The purpose of the preface is to explain the book's objectives and how to use it; give warnings, disclaimers, and the like.* The main objective of Protein and Peptide Analysis by Mass Spec trometry is quite straightforward-to present authoritative, up-to-date, and practical accounts of the use of mass spectrometry in the analysis of pep tides and proteins. How to use it? Every reader will have their own particular interests and will surely be drawn toward the chapters that cover these interests. Within the remaining chapters, however, techniques are described with analytical possibilities that such a reader can then only guess at. So, read the book fully. Again, as is customary in the Methods in Molecular Biology series, the chapter format (Introduction, Materials, Methods, and Notes) allows the authors to introduce the techniques, to explain their relevance and applicability, and, above all, to provide detail-detail that represents each author's accumulated experience and enables the reader to use and benefit from these methods. So, read the book fully, and read it diligently. Warnings and disclaimers: Mass spectrometry today offers the pro tein chemist ready access to a wealth of information that is otherwise avail able only with great difficulty, or perhaps not at all. With this goal in sight, any warnings and disclaimers will almost surely be ignored. So, a warning anyway; the use of mass spectrometry might be habit forming."

The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. * Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection * Includes contributions from experts from various fields of applications who explore CAD s advantages over traditional HPLC techniques, as well its limitations * Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences * Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.

Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr

This is the second volume of Advances in Acoustic Microscopy. It continues the aim of presenting applications and developments of techniques that are related to high-resolution acoustic imaging. We are very grateful to the authors who have devoted considerable time to preparing these chapters, each of which describes a field of growing importance. Laboratories that have high-performance acoustic microscopes are frequently asked to examine samples for which the highest available resolution is not necessary, and the ability to penetrate opaque layers is more significant. Such applications can be thought of as bridging the gap be tween acoustic microscopy at low gigahertz frequencies, and on the one hand nondestructive testing of materials at low megahertz frequencies and on the other hand medical ultrasonic imaging at low megahertz frequencies. Commercial acoustic microscopes are becoming increasingly available and popular for such applications. We are therefore delighted to be able to begin the volume with chapters from each of those two fields. The first chapter, by Gabriele Pfannschmidt, describes uses of acoustic microscopy in the semiconductor industry. It provides a splendid balance to the opening chapter of Volume 1, which came from a national research center, being written from within a major European electronics industry itself. Dr Pfann schmidt describes the use of two quite different types of acoustic microscopes, and points out the advantages of each for specific purposes.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes." For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Molecular Sieves - Science and Technology covers, in a comprehensive manner, the science and technology of zeolites and all related microporous and mesoporous materials. Authored by renowned experts, the contributions are grouped together topically in such a way that each volume of the book series deals with a specific sub-field. Volume 4 covers the characterization of molecular sieves with the help of the most important spectroscopic techniques (Characterization I), i.e. IR, Raman, NMR, EPR, UV-VIS Spectroscopy, X-ray absorption, photoelectron and Mössbauer Spectroscopy. Theory, experiment and application in selected examples are discussed.

This ASI brought together a diverse group of experts who span virology, biology, biophysics, chemistry, physics and engineering. Prominent lecturers representing world renowned scientists from nine (9) different countries, and students from around the world representing eighteen (18) countries, participated in the ASI organized by Professors Joseph Puglisi (Stanford University, USA) and Alexander Arseniev (Moscow, RU). The central hypothesis underlying this ASI was that interdisciplinary research, merging principles of physics, chemistry and biology, can drive new discovery in detecting and fighting chemical and bioterrorism agents, lead to cleaner environments and improved energy sources, and help propel development in NATO partner countries. At the end of the ASI students had an appreciation of how to apply each technique to their own particular research problem and to demonstrate that multifaceted approaches and new technologies are needed to solve the biological challenges of our time. The course succeeded in training a new generation of biologists and chemists who will probe the molecular basis for life and disease.

The 43rd Annual Conference on Applications ofX-ray Analysis was held August 1-5, 1994, at the Sheraton Steamboat Resort & Conference Center in Steamboat Springs, Colorado. The Denver X-Ray Conference has evolved from the 1950's into an international forum for the interaction of scientists, engineers and technologists interested in the use of x-rays in materials characterization. It has not only acted as a venue but has both stimulated and nurtured many of the principal developments in this field over the years. The major changes that have been occurring on the national and international scene as a result of the end of the cold war have dramatic-ally affected the way the materials community does business. The removal of defense priorities and development funds from most new materials initiatives has stimulated the char acterization communities to look to increasing the speed of their methods. This is being accom plished via the development of very fast dynamic characterization procedures which can rapidly and intelligently monitor and optimize the formation of a desired microstructure. The develop ment of intelligent characterization procedures applied in real-time during the manufacturing process can lead to the ability to design desired microstructures. Another potential advantage to this approach is its ability to characterize the actual amount of material which goes into a final product; permitting a rapid transition from R&D to manufacturing by avoiding the prob lems associated with scale-up.

This book describes methods for calculating magnetic resonance spectra which are observed in the presence of random processes. The emphasis is on the stochastic Liouville equation (SLE), developed mainly by Kubo and applied to magnetic resonance mostly by J H Freed and his co-workers. Following an introduction to the use of density matrices in magnetic resonance, a unified treatment of Bloch-Redfield relaxation theory and chemical exchange theory is presented. The SLE formalism is then developed and compared to the other relaxation theories. Methods for solving the SLE are explained in detail, and its application to a variety of problems in electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) is studied. In addition, experimental aspects relevant to the applications are discussed. Mathematical background material is given in appendices.

This book addresses the development of electronic devices using redox-active organic molecules and their porous coordination networks (PCNs), and highlights the importance of the molecular arrangement. Redox-active organic molecules hold considerable promise as flexible electronic elements, because their electronic state can easily be controlled using external energy. Although various kinds of redox-active organic molecules have been synthesized, attempts to apply them to electronic devices have been limited, owing to the lack of proper structural design. Moreover, ligand-based redox-active PCNs remain largely unexplored because of the limited availability of redox-active ligands. In addition to developing new redox-active organic molecules, in order to design electronic devices based on these molecules/PCNs, it is essential to understand the connections between their molecular arrangement, electrical properties, and redox activity. In this thesis, the redox-active organic molecule 2,5,8-tri(4-pyridyl)1,3-diazaphenalene (TPDAP), which features a large pi plane and multi-intermolecular interactivity, is used to develop a resistive switching memory device. In addition, its PCNs are synthesized to fabricate chemiresistive sensors, and the electrical properties are modulated using post-synthetic modification. Each mechanism is systematically investigated by means of structural determination and well-defined control experiments. Subsequently, the book proposes general guidelines for designing electronic devices using redox-active organic molecules. The book will appeal to a broad range of readers, from basic scientists to materials engineers, as well as general, non-expert readers.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

The 2nd International Multidisciplinary Microscopy and Microanalysis Congress & Exhibition (InterM 2014) was held on 16-19 October 2014 in Oludeniz, Fethiye/ Mugla, Turkey. The aim of the congress was to gather scientists from various branches and discuss the latest improvements in the field of microscopy. The focus of the congress has been widened in an "interdisciplinary" manner, so as to allow all scientists working on several related subjects to participate and present their work. These proceedings include 33 peer-reviewed technical papers, submitted by leading academic and research institutions from over 17 countries and representing some of the most cutting-edge research available. The papers were presented at the congress in the following sessions: * Applications of Microscopy in the Physical Sciences * Applications of Microscopy in the Biological Sciences

Impurities, disorder or amorphous systems - ill-condensed matter - are mostly considered inconveniences in the study of materials, which is otherwise heavily based on idealized perfect crystals. The Kondo effect and the scaling theory of localization are among the fundamental and early discoveries which revealed the novelty hidden in impure or disordered systems. Recent advances in condensed matter physics have emphasized the role of topology, spin-orbit coupling, and certain discrete symmetries such as time reversal in many physical phenomena. These have irreversibly transformed the essential ideas and purview of condensed matter physics, both in theoretical and experimental directions. However, many of these recent developments and their implications are limited to, or by, ideas that pertain to clean systems. This thesis deals with various aspects of these new developments, but in the case of unclean systems. The author introduces new ideas such as amorphous topological insulators, fractalized metals and fractionalized spins.

This book collects all the latest advances in the leading research of the circularly polarized luminescence (CPL) of small organic molecules. Compared with that of lanthanide-based fluorophores, the research into the CPL of small organic molecules is still at the developmental stage for their relatively smaller dissymmetric factors, but has been a source of widespread attention recently. The book includes the state of the art of the discoveries in CPL organic molecules, such as helicenes, biaryls, cyclophanes, boron dipyrromethene dyes, and other chiral molecules, mostly in their isolated states, covering all possible chiral substances for future applications. This book also highlights the recent development of CPL instruments as well as time-resolved circular dichroism spectroscopy, to facilitate the further development and future design of CPL molecules.

''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' "--- Quarterly Review of Biology," March 1997 '' T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' "--- American Scientist" ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' "--- Nahrung," 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

This book provides a concise introduction to the newly created sub-discipline of solid state physics isotopetronics. The role of isotopes in materials and their properties are describe in this book. The problem of the enigma of the atomic mass in microphysics is briefly discussed. The range of the applications of isotopes is wide: from biochemical process in living organisms to modern technical applications in quantum information. Isotopetronics promises to improve nanoelectronic and optoelectronic devices. With numerous illustrations this book is useful to researchers, engineers and graduate students.

This series provides an unequalled source of information on an area of chemistry that continues to grow in importance. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in the field, researchers will find this an invaluable source of information on current methods and applications.

Gas phase molecular spectroscopy is a powerful tool for obtaining information on the geometry and internal structure of isolated molecules and their interactions with others. It enables the understanding and description, through measurements and modeling, of the influence of pressure on light absorption, emission, and scattering by gas molecules, which must be taken into account for the correct analysis and prediction of the resulting spectra. Collisional Effects on Molecular Spectra: Laboratory Experiments and Models, Consequences for Applications, Second Edition provides an updated review of current experimental techniques, theoretical knowledge, and practical applications. After an introduction to collisional effects on molecular spectra, the book moves on by taking a threefold approach: it highlights key models, reviews available data, and discusses the consequences for applications. These include areas such as heat transfer, remote sensing, optical sounding, metrology, probing of gas media, and climate predictions. This second edition also contains, with respect to the first one, significant amounts of new information, including 23 figures, 8 tables, and around 700 references. Drawing on the extensive experience of its expert authors, Collisional Effects on Molecular Spectra: Laboratory Experiments and Models, Consequences for Applications, Second Edition, is a valuable guide for all those involved with sourcing, researching, interpreting, or applying gas phase molecular spectroscopy techniques across a range of fields.

Electron Paramagnetic Resonance (EPR) Volume 19 highlights major developments in this area reported up to the end of 2002, with results being set into the context of earlier work and presented as a set of critical yet coherent overviews. The topics covered describe contrasting types of application, ranging from biological areas such as EPR studies of free-radical reactions in biology and medically-related systems, to experimental developments and applications involving EPR imaging, the use of very high fields, and time-resolved methods. Critical and up-to-the-minute reviews of advances involving the design of spin-traps, advances in spin-labelling, paramagnetic centres on solid surfaces, exchange-coupled oligomers, metalloproteins and radicals in flavoenzymes are also included. As EPR continues to find new applications in virtually all areas of modern science, including physics, chemistry, biology and materials science, this series caters not only for experts in the field, but also those wishing to gain a general overview of EPR applications in a given area. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Molecular Sieves- Science and Technology will cover, in a comprehensive manner, the science and technology of zeolites and all related microporous and mesoporous materials. Authored by renowned experts, the contributions will be grouped together topically in such a way that each volume of the book series will be dealing with a specific sub-field. Volume 3 deals with the most widely employed techniques for the post-synthesis modificaton of molecular sieves. Among the topics covered in considerable detail are ion exchange, both in the more conventional variant in aqueous suspension and in the solid-state variant, the various methods for dealumination of zeolites, and the techniques for introducing metallic, ionic, oxidic and sulfidic clusters into the cages and channels of microporous materials.

