This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

Biomedical imaging enables physicians to evaluate areas of the body not normally visible, helping to diagnose and examine disease in patients. ""The Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications"" includes recent state-of-the-art methodologies that introduce biomedical imaging in decision support systems and their applications in clinical practice. This ""Handbook of Research"" provides readers with an overview of the emerging field of image-guided medical and biological decision support, bringing together various research studies and highlighting future trends. It includes: 30 authoritative contributions by over 90 of the world's leading experts on diagnostic imaging and biomedical applications from 9 countries; comprehensive coverage of each specific topic, highlighting recent trends and describing the latest advances in the field; and, more than 1,200 references to existing literature and research on diagnostic imaging and biomedical applications. A compendium of over 200 key terms with detailed definitions, this book is organized by topic and indexed, making it a convenient method of reference for all IT/IS scholars and professionals. It features cross-referencing of key terms, figures, and information pertinent to diagnostic imaging and biomedical applications.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

In modern medicine, imaging is the most effective tool for diagnostics, treatment planning and therapy. Almost all modalities have went to directly digital acquisition techniques and processing of this image data have become an important option for health care in future. This book is written by a team of internationally recognized experts from all over the world. It provides a brief but complete overview on medical image processing and analysis highlighting recent advances that have been made in academics. Color figures are used extensively to illustrate the methods and help the reader to understand the complex topics.

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Here is an informative book that provides theoretical perspectives on the study of fetal movement and introduces observational assessments that can be used in fetal research. It provides research tools that can be used to delineate early patterns of movement, preparing therapists for neonatal intervention and leading to a better understanding of functional activity of the fetus. Concepts in Fetal Movement Research describes various ideas in fetal development and contains original research on a variety of topics, including: the way in which events experienced in utero help neonatal interaction with parents inductive and deductive approaches to assessment development scapular movement activity/inactivity of the 12-20 week old fetus two different research tools for assessing fetal movement. future directions for research by physical therapists in collaboration with other researchersResearchers, clinicians, obstetricians, radiologists, sonographers, and neonatologists will all find this book full of helpful information. Concepts in Fetal Movement Research is an invaluable guide for both their research and their day-to-day work with patients.

Towards the end of this century we celebrate three great discoveries of the last one - of X-rays in 1895, of radioactivity in 1896 and of radium in 1898 - and recall the pioneering achievements that founded the new science of radiology and changed the face of medicine forever. Dr Mould's comprehensive centennial history makes a unique contribution to the telling of this entertaining story - in the unusual and accessible style of a 'radiological photograph album'. Over 700 historical illustrations, with full and informative captions, are supported by short introductory essays to blow the dust off our fascinating radiological past in an easily readable style. The focus of this book is on the historically more interesting earlier years - of discovery and invention, diagnosis and therapy, dosimetry, risk and protection. The photographic record is complemented by archival accounts of the pioneer scientists and physicians, and of their early patients, and is interspersed with a variety of radiological anecdotes. In the several chapters on diagnostic techniques, radiotherapy and nuclear medicine the history is nevertheless brought up to date so that the old methodologies may be contrasted with newer technologies. The medical theme is itself complemented by two interesting chapters on museum and industrial applications of radiography. The predominantly photographic presentation of this book is derived from the author's earlier but smaller A History of X-rays and Radium, no longer available yet still of enduring interest. Research has been based on original source material which is fully cited and the illustrations and text are comprehensively indexed for easy retrieval of the wide variety ofpeople, techniques, apparatus and examples featured throughout this radiological journey.

Effective stroke therapy can be improved through real-time monitoring of the neurological and cardiovascular responses to treatment. This requires crucial knowledge on behalf of both the sonographer and stroke physician to make the best decisions for the patient so as to minimize the damage caused by the original stroke and the risk of further stroke.

"Cerebrovascular Ultrasound in Stroke Prevention and Treatment, Second Edition, " takes a practical approach to the examination of patients, the interpretation of ultrasound studies and the application of cerebrovascular ultrasound in the development of management and treatment studies, assisting neurologists, radiologists, and ultrasonographers in stroke therapy.

Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models describes the latest imaging and imag analysis techniques that have been developed at leading centers for the visualization, analysis, and understanding of normal and abnormal cardiac motion with magnetic resonance imaging (MRI). The use of MRI in measuring cardiac motion is particularly important because MRI is non-invasive, and it is the only modality capable of imaging detailed intramural motion within the myocardium. Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. In particular, it is more tutorial in nature than most of the technical papers where the research was originally published. Practitioners and researchers working in the field of cardiovascular MRI will find the book to be filled with practical technical details and references to other work, enabling the implementation of existing methods and serving as a basis for further research in the area.

This book highlights recent technological advances, reviews and applications in the field of cardiovascular engineering, including medical imaging, signal processing and informatics, biomechanics, as well as biomaterials. It discusses the use of biomaterials and 3D printing for tissue-engineered heart valves, and also presents a unique combination of engineering and clinical approaches to solve cardiovascular problems. This book is a valuable resource for students, lecturers and researchers in the field of biomedical engineering.

The book comprises three parts. The first part provides the state-of-the-art of robots for endoscopy (endorobots), including devices already available in the market and those that are still at the R&D stage. The second part focusses on the engineering design; it includes the use of polymers for soft robotics, comparing their advantages and limitations with those of their more rigid counterparts. The third part includes the project management of a multidisciplinary team, the health cost of current technology, and how a cost-effective device can have a substantial impact on the market. It also includes information on data governance, ethical and legal frameworks, and all steps needed to make this new technology available.

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer's disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences. The Authors of this volume are leaders in the development of PET and MRI methods as well as clinical and translational researchers skilled in their use in patients with brain disorders. Individual chapters of this volume focus on the use of specific methodologies, covering the full range of PET chemistry based approaches as well as MRI methods from structural and diffusion tensor based imaging, to functional MRI of functional brain circuitry, to pharmacological MRI and MRI spectroscopic molecular imaging.

The Comatose Patient, Second Edition, is a critical historical overview of the concepts of consciousness and unconsciousness, covering all aspects of coma within 100 detailed case vignettes. This comprehensive text includes principles of neurologic examination of comatose patients as well as instruction of the FOUR Score coma scale, and also discusses landmark legal cases and ethical problems. As the Chair of Division of Critical Care Neurology at Mayo Clinic, Dr. Wijdicks uses his extensive knowledge to discuss a new practical multistep approach to the diagnosis of the comatose patient. Additionally, this edition includes extensive coverage of the interpretation of neuroimaging and its role in daily practice and decision making, as well as management in the emergency room and ICU. Dr. Wijdicks details long-term supportive care and an appropriate approach to communication with family members about end-of-life decision making.

This book is instrumental to building a bridge between scientists and clinicians in the field of spine imaging by introducing state-of-the-art computational methods in the context of clinical applications. Spine imaging via computed tomography, magnetic resonance imaging, and other radiologic imaging modalities, is essential for noninvasively visualizing and assessing spinal pathology. Computational methods support and enhance the physician's ability to utilize these imaging techniques for diagnosis, non-invasive treatment, and intervention in clinical practice. Chapters cover a broad range of topics encompassing radiological imaging modalities, clinical imaging applications for common spine diseases, image processing, computer-aided diagnosis, quantitative analysis, data reconstruction and visualization, statistical modeling, image-guided spine intervention, and robotic surgery. This volume serves a broad audience as contributions were written by both clinicians and researchers, which reflects the intended readership as well, being a potentially comprehensive book for all spine related clinicians, technicians, scientists, and graduate students.

