This volume gives a survey on mathematical and computational methods in image registration. During the last year sophisticated numerical models for registration and efficient numerical methods have been proposed. Many of them are contained in this volume. The book also summarizes the state-of-the-art in mathematical and computational methods in image registration. In addition, it covers some practical applications and new directions with industrial relevance in data processing.

The present work is the second in a series constituting an extension of my doctoral thesis done at Stanford in the early 1970s. Like the earlier work, The Reciprocal Modular Brain in Economics and Politics, Shaping the Rational and Moral Basis ofOrganization, Exchange, and Choice (Plenum Publishing, 1999), it may also be considered to respond to the call for consilience by Edward O. Wilson. I agree with Wilson that there is a pressing need in the sciences today for the unification of the social with the natural sciences. I consider the present work to proceed from the perspective of behavioral ecology, specifically a subfield which I choose to call interpersonal behavioral ecology th Ecology, as a general field, has emerged in the last quarter of the 20 century as a major theme of concern as we have become increasingly aware that we must preserve the planet whose limited resources we share with all other earthly creatures. Interpersonal behavioral ecology, however, focuses not on the physical environment, but upon our social environment. It concerns our interpersonal behavioral interactions at all levels, from simple dyadic one-to-one personal interactions to our larger, even global, social, economic, and political interactions.

Exploration of Cortical Function summarizes recent research efforts aiming at the revelation of cortical population coding and signal processing strategies. Topics include optical detection techniques of population activity in the sub-millimeter range, advanced methods for the statistical analysis of these data, and biologically inspired neuronal modeling techniques for population activities in the frameworks of optimal coding, statistical learning theory, and mean-field recurrent networks.

Exploration of Cortical Function is unique in that it covers one complete branch of population-based brain research ranging from techniques for data acquisition over data analysis up to modeling techniques for the quantification of functional principles. The volume covers an area which is of great current interest to researchers working on cerebral cortex. The combination of models and image analysis techniques to examine the activity of large cohorts of neurons is especially intriguing and prone to considerable error and debate.

The intended readership is students and researchers from many disciplines, including neuroscience, biology, physics, and computer science, interested in how an interdisciplinary framework from biology advanced statistics and computational neuroscience can be used to gather a quantitative understanding of cortical function. Experimentalists may gain insight into statistical and neuronal modeling techniques, whereas theoreticians will find an introductory treatment of neuroanatomy, neurophysiology, and measurement techniques.

A half century after its invention, and after several waves of optimism and pessimism, holography is now poised to achieve widespread application. Holograms are now being used as tools in many industries, from heads-up displays in aircraft to directing interconnections in massively parallel computing. Acoustic holograms can provide three-dimensional images of internal organs without surgery or dangerous radiation, and holography forms the basis of several other forms of nondestructive testing. This book provides both a review of the development of the field and of the applications likely to be important in the 21st century. It begins with a review by Emmett Leith, one of the inventors of holography - or re-inventors, after Denis Gabor's original work in 1947. Two chapters discuss the frontiers of holographic imaging, including color holograms and stereographic movies. Several subsequent chapters describe novel methods of forming and viewing holographic images, including the use of low-coherence sources or even computers to generate the holograms. The book concludes with a sampling of new applications of holography, including its uses in improving the efficiency of solar cells, in nondestructive testing, in improving the coherence properties of light, in data storage, and in investigations of fundamental physics.

In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.

Computers have become an integral part of medical imaging systems and are used for everything from data acquisition and image generation to image display and analysis. As the scope and complexity of imaging technology steadily increase, more advanced techniques are required to solve the emerging challenges. Biomedical Image Analysis demonstrates the benefits reaped from the application of digital image processing, computer vision, and pattern analysis techniques to biomedical images, such as adding objective strength and improving diagnostic confidence through quantitative analysis. The book focuses on post-acquisition challenges such as image enhancement, detection of edges and objects, analysis of shape, quantification of texture and sharpness, and pattern analysis, rather than on the imaging equipment and imaging techniques. Each chapter addresses several problems associated with imaging or image analysis, outlining the typical processes, then detailing more sophisticated methods directed to the specific problems of interest. Biomedical Image Analysis is useful for senior undergraduate and graduate biomedical engineering students, practicing engineers, and computer scientists working in diverse areas such as telecommunications, biomedical applications, and hospital information systems.

