The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

"Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. "Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, "Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment" appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.
Provides a background to translational research and the use of brain imaging in neuropsychiatric disordersCritical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkersIdentifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disordersFeatures an accompanying website with additional images and text

This issue gives the general radiologist a solid overview of lung cancer imaging techniques. CT screening for lung cancer is discussed, and the evaluation and management of indeterminate pulmonary nodules is reviewed. Revised TNM lung cancer staging, as well as the optimal imaging protocols for lung cancer staging (CT, MR and PET) are thoroughly examined. A multidisciplinary approach to tissue sampling and updated histopathologic classification of lung cancer are discussed. Image-guided ablative therapies for lung cancer are reviewed. Finally, future trends in lung cancer diagnosis and staging and genetics are reviewed, as well as novel biomarkers for lung cancer detection.

CT, contrast CT, MRI, functional MRI, SPECT, CTA, and x-ray as tools to identify pathogens and diagnose intracranial infections are presented. Topics include: Epidemiology of Central Nervous System Infections; Imaging of Cranial Meningitis and Ventriculitis; Encephalitis, Cerebritis and Brain Abscess; Imaging of Central Nervous System Tuberculosis; Imaging of Rickettsial, Spirochetal, and Parasitic Infections; Imaging of Neurocysticercosis; Fungal Infections of the Central Nervous System; Central Nervous System Infections in the Pediatric Population; Imaging of Infectious Diseases of Spine; Neuropathological Findings in Intracranial Infections; Neurosurgical Approach to Infectious Disease of the Brain; Head and Neck Infections.

The discovery and genetic engineering of fluorescent proteins has revolutionized cell biology. What was previously invisible in the cell often can be made visible with the use of fluorescent proteins. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols presents state-of-the-art research that has contributed to the fluorescent protein revolution to visualize biological processes in the live animal. This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols is the first volume in the new field of in vivo cell biology and it serves both professionals and novices with its well-honed methodologies.

The book has focussed on the different aspects of sensing technology, i.e. high reliability, adaptability, recalibration, information processing, data fusion, validation and integration of novel and high performance sensors specifically aims to use to inspect mechanical health of structure and similar applications. This book is dedicated to Sensing systems for Structural Health Monitoring offers to variety of users, namely, Master and PhD degree students, researchers, practitioners, especially Civil and Construction engineers. The book will provide an opportunity of a dedicated and a deep approach in order to improve their knowledge in this specific field.

Podrid's Real-World ECGs: A Master's Approach to the Art and Practice of Clinical ECG Interpretation Podrid's Real-World ECGs combines traditional case-based workbooks with a versatile Web-based program to offer students, health care professionals, and physicians an indispensable resource for developing and honing the technical skills and systematic approach needed to interpret ECGs with confidence. ECGs from real patient cases offer a complete and in-depth learning experience by focusing on fundamental electrophysiologic properties and clinical concepts as well as detailed discussion of important diagnostic findings and relevant management decisions. Six comprehensive volumes encompass more than 600 individual case studies--plus an online repository of hundreds more interactive case studies (www.realworldECGs.com)--that include feedback and discussion about the important waveforms and clinical decision-making involved. From an introductory volume that outlines the approaches and tools utilized in the analysis of all ECGs to subsequent volumes covering particular disease entities for which the ECG is useful, readers will take away the in-depth knowledge needed to successfully interpret the spectrum of routine to challenging ECGs they will encounter in their own clinical practice. Volume 2, Myocardial Abnormalities, breaks down the essential skills necessary for diagnosing acute myocardial ischemia as well as acute and chronic myocardial infarction--arguably the most important component of the ECG armamentarium across the spectrum of health care professions. It also demonstrates the skills needed for the diagnosis of myocardial hypertrophy, atrial abnormality, and pericarditis.

PET/CT is an integral part of the evaluation of patients who have head and neck cancer. In this issue, the state of the art in PET/CT imaging is discussed. The issue starts with an overview of FDG-PET/CT, PET and MRI for normal anatomy, including pitfalls and artifacts. This topic is followed by a review of FDG-PET/CT for initial and subsequent therapy evaluation; progressing to PET and MRI. Other articles discuss SUV as a prognostic factor in head and neck squamous cell carcinoma, PET in head and neck cancer radiotherapy treatment planning, PET in decision making for neck dissection after radiation treatment, and newer methods for improving yield from FDG-PET imaging for accurate staging, determining tumor biology, and assessing prognosis. The issue focuses on some of the most cutting-edge applications, such as new tracers PET in head and neck squamous cell carcinoma (including FLT and hypoxia imaging). PET scans in thyroid cancer is also discussed.

