Developing an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can significantly increase the patient's chance for survival. For this reason, CAD systems for lung cancer have been investigated in a large number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This book overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. Overviews the latest state-of-the-art diagnostic CAD systems for lung cancer imaging and diagnosis Offers detailed coverage of 3D and 4D image segmentation Illustrates unique fully automated detection systems coupled with 4D Computed Tomography (CT) Written by authors who are world-class researchers in the biomedical imaging sciences Includes extensive references at the end of each chapter to enhance further study Ayman El-Baz is a professor, university scholar, and chair of the Bioengineering Department at the University of Louisville, Louisville, Kentucky. He earned his bachelor's and master's degrees in electrical engineering in 1997 and 2001, respectively. He earned his doctoral degree in electrical engineering from the University of Louisville in 2006. In 2009, he was named a Coulter Fellow for his contributions to the field of biomedical translational research. He has 17 years of hands-on experience in the fields of bio-imaging modeling and noninvasive computer-assisted diagnosis systems. He has authored or coauthored more than 500 technical articles (132 journals, 23 books, 57 book chapters, 211 refereed-conference papers, 137 abstracts, and 27 U.S. patents and disclosures). Jasjit S. Suri is an innovator, scientist, a visionary, an industrialist, and an internationally known world leader in biomedical engineering. He has spent over 25 years in the field of biomedical engineering/devices and its management. He received his doctorate from the University of Washington, Seattle, and his business management sciences degree from Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio. He was awarded the President's Gold Medal in 1980 and named a Fellow of the American Institute of Medical and Biological Engineering for his outstanding contributions in 2004. In 2018, he was awarded the Marquis Life Time Achievement Award for his outstanding contributions and dedication to medical imaging and its management.

This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.

The use of more robust, affordable, and efficient techniques and technologies in the application of medicine is presently a subject of huge interest and demand. Technology and Medical Sciences solidifies knowledge in the fields of technology and medical sciences and to define their key stakeholders. The book is designed for academics in engineering, mathematics, medicine, biomechanics, computation sciences, hardware development and manufacturing, electronics and instrumentation, and materials science.

This book provides structured up-to-date information on all routine protocols used for multislice (multidetector row) CT. The volume contains a detailed technical section and covers the prevailing investigations of the brain, neck, lungs and chest, abdomen with parenchymal organs and gastrointestinal tract, the musculoskeletal system and CTA as well as dedicated protocols for the heart. Separate chapters address the how-to of CT-guided interventions such as punctures, drainages, and therapeutic approaches. Each protocol is displayed en bloc, enabling rapid appreciation of indications and the necessary scanner settings.

The second edition includes contributions by renowned experts in the field, who not only provide their clinical experience on each topic, but also give guidelines for indications, workflow, postprocessing and reconstruction algorithms.

Goals of the Book Overthelast thirty yearsthere has been arevolutionindiagnostic radiology as a result oftheemergenceofcomputerized tomography (CT), which is the process of obtaining the density distribution within the human body from multiple x-ray projections. Since an enormous variety of possible density values may occur in the body, a large number of projections are necessary to ensure the accurate reconstruction oftheir distribution. There are other situations in which we desire to reconstruct an object from its projections, but in which we know that the object to be recon structed has only a small number of possible values. For example, a large fraction of objects scanned in industrial CT (for the purpose of nonde structive testing or reverse engineering) are made of a single material and so the ideal reconstruction should contain only two values: zero for air and the value associated with the material composing the object. Similar as sumptions may even be made for some specific medical applications; for example, in angiography ofthe heart chambers the value is either zero (in dicating the absence of dye) or the value associated with the dye in the chamber. Another example arises in the electron microscopy of biological macromolecules, where we may assume that the object to be reconstructed is composed of ice, protein, and RNA. One can also apply electron mi croscopy to determine the presenceor absence ofatoms in crystallinestruc tures, which is again a two-valued situation."

This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.

Interventional cardiology has transitioned from angiographic subjective analysis of stenosis severity into assessment of plaque characteristics and objective assessment of stenosis severity. The evolution of novel interventional imaging modalities is progressively altering our understanding of coronary artery disease diagnosis and prognosis. This book will be an essential companion to assist interventional cardiologists in better assessing patients with Coronary Artery Disease. It will encompass and review all interventional imaging modalities and provide guidance for interventional cardiologists to use these modalities.

This book contains invited lecturers and full papers presented at VIPIMAGE 2011 - III ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (Olhao, Algarve, Portugal, 12-14 October 2011). International contributions from 16 countries provide a comprehensive coverage of the current state-of-the-art in: Image Processing and Analysis; Tracking and Analyze Objects in Images; Segmentation of Objects in Images; 3D Vision; Signal Processing; Data Interpolation, Registration, Acquisition and Compression; Objects Simulation; Medical Imaging; Virtual Reality; Software Development for Image Processing and Analysis; Computer Aided Diagnosis, Surgery, Therapy and Treatment; Computational Bioimaging and Visualization; Telemedicine Systems and their Applications. Related techniques also covered in this book include the level set method, finite element method, modal analyses, stochastic methods, principal and independent components analyses and distribution models. Computational Vision and Medical Image Processing - VIPIMAGE 2011 will be useful to academics, researchers and professionals in Computational Vision (Image Processing and Analysis), Computer Sciences, Computational Mechanics and Medicine.

