The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results. Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.

The ECG is one of the most commonly used investigations in contemporary medicine. Interpretation of the ECG can appear daunting, but it is actually relatively straightforward as long as a systematic approach is taken. Pocket ECGs for Nurses assists with this task by providing a detailed yet readable introduction to ECG interpretation, supplemented by clinical information about how to act based on its findings. The book begins by covering the basics of cardiac anatomy and physiology and how these relate to the ECG. It then guides nurses on how to perform a high-quality ECG recording, interpret it and make sense of common ECG abnormalities. The book also includes a guide to ambulatory and bedside monitoring as well as useful chapter summaries. This pocketbook is an essential reference for the non-specialist who needs to be able to record and perform a basic and safe interpretation of an ECG. Written in plain language with clear explanations, bullet lists and summaries throughout, this handy guide will benefit nurses as well as paramedics and other allied health professionals in recording and reading ECGs.

Infra-red thermal imaging is a rapid and non-invasive procedure for mapping skin temperature distribution of the human body. The natural infra-red emission from the skin is captured by the imaging camera, and is displayed as a digital image. Advanced software and high resolution infra-red detectors has allowed for a renaissance in the use of infra-red thermal imaging or thermography in medical research and practice. Thermal imaging provides a two dimensional map of skin temperature, which can often indicate a localisation of hypo or hyperthermia and its major clinical value is in its high sensitivity to pathology in the vascular, muscular, neural and skeletal systems and as such can contribute to the pathogenesis and diagnosis. After a brief review of theory and technology of infra-red imaging the bulk of the book consists of a collection of clinical case studies demonstrating the wide variety of applications for thermography in modern medicine. The combined expertise from a number of centres is used to create a database of images that will be invaluable for practitioners in making diagnoses and measuring treatment efficacy.

"Handbook of Capsule Endoscopy "is a concise guide to the clinical diagnostic use of capsule endoscopy, a non-invasive imaging technology of the gastrointestinal tract. This book is written by an international team with over 30 authors from 8 countries, mainly China, Britain, Israel, Italy, Germany, Korea, United Arab Emirates and the United States.

This book introduces nearly all aspects of capsule endoscopy, including the six devices currently in use, the set up procedures, indications and contraindications, its application in three organs, special use in pediatrics, safety issues and case presentations. This book is an ideal reference work for physicians and surgeons who wish to utilize this helpful imaging technology.

Prof. Zhaoshen Li and Associate Prof. Zhuan Liao are doctors in Changhai Hospital, the Second Military Medical University, Shanghai, China. Mark McAlindon is a consultant gastroenterologist and the directorate of gastroenterology in Royal Hallamshire Hospital, England, the United Kingdom.

This encyclopedia examines more than 125 of the most important and commonly performed medical tests, providing readers with information about how and why they are performed and how each test contributes to monitoring health and diagnosing and treating medical conditions. Whether it's to proactively monitor health, diagnose a condition, or assess how well a particular treatment is working, we all undergo a variety of medical tests throughout our lives. While these tests provide valuable information for doctors and patients, they can sometimes carry significant risks, provide ambiguous or incorrect results, or raise more questions than they answer. Contrary to what some may think, medical testing isn't a simple "yes or no" science carried out by computers in a lab—it is a dynamic process that relies heavily on human detective work and interpretation. Medical Tests in Context: Innovations and Insights highlights more than 125 tests performed across a wide range of medical specialties. Each entry in this encyclopedia follows a standardized format that provides readers with information about how, when, and why the test is conducted; the preparation and risks; how results are determined and where errors might occur; and its history. A collection of case studies offers real-world examples of the successes—and shortcomings—of medical testing.

Get immediate access to crucial information about the most common EMG studies.

This handy, practical resource designed for quick reference at the point of care covers a wide spectrum of electrodiagnostic tests. Written for both novice and experienced electromyographers, this at-a-glance guide is concise enough to fit in a pocket, yet replete with essential technical detail, pearls, and clinical photos to illustrate proper study set-ups.

"Pocket EMG" covers what you need to know to successfully perform nerve conduction and needle EMG studies in a fast-paced clinical environment. It also includes helpful protocols for specific clinical problems.

The first section is devoted to nerve conduction studies and covers sensory and motor studies of the upper and lower extremities, late responses, and other tests including facial motor nerves, blink reflex, and repetitive nerve stimulation. Section two covers needle electromyography and catalogs set-ups for upper and lower extremity tests, paraspinals, and facial muscles. The final two sections contain study protocols for presenting chief complaints or suspected diagnoses, normal values, and high-yield tables and lists. Each test includes a photograph of the proper set-up, indications for performing the test, technical pointers, and physiological considerations.

Key Features:

Organized consistently and pocket-sized for quick reference in the EMG lab Includes a photo of the proper set-up for each test, indications for performing the test, and clinical pearls and pointers to enhance skills Contains study protocols for common complaints, normal value ranges for individual tests, and high-yield tables and lists

The comparison of MR images and cadaver microangiograms of the basal perforating arteries is crucial for understanding the courses and supply areas of these vessels and in turn, for diagnosing pathologies in this region. Divided into three sections- normal anatomy of brain vessels; neurovascular imaging in pathology; and anatomy and imaging of spinal vessels- Neurovascular Imaging contains a rich collection of images to teach the reader how to interpret MR images of the brain vessels and spinal vessels, and how to identify pathological signs. Written and edited by a group of highly acclaimed experts in the field, Neurovascular Imaging is an authoritative account of the interpretation of MR images of the brain vessels and spinal vessels, and is a valuable addition to the library of the diagnostic radiologist.

Over the last two decades, there have been numerous exciting developments in the surgical field of articular cartilage repair. Magnetic resonance imaging plays a critical role in pre-operative surgical planning, through its ability to identify the extent and severity of cartilage lesions. It also plays an important role in post-operative management, by allowing surgeons to noninvasively monitor the morphological status of repaired cartilage tissue.This book covers recent advances in ultra high field MRI and biochemical MRI techniques such as T2 mapping, delayed gadolinium enhanced MRI of cartilage (dGEMRIC), gagCEST and sodium MRI. It is written by a multidisciplinary team including basic scientists, radiologists, orthopaedic surgeons and biomedical engineers. The volume is an ideal reference guide for musculoskeletal radiologists, basic research scientists, orthopedic surgeons and biomedical engineers etc.

Radiation therapy has developed and advanced dramatically in the last few decades. However, very little has been published or done in the area of biologically optimized treatment planning. Development of Biologically Optimized Radiation Therapy aims to fill and close an important gap in the literature with a well-focused and in-depth content. The book covers the biological, physical and clinical background of advanced biologically based radiation therapy optimization with focus on modern radiation therapy modalities such as electron, photon and light ion therapy. Highly recommended for its strong interdisciplinary profile, the book contains a meritorious compilation of previously unpublished materials in many areas of modern science. Undergraduates, researchers and practitioners such as oncologists, medical physicists and radiation biologists alike should find the book immensely informative and comprehensively thorough.

Digital fundus images can effectively diagnose glaucoma and diabetes retinopathy, while infrared imaging can show changes in the vascular tissues. Likening the eye to the conventional camera, Image Analysis and Modeling in Ophthalmology explores the application of advanced image processing in ocular imaging. This book considers how images can be used to effectively diagnose ophthalmologic problems. It introduces multi-modality image processing algorithms as a means for analyzing subtle changes in the eye. It details eye imaging, textural imaging, and modeling, and highlights specific imaging and modeling techniques. The book covers the detection of diabetes retinopathy, glaucoma, anterior segment eye abnormalities, instruments on detection of glaucoma, and development of human eye models using computational fluid dynamics and heat transfer principles to predict inner temperatures of the eye from its surface temperature. It presents an ultrasound biomicroscopy (UBM) system for anterior chamber angle imaging and proposes an automated anterior segment eye disease classification system that can be used for early disease diagnosis and treatment management. It focuses on the segmentation of the blood vessels in high-resolution retinal images and describes the integration of the image processing methodologies in a web-based framework aimed at retinal analysis. The authors introduce the A-Levelset algorithm, explore the ARGALI system to calculate the cup-to-disc ratio (CDR), and describe the Singapore Eye Vessel Assessment (SIVA) system, a holistic tool which brings together various technologies from image processing and artificial intelligence to construct vascular models from retinal images. The text furnishes the working principles of mechanical and optical instruments for the diagnosis and healthcare administration of glaucoma, reviews state-of-the-art CDR calculation detail, and discusses the existing methods and databases. Image Analysis and Modeling in Ophthalmology includes the latest research development in the field of eye modeling and the multi-modality image processing techniques in ocular imaging. It addresses the differences, performance measures, advantages and disadvantages of various approaches, and provides extensive reviews on related fields.

The book has two intentions. First, it assembles the latest research in the field of medical imaging technology in one place. Detailed descriptions of current state-of-the-art medical imaging systems (comprised of x-ray CT, MRI, ultrasound, and nuclear medicine) and data processing techniques are discussed. Information is provided that will give interested engineers and scientists a solid foundation from which to build with additional resources. Secondly, it exposes the reader to myriad applications that medical imaging technology has enabled.

