Measurements and experiments are made each and every day, in fields as disparate as particle physics, chemistry, economics and medicine, but have you ever wondered why it is that a particular experiment has been designed to be the way it is. Indeed, how do you design an experiment to measure something whose value is unknown, and what should your considerations be on deciding whether an experiment has yielded the sought after, or indeed any useful result? These are old questions, and they are the reason behind this volume. We will explore the origins of the methods of data analysis that are today routinely applied to all measurements, but which were unknown before the mid-19th Century. Anyone who is interested in the relationship between the precision and accuracy of measurements will find this volume useful. Whether you are a physicist, a chemist, a social scientist, or a student studying one of these subjects, you will discover that the basis of measurement is the struggle to identify the needle of useful data hidden in the haystack of obscuring background noise.

"Annual Reports in Computational Chemistry" is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. "Annual Reports in Computational Chemistry" is a "must" for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
* Broad coverage of computational chemistry and up-to-date information
* Topics covered include bioinformatics, drug discovery, protein NMR, simulation methodologies, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

Did the universe start with a Big Bang? Is light a wave, a particle – or both? Is a "Theory of Everything" possible?

Explaining the key milestones in the field of science in a clear and simple way, The Science Book answers these questions and more besides, and is the perfect introduction to the subject. Untangling knotty theories and shedding light on abstract concepts, entries unpack each complex idea with a combination of easy-to-follow explanations, innovative graphics, and intriguing quotes.

Discover the most important theories of history’s greatest scientists, why Copernicus’s ideas were so contentious, how Einstein developed the concept general and special relativity, and the reasoning behind Crick and Watson’s proposed structure for DNA, and much more besides.

Fully revised and updated with eight brand-new pages of content, The Science Book is a truly accessible and comprehensive route into a fascinating subject. Packed with scientific quotations, profiles of key figures and discoveries, and flowcharts and infographics that explain the most significant concepts clearly and simply, it is perfect for anyone with an interest in any of the sciences.

THIS VOLUME, WHICH IS DESIGNED FOR STAND-ALONE USE IN TEACHING AND RESEARCH, FOCUSES ON QUANTUM CHEMISTRY, AN AREA OF SCIENCE THAT MANY CONSIDER TO BE THE CENTRAL CORE OF COMPUTATIONAL CHEMISTRY. TUTORIALS AND REVIEWS COVER
* HOW TO OBTAIN SIMPLE CHEMICAL INSIGHT AND CONCEPTS FROM DENSITY FUNCTIONAL THEORY CALCULATIONS,
* HOW TO MODEL PHOTOCHEMICAL REACTIONS AND EXCITED STATES, AND
* HOW TO COMPUTE ENTHALPIES OF FORMATION OF MOLECULES.
* A FOURTH CHAPTER TRACES CANADIAN RESEARCH IN THE EVOLUTION OF COMPUTATIONAL CHEMISTRY.
* ALSO INCLUDED WITH THIS VOLUME IS A SPECIAL TRIBUTE TO QCPE. FROM REVIEWS OF THE SERIES
"Reviews in Computational Chemistry proves itself an invaluable resource to the computational chemist. This series has a place in every computational chemist's library."-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

This manual is designed as an intensive introduction to the various tools of molecular biology. It introduces all the basic methods of molecular biology including cloning, PCR, Southern (DNA) blotting, Northern (RNA) blotting, Western blotting, DNA sequencing, oligo-directed mutagenesis, and protein expression.
Key Features
* Provides well-tested experimental protocols for each technique
* Lists the reagents and preparation of each experiment separately
* Contains a complete schedule of experiments and the preparation required
* Includes study questions at the end of each chapter

This book focuses on the morphology, exine ornamentation and the associated evolutionary trends of crabapple pollen and anatomical developmental patterns. To examine the genetic evolutionary patterns of crabapple pollen traits, we constructed an interval distribution function based on characteristic pollen parameters and used a binary trivariate data matrix (Xi Yi Zi) to reflect the exine ornamentation regularity of the pollen. Our findings should inform the taxonomic status of the genus Malus. Pollen electron micrographs from a total of 26 species and 81 cultivars of Malus were recorded in this book. All 107 figures and 642 scanned pollen images constitute primary data obtained by the authors. The images in this book are clear, three-dimensional, and aesthetically pleasing. They are accompanied with text descriptions and provided a method for the indication of the different types of information that can be expected. This book can provide a reference for scientific researchers, students, and teachers in tertiary institutions that are engaged in research concerning crabapple production.