This monograph covers all aspects of the radiologic diagnosis of urinary tract diverticula, including calyceal, ureteral, bladder, and urethral diverticula. Characteristic and subtle diagnostic features are identified with the aid of numerous high-quality ultrasound, X-ray, and magnetic resonance images, the vast majority of which are drawn from the author's personal clinical practice. In addition, issues relating to terminology, classification, statistics, etiology, pathogenesis, clinical presentation, and differential diagnosis are discussed. The text is complemented by two helpful appendices that document the latest recommendations of the European Society of Urogenital Radiology regarding use of contrast media and the European Medicines Agency on minimizing the risk of nephrogenic systemic fibrosis when using gadolinium- containing contrast agents. This book will be of value for specialists in radiology and urology and also trainees and medical students.

Electromyography remains a main diagnostic tool within neurology. This issue of Neurologic Clinics addresses the most recent developments in the clinical application of EMG. Articles in this issue include: Nerve conduction studies: Basic Concepts and Patterns of Abnormalities; Needle Electromyography-Basic Concepts andInterpretation of Recorded Potentials;Electrodiagnostic Evaluation of Carpal TunnelSyndrome;Electrodiagnostic Evaluation of Ulnar Neuropathyand Other Upper Extremity Mononeuropathy; Lower Extremity Mononeuropathies;Electrodiagnostic Evaluation of Brachial Plexopathies; Evaluation ofRadiculopathies;Electrodiagnostic Approach to Motor NeuronDiseases;Electrophysiologic Findings in PeripheralNeuropathies; Evaluation of Neuromuscular Junction Disorders in the EMGLaboratory;Electrodiagnostic Findings inMyopathy;Electrodiagnostic Approach to CranialNeuropathies; Technical Issues with Nerve Conduction Studies and Needle EMG;andCoding and Reimbursement of ElectrodiagnosticStudies.

Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.

Congenital spine and spinal cord malformations; Congenital brain malformations (except cortical malformations); Malformations of cortical development; Congenital cystic neck lesions; A simplified approach to pediatric vascular malformations of the head and neck; Congenital face, maxillofacial anomalies; Congenital arterial and venous anomalies of brain, spine and neck; Fetal neuroimaging; Temporal bone malformations; Pediatric orbit; Neurosurgeon's perspective to congenital brain and spine malformations

A global pool of surgeons and researchers using 3-dimensional imaging for facial plastic surgery present topics on: Image fusion in pre-operative planning; The use of 3D imaging tools including stereolithographic modeling and intraoperative navigation for maxillo-mandibular and complex orbital reconstruction; Custom-made, three-dimensional, intraoperative surgical guides for nasal reconstruction; The benefits and limits of using an integrated 3D virtual approach for maxillofacial surgery; 3D volume assessment techniques and computer-aided design and manufacturing for pre-operative fabrication of implants in head and neck reconstruction; A comparison of different new 3D imaging technologies in facial plastic surgery; 3-D photography in the objective analysis of volume augmentation including fat augmentation and dermal fillers; Assessment of different rhinoplasty techniques by overlay of before and after 3D images; 3D volumetric analysis of combined facial lifting and volumizing (volume enhancement); 3-D facial measurements and perceptions of attractiveness; Teaching 3-D sculpting to Facial Plastic Surgeons, 3-D insights on aesthetics; Creation of the virtual patient for the study of facial morphology; 3-dimensional video analysis of facial movement; 3D modeling of the behavior of facial soft tissues for understanding facial plastic surgery interventions

Dr. Leonard Swischuk has revised his outstanding work on imaging the cervical spine in children. He draws upon his extensive experience to provide practitioners with an insightful approach to pediatric cervical spine injuries. The text covers developmental anatomy, normal variants, congenital anomalies, abnormalities of the dens, trauma, and miscellaneous abnormalities of the cervical spine. The book has several strengths that appeal to radiology residents, such as its succinct overview of the topic and helpful reference lists that guide readers to additional resources. Dr. Swischuk illustrates conditions he discusses with excellent plain film examples that help residents identify cases they are likely to encounter during board exams and in practice. Accompanying CT and MR images clarify and qualify the findings. Dr. Swischuk's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

This unique text/reference discusses in depth the two integral components of reconstructive surgery; fracture detection, and reconstruction from broken bone fragments. In addition to supporting its application-oriented viewpoint with detailed coverage of theoretical issues, the work incorporates useful algorithms and relevant concepts from both graph theory and statistics. Topics and features: presents practical solutions for virtual craniofacial reconstruction and computer-aided fracture detection; discusses issues of image registration, object reconstruction, combinatorial pattern matching, and detection of salient points and regions in an image; investigates the concepts of maximum-weight graph matching, maximum-cardinality minimum-weight matching for a bipartite graph, determination of minimum cut in a flow network, and construction of automorphs of a cycle graph; examines the techniques of Markov random fields, hierarchical Bayesian restoration, Gibbs sampling, and Bayesian inference.