This book highlights progress in terms of Virus Biology and Infection Detection, Prevention, and Control, along with Screening, Testing, and Detection Techniques, that will provide learners and researchers (from basic to advanced) with the most innovative computer-driven methodologies for the fight against COVID-19. In addition, this book also covers the Pre- and Post-Impact of the COVID-19 Pandemic Crisis that will definitely provide useful content for researchers to think broadly about the analytical areas affected by COVID-19. This ultimately shows different paths to the same destination to help understand the nature of the COVID-19 pandemic and how to avoid it in the future.

Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia. Individual chapters address the role of imaging in differential diagnosis and in the evaluation of pharmacologic and surgical treatment effects. In-depth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the roles of neuroinflammation, protein aggregation, and abnormal network organization in parkinsonism. Additionally, the text covers a number of relevant novel topics including recent advances in volumetric and functional MRI, echosonography, dopaminergic and cholinergic neurotransmitter imaging, and applications to experimental interventions such as gene therapy and transplantation. Covering a wide range of subjects and beautifully illustrated, Imaging in Parkinson's Disease is a valuable reference for neurologists, neurosurgeons and neuropsychologists, and a helpful resource for students engaged in postgraduate biomedical and clinical training.

The evolution of technological advances in infrared sensor technology, image processing, "smart" algorithms, knowledge-based databases, and their overall system integration has resulted in new methods of research and use in medical infrared imaging. The development of infrared cameras with focal plane arrays no longer requiring cooling, added a new dimension to this modality. Medical Infrared Imaging: Principles and Practices covers new ideas, concepts, and technologies along with historical background and clinical applications. The book begins by exploring worldwide advances in the medical applications of thermal imaging systems. It covers technology and hardware including detectors, detector materials, un-cooled focal plane arrays, high performance systems, camera characterization, electronics for on-chip image processing, optics, and cost-reduction designs. It then discusses the physiological basis of the thermal signature and its interpretation in a medical setting. The book also covers novel and emerging techniques, the complexities and importance of protocols for effective and reproducible results, storage and retrieval of thermal images, and ethical obligations. Of interest to both the medical and biomedical engineering communities, the book explores many opportunities for developing and conducting multidisciplinary research in many areas of medical infrared imaging. These range from clinical quantification to intelligent image processing for enhancement of the interpretation of images, and for further development of user-friendly high-resolution thermal cameras. These would enable the wide use of infrared imaging as a viable, noninvasive, low-cost, first-line detection modality.

Chest X-rays for Medical Students offers a fresh analytical approach to identifying chest abnormalities, helping medical students, junior doctors, and nurses understand the underlying physics and basic anatomical and pathological details of X-ray images of the chest. The authors provide a memorable framework for analysing and presenting chest radiographs, with each radiograph appearing twice in a side-by-side comparison, one as seen in a clinical setting and the second highlighting the pathology. This new second edition includes significant revisions, improved annotations of X-rays, expanded pathologies, and numerous additional high-quality images. A comprehensive one-stop guide to learning chest radiograph interpretation, this book: Aligns with the latest Royal College of Radiologists' Undergraduate Radiology Curriculum Offers guidance on how to formulate normal findings Features self-assessment tests, presentation exercises, and varied examples Includes sections on radiograph quality X-ray hazards and precautions Chest X-rays for Medical Students is an ideal study guide and clinical reference for any medical student, junior doctor, nurse or radiographer.

This book covers all one needs to know about the utility of endomicroscopy in the diagnosis and management of gastrointestinal diseases. It provides a comprehensive description of the latest in diagnostic criteria and advances in the basic science pertaining to endomicroscopy of the gastrointestinal system. Each chapter introduces the key histologic, endoscopic, and endomicroscopic features of common gastrointestinal conditions, with generous illustration using typical images. The book will provide the practicing physicians with the principles of practice, and procedural techniques of endomicroscopy, as well as demonstrate the bench-to-bedside translational potential of endomicrosocpy in helping endoscopists manage their patients' gastrointestinal conditions. This book fills an enormous gap in providing a much needed atlas in GI endomicroscopic diagnosis. Readers can learn the diagnostic criteria of various gastrointestinal conditions as illustrated by high quality endoscopic, endomicroscopic and histology images. It contains the most extensive review of currently published studies of endomicroscopy in gastrointestinal conditions. It has numerous high quality endomicroscopic images along with high definition endoscopy and histology images illustrating the common gastrointestinal diseases. It will provide a platform for standardizing endomicroscopic practice and learning.