With respect to chemical applications, surface-launched acoustic wave sensors were originally developed as sensing devices for specific chemical and biological species, but more recently have been applied to the study of thin film and interfacial properties. These devices exploit the phenomenon of piezoelectricity, the instigation of mechanical motion in solids by oscillating electrical fields. This text/reference presents the principles of design and operation of these sensors and explores their traditional and emerging applications with a focus on devices that employ acoustic waves launched and received on the same surface.

The book begins with a review of piezoelectricity and the genesis of acoustic wave devices, and the advent of chemical sensor technology. Subsequent chapters explore acoustic waves in solids and device structure, theory of acoustic wave response, and the various categories of acoustic wave device. The book describes the design of these devices and how they are applied in chemistry for the detection of species present in the gas and liquid phase, as well as the study of thin films placed on the sensor surface. Other topics covered include polymeric glass transitions, polymer properties, biosensor technology, and the development of sensor arrays. Each of the various types of device is examined with a view toward its application in chemistry in general and analytical chemistry in particular.

Presenting the most up-to-date information available on this rapidly evolving technology, and supplemented with scores of helpful illustrations and tables, Surface-Launched Acoustic Wave Sensors draws information from such diverse areas of scientific investigation as acoustic wave physics, applied mathematics, chemistry, electronics, fluid mechanics, materials science, piezoelectricity, and polymer science. The material presented on these topics is both self-consistent and readable for the nonexpert—allowing industrial chemists, graduate students, and undergraduates to gain a deeper understanding of these devices, their designs, and applications.

A focused and accessible presentation of a burgeoning new technology

This book concerns the design, operation, and application of devices capable of generating acoustic waves in the ultrasonic frequency range. The clear emphasis of the text is the study of chemical and/or biochemical systems imposed on the surface of such devices, whether operated in the gas or liquid phase, i.e., on acoustic wave chemical and biological sensors. Presenting the most up-to-date information available on this rapidly evolving technology, and supplemented with scores of helpful illustrations and tables, this book

• Reviews piezoelectricity and the genesis of acoustic wave devices as well as the advent of chemical sensor technology
• Explores acoustic waves in solids and device structure, theory of acoustic wave response, and the various categories of acoustic wave device
• Describes device design and how these devices are applied in chemistry to detect species present in the gas and liquid phase, as well as to study thin films placed on the sensor surface
• Covers polymeric glass transitions, polymer properties, biosensor technology, and the development of sensor arrays
• Examines each of the various types of device with a view toward its application in analytical chemistry and chemistry in general

The participation in interlaboratory studies and the use of Certified Reference Materials (CRMs) are widely recognised tools for the verification of the accuracy of analytical measurements and they form an integral part of quality control systems used by many laboratories, e.g. in accreditation schemes. As a response to the need to improve the quality of environmental analysis, the European Commission has been active in the past fifteen years, through BCR activity (now renamed Standards, Measurements and Testing Programme) in the organisation of series of interlaboratory studies involving expert laboratories in various analytical fields (inorganic, trace organic and speciation analysis applied to a wide variety of environmental matrices). The BCR and its successor have the task of helping European laboratories to improve the quality of measurements in analytical sectors which are vital for the European Union (biomedical, agriculture, food, environment and industry); these are most often carried out in support of EC regulations, industrial needs, trade, monitoring activities (including environment, agriculture, health and safety) and, more generally, when technical difficulties hamper a good comparability of data among EC laboratories. The collaborative projects carried out so far have placed the BCR in the position of second world CRM producer (after NIST in the USA).

"Interlaboratory Studies and Certification of Reference Materials for Environmental Analysis" gives an account of the importance of reference materials for the quality control of environmental analysis and describes in detail the procedures followed by BCR to prepare environmental reference materials, including aspects related to sampling, stabilization, homogenisation, homogeneity and stability testing, establishment of reference (or certified) values, and use of reference materials. Examples of environmental CRMs produced by BCR within the last 15 years are given, which represent more than 70 CRMs covering different types of materials (plants, biological materials, waters, sediments, soils and sludges, coals, ash and dust materials) certified for a range of chemical parameters (major and trace elements, chemical species, PAHs, PCBs, pesticides and dioxins).

