Guest edited by Bonnie Joe, this issue of MRI Clinics covers breast screening protocols, imaging the newly diagnosed cancer patient, imaging to monitor response to therapy, breast MR spectroscopy, and more.

This detailed volume presents a number of chapters that will aid researchers in jumping the hurdle preventing the popularization of advanced intravital imaging technology usage, namely the complicated experimental protocols. Leading researchers undertaking imaging studies in the field of bone and immune systems have contributed the chapters that aim to guide readers through these complex methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Intravital Imaging of Dynamic Bone and Immune Systems: Methods and Protocols will serve as an idea guide for general readers in order to establish and perform these experiments by their own.

Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia. Individual chapters address the role of imaging in differential diagnosis and in the evaluation of pharmacologic and surgical treatment effects. In-depth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the roles of neuroinflammation, protein aggregation, and abnormal network organization in parkinsonism. Additionally, the text covers a number of relevant novel topics including recent advances in volumetric and functional MRI, echosonography, dopaminergic and cholinergic neurotransmitter imaging, and applications to experimental interventions such as gene therapy and transplantation. Covering a wide range of subjects and beautifully illustrated, Imaging in Parkinson's Disease is a valuable reference for neurologists, neurosurgeons and neuropsychologists, and a helpful resource for students engaged in postgraduate biomedical and clinical training.

Detect and identify breast lesions at the earliest possible stage with Making the Diagnosis: A Practical Guide to Breast Imaging. Dr. Jennifer Harvey and Dr. David E. March utilize a practical, case-based approach to help you select and make optimal use of today's imaging options. Learn the right questions to ask when viewing a mammogram, MRI, or ultrasound. Zero in on the key information you need to know with highly templated, concise chapters followed by case studies that reinforce and expand your knowledge. Distinguish normal variants and lookalike lesions from cancer thanks to expert, highly visual guidance on all relevant imaging modalities. Interpret the findings you're likely to see in practice with the aid of high-quality images, enhanced with arrows and labels to help you recognize and identify suspicious lesions. Access the entire text and images online at www.expertconsult.com.

"Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. "Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, "Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.
Provides a background to translational research and the use of brain imaging in neuropsychiatric disordersCritical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkersIdentifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disordersFeatures an accompanying website with additional images and text

The discovery and genetic engineering of fluorescent proteins has revolutionized cell biology. What was previously invisible in the cell often can be made visible with the use of fluorescent proteins. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols presents state-of-the-art research that has contributed to the fluorescent protein revolution to visualize biological processes in the live animal. This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols is the first volume in the new field of in vivo cell biology and it serves both professionals and novices with its well-honed methodologies.

PET/CT is an integral part of the evaluation of patients who have head and neck cancer. In this issue, the state of the art in PET/CT imaging is discussed. The issue starts with an overview of FDG-PET/CT, PET and MRI for normal anatomy, including pitfalls and artifacts. This topic is followed by a review of FDG-PET/CT for initial and subsequent therapy evaluation; progressing to PET and MRI. Other articles discuss SUV as a prognostic factor in head and neck squamous cell carcinoma, PET in head and neck cancer radiotherapy treatment planning, PET in decision making for neck dissection after radiation treatment, and newer methods for improving yield from FDG-PET imaging for accurate staging, determining tumor biology, and assessing prognosis. The issue focuses on some of the most cutting-edge applications, such as new tracers PET in head and neck squamous cell carcinoma (including FLT and hypoxia imaging). PET scans in thyroid cancer is also discussed.

This issue gives the general radiologist a solid overview of lung cancer imaging techniques. CT screening for lung cancer is discussed, and the evaluation and management of indeterminate pulmonary nodules is reviewed. Revised TNM lung cancer staging, as well as the optimal imaging protocols for lung cancer staging (CT, MR and PET) are thoroughly examined. A multidisciplinary approach to tissue sampling and updated histopathologic classification of lung cancer are discussed. Image-guided ablative therapies for lung cancer are reviewed. Finally, future trends in lung cancer diagnosis and staging and genetics are reviewed, as well as novel biomarkers for lung cancer detection.

CT, contrast CT, MRI, functional MRI, SPECT, CTA, and x-ray as tools to identify pathogens and diagnose intracranial infections are presented. Topics include: Epidemiology of Central Nervous System Infections; Imaging of Cranial Meningitis and Ventriculitis; Encephalitis, Cerebritis and Brain Abscess; Imaging of Central Nervous System Tuberculosis; Imaging of Rickettsial, Spirochetal, and Parasitic Infections; Imaging of Neurocysticercosis; Fungal Infections of the Central Nervous System; Central Nervous System Infections in the Pediatric Population; Imaging of Infectious Diseases of Spine; Neuropathological Findings in Intracranial Infections; Neurosurgical Approach to Infectious Disease of the Brain; Head and Neck Infections.

This 6 volume set presents a groundbreaking resource in this branch of natural organic compounds and demonstrates how proton nuclear magnetic resonance (NMR) spectroscopy can be manipulated in structures of natural organic compounds. The authors provide the most comprehensive data of 17 kinds amounting to over 10,000 natural organic compounds. The 1st volume mainly illustrates the molecular formula and structures of alkaloids.

This monograph covers all aspects of the radiologic diagnosis of urinary tract diverticula, including calyceal, ureteral, bladder, and urethral diverticula. Characteristic and subtle diagnostic features are identified with the aid of numerous high-quality ultrasound, X-ray, and magnetic resonance images, the vast majority of which are drawn from the author's personal clinical practice. In addition, issues relating to terminology, classification, statistics, etiology, pathogenesis, clinical presentation, and differential diagnosis are discussed. The text is complemented by two helpful appendices that document the latest recommendations of the European Society of Urogenital Radiology regarding use of contrast media and the European Medicines Agency on minimizing the risk of nephrogenic systemic fibrosis when using gadolinium- containing contrast agents. This book will be of value for specialists in radiology and urology and also trainees and medical students.

This volume of Methods in Enzymology is thethird of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.
The third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cellsThe chapters provide hints and tricks not available in primary research publicationsIt is an invaluable resource for academics, researchers and students alike"

The book has focussed on the different aspects of sensing technology, i.e. high reliability, adaptability, recalibration, information processing, data fusion, validation and integration of novel and high performance sensors specifically aims to use to inspect mechanical health of structure and similar applications. This book is dedicated to Sensing systems for Structural Health Monitoring offers to variety of users, namely, Master and PhD degree students, researchers, practitioners, especially Civil and Construction engineers. The book will provide an opportunity of a dedicated and a deep approach in order to improve their knowledge in this specific field.

This volume of Methods in Enzymology is the first of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.
Expert authors who are leaders in the fieldExtensively referenced and useful figures and tablesProvides hints and tricks to facilitate reproduction of methods

Congenital spine and spinal cord malformations; Congenital brain malformations (except cortical malformations); Malformations of cortical development; Congenital cystic neck lesions; A simplified approach to pediatric vascular malformations of the head and neck; Congenital face, maxillofacial anomalies; Congenital arterial and venous anomalies of brain, spine and neck; Fetal neuroimaging; Temporal bone malformations; Pediatric orbit; Neurosurgeon's perspective to congenital brain and spine malformations

Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.

Electromyography remains a main diagnostic tool within neurology. This issue of Neurologic Clinics addresses the most recent developments in the clinical application of EMG. Articles in this issue include: Nerve conduction studies: Basic Concepts and Patterns of Abnormalities; Needle Electromyography-Basic Concepts andInterpretation of Recorded Potentials;Electrodiagnostic Evaluation of Carpal TunnelSyndrome;Electrodiagnostic Evaluation of Ulnar Neuropathyand Other Upper Extremity Mononeuropathy; Lower Extremity Mononeuropathies;Electrodiagnostic Evaluation of Brachial Plexopathies; Evaluation ofRadiculopathies;Electrodiagnostic Approach to Motor NeuronDiseases;Electrophysiologic Findings in PeripheralNeuropathies; Evaluation of Neuromuscular Junction Disorders in the EMGLaboratory;Electrodiagnostic Findings inMyopathy;Electrodiagnostic Approach to CranialNeuropathies; Technical Issues with Nerve Conduction Studies and Needle EMG;andCoding and Reimbursement of ElectrodiagnosticStudies.

Since scientists began experimenting with green fluorescent proteins in the middle of the 1990s, these proteins have become one of the most important tools available to researchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are a part of over three million experiments a year, and are invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existence of cancerous stem cells. In Illuminating Disease, Marc Zimmer introduces us to these revolutionary proteins, acquainting readers both with the researchers responsible for the proteins' discovery as well as their wide utility. The book details the history of genetically modified fluorescent parasites and viruses, which provide scientists with new information about the spread of diseases. Green fluorescent proteins have played crucial roles in the research of malaria, AIDS/HIV, swine and bird flu, dengue, cancer, and chagas. They allow scientists and doctors to understand these diseases better, by quite literally illuminating various microscopic pieces that otherwise would have gone unseen. The book is richly illustrated, showing the many visually striking uses of GFP. Many of these scans have won awards in biological imaging competitions. Illuminating Disease is an accessible and illustrated introduction to one of the most important developments in medical research of the last several decades.

Dr. Leonard Swischuk has revised his outstanding work on imaging the cervical spine in children. He draws upon his extensive experience to provide practitioners with an insightful approach to pediatric cervical spine injuries. The text covers developmental anatomy, normal variants, congenital anomalies, abnormalities of the dens, trauma, and miscellaneous abnormalities of the cervical spine. The book has several strengths that appeal to radiology residents, such as its succinct overview of the topic and helpful reference lists that guide readers to additional resources. Dr. Swischuk illustrates conditions he discusses with excellent plain film examples that help residents identify cases they are likely to encounter during board exams and in practice. Accompanying CT and MR images clarify and qualify the findings. Dr. Swischuk's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

A global pool of surgeons and researchers using 3-dimensional imaging for facial plastic surgery present topics on: Image fusion in pre-operative planning; The use of 3D imaging tools including stereolithographic modeling and intraoperative navigation for maxillo-mandibular and complex orbital reconstruction; Custom-made, three-dimensional, intraoperative surgical guides for nasal reconstruction; The benefits and limits of using an integrated 3D virtual approach for maxillofacial surgery; 3D volume assessment techniques and computer-aided design and manufacturing for pre-operative fabrication of implants in head and neck reconstruction; A comparison of different new 3D imaging technologies in facial plastic surgery; 3-D photography in the objective analysis of volume augmentation including fat augmentation and dermal fillers; Assessment of different rhinoplasty techniques by overlay of before and after 3D images; 3D volumetric analysis of combined facial lifting and volumizing (volume enhancement); 3-D facial measurements and perceptions of attractiveness; Teaching 3-D sculpting to Facial Plastic Surgeons, 3-D insights on aesthetics; Creation of the virtual patient for the study of facial morphology; 3-dimensional video analysis of facial movement; 3D modeling of the behavior of facial soft tissues for understanding facial plastic surgery interventions