First published in 2005, Biomedical Signal and Image Processing received wide and welcome reception from universities and industry research institutions alike, offering detailed, yet accessible information at the reference, upper undergraduate, and first year graduate level. Retaining all of the quality and precision of the first edition, Biomedical Signal and Image Processing, Second Edition offers a number of revisions and improvements to provide the most up-to-date reference available on the fundamental signal and image processing techniques that are used to process biomedical information. Addressing the application of standard and novel processing techniques to some of today's principle biomedical signals and images over three sections, the book begins with an introduction to digital signal and image processing, including Fourier transform, image filtering, edge detection, and wavelet transform. The second section investigates specifically biomedical signals, such as ECG, EEG, and EMG, while the third focuses on imaging using CT, X-Ray, MRI, ultrasound, positron, and other biomedical imaging techniques. Updated and expanded, Biomedical Signal and Image Processing, Second Edition offers numerous additional, predominantly MATLAB, examples to all chapters to illustrate the concepts described in the text and ensure a complete understanding of the material. The author takes great care to clarify ambiguities in some mathematical equations and to further explain and justify the more complex signal and image processing concepts to offer a complete and understandable approach to complicated concepts.

The field of medical imaging seen rapid development over the last two decades and has consequently revolutionized the way in which modern medicine is practiced. Diseases and their symptoms are constantly changing therefore continuous updating is necessary for the data to be relevant. Diseases fall into different categories, even a small difference in symptoms may result in categorising it in a different group altogether. Thus analysing data accurately is of critical importance. This book concentrates on diagnosing diseases like cancer or tumor from different modalities of images. This book is divided into the following domains: Importance of big data in medical imaging, pre-processing, image registration, feature extraction, classification and retrieval. It is further supplemented by the medical analyst for a continuous treatment process. The book provides an automated system that could retrieve images based on user's interest to a point of providing decision support. It will help medical analysts to take informed decisions before planning treatment and surgery. It will also be useful to researchers who are working in problems involved in medical imaging.

Because of the current progress in molecular medicine (genomics, proteomics), a plethora of new and often human-specific targets are being identified. These targets often play a significant role in the pathogenesis of diseases, and identifying them offers the potential for early diagnosis and intervention. An early in vivo validation of specific ligands binding to these targets in humans is needed to as- sess their potential for targeted imaging and radiotherapy. Further- VI Preface more, such validation studies may allow for a better understanding of the molecular processes underlying phannacologic activity and therefore for a more successful development of phannaceuticals in general. The purpose of the Ernst Schering Research Foundation (ESRF) Workshop 48 was to provide a forum for an open exchange on the state of the art in the early development of such radiophanna- ceuticals. Experts from academia, industry, and regulatory authori- ties were invited to give presentations on aspects covering the identi- fication of targets, preclinical studies on the safety of ligands, as well as their validation in human clinical trials. It was our intention to cover both the opportunities and the challenges that scientists in this field are facing. Radiopharmaceuticals are uniquely suitable for the above-men- tioned target validation studies.

This text provides a comprehensive review of ERCP and EUS and the clinical conditions for which they are employed. Presented in a case-based format with accompanying videos, it will serve as a valuable practical clinical resource for gastroenterologists with an interest in ERCP and EUS. The text highlights major techniques involved in ERCP, reviews complications and recent data on preventing post-ERCP pancreatitis, and discusses important issues in training in ERCP including use of endoscopic simulators and assessment of competency as emphasized in the new ACGME guidelines. For biliary diseases, new techniques for managing biliary stones, novel technologies for diagnosing indeterminate biliary strictures, and new devices for treating benign and malignant strictures are also highlighted. For pancreatic diseases, advances in minimally invasive endoscopic techniques for pancreatic stones and strictures, and management of the complications of pancreatitis are reviewed. Furthermore, ERCP is not limited by age, pregnancy or history of abdominal surgeries and special considerations particular to these patient populations are also discussed. The EUS chapters review the breadth of equipment available for performing EUS and EUS-FNA, detail the technique of performing EUS-FNA, and explore pertinent issues with training and assessing competency analogous to ERCP training. Valuable insights on the basics of cytopathology relevant to the endosonographer are summarized. The classic indication for EUS of staging luminal cancers is examined in detail while pancreaticobiliary indications are discussed highlighting newer adjunctive technologies including elastography and contrast-enhanced EUS. Although in its infancy, the brave new world of therapeutic EUS is explored with a focus on endoscopic necrosectomy, EUS-guided biliary and pancreatic access as well as the exciting possibilities of EUS-guided radiofrequency ablation and injection of anti-tumor agents. ERCP and EUS: A Case Based Approach will serve as a very useful resource for physicians who perform or refer patients for ERCP and EUS. It provides a concise yet comprehensive summary of the current status of ERCP and EUS that will help guide patient management and stimulate clinical research.