The final section of the book describes how to organise improvement schemes for the evaluation method and/or laboratory performance. Examples of interlaboratory studies (learning scheme, proficiency testing and intercomparison in support to prenormative research) are also given.

Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.

For many years, evidence suggested that all solid materials either possessed a periodic crystal structure as proposed by the Braggs or they were amorphous glasses with no long-range order. In the 1970s, Roger Penrose hypothesized structures (Penrose tilings) with long-range order which were not periodic. The existence of a solid phase, known as a quasicrystal, that possessed the structure of a three dimensional Penrose tiling, was demonstrated experimentally in 1984 by Dan Shechtman and colleagues. Shechtman received the 2011 Nobel Prize in Chemistry for his discovery. The discovery and description of quasicrystalline materials provided the first concrete evidence that traditional crystals could be viewed as a subset of a more general category of ordered materials. This book introduces the diversity of structures that are now known to exist in solids through a consideration of quasicrystals (Part I) and the various structures of elemental carbon (Part II) and through an analysis of their relationship to conventional crystal structures. Both quasicrystals and the various allotropes of carbon are excellent examples of how our understanding of the microstructure of solids has progressed over the years beyond the concepts of traditional crystallography.

This book describes modern focused ion beam microscopes and techniques and how they can be used to aid materials metrology and as tools for the fabrication of devices that in turn are used in many other aspects of fundamental metrology. Beginning with a description of the currently available instruments including the new addition to the field of plasma-based sources, it then gives an overview of ion solid interactions and how the different types of instrument can be applied. Chapters then describe how these machines can be applied to the field of materials science and device fabrication giving examples of recent and current activity in both these areas.

Originally published in 1665, Micrographia is the most famous and influential work of English scholar ROBERT HOOKE (1635-1703), a notable member of the Royal Society and the scientist for whom Hooke's Law of elasticity is named. Here, Hooke describes his observations of various household and biological specimens, such as the eye of a fly and the structure of plants, and became the first person to use the term cell in biology, as the cells in plants reminded him of monk's living quarters. In addition to his studies using a microscope, Hooke also discusses the heavenly bodies as visible through a telescope. Students of science and the history of science will find Hooke's early forays into biology and optics a good primer for further learning.

This volume is a new follow-up volume that complements Dynamic Light Scattering (1993) by the same author. The volume is directed to the recent development in the light scattering technique and to describing a wide spectrum of its applications. Both the theoretical development and utilization are traced by authors who are expert in their fields. Development in static light scattering as applied to simple liquids, polymer solutions, and multi-component polymer mixtures are dealt with. The scattering theory of colloidal dispersions is described and scattering from rod-like polyelectolytes is reviewed. There are chapters on concentrated polymer systems, aggregation phenomena, polymer-polymer interactions, polyelectrolytes in solution. Emphasis is given to more complex systems, for example, ternary polymer systems, complex micellar systems, and block copolymers in the ordered and disordered states. Low-angle light scattering is reviewed, as well as simultaneous static and dynamic light scattering. The determination of particle size distributions and combined chromatographic light scattering techniques are also treated.

Unifies the complex welter of techniques used for chemical separations by clearly formulating the concepts that are common to them. The mass transport phenomena underlying all separation processes are developed in a simple physical-mathematical form. The limitations and optimum performance of alternative separation techniques and the factors enhancing and limiting separation power can thus be described and explored. Generously illustrated and contains numerous exercises. Long awaited in the scientific community, it breaks new ground in understanding separation processes.

Since its inception, patch-clamp has continued to be widely considered the gold standard method to record ion channel activity. "Patch-Clamp Methods and Protocols, Second Edition," provides a comprehensive collection of new techniques for the development of automated, high-throughput screening systems for pharmacological evaluation, the use of various patch-clamp configurations together with novel molecular biological and imaging methodologies and enhanced stimulation protocols and perfusion systems. Divided into sections on pharmacology, physiology and biophysics, the chapters cover methods to generate more physiologically relevant conditions for drug application and screening technologies, recently developed applications such as optogenetic stimulation, advances in whole-cell recordings in freely-moving animals and novel technologies to create custom microelectrodes designed for reducing the access resistance and improving the rate of molecular diffusion. Patch-clamp is an indispensable technique for conducting pharmacological, physiological and biophysical research aimed at understanding crucial aspects of cellular and network function. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Patch-Clamp Methods and Protocols, Second Edition" will provide a useful technical and methodological guide to diverse audiences of electrophysiologists, from students to experienced investigators.

