Mass Spectrometry: A Foundation Course is a textbook covering the field of mass spectrometry across the chemical, physical, biological, medical and environmental sciences. Sufficient depth is provided for the reader to appreciate the reasons behind and basis for particular experiments. It is uniquely and logically organised to enable the book to form the basis for a university course in mass spectrometry at the undergraduate or postgraduate level. This is achieved by combining specific core sections coupled to optional areas of study tailored to students of the chemical, physical, biological, medical and environmental sciences. Recommended course structures are provided in the front of the book.

Dedicated chapters are included on: organic mass spectrometry; ion chemistry - to emphasise the role of mass spectrometry in fundamental chemistry and physics; biological mass spectrometry including proteomics; mass spectrometry in medicine, environmental and surface science and accelerator mass spectrometry, to emphasise the importance of these areas. Each chapter concludes with key references and additional recommended reading material, making the book an excellent springboard to further study.

Highly readable, easy-to-use and logically presented, Mass Spectrometry: A Foundation Course is an ideal text for students and for those who work with mass spectrometers who wish to gain a solid understanding of the basics in modern mass spectrometry.

"From the reviews: "

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Although I am not a fan or either "eras" or "omes" you hear all the time that we now live in the era of the proteome. Setting aside the issues of what constitutes proteomics (after all people have been sequencingproteins and studying their structure for a few years nowA... ), and whether the regular appearance of reports of another organisms genome sequence prevents you from saying that we are in the post-genomic era, it is clear that the analysis of large numbers of complex protein mixtures is just about in all of our reach. This is going to be a very important way to look for molecular markers and targets in the battle against cancer.

The bedrock of proteomic analysis is mass spectrometry, which allows you to accurately measure the mass of molecules. In proteomics this can mean studying the mass of intact proteins, which can give you a clue as to their identity, and help you rapidly identify modifications. It can also mean busting the protein into many component fragments and measuring their mass, which can lead to protein identification via clever algorithms that compare measured fragment sizes to predicted ones using the genome databases.
One sign that this technology is about to become widely distributed is the appearance of relatively small softcover textbooks for beginners. These represent a reasonable first step towards initiation in this area, for those of us who left school a few years ago. There are two recent ones that I have read that I found to be particularly useful.

The first is Mass Spectrometry: A Foundation Course by Kevin Downard of Sydney, Australia.

This book covers many aspects of the field in under 200 pages, and has a handy guide to what sections are useful to individuals from different disciplines. It starts with history and concepts, and then devotes a significant amount of space to the instrumentation. This is very useful to anyone who has been to a massspectrometry meeting and trade show or even browsed the relevant companies websites. Dr. Downard covers the basics of how each variant works, and what it is best suited for, and includes discussion of single and tandem instruments. By the end you'll be able to raise your eyebrows appreciatively the next time a salesman fires an acronym and figure at you (or at least you'll know where to look it up once you have reached a safe distance). The second half of the book looks at specific applications for mass spectrometry, and here you can read selectively on what you are interested in doing. The sections on protein analysis were good primers. The book is quite mathematical throughout, and since I have no talent in this direction, the equations merely confirmed my deficiency in this area - to those of you who like it, it is there. Then at the end are a series of very useful appendices that show amino acid masses, masses of common protein modifications and websites for further reading or for protein identification, among other useful things. I recommend this book highly to anyone looking for a first port of call on the journey to mass spectrometry." [Oliver Bogler]

"From the reviews: "

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Mass spectrometry today plays a vital role in a range of scientific disciplines including synthetic and physical organic chemistry, biological and medicinal chemistry and environmental and surface sciences.
In the past two decades, advances in instrument design and in computer control have brought the technique out of the basements of chemical laboratories and onto the bench of modern analytical laboratories. Advances in linking mass spectrometry to both gas and liquid chromatography have meantthat chromatographers have had to learn the extra dimensions of experiment that such multi-dimensional techniques can provide. Mass spectrometry is not now confined to research but is being increasingly used by environmental agencies, clinical chemistry laboratories and anywhere advanced analytical chemistry is required.

Few introductory texts have kept up with these advances, although there have been recent specialist texts on biotechnology and on LC/MS. Downard's book seeks to provide a basis for instruction of undergraduate and new postgraduate students. His philosophy has been to write introductory sections for all the basic aspects of mass spectrometry - his 'core' course - and to add sections for the major areas in which it is employed. These additional sections can be optionally added to the core course, as desired. Downard provides a menu suggesting how they can be put together. Each core section is well written and covers the basis of the science concerned very satisfactorily.

The sections that describe the different applications are necessarily condensed and the author tries to give extra reading with a good set of references.

Students who plan to use mass spectrometry in proteomic research will require much further assistance and the same goes for metabolomic/metabonomic studies and for users of quantitative analysis, but, for both, the core sections will be valuable." [Tony Mallet]

This series describes selected advances in the area of atomic spectroscopy. It is promarily intended for the reader who has a background in atmoic spectroscopy; suitable to the novice and expert. Although a widely used and accepted method for metal and non-metal analysis in a variety of complex samples, "Advances in Atomic Spectroscopy" covers a wide range of materials. Each Chapter will completely cