Hydronamics of Explosion presents the research results for the problems of underwater explosions and contains a detailed analysis of the structure and the parameters of the wave fields generated by explosions of cord and spiral charges, a description of the formation mechanisms for a wide range of cumulative flows at underwater explosions near the free surface, and the relevant mathematical models. Shock-wave transformation in bubbly liquids, shock-wave amplification due to collision and focusing, and the formation of bubble detonation waves in reactive bubbly liquids are studied in detail. Particular emphasis is placed on the investigation of wave processes in cavitating liquids, which incorporates the concepts of the strength of real liquids containing natural microinhomogeneities, the relaxation of tensile stress, and the cavitation fracture of a liquid as the inversion of its two-phase state under impulsive (explosive) loading. The problems are classed among essentially nonlinear processes that occur under shock loading of liquids and may be of interest to researchers in physical acoustics, mechanics of multiphase media, shock-wave processes in condensed media, explosive hydroacoustics, and cumulation.

A nonneutral plasma is a many-body collection of charged particles in which there is not overall charge neutrality. The diverse areas of application of nonneutral plasmas include: precision atomic clocks, trapping of antimatter plasmas and antihydrogen production, quantum computers, nonlinear vortex dynamics and fundamental transport processes in trapped nonneutral plasmas, strongly-coupled one-component plasmas and Coulomb crystals, coherent radiation generation in free electron devices, such as free electron lasers, magnetrons and cyclotron masers, and intense charged particle beam propagation in periodic focusing accelerators and transport systems, to mention a few examples. Physics of Nonneutral Plasmas is a graduate-level text - complete with 138 assigned problems and the results from several classic experiments - which covers a broad range of topics related to the fundamental properties of collective processes and nonlinear dynamics of one-component and multispecies charged particle systems in which there is not overall charge neutrality. The subject matter is treated systematically from first principles, using a unified theoretical approach, and the emphasis is on the development of basic concepts that illustrate the underlying physical processes in circumstances where intense self fields play a major role in determining the evolution of the system. The theoretical analysis includes the full influence of dc space charge effects on detailed equilibrium, stability and transport properties. The statistical models used to describe the properties of nonneutral plasmas are based on the nonlinear Vlasov-Maxwell equations, the macroscopic fluid-Maxwell equations, or the Klimontovich-Maxwell equations, as appropriate, and extensive use is made of theoretical techniques developed in the description of multispecies electrically-neutral plasmas, as well as established techniques in classical mechanics, electrodynamics and statistical physics.Physics of Nonneutral Plasmas emphasizes basic physics principles, and the thorough presentation style is intended to have a lasting appeal to graduate students and researchers alike. Because of the advanced theoretical techniques developed for describing one-component charged particle systems, this book serves as a useful companion volume to Physics of Intense Charged Particle Beams in High Energy Accelerators by Ronald C Davidson and Hong Qin.

A nonneutral plasma is a many-body collection of charged particles in which there is not overall charge neutrality. The diverse areas of application of nonneutral plasmas include: precision atomic clocks, trapping of antimatter plasmas and antihydrogen production, quantum computers, nonlinear vortex dynamics and fundamental transport processes in trapped nonneutral plasmas, strongly-coupled one-component plasmas and Coulomb crystals, coherent radiation generation in free electron devices, such as free electron lasers, magnetrons and cyclotron masers, and intense charged particle beam propagation in periodic focusing accelerators and transport systems, to mention a few examples. Physics of Nonneutral Plasmas is a graduate-level text - complete with 138 assigned problems and the results from several classic experiments - which covers a broad range of topics related to the fundamental properties of collective processes and nonlinear dynamics of one-component and multispecies charged particle systems in which there is not overall charge neutrality. The subject matter is treated systematically from first principles, using a unified theoretical approach, and the emphasis is on the development of basic concepts that illustrate the underlying physical processes in circumstances where intense self fields play a major role in determining the evolution of the system. The theoretical analysis includes the full influence of dc space charge effects on detailed equilibrium, stability and transport properties. The statistical models used to describe the properties of nonneutral plasmas are based on the nonlinear Vlasov-Maxwell equations, the macroscopic fluid-Maxwell equations, or the Klimontovich-Maxwell equations, as appropriate, and extensive use is made of theoretical techniques developed in the description of multispecies electrically-neutral plasmas, as well as established techniques in classical mechanics, electrodynamics and statistical physics.Physics of Nonneutral Plasmas emphasizes basic physics principles, and the thorough presentation style is intended to have a lasting appeal to graduate students and researchers alike. Because of the advanced theoretical techniques developed for describing one-component charged particle systems, this book serves as a useful companion volume to Physics of Intense Charged Particle Beams in High Energy Accelerators by Ronald C Davidson and Hong Qin.