The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Non-Invasive Imaging of Atherosclerosis is a primer, reference and review of some of the key features of current activities in the field of atherosclerosis. The Editors' goal is to provide material and stimulating ideas to basic scientists and clinical researchers in order to extend the application of vascular imaging and to further develop methods suitable for investigation of the arterial wall. The first section presents current knowledge about pathology, vascular mechanics and compensatory mechanisms active during atherogenesis. It explores the early lesion, complications of plaques and early detection of plaques. Section II reviews several key methodological issues of B-mode ultrasound imaging and some of the most current data. Quantitative B-mode ultrasound is an established non-invasive tool widely used in large epidemiologic studies and interventional clinical trials of atherosclerosis. The last section addresses the most promising areas of development in vascular imaging. This involves new techniques to evaluate the atherosclerotic bed, to follow atheroma progression/regression and to evaluate vascular mechanics in atherosclerotic arteries. The last chapter places the application of non-invasive imaging in perspective.

Ischemic heart disease (IHD) is the main cause of morbidity and mortality in the developed world. Despite advances and new developments in primary and secondary prevention, the prevalence of the disease and its complications remain high. Early detection has been shown to reduce significantly the risk of cardiac events such as myocardial infarction and death, while modern cardiology now provides specialists and general physicians with a variety of procedures for the assessment of IHD using noninvasive methods. This book reviews the currently available imaging techniques for the diagnosis and management of IHD. In addition, the role of cardiac imaging for the detection of viability and hibernation is discussed in detail. A series of highly illustrated cases is included on the CD-ROM to illustrate the applications and rationale behind the use of cardiac imaging for the evaluation of patients with IHD in different clinical scenarios.

Since its discovery 50 years ago, brain dopamine has been implicated in the control of movement and cognition, and is concerned with diverse brain diseases such as Parkinson's disease, schizophrenia and drug addiction. This book is an illustrated biography of the dopamine molecule, from its synthesis in the brain to its signalling mechanisms and ultimately to its metabolic breakdown. Using colour illustrations of positron emission tomography (PET) scans, each chapter presents a specific stage in the biochemical pathway for dopamine. Writing for researchers and graduate students, Paul Cumming presents a compilation of all that has been learned about dopamine through molecular imaging, a technology which allows the measurement of formerly invisible processes in the living brain. He reviews current technical controversies in the interpretation of dopamine imaging, and presents key results illuminating brain dopamine in illness and health.

Intravascular ultrasound imaging (IVUS) plays very important roles in clinical cardiology. This book describes the newest advances in vascular ultrasound imaging and the surrounding technologies for high frequency vascular ultrasound imaging. Most important topics of the book are technical applications of IVUS (elasticity imaging, chromaflow...) and the basic data (vibration, acoustic microscopy) that should provide very important information to understand clinical IVUS imaging.

Image registration is the process of systematically placing separate images in a common frame of reference so that the information they contain can be optimally integrated or compared. This is becoming the central tool for image analysis, understanding, and visualization in both medical and scientific applications. Medical Image Registration provides the first comprehensive coverage of this emerging field.

This monograph details the theory, technology, and practical implementations in a variety of medical settings. International experts thoroughly explain why image registration is important, describe its applications in a nonmathematical way, and include rigorous analysis for those who plan to implement algorithms themselves. It is accessible and informative to those new to the field, yet it provides in-depth treatment for the expert. With its practical examples, extensive illustrations, and comprehensible approach, Medical Image Registration is a must have guide for medical physicists, clinicians, and researchers.