Since scientists began experimenting with green fluorescent proteins in the middle of the 1990s, these proteins have become one of the most important tools available to researchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are a part of over three million experiments a year, and are invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existence of cancerous stem cells. In Illuminating Disease, Marc Zimmer introduces us to these revolutionary proteins, acquainting readers both with the researchers responsible for the proteins' discovery as well as their wide utility. The book details the history of genetically modified fluorescent parasites and viruses, which provide scientists with new information about the spread of diseases. Green fluorescent proteins have played crucial roles in the research of malaria, AIDS/HIV, swine and bird flu, dengue, cancer, and chagas. They allow scientists and doctors to understand these diseases better, by quite literally illuminating various microscopic pieces that otherwise would have gone unseen. The book is richly illustrated, showing the many visually striking uses of GFP. Many of these scans have won awards in biological imaging competitions. Illuminating Disease is an accessible and illustrated introduction to one of the most important developments in medical research of the last several decades.

This issue of Neurosurgery Clinics will focus on Functional Imaging. Guest Editors Alexandra Golby and Peter Black will divide the issue into three parts: Technique, Neurological Functions and Clinical Applications, and Special Neurosurgical Situations.

The clinical implications of obesity have pervaded several specialties since treatments include medical and surgical intervention. In this issue, Dr. Thompson has created an issue that addresses topics of concern to endoscopists: important concerns in the endoscopic unit, presurgical evaluation, postoperative care, sedation, and endoscopic management of common complications. Further, special articles are included on endoscopic revisions to failed gastric bypass as well as reimbursement and regulatory issues.

Diagnostic Imaging for the Emergency Physician, written and edited by a practicing emergency physician for emergency physicians, takes a step-by-step approach to the selection and interpretation of commonly ordered diagnostic imaging tests. Dr. Joshua Broder presents validated clinical decision rules, describes time-efficient approaches for the emergency physician to identify critical radiographic findings that impact clinical management and discusses hot topics such as radiation risks, oral and IV contrast in abdominal CT, MRI versus CT for occult hip injury, and more. Diagnostic Imaging for the Emergency Physician was awarded a 2011 PROSE Award for Excellence for the best new publication in Clinical Medicine. Access the fully searchable text online at Expert Consult, along with downloadable images suitable for use in educational presentations. Choose the best test for each indication through clear explanations of the "how" and "why" behind emergency imaging. Interpret head, spine, chest, and abdominal CT images using a detailed and efficient approach to time-sensitive emergency findings. Stay on top of current developments in the field, including evidence-based analysis of tough controversies - such as indications for oral and IV contrast in abdominal CT and MRI versus CT for occult hip injury; high-risk pathology that can be missed by routine diagnostic imaging - including subarachnoid hemorrhage, bowel injury, mesenteric ischemia, and scaphoid fractures; radiation risks of diagnostic imaging - with practical summaries balancing the need for emergency diagnosis against long-terms risks; and more. Optimize diagnosis through evidence-based guidelines that assist you in discussions with radiologists, coverage of the limits of "negative" or "normal" imaging studies for safe discharge, indications for contrast, and validated clinical decision rules that allow reduced use of diagnostic imaging. Clearly recognize findings and anatomy on radiographs for all major diagnostic modalities used in emergency medicine from more than 1000 images. Find information quickly and easily with streamlined content specific to emergency medicine written and edited by an emergency physician and organized by body system. The "must-have" resource for emergency physicians to make critical diagnostic imaging decisions.

Cutting edge information for all surgeons on the latest imaging techniques Topics will include basic principles, imaging for breast, thyroid/parathyroid, pancreatic/biliary, active gastrointestinal bleeding, and cervical spine; Hollow Viscous Imaging for SBO--fluoroscopy vs CT; CT Colonoscopy/Virtual Colonoscopy; Ultrasound for Central line, IVC filter placement and for diagnosis and treatment of femoral pseudoaneurysms; CTA For AAA; FAST--including Pericardial evaluation; Imaging for Blunt Carotid and Arterial Injury Screening; CT for Chest, Abdomen, Pelvis; PET Scans; and Bariatic Surgery and Postoperative Imaging, and more

Genitourinary Imaging - A Case Based Approach is a user friendly, portable guide that offers a comprehensive coverage of the subspecialty with an emphasis on all modalities. As subspecialty practice has become the norm in radiology, it becomes increasingly important to keep abreast of the latest information within the specialty that one is practising. The case based nature of this book, with modality independent content, allows the reader to assimilate practice specific information with ease. Full color images with tabular salient points, imaging algorithms and evidence based criterion support the text. Key points provide succinct explanations of the disease and an appropriate differential diagnosis, as well as providing a brief description of therapy and prognosis. Genitourinary Imaging - A Case Based Approach is aimed at residents and training and practicing genitourinary radiologists.