Molecular imaging of drugs or drug carriers is a valuable tool that can provide important information on spatiotemporal distribution of drugs, allowing improved drug distribution at target sites. Chemically labelled drugs can be used to both diagnose and treat diseases. This book introduces the topic of image guided drug delivery and covers the latest imaging techniques and developments in theranostics, highlighting the interdisciplinary nature of this field as well as its translational ability. These technologies and techniques hold potential for individualised, safer therapies. The book introduces the chemistry behind labelling drugs or drug carriers for imaging. It then discusses current scientific progress in the discovery and development of theranostic agents as well as the latest advances in triggered drug delivery. Novel imaging techniques that can be combined with therapeutics are presented, as well as results and findings from early clinical trials. This text will provide postgraduates and researchers in various disciplines associated with drug discovery, including chemistry, device engineering, oncology, neurology, cardiology, imaging, and nanoscience, an overview of this important field where several disciplines have been combined to improve treatments. Readers will be introduced to techniques that can be translated to the clinic and be applied widely.

"This book presents the technology evaluation methodology from the point of view of radiological physics and contrasts the purely physical evaluation of image quality with the determination of diagnostic outcome through the study of observer performance. The reader is taken through the arguments with concrete examples illustrated by code in R, an open source statistical language." - from the Foreword by Prof. Harold L. Kundel, Department of Radiology, Perelman School of Medicine, University of Pennsylvania "This book will benefit individuals interested in observer performance evaluations in diagnostic medical imaging and provide additional insights to those that have worked in the field for many years." - Prof. Gary T. Barnes, Department of Radiology, University of Alabama at Birmingham This book provides a complete introductory overview of this growing field and its applications in medical imaging, utilizing worked examples and exercises to demystify statistics for readers of any background. It includes a tutorial on the use of the open source, widely used R software, as well as basic statistical background, before addressing localization tasks common in medical imaging. The coverage includes a discussion of study design basics and the use of the techniques in imaging system optimization, memory effects in clinical interpretations, predictions of clinical task performance, alternatives to ROC analysis, and non-medical applications. Dev P. Chakraborty, PhD, is a clinical diagnostic imaging physicist, certified by the American Board of Radiology in Diagnostic Radiological Physics and Medical Nuclear Physics. He has held faculty positions at the University of Alabama at Birmingham, University of Pennsylvania, and most recently at the University of Pittsburgh.

Intracoronary ultrasound is a rapidly evolving imaging modality and the increasing number of published studies indicates that the technique is safe and provides incremental and more detailed diagnostic information than coronary angiography. The technique has the potential to study the pathobiology of atherosclerosis, to clarify the significance of angiographically equivocal lesions and has helped us to understand the mechanisms, effects and complications of catheter-based revascularization procedures. Combinations of imaging and therapeutic devices are being developed for both guidance and assessment of the revascularization procedure. Three-dimensional reconstruction of coronary segments is now possible in real time and provides the opertor with more detailed information on coronary pathology. In this monograph, leading experts in the field present the state of the art of all these new developments.

High Efficiency Video Coding and Other Emerging Standards provides an overview of high efficiency video coding (HEVC) and all its extensions and profiles. There are nearly 300 projects and problems included, and about 400 references related to HEVC alone. Next generation video coding (NGVC) beyond HEVC is also described. Other video coding standards such as AVS2, DAALA, THOR, VP9 (Google), DIRAC, VC1, and AV1 are addressed, and image coding standards such as JPEG, JPEG-LS, JPEG2000, JPEG XR, JPEG XS, JPEG XT and JPEG-Pleno are also listed. Understanding of these standards and their implementation is facilitated by overview papers, standards documents, reference software, software manuals, test sequences, source codes, tutorials, keynote speakers, panel discussions, reflector and ftp/web sites - all in the public domain. Access to these categories is also provided.

This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound.