Every second, users produce large amounts of image data from medical and satellite imaging systems. Image mining techniques that are capable of extracting useful information from image data are becoming increasingly useful, especially in medicine and the health sciences. Biomedical Image Analysis and Mining Techniques for Improved Health Outcomes addresses major techniques regarding image processing as a tool for disease identification and diagnosis, as well as treatment recommendation. Highlighting current research intended to advance the medical field, this publication is essential for use by researchers, advanced-level students, academicians, medical professionals, and technology developers. An essential addition to the reference material available in the field of medicine, this timely publication covers a range of applied research on data mining, image processing, computational simulation, data visualization, and image retrieval.

This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Evidence-Based Imaging presents the radiologist with a user-friendly guide to the evidence-based science and the merit behind the diagnostic imaging studies performed in medicine. This book gives the reader a clinically relevant overview of epidemiology, selection of subjects for imaging, selection of imaging strategies, imaging test performance and cost, cost-effectiveness analysis, and applicability to children. Nine major areas of medical imaging are covered, with an emphasis on common diseases. These include Oncology, Neuroimaging, Gastroenterology, Pediatrics, Respiratory System, Musculoskeletal, Cardiovascular, Trauma, and Urologic.

Radiologists, clinicians, residents, and others with an interest in medical imaging and a desire to keep current with the vast amount of evidence-based literature will find this text extremely useful.

Biomedical imaging enables physicians to evaluate areas of the body not normally visible, helping to diagnose and examine disease in patients. ""The Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications"" includes recent state-of-the-art methodologies that introduce biomedical imaging in decision support systems and their applications in clinical practice. This ""Handbook of Research"" provides readers with an overview of the emerging field of image-guided medical and biological decision support, bringing together various research studies and highlighting future trends. It includes: 30 authoritative contributions by over 90 of the world's leading experts on diagnostic imaging and biomedical applications from 9 countries; comprehensive coverage of each specific topic, highlighting recent trends and describing the latest advances in the field; and, more than 1,200 references to existing literature and research on diagnostic imaging and biomedical applications. A compendium of over 200 key terms with detailed definitions, this book is organized by topic and indexed, making it a convenient method of reference for all IT/IS scholars and professionals. It features cross-referencing of key terms, figures, and information pertinent to diagnostic imaging and biomedical applications.

The Oxford Handbook of Functional Brain Imaging in Neuropsychology and Cognitive Neurosciences describes in a readily accessible manner the several functional neuroimaging methods and critically appraises their applications that today account for a large part of the contemporary cognitive neuroscience and neuropsychology literature. The complexity and the novelty of these methods often cloud appreciation of the methods' contributions and future promise. The Handbook begins with an overview of the basic concepts of functional brain imaging common to all methods, and proceeds with a description of each of them, namely magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), diffusion tensor imaging (DTI), and transcranial magnetic stimulation (TMS). Its second part covers the various research applications of functional neuroimaging on issues like the function of the default mode network; the possibility and the utility of imaging of consciousness; the search for mnemonic traces of concepts; human will and decision-making; motor cognition; language; the mechanisms of affective states and pain; the presurgical mapping of the brain; and others. As such, the volume reviews the methods and their contributions to current research and comments on the degree to which they have enhanced our understanding of the relation between neurophysiological activity and sensory, motor, and cognitive functions. Moreover, it carefully considers realistic contributions of functional neuroimaging to future endeavors in cognitive neuroscience, medicine, and neuropsychology.

Here is an informative book that provides theoretical perspectives on the study of fetal movement and introduces observational assessments that can be used in fetal research. It provides research tools that can be used to delineate early patterns of movement, preparing therapists for neonatal intervention and leading to a better understanding of functional activity of the fetus. Concepts in Fetal Movement Research describes various ideas in fetal development and contains original research on a variety of topics, including: the way in which events experienced in utero help neonatal interaction with parents inductive and deductive approaches to assessment development scapular movement activity/inactivity of the 12-20 week old fetus two different research tools for assessing fetal movement. future directions for research by physical therapists in collaboration with other researchersResearchers, clinicians, obstetricians, radiologists, sonographers, and neonatologists will all find this book full of helpful information. Concepts in Fetal Movement Research is an invaluable guide for both their research and their day-to-day work with patients.