Sharmila Majumdar In the area of osteoporosis and skeletal changes, it is currently accepted that bone mineral density (BMD), widely used for screening, monitoring and assessing therapeutic efficacy, does not adequately explain the pathogenesis of osteoporosis, the process of aging, or the therapeutic efficacy of various treatments. In this context, trabecular micro- architecture has enormous potential to contribute to understanding the pathophysiology of osteopor.osis and therapy assessment. The use and value of noninvasive imaging and quantitative image analysis and processing of trabecular bone micro-architecture have increased dramatically due to recent advances in instrumentation and software. This emerging field is diverse, interdisciplinary, and encompasses many different imaging modalities. Interested researchers include those involved in technique development, basic science and animal studies, as well as clinical researchers and practicing physicians. With the growth of this area of research, a group of investigators at the 11th Interna- tional Workshop of Bone Densitometry, 1 concluded that a forum dedicated to this matter was urgently needed. With this agenda, Dr. Peter Ruegsegger organized the first sympo- 2 sium on conjunction with the 10th Conference of the European Society of Biomechanics. The symposium on Bone Architecture and Competence was a two-hourlong event which resulted in five chapters in Bone Research and Biomechanics, edited by G. Lowet, P. Ruegsegger, H. Weinans, and A. Meunier, published by lOS Press, 1997. The second symposium was held as a pre-symposium to the 12th Workshop on Bone Denistometry,3 and flourished as a daylong event.

Deep Learning Models for Medical Imaging explains the concepts of Deep Learning (DL) and its importance in medical imaging and/or healthcare using two different case studies: a) cytology image analysis and b) coronavirus (COVID-19) prediction, screening, and decision-making, using publicly available datasets in their respective experiments. Of many DL models, custom Convolutional Neural Network (CNN), ResNet, InceptionNet and DenseNet are used. The results follow 'with' and 'without' transfer learning (including different optimization solutions), in addition to the use of data augmentation and ensemble networks. DL models for medical imaging are suitable for a wide range of readers starting from early career research scholars, professors/scientists to industrialists.

The definite treatment ofaortic disorders goes back to the resection ofisthmic coarctation by Clarence Crafoord in 1944. It took another third of a century until all portionsofthe aortabecameaccessible to highly standardized surgery. This progress, delayed as it was in relation to most other cardiovascular in- terventions, depended on the availability of safe protective methods for the heart and central nervous system, of reliable vascular grafts and atraumatic instruments, novel suture material and tissue adhesives. The development ofadvanced surgical techniques went hand in hand with, and depended upon, the emergence of proper diagnostic tools, starting with aortography andultimately culminating inCT-scanning, transesophageal echo- cardiography and magnetic resonance imaging. These tools now allow for the rational planning and conductofany aortic intervention which may be surgical or, more recently, catheter-guided. Nienaber's and Fattori's new book aptly is addressing both the diagnos- tic procedure as well as the treatment of aortic disease. The authors are well known experts in the fields of advanced diagnostics of aortic pathology, both spearheading a remarkably innovative group of aortic interventionalists as well. On account of their expertise, their chapters are able to answer any question rising in conjunction with these subjects.

Ultrasound Guided Musculoskeletal Procedures in Sports Medicine: A Practical Atlas provides the support practitioners need based on practical, first-hand experience of a Sports and Exercise Medicine Physician who trained in musculoskeletal sonography. Over the years, and with much practice, the lessons learned and techniques developed are summarized with relevant pictures that guide those undertaking the procedure. As musculoskeletal ultrasound forms an important tool for physicians working in this field of medicine, this book helps physicians provide increasing expectation for patients who want a safe, guided procedure when clinically warranted. While an understanding of ultrasound imaging is essential prior to ultrasound guided procedures, there are few practical guides that provide practicing clinicians with a quick reference when faced with a procedure. This book fills that void.

Prominent physicians review past, current, and future applications of the many powerful imaging techniques now used in the diagnosis, staging, treatment, and outcomes assessment of cancers of the prostate, central nervous system (CNS), and breast. Topics range from the use of screening mammography and approaches to breast cancer detection using MRI to improved visualization of the prostate gland from transrectal ultrasound and MRI, to MRI-guided resection of neoplasms.