MRI in Practice continues to be the number one reference book and study guide for the registry review examination for MRI offered by the American Registry for Radiologic Technologists (ARRT). This latest edition offers in-depth chapters covering all core areas, including: basic principles, image weighting and contrast, spin and gradient echo pulse sequences, spatial encoding, k-space, protocol optimization, artefacts, instrumentation, and MRI safety. The leading MRI reference book and study guide. Now with a greater focus on the physics behind MRI. Offers, for the first time, equations and their explanations and scan tips. Brand new chapters on MRI equipment, vascular imaging and safety. Presented in full color, with additional illustrations and high-quality MRI images to aid understanding. Includes refined, updated and expanded content throughout, along with more learning tips and practical applications. Features a new glossary. MRI in Practice is an important text for radiographers, technologists, radiology residents, radiologists, and other students and professionals working within imaging, including medical physicists and nurses.

Automatic detection and segmentation of anatomical structures in medical images are prerequisites to subsequent image measurements and disease quantification, and therefore have multiple clinical applications. This book presents an efficient object detection and segmentation framework, called Marginal Space Learning, which runs at a sub-second speed on a current desktop computer, faster than the state-of-the-art. Trained with a sufficient number of data sets, Marginal Space Learning is also robust under imaging artifacts, noise and anatomical variations. The book showcases 35 clinical applications of Marginal Space Learning and its extensions to detecting and segmenting various anatomical structures, such as the heart, liver, lymph nodes and prostate in major medical imaging modalities (CT, MRI, X-Ray and Ultrasound), demonstrating its efficiency and robustness.

Specific 3-D measurement techniques, based on optical or opto-electronic principles of image capture, can today provide a complete set of results to quantify, without any risk for the patient, the actual state of the rachis and the effects induced by the disease on the whole postural performance. The book deals with theoretical and clinical aspects of spinal deformities. It covers topics such as 3-D acquisition, reconstruction and modelling techniques; 3-D biomechanical analysis; 3-D etiological and prognostic aspects; 3-D treatment of scoliosis; surface topography and internal 3-D spinal and/or trunk anatomy.

This 6 volume set presents a groundbreaking resource in this branch of natural organic compounds and demonstrates how proton nuclear magnetic resonance (NMR) spectroscopy can be manipulated in structures of natural organic compounds. The authors provide the most comprehensive data of 17 kinds amounting to over 10,000 natural organic compounds. The 1st volume mainly illustrates the molecular formula and structures of alkaloids.

Advanced techniques in image processing have led to many innovations supporting the medical field, especially in the area of disease diagnosis. Biomedical imaging is an essential part of early disease detection and often considered a first step in the proper management of medical pathological conditions. Classification and Clustering in Biomedical Signal Processing focuses on existing and proposed methods for medical imaging, signal processing, and analysis for the purposes of diagnosing and monitoring patient conditions. Featuring the most recent empirical research findings in the areas of signal processing for biomedical applications with an emphasis on classification and clustering techniques, this essential publication is designed for use by medical professionals, IT developers, and advanced-level graduate students.

This detailed volume presents a number of chapters that will aid researchers in jumping the hurdle preventing the popularization of advanced intravital imaging technology usage, namely the complicated experimental protocols. Leading researchers undertaking imaging studies in the field of bone and immune systems have contributed the chapters that aim to guide readers through these complex methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Intravital Imaging of Dynamic Bone and Immune Systems: Methods and Protocols will serve as an idea guide for general readers in order to establish and perform these experiments by their own.

The second edition of Rad Tech's Guide to MRI provides practicing and training technologists with a succinct overview of magnetic resonance imaging (MRI). Designed for quick reference and examination preparation, this pocket-size guide covers the fundamental principles of electromagnetism, MRI equipment, data acquisition and processing, image quality and artifacts, MR Angiography, Diffusion/Perfusion, and more. Written by an expert practitioner and educator, this handy reference guide: Provides essential MRI knowledge in a single portable, easy-to-read guide Covers instrumentation and MRI hardware components, including gradient and radio-frequency subsystems Provides techniques to handle flow imaging issues and improve the quality of MRIs Explains the essential physics underpinning MRI technology Rad Tech's Guide to MRI is a must-have resource for student radiographers, especially those preparing for the American Registry of Radiation Technologist (ARRT) exams, as well as practicing radiology technologists looking for a quick reference guide.

Computational Intelligence in Biomedical Imaging is a comprehensive overview of the state-of-the-art computational intelligence research and technologies in biomedical images with emphasis on biomedical decision making. Biomedical imaging offers useful information on patients' medical conditions and clues to causes of their symptoms and diseases. Biomedical images, however, provide a large number of images which physicians must interpret. Therefore, computer aids are demanded and become indispensable in physicians' decision making. This book discusses major technical advancements and research findings in the field of computational intelligence in biomedical imaging, for example, computational intelligence in computer-aided diagnosis for breast cancer, prostate cancer, and brain disease, in lung function analysis, and in radiation therapy. The book examines technologies and studies that have reached the practical level, and those technologies that are becoming available in clinical practices in hospitals rapidly such as computational intelligence in computer-aided diagnosis, biological image analysis, and computer-aided surgery and therapy.

Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia. Individual chapters address the role of imaging in differential diagnosis and in the evaluation of pharmacologic and surgical treatment effects. In-depth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the roles of neuroinflammation, protein aggregation, and abnormal network organization in parkinsonism. Additionally, the text covers a number of relevant novel topics including recent advances in volumetric and functional MRI, echosonography, dopaminergic and cholinergic neurotransmitter imaging, and applications to experimental interventions such as gene therapy and transplantation. Covering a wide range of subjects and beautifully illustrated, Imaging in Parkinson's Disease is a valuable reference for neurologists, neurosurgeons and neuropsychologists, and a helpful resource for students engaged in postgraduate biomedical and clinical training.

This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.

The discovery and genetic engineering of fluorescent proteins has revolutionized cell biology. What was previously invisible in the cell often can be made visible with the use of fluorescent proteins. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols presents state-of-the-art research that has contributed to the fluorescent protein revolution to visualize biological processes in the live animal. This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols is the first volume in the new field of in vivo cell biology and it serves both professionals and novices with its well-honed methodologies.

This monograph covers all aspects of the radiologic diagnosis of urinary tract diverticula, including calyceal, ureteral, bladder, and urethral diverticula. Characteristic and subtle diagnostic features are identified with the aid of numerous high-quality ultrasound, X-ray, and magnetic resonance images, the vast majority of which are drawn from the author's personal clinical practice. In addition, issues relating to terminology, classification, statistics, etiology, pathogenesis, clinical presentation, and differential diagnosis are discussed. The text is complemented by two helpful appendices that document the latest recommendations of the European Society of Urogenital Radiology regarding use of contrast media and the European Medicines Agency on minimizing the risk of nephrogenic systemic fibrosis when using gadolinium- containing contrast agents. This book will be of value for specialists in radiology and urology and also trainees and medical students.

Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.

The application of optical methods for investigating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function. Optical Imaging of Neocortical Dynamics presents a guide to these indispensible tools, which cover a broad range of spatiotemporal scales and a large variety of signaling aspects, ranging from voltage changes to metabolic states. This detailed volume specifically explores methods that are applied in experiments on living brains (in vivo) and that relate to functional properties on the spatial scale of cortical circuits. Beginning with an introductory section that focuses on physical fundamentals of optical imaging as well as molecular tools used for in vivo optical imaging and optogenetic control, the book continues with the most relevant methods and their applications to investigate changes in neuronal and glial activity states as well as optical imaging methods probing metabolic states. Written for the Neuromethods series, this volume contains the kind of detail and key implementation advice that ensures successful results in the lab. Practical and easy to use, Optical Imaging of Neocortical Dynamics serves as an ideal guide for researchers who aim to apply these highly valuable tools to their own neuroscientific studies.

Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.

The book has focussed on the different aspects of sensing technology, i.e. high reliability, adaptability, recalibration, information processing, data fusion, validation and integration of novel and high performance sensors specifically aims to use to inspect mechanical health of structure and similar applications. This book is dedicated to Sensing systems for Structural Health Monitoring offers to variety of users, namely, Master and PhD degree students, researchers, practitioners, especially Civil and Construction engineers. The book will provide an opportunity of a dedicated and a deep approach in order to improve their knowledge in this specific field.

This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move from real measured data to the model of the corresponding signals. This book proposes a generic framework for this procedure. It can be used as a guide for modelling impedance cardiography (ICG) and impedance respirography (IRG) signals, as well as for developing the corresponding bio-impedance signal simulator (BISS).

Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.

Dr. Leonard Swischuk has revised his outstanding work on imaging the cervical spine in children. He draws upon his extensive experience to provide practitioners with an insightful approach to pediatric cervical spine injuries. The text covers developmental anatomy, normal variants, congenital anomalies, abnormalities of the dens, trauma, and miscellaneous abnormalities of the cervical spine. The book has several strengths that appeal to radiology residents, such as its succinct overview of the topic and helpful reference lists that guide readers to additional resources. Dr. Swischuk illustrates conditions he discusses with excellent plain film examples that help residents identify cases they are likely to encounter during board exams and in practice. Accompanying CT and MR images clarify and qualify the findings. Dr. Swischuk's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

This unique text/reference discusses in depth the two integral components of reconstructive surgery; fracture detection, and reconstruction from broken bone fragments. In addition to supporting its application-oriented viewpoint with detailed coverage of theoretical issues, the work incorporates useful algorithms and relevant concepts from both graph theory and statistics. Topics and features: presents practical solutions for virtual craniofacial reconstruction and computer-aided fracture detection; discusses issues of image registration, object reconstruction, combinatorial pattern matching, and detection of salient points and regions in an image; investigates the concepts of maximum-weight graph matching, maximum-cardinality minimum-weight matching for a bipartite graph, determination of minimum cut in a flow network, and construction of automorphs of a cycle graph; examines the techniques of Markov random fields, hierarchical Bayesian restoration, Gibbs sampling, and Bayesian inference.