This volume, which addresses various basic sensor principles, covers micro gravimetric sensors, semiconducting and nano tube sensors, calorimetric sensors and optical sensors. Furthermore, the authors discuss recent developments in the related sensitive layers including new properties of nano structured metal oxide layers. They provide in-depth insights into the unique chemistry and signal generation of copper oxide in percolating sensors and present a variety of applications of functional polymers made possible by proper imprinting.

Highlights of the subjects covered include:

requirements for high-temperature sensors

carbon nano tube sensors

new sensing model for nanostructured In2O3

bio mimetic approach for semiconductor sensor-based systems

optical readout for inorganic and organic semiconductor sensors

concept of virtual multisensors to improve specificity and selectivity

calorimetric sensors for hydrogen peroxide detection

percolation effect-based sensors to implement dosimeters

imprinted polymer layers for bulk and surface acoustic wave sensors"

We are pleased to present the ?fth volume of Progress in Ultrafast Intense LaserScience.Asthefrontiersofultrafastintenselasersciencerapidlyexpand ever outward, there continues to be a growing demand for an introduction to this interdisciplinary research ?eld that is at once widely accessible and ca- ble of delivering cutting-edge developments. Our series aims to respond to this call by providing a compilation of concise review-style articles written by researchers at the forefront of this research ?eld, so that researchers with d- ferent backgrounds as well as graduate students can easily grasp the essential aspects. As in the previous volumes of PUILS, each chapter of this book begins with an introductory part, in which a clear and concise overview of the topic and its signi?cance is given, and moves onto a description of the authors' most recent research results. All the chapters are peer-reviewed. The articles ofthis?fth volumecovera diverserangeofthe interdisciplinaryresearch?eld, and the topics may be grouped into three categories: coherent responses of gaseousand condensed matter to ultrashortintense laser pulses (Chaps. 1-4), propagationof intense laser pulses (Chaps. 5, 6), and laser-plasma interaction and its applications (Chaps. 7-10). From the third volume, the PUILS series has been edited in liaison with the activities of Center for Ultrafast Intense Laser Science in The University of Tokyo, and JILS (Japan Intense Light Field Science Society), the latter of which has also been responsible for sponsoring the series and making the regularpublicationofitsvolumespossible.Fromthe presentvolume,the C- sortiumonEducationandResearchonAdvancedLaserScience,theUniversity of Tokyo, joins this publication activity as one of the sponsoring programs.

Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in bioscience and medicine ensures a competitive advantage for today's researchers.

Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr

This book highlights key technologies and identifies areas for further development in proteogenomics. The utility and usefulness of very large Omics data sets (Next Gen Sequencing of DNA, RNA-seq, ribosome profiling, mass spectrometry- and antibody-based proteomics) is discussed and opportunities and challenges of related bioinformatics applications are outlined. The reader will be able to appreciate the interdisciplinary nature of the continuously evolving area of proteogenomics, which has already grown beyond its original concept of verifying gene annotations by proteomics. The chapters presented in this book are arranged to offer a general overview, rather than to provide detailed descriptions of technologies. The selected applications will provide useful insight into the level of detail that can be obtained in relation to certain diseases areas, including cancer biology and personalized medicine. The readers will find that each chapter delivers a comprehensive approach to proteogenomics, each from the point of view of a specific application. Research scientists interested in innovative processes that can offer a unique and at the same time a more complete access to technological developments and concepts that in turn can contribute to a better understand biological functions should read this book.