Optical frequency measurement is an extremely challenging field of experimental physics which is presently undergoing a renaissance driven by the needs of modern high density optical communication systems as well as by requirements of high-resolution laser spectroscopy. This text is the first to discuss the development of traditional and second generation frequency chains together with their enabling technology. Reviews written by some of the most experienced researchers in their respective fields address the technology of frequency metrology such as: low noise microwave oscillators and microwave frequency standards, low noise and high stability optical frequency sources, optical frequency standards, traditional and second-generation optical frequency measurement and synthesis techniques as well as optical frequency comb generators. It should prove useful to researchers just entering the field of frequency metrology or equally well to the experienced practitioner.

Bridging the gap between statistical theory and physical experiment, this is a thorough introduction to the statistical methods used in the experimental physical sciences and to the numerical methods used to implement them. An accompanying CD-ROM provides detailed code for implementing many of these algorithms. The treatment emphasises concise but rigorous mathematics but always retains its focus on applications. Readers are assumed to have a sound basic knowledge of differential and integral calculus and some knowledge of vectors and matrices. After an introduction to probability, random variables, computer generation of random numbers and important distributions, the book turns to statistical samples, the maximum likelihood method, and the testing of statistical hypotheses. The discussion concludes with several important statistical methods: least squares, analysis of variance, polynomial regression, and analysis of time series. Appendices provide the necessary methods of matrix algebra, combinatorics, and many sets of useful algorithms and formulae.

It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Chemistry is an experimental subject, and what can be more stimulating than carrying out a laboratory experiment where the results are memorable either by their visual nature or by their tying together of theory. This collection of 100 chemistry experiments has been developed with the help and support of teachers throughout the UK. Each student worksheet is accompanied by a teachers' notes sheet which gives details for teachers and technicians on apparatus and chemicals, timing, context, teaching tips, background theory and answers to any questions on the student worksheets. The student worksheets are also available on the web, and can be downloaded or adapted as necessary by teachers. Classic Chemistry Experiments is designed as a teaching aid to help communicate the excitement and wonder of chemistry to students, and is ideal for both experienced chemistry teachers and to scientists from other disciplines who are teaching chemistry. Additional resources can be downloaded from: http://www.rsc.org/learn-chemistry/resource/res00001938/classic-chemistry-experiments-book#!cmpid=CMP00000454

Silicon, the basic material for a multibillion-dollar industry, is the most widely researched and applied semiconductor, and its surfaces are the most thoroughly studied of all semiconductor surfaces. Silicon Surfaces and Formation of Interfaces may be used as an introduction to graduate-level physics and chemical physics. Moreover, it gives a specialized and comprehensive description of the most common faces of silicon crystals as well as their interaction with adsorbates and overlayers. This knowledge is presented in a systematic and easy-to-follow way. Discussion of each system is preceded by a brief overview which categorizes the features and physical mechanisms before the details are presented. The literature is easily available, and the references am numerous and organized in tables, allowing a search without the need to browse through the text.

Though this volume focuses on a scientific understanding of physics on the atomistic and mesoscopic levels, it also highlights existing and potential links between basic research in surface science and applications in the silicon industry. It will be valuable to anyone writing a paper, thesis, or proposal in the field of silicon surfaces.

With its focus on the practical application of the techniques of multivariate statistics, this book shapes the powerful tools of statistics for the specific needs of ecologists and makes statistics more applicable to their course of study. It gives readers a solid conceptual understanding of the role of multivariate statistics in ecological applications and the relationships among various techniques, while avoiding detailed mathematics and the underlying theory. More importantly, the reader will gain insight into the type of research questions best handled by each technique and the important considerations in applying them. Whether used as a textbook for specialised courses or as a supplement to general statistics texts, the book emphasises those techniques that students of ecology and natural resources most need to understand and employ in their research. While targeted for upper-division and graduate students in wildlife biology, forestry, and ecology, and for professional wildlife scientists and natural resource managers, this book will also be valuable to researchers in any of the biological sciences.