Focusing on time-tested protocols, tailored imaging and current procedural equipment, this popular, practical handbook by Drs. Krishna Kandarpa, Lindsay Machan, Robert Lewandoski, and Parag J. Patel features extensive updates to keep you current with rapid growth in the field. Now in brilliant full color throughout, Kandarpa's Handbook of Interventional Radiologic Procedures, 6th Edition, is a convenient, easy-access guide to all current radiologic procedures. It's an ideal resource not only for practicing interventional and general radiologists, but also for fellows and residents in training, IR nurses, and special procedure technologists. . Covers indications, contraindications, preparation, technique, postprocedural management, prevention, and management of complications for every procedure. Includes expanded information on innovative oncological & lymphatic interventions. Features an all-new full-color design and illustrations, and an outline format for quick reference. Provides must-know information on vascular access and catheter-directed angiography, vascular imaging, trans-arterial procedures, trans-venous procedures, non-vascular procedures, and intra-procedural patient management. Discusses risk management, nursing management (eBook only), and drugs and dosages. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This volume provides a comprehensive overview of quality metrics and methods used to improve quality for all major modalities of CRC screening. It introduces the readers to the evidence of effectiveness behind various CRC screening modalities: stool-based tests (Fecal Occult Blood, Fecal Immunochemical and Fecal DNA tests), flexible sigmoidoscopy, colonoscopy and CT colonography. In-depth chapters review the latest guidelines for CRC screening, compare differences among the five major national guidelines, and highlight the need for valid quality and cost indicators. While the main focus of this volume is on colonoscopy, since most quality indicators and analyses have focused on this modality of screening and surveillance, one chapter is devoted to quality indicators of other screening modalities. Differences between process and outcome measures are also highlighted and a small but valid set of recommended national measures are listed. Written by experts in the field, Colorectal Cancer Screening: Quality and Benchmarks is an important and useful resource written for gastroenterologists, primary care physicians, general and colorectal surgeons, family physicians, and investigators with research focus in screening and quality metrics.

Diagnostic imaging is an essential component in the evaluation of the patient with known or suspected respiratory tract disease. While chest radiography continues to serve as the primary tool for imaging the chest, advances in computed tomography (CT) have led to a variety of applications such as high-resolution CT (HRCT), advanced 3-D airway imaging, and image-guided procedures. The aim of this book is to deliver a clinically-oriented approach to pulmonary imaging. Each chapter of the book will provide an organized approach to the different facets of imaging of specific clinical scenarios, focusing on strengths and weaknesses of available imaging tests. High quality examples of typical imaging findings of specific conditions will supplement the text. The target readers include practicing internists, pulmonologists, thoracic surgeons, and primary care practitioners. Other readers will include respiratory care therapists and medical students. The proposed cohort of authors represents experts in the field of thoracic radiology. These authors have experience in thoracic radiology and medical writing, each will deliver a high-quality chapter meeting the aims and scope of this book while addressing the target audience. Aside from the first three chapters, which are introductory materials, each author will be invited to select a clinician with whom they work closely to serve as a co-author in order to provide a chapter that maintains the clinical orientation of this book.

The book has two intentions. First, it assembles the latest research in the field of medical imaging technology in one place. Detailed descriptions of current state-of-the-art medical imaging systems (comprised of x-ray CT, MRI, ultrasound, and nuclear medicine) and data processing techniques are discussed. Information is provided that will give interested engineers and scientists a solid foundation from which to build with additional resources. Secondly, it exposes the reader to myriad applications that medical imaging technology has enabled.

The evolution of technological advances in infrared sensor technology, image processing, "smart" algorithms, knowledge-based databases, and their overall system integration has resulted in new methods of research and use in medical infrared imaging. The development of infrared cameras with focal plane arrays no longer requiring cooling, added a new dimension to this modality. Medical Infrared Imaging: Principles and Practices covers new ideas, concepts, and technologies along with historical background and clinical applications. The book begins by exploring worldwide advances in the medical applications of thermal imaging systems. It covers technology and hardware including detectors, detector materials, un-cooled focal plane arrays, high performance systems, camera characterization, electronics for on-chip image processing, optics, and cost-reduction designs. It then discusses the physiological basis of the thermal signature and its interpretation in a medical setting. The book also covers novel and emerging techniques, the complexities and importance of protocols for effective and reproducible results, storage and retrieval of thermal images, and ethical obligations. Of interest to both the medical and biomedical engineering communities, the book explores many opportunities for developing and conducting multidisciplinary research in many areas of medical infrared imaging. These range from clinical quantification to intelligent image processing for enhancement of the interpretation of images, and for further development of user-friendly high-resolution thermal cameras. These would enable the wide use of infrared imaging as a viable, noninvasive, low-cost, first-line detection modality.

The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

This book encompasses the full breadth of the super-resolution imaging field, representing modern techniques that exceed the traditional diffraction limit, thereby opening up new applications in biomedicine. It shows readers how to use the new tools to increase resolution in sub-nanometer-scale images of living cells and tissue, which leads to new information about molecules, pathways and dynamics. The book highlights the advantages and disadvantages of the techniques, and gives state-of-the-art examples of applications using microscopes currently available on the market. It covers key techniques such as stimulated emission depletion (STED), structured illumination microscopy (SSIM), photoactivated localization microscopy (PALM), and stochastic optical reconstruction microscopy (STORM). It will be a useful reference for biomedical researchers who want to work with super-resolution imaging, learn the proper technique for their application, and simultaneously obtain a solid footing in other techniques.

Authored by a leading educator, this book teaches the fundamental mathematics and physics concepts associated with medical imaging systems. Going beyond mere description of imaging modalities, this book delves into the mechanisms of image formation and image quality common to all imaging systems: contrast mechanisms, noise, and spatial and temporal resolution, making it an important reference for medical physicists and biomedical engineering students. This is an extensively revised new edition of The Physics of Medical X-Ray Imaging by Bruce Hasegawa (Medical Physics Publishing, 1991), and includes a wide range of modalities such as X-ray CT, MRI and SPECT.

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.