The electric dipole moment (EDM) challenge measures a non-zero proton EDM value and this book suggests how the challenge can be met. Any measurably large proton EDM would violate the standard model. The method to be employed uses an intense beam of 'frozen spin' protons circulating for hour-long times in a storage ring 'trap'. The smallness of EDMs allows them to test existing theories, but also makes them hard to measure. Such EDM experiments are inexpensive, at least compared to building accelerators of ever-greater energy.

The previous edition of this book marked the shift in technology from video to digital camera use with microscope use in biological science. This new edition presents some of the optical fundamentals needed to provide a quality image to the digital camera. Specifically, it covers the fundamental geometric optics of finite- and infinity-corrected microscopes, develops the concepts of physical optics and Abbe's theory of image formation, presents the principles of Kohler illumination, and finally reviews the fundamentals of fluorescence and fluorescence microscopy. The second group of chapters deals with digital and video fundamentals: how digital and video cameras work, how to coordinate cameras with microscopes, how to deal with digital data, the fundamentals of image processing, and low light level cameras. The third group of chapters address some specialized areas of microscopy that allow sophisticated measurements of events in living cells that are below the optical limits of resolution.
* Expands coverage to include discussion of confocal microscopy not found in the previous edition
* Includes "traps and pitfalls" as well as laboratory exercises to help illustrate methods

Biobanking, an emerging field supported by academia, industry and health administrators alike, is distinctly different today from the practice that once defined it. The science of Biobanking, which initially involved simply storing blood or tissue samples in a freezer, is now a highly sophisticated field of research, and expected to grow exponentially over the next decade or two. This book aims to serve the purpose of further enriching the available literature on Biobanking, by offering unique and more useful collection of ideas for the future. The book outlines the experiences of developing modern Biobanking repositories in different countries, whilst covering specific topics regarding the many aspects of Biobanking. This book will be of interest to a wide range of readers including: academics, students, volunteers and advocates of patients' rights.

The principles and procedures used to obtain structural measurements of terrestrial vegetation communities are presented in this text/reference. Designed to be the standard work on the topic, it provides a balance between conceptual and practical aspects of measurement procedures and techniques. The four commonly used measurements of vegetation - frequency, cover, density, and biomass - are introduced, along with their associated units. There is also up-to-date coverage of vegetation measurement using remote sensing techniques.

Heavy electrons are found among a number of lanthanide and actinide compounds, and are characterized by a large effective mass which becomes comparable to the mass of a muon. Heavy electrons exhibit rich phenomena such as unconventional superconductivity, weak anti- ferromagnetism, or pseudo meta-magnetism. This book is intended not only as a monograph, but can readily serve as an advanced textbook on theoretical and experimental physics of strongly correlated electrons. Over the last two decades, heavy electrons have been the focus of very active experimental and theoretical studies. Many established ideas and techniques have been insufficient to describe and understand heavy electrons and their impact properly. On the theoretical side, quantum fluctuations make mean-field theories difficult to handle, while on the experimental side, extreme conditions such as strong magnetic fields and pressure at ultra-low temperatures may be required. Heavy electron systems as described in this book offer a case study for applying and testing most of the major tools in theoretical and experimental condensed matter physics. Graduate students and researchers working on strongly correlated condensed matter systems will find in this book a comprehensive introduction and many examples how conventional concepts of solids may work or not work, and how they can be refined and sharpened in the context of heavy electron systems.

The new edition of this widely-used sourcebook details the startlingly array of diagnostic equipment available in the medical laboratory of the nineties, and also covers maintenance and quality assurance for each type of instrument. This book includes 17 completely rewritten chapters and 7 new ones, on nephelometry and turbidimetry, gas chromatography, mass spectrometry, flow cytometry, automated immunoassay systems, automated blood bank systems, and physician's office laboratory instrumentation.

This book is about China's ambitions in its most complex and internationally visible space endeavor, namely its human space exploration programme. It provides a comprehensive reflection on Chinas strategic direction and objectives in space, including in particular those set forth in its human spaceflight programme and analyses the key domestic and external factors affecting the country's presumed manned lunar ambitions. The objective of the book is to disentangle the opportunities and challenges Chinas space ambitions are creating for other spacefaring nations and for Europe in particular. It therefore includes an in-depth analysis of possible European postures towards China in space exploration and seeks to stimulate a debate on future space strategies in the broader context of world politics.