Heart Syndrome; Outcomes in Adult Congenital Heart Disease (Neurocognitive Issues and Transition); Innovations in Pediatric Cardiology; The Next Frontier in Pediatric Cardiology: Artificial Intelligence. Readers will come away with the latest clinical coverage of diagnosis and treatment for pediatric cardiology issues.

The fourth edition of this textbook offers a scientific and practical context within which to understand and conduct clinical assessments of children's and adolescent's personality and behavior. The new edition ensures that the content is relevant to diagnostic criteria for major forms of child and adolescent psychopathology in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It provides updated information on specific tests and discusses advances in research that have occurred since the last edition that are relevant for assessing the most common forms of psychopathology shown by children and adolescents. The volume is unique in providing both the scientific and ethical basis to guide psychological testing, as well as providing practical advice for using specific tests and assessing specific forms of psychopathology. This new edition: Highlights how current trends in psychological classification, such as the DSM-5 and the Research Domain Criteria, should influence the clinical assessment of children and adolescents. Provides updates to professional standards that should guide test users. Discusses practical considerations in planning and conducting clinical assessments. Evaluates the most recent editions of common tests used in the clinical assessment of child and adolescent personality and behavior. Provides an overview of how to screen for early signs of emotional and behavioral risk for mental problems in children and adolescents. Discusses practical methods for integrating assessment information collecting as part of a clinical assessment. Uses current research to guide clinical assessments of children with Attention-deficit/Hyperactivity Disorder, conduct problems, depression, anxiety, and autism spectrum disorder. Clinical Assessment of Child and Adolescent Personality and Behavior is a valuable updated resource for graduate students as well as veteran and beginning clinicians across disciplines, including school, clinical child, developmental, and educational psychology; psychiatry; counseling; and social work; as well as related disciplines that provide mental health and educational services to children and adolescents.

This book provides useful information on conventional radiology which will help the pediatricians in their day-to-day office practice as a ready to refer guide in pediatric radiological investigations. Discusses the discovery and evolution of X-rays. Provides an outline of radiation hazards, types of X-rays and radiographic positions in pediatrics. Advent of Digital Radiography and case scenarios of clinical importance added in all essential chapters. Contains information on emergency radiological investigation. This book will be of immense help for UG and PG students, practicing pediatricians and teaching faculties alike.

In collaboration with Consulting Editor Dr. Bonita Stanton, the Guest Editors of this issue of Pediatric Clinics of North America have comprehensively review the current and future opportunities for implementing telehealth into pediatric practice. Expert authors have written review articles that provide information based on current knowledge of implementation of technologies but also ask questions about how to implement and what potential challenges there will be. Articles are specifically devoted to: Overview of Telehealth for Pediatricians; Role of Doctor-Patient Relationship in Telehealth; Design Purpose and Design Thinking for Telehealth; How to Implement Telehealth in Pediatrics; Issues Related to Adoption of Health Apps and Telemedicine Programs; Workforce Trends and Business Model for Telehealth; Moral, Political and Economic and Social Dilemmas of Telehealth; Automated Digital Health with Big Data, Predictive Analytics and AI; Tele-rounds and Cased-Based Training; Role of Text-messaging and Messaging apps in telehealth; High-Quality Telehealth Training Programs; Technical and Regulatory Issues of Telehealth Medicine; and Global Health Perspective on Telehealth. Pediatricians will come away with the information they need to employ telemedicine in their clinical practice

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

Each year, Advances in Pediatrics focuses on providing current clinical information on important topics in pediatrics. Dr. Carol Berkowitz and her editorial board, comprised of top experts in the field, have assembled authors to provide updates on the following topics: Evaluation and Management of Febrile Infants; Pediatric Emergency Medicine and Ultrasonography; The Patient-Centered Pediatric Emergency Department; Health Considerations of Refuge and Immigrant Children; Management of scoliosis; Health and Wellness for LGBTQ Youth; Sexually exploited children: recognizing and addressing; Movement disorders in children; Childhood trauma management in primary care; Feeding issues in young children; Physician Well-being and Burnout; New Molecular Methods for Diagnosing Infectious Diseases; Parental refusal: treatments, procedures and vaccines; Pediatric oncology in the ICU setting; Diaphragmatic hernia: Management and Outcomes; and Global Health and Pediatric Education: Opportunities and Challenges. Readers will come away with the clinical information that supplements their professional knowledge so they can make informed clinical decisions that improve patient outcomes.

In the fall of 2009, Amy Lutz and her husband, Andy, struggled with one of the worst decisions parents could possibly face: whether they could safely keep their autistic ten-year-old son, Jonah, at home any longer. Multiple medication trials, a long procession of behavior modification strategies, and even an almost year-long hospitalization had all failed to control his violent rages. Desperate to stop the attacks that endangered family members, caregivers, and even Jonah himself, Amy and Andy decided to try the controversial procedure of electroconvulsive therapy or ECT. Over the last three years, Jonah has received 136 treatments. His aggression has greatly diminished, and for the first time Jonah, now fourteen, is moving to a less restricted school.

"Each Day I Like It Better" recounts the journeys of Jonah and seven other children and their families (interviewed by the author) in their quests for appropriate educational placements and therapeutic interventions. The author describes their varied, but mostly successful, experiences with ECT.

A survey of research on pediatric ECT is incorporated into the narrative, and a foreword by child psychiatrist Dirk Dhossche and ECT researcher and practitioner Charles Kellner explains how ECT works, the side effects patients may experience, and its current use in the treatment of autism, catatonia, and violent behavior in children.

The field commonly known as "infant mental health" integrates current research from developmental psychology, genetics and neuroscience to form a model of prevention, intervention and treatment well beyond infancy. This book presents the core concepts of this vibrant field and applies them to common childhood problems, from attention deficits to anxiety and sleep disorders. Readers will find a friendly guide that distills this developmental science into key ideas and clinical scenarios that practitioners can make sense of and use in their day-to-day work. Part I offers an overview of the major areas of research and theory, providing a pragmatic knowledge base to comfortably integrate the principles of this expansive field in clinical practise. It reviews the newest science, exploring the way relationships change the brain, breakthrough attachment theory, epigenetics, the polyvagal theory of emotional development, the role of stress response systems, and many other illuminating concepts. Part II then guides the reader through the remarkable applications of these concepts in clinical work. Chapters address how to take a textured early developmental history, navigate the complexity of postpartum depression, address the impact of trauma and loss on children's emotional and behavioural problems, treat sleep problems through an infant mental health lens, and synthesise tools from the science of the developing mind in the treatment of specific problems of regulation of emotion, behaviour and attention. Fundamental knowledge of the science of early brain development is deeply relevant to mental health care throughout a client's lifespan. In an era when new research is illuminating so much, mental health practitioners have much to gain by learning this leading-edge discipline's essential applications. This book makes those applications and their robust benefits in work with clients, readily available to any professional.

* What is trauma? * How does it affect children? * How can adults help? Providing straightforward answers to these complex questions, The Simple Guide to Child Trauma is the perfect starting point for any adult caring for or working with a child who has experienced trauma. It will help them to understand more about a child's emotional and behavioural responses following trauma and provides welcome strategies to aid recovery. Reassuring advice will also rejuvenate adults' abilities to face the challenges of supporting children.

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.