The field of high performance computing achieved prominence through advances in electronic and integrated technologies beginning in the 1940s. Current times are very exciting and the years to come will witness a proliferation of the use of parallel and distributed systems. The scientific and engineering application domains have a key role in shaping future research and development activities in academia and industry, especially when the solution of large and complex problems must cope with harder and harder timing.
High Performance Scientific And Engineering Computing: Hardware/Software Support contains selected chapters on hardware/software support for high performance scientific and engineering computing from prestigious workshops in the fields such as PACT-SHPSEC, IPDPS-PDSECA and ICPP-HPSECA. This edited volume is basically divided into six main sections which include invited material from prominent researchers around the world. We believe all of these contributed chapters and topics not only provide novel ideas, new results and state-of-the-art techniques in this field, but also stimulate the future research activities in the area of high performance computing for science and engineering applications.
High Performance Scientific And Engineering Computing: Hardware/Software Support is designed for a professional audience, composed of researchers and practitioners in industry. This book is also suitable as a secondary text for graduate-level students in computer science and engineering.

This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Spark scientific curiosity from a young age with this six-level course through an enquiry-based approach and active learning. Collins International Primary Science fully meets the requirements of the Cambridge Primary Science Curriculum Framework from 2020 and has been carefully developed for a range of international contexts. The course is organised into four main strands: Biology, Chemistry, Physics and Earth and Space and the skills detailed under the 'Thinking and Working Scientifically' strand are introduced and taught in the context of those areas. For each Workbook at Stages 1 to 6, we offer: A write-in Workbook linked to the Student's Book New language development activities help build science vocabulary Earth and Space content covers the new curriculum framework Thinking and Working Scientifically deepens and enhances the delivery of Science skills Actively learn through practical activities that don't require specialist equipment or labs Scaffolding allows students of varying abilities to work with common content and meet learning objectives Supports Cambridge Global Perspectives (TM) with activities that develop and practise key skills Provides learner support as part of a set of resources for the Cambridge Primary Science curriculum framework (0097) from 2020 This series is endorsed by Cambridge Assessment International Education to support the new curriculum framework 0097 from 2020.

Antibodies tagged with fuorescent markers have been used in histochemistry for over 50 years. Although early applications were focused on the detection of microbial antigens in tissues, the use of immunocytochemical methods now has spread to include the det- tion of a wide array of antigens including proteins, carbohydrates, and lipids from virtually any organism. Today, immunohistochemistry is widely used to identify, in situ, various components of cells and tissues in both normal and pathological conditions. The method gains its strength from the extremely sensitive interaction of a specifc antibody with its antigen. For some scientifc areas, books have been published on applications of immu- cytochemical techniques specifc to that area. What distinguished Immunocytochemical Methods and Protocols from earlier books when it was frst published was its broad appeal to investigators across all disciplines, including those in both research and clinical settings. The methods and protocols p- sented in the frst edition were designed to be general in their application; the accompa- ing "Notes" provided the reader with invaluable assistance in adapting or troubleshooting the protocols. These strengths continued to hold true for the second edition and again for the third edition. Since the publication of the frst edition, the application of immuno- tochemical techniques in the clinical laboratory has continued to rise and this third edition provides methods that are applicable to basic research as well as to the clinical laboratory.

In the hopes of preserving these delightful devices for future generations, this collector of slide rules covers everything one could possibly want to know about this crude form of analog computer: from its invention in the 17th century to manufacturers- retailers, 1850-1998, and the Oughtred Soci

Purification of Laboratory Chemicals: Part Two, Inorganic Chemicals, Catalysts, Biochemicals, Physiologically Active Chemicals, Nanomaterials, Ninth Edition describes contemporary methods for the purification of chemical compounds. The work includes tabulated methods taken from literature for purifying thousands of individual commercially available chemical substances. To help in applying this information, the more common processes currently used for purification in chemical laboratories and new methods are discussed. For dealing with substances not separately listed, another chapter is included, setting out the usual methods for purifying specific classes of compounds. Laboratory workers, whether carrying out research or routine work, will invariably need to consult this book. Apart from the procedures described, the large amount of physical data about listed chemicals is essential. This fully updated, revised and expanded new edition includes the purification of many new substances that have been available commercially since 2017, along with previously available substances which have found new applications.

The central role of RNA in many cellular processes, in biotechnology, and as pharmaceutical agents, has created an interest in experimental methods applied to RNA molecules. This book provides scientists with a comprehensive collection of thoroughly tested up-to-date manuals for investigating RNA-protein complexes "in vitro." The protocols can be performed by researchers trained in standard molecular biological techniques and require a minimum of specialized equipment. The procedures include recommendation of suppliers of reagents.

The central role of RNA in many cellular processes, in biotechnology, and as pharmaceutical agents, has created an interest in experimental methods applied to RNA molecules. This book provides scientists with a comprehensive collection of thoroughly tested up-to-date manuals for investigating RNA-protein complexes "in vitro." The protocols can be performed by researchers trained in standard molecular biological techniques and require a minimum of specialized equipment. The procedures include recommendation of suppliers of reagents.

Ribonucleic acids are central to cellular and molecular processes and perform vital functions in both structural and functional roles. RNA molecules form the bridge between the stable genetic information contained within DNA and enzymes and proteins that carry out much of the metabolism within the cell. Many of the sites of protein synthesis, the ribosomes within the cell, are composed of these ribonucleic acids as are the tRNA molecules that deliver the amino acid building blocks to the ribosomes. Of all the RNA species, the nucleic acid intermediate, messenger RNA, is a desirable source of material to biologists, since this reflects much of, what ultimately, is translated into enzymes and proteins. In order to determine the qualitative and quantitative changes in mRNA expression, a vast number of molecular biological techniques have been developed. Key molecular methods that provide the means to initially isolate and analyze RNA molecules are the focus of this volume. In putting together this collection of protocols, we have tried to provide techniques that are most applicable and widely used. In particular, there are a number of iso- tion techniques included that have been developed, modified, or adapted to enable extraction from a variety of cell types, organisms, or subcellular organelles. Successful isolation of intact RNA is an essential starting point for any sub- quent analysis. This is why we have aimed to make this section comprehensive. The analysis of RNA is the focus of the following chapters.

Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing."

If you're not sure what to make of all the claims and counterclaims, this new book will help cut through the conflicting reports and contradictory findings.
We are bombarded daily with media reports of startling new findings from "just released" studies often in major, authoritative publications on consumer products, medications, foods, alcohol, safety devices, social behavior, public policy, and much more. The decisions of millions of consumers, professionals, and government agencies can be influenced by just one study.
Light, humorous, and entertaining, Studies Show reviews sample studies to expose their traps and pitfalls. In plain English, statistics analyst John H. Fennick discusses the methods of good and bad studies to explain how scientific results can differ sometimes radically. Fennick shows that when armed with common sense and critical intelligence, we can understand almost any study.

The purpose of Ribozyme Protocols is to provide a helpful compilation of protocols that will be of use- DEGREESnot only to those with some experience of ribozymes- DEGREESbut also to those wishing to use ribozymes for the first time. Although it is usually impossible to cover every aspect of a scientific field, I believe this book approaches that ideal and should help all readers perform meaningful experiments using ribozymes. To design ribozymes, one must consider whether the target site will be accessible; this task can be facilitated by using computer programs that pre dict the folding of the target RNA. Such programs are detailed in Chapters 2 and 3. If the chosen target is an RNA virus that can mutate rapidly, it makes sense to consider those parts of the genome that are least likely to change during viral replication. An example of how this can be done is described in Chapter 4. Although computer analysis may be a useful starting point to select tar get sites, there seems, at the moment, to be no guarantee that any particular chosen site will be efficiently cleaved. Some workers have deliberately bypassed this problem by using libraries of ribozyme sequences and by select ing those that actually hybridize to and/or cleave the target; these methods are described in Chapters 5

In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Photobiology integrates a wide variety of scientific disciplines. As more people become aware of the many ways light interacts with chemical and biological systems, the need for a concise treatment of photobiology has become more critical. Kohen "et al." Have written just such a book, intended both as a textbook and as a reference.
The authors begin by providing a brief description of the nature of light, how it affects matter, and the means and methods of measuring it. A major section of the book is devoted to how light influences living systems, including discussions of photosynthesis, bioluminescence, regulatory mechanisms, and visual transduction of light. The last half of the book is devoted to the biomedical aspects of light, including photoimmunology, photoallergic reactions and other forms of light sensitivity, the optical properties of skin, and various ways that light can be used in therapy treatments.
Useful to photobiologists as a comprehensive overview, this book should also appeal to biomedical researchers and advanced students of photobiology.