Towards the end of this century we celebrate three great discoveries of the last one - of X-rays in 1895, of radioactivity in 1896 and of radium in 1898 - and recall the pioneering achievements that founded the new science of radiology and changed the face of medicine forever. Dr Mould's comprehensive centennial history makes a unique contribution to the telling of this entertaining story - in the unusual and accessible style of a 'radiological photograph album'. Over 700 historical illustrations, with full and informative captions, are supported by short introductory essays to blow the dust off our fascinating radiological past in an easily readable style. The focus of this book is on the historically more interesting earlier years - of discovery and invention, diagnosis and therapy, dosimetry, risk and protection. The photographic record is complemented by archival accounts of the pioneer scientists and physicians, and of their early patients, and is interspersed with a variety of radiological anecdotes. In the several chapters on diagnostic techniques, radiotherapy and nuclear medicine the history is nevertheless brought up to date so that the old methodologies may be contrasted with newer technologies. The medical theme is itself complemented by two interesting chapters on museum and industrial applications of radiography. The predominantly photographic presentation of this book is derived from the author's earlier but smaller A History of X-rays and Radium, no longer available yet still of enduring interest. Research has been based on original source material which is fully cited and the illustrations and text are comprehensively indexed for easy retrieval of the wide variety ofpeople, techniques, apparatus and examples featured throughout this radiological journey.

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models describes the latest imaging and imag analysis techniques that have been developed at leading centers for the visualization, analysis, and understanding of normal and abnormal cardiac motion with magnetic resonance imaging (MRI). The use of MRI in measuring cardiac motion is particularly important because MRI is non-invasive, and it is the only modality capable of imaging detailed intramural motion within the myocardium. Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. In particular, it is more tutorial in nature than most of the technical papers where the research was originally published. Practitioners and researchers working in the field of cardiovascular MRI will find the book to be filled with practical technical details and references to other work, enabling the implementation of existing methods and serving as a basis for further research in the area.

Effective stroke therapy can be improved through real-time monitoring of the neurological and cardiovascular responses to treatment. This requires crucial knowledge on behalf of both the sonographer and stroke physician to make the best decisions for the patient so as to minimize the damage caused by the original stroke and the risk of further stroke.

"Cerebrovascular Ultrasound in Stroke Prevention and Treatment, Second Edition, " takes a practical approach to the examination of patients, the interpretation of ultrasound studies and the application of cerebrovascular ultrasound in the development of management and treatment studies, assisting neurologists, radiologists, and ultrasonographers in stroke therapy.

Master the latest imaging procedures and technologies in nuclear medicine! Nuclear Medicine and Molecular Imaging: Technology and Techniques, 9th Edition provides comprehensive, state-of-the-art information on all aspects of nuclear medicine. Coverage of body systems includes anatomy and physiology, along with details on how to perform and interpret related diagnostic procedures. The leading technologies - SPECT, PET, CT, MRI, and PET/CT - are presented with an emphasis on radiation safety and patient care. Comprehensive coverage of nuclear medicine and molecular imaging makes this a complete resource. Accessible writing style simplifies topics, first introducing fundamentals and progressing to more complex concepts. Procedure boxes provide step-by-step instructions for clinical procedures and protocols so they can be performed with confidence. NEW! Full-color design provides clear and realistic examples of PET/CT scans seen in practice. NEW! Expanded content on radiopharmacy reflects current practice. NEW! Coverage of new technologies explores emerging topics related to therapeutics, MRI, and the growth of PET/CT due to the increased use of radiopharmaceuticals for diagnosis and treatment.