Informatics in Medical Imaging provides a comprehensive survey of the field of medical imaging informatics. In addition to radiology, it also addresses other specialties such as pathology, cardiology, dermatology, and surgery, which have adopted the use of digital images. The book discusses basic imaging informatics protocols, picture archiving and communication systems, and the electronic medical record. It details key instrumentation and data mining technologies used in medical imaging informatics as well as practical operational issues, such as procurement, maintenance, teleradiology, and ethics.

Highlights

• Introduces the basic ideas of imaging informatics, the terms used, and how data are represented and transmitted
• Emphasizes the fundamental communication paradigms: HL7, DICOM, and IHE
• Describes information systems that are typically used within imaging departments: orders and result systems, acquisition systems, reporting systems, archives, and information-display systems
• Outlines the principal components of modern computing, networks, and storage systems
• Covers the technology and principles of display and acquisition detectors, and rounds out with a discussion of other key computer technologies
• Discusses procurement and maintenance issues; ethics and its relationship to government initiatives like HIPAA; and constructs beyond radiology

The technologies of medical imaging and radiation therapy are so complex and computer-driven that it is difficult for physicians and technologists responsible for their clinical use to know exactly what is happening at the point of care. Medical physicists are best equipped to understand the technologies and their applications, and these individuals are assuming greater responsibilities in the clinical arena to ensure that intended care is delivered in a safe and effective manner. Built on a foundation of classic and cutting-edge research, Informatics in Medical Imaging supports and updates medical physicists functioning at the intersection of radiology and radiation.

The book presents a clear and comprehensive review of the current status of the holographic microscopy with discussion of the positive and negative features of classical and holographic methods for solving the problem of three-dimesional (3D) imaging of phase microscopic objects. Classical and holographic methods of phase, interference and polarization contrast are discussed. Combination of the developed holographic methods with the methods of digital image processing allowed creating the digital holographic interference microscope (DHIM). The first 3D images of native phase microscopic objects such as blood cells were obtained using the DHIM. The results of DHIM application for study of blood erythrocytes, thin films, micro-crystals are presented.

The use of more robust, affordable and efficient techniques and technologies in the application of medicine is presently a subject of huge interest and demand. The main purposes of Technology and Medical Sciences is to solidify knowledge in the fields of Technology and Medical Sciences and to define their key stakeholders. The book is of interest to academics in Engineering, Mathematics, Medicine, Biomechanics, Computation Sciences, Hardware Developers and Manufactures, Electronic and Instrumentation and Materials Science.

"Imaging and Technology: Principles and Clinical Applications"is a practical and user-friendly consolidated source book for urologists, and urologists in training, regarding the basic science of imaging modalities used on a day-to-day basis in urological practice. Similarly, the intention is to provide an introduction to the technology that is used in the practice of urological surgery and the management of urological patients in the clinical setting. This knowledge level is appropriate for certification for independent consultant practice in urology in the UK. The book is also valuable to urologists and urological trainees outside of the UK and in other surgical specialities."

Informatics in Medical Imaging provides a comprehensive survey of the field of medical imaging informatics. In addition to radiology, it also addresses other specialties such as pathology, cardiology, dermatology, and surgery, which have adopted the use of digital images. The book discusses basic imaging informatics protocols, picture archiving and communication systems, and the electronic medical record. It details key instrumentation and data mining technologies used in medical imaging informatics as well as practical operational issues, such as procurement, maintenance, teleradiology, and ethics. Highlights Introduces the basic ideas of imaging informatics, the terms used, and how data are represented and transmitted Emphasizes the fundamental communication paradigms: HL7, DICOM, and IHE Describes information systems that are typically used within imaging departments: orders and result systems, acquisition systems, reporting systems, archives, and information-display systems Outlines the principal components of modern computing, networks, and storage systems Covers the technology and principles of display and acquisition detectors, and rounds out with a discussion of other key computer technologies Discusses procurement and maintenance issues; ethics and its relationship to government initiatives like HIPAA; and constructs beyond radiology The technologies of medical imaging and radiation therapy are so complex and computer-driven that it is difficult for physicians and technologists responsible for their clinical use to know exactly what is happening at the point of care. Medical physicists are best equipped to understand the technologies and their applications, and these individuals are assuming greater responsibilities in the clinical arena to ensure that intended care is delivered in a safe and effective manner. Built on a foundation of classic and cutting-edge research, Informatics in Medical Imaging supports and updates medical physicists functioning at the intersection of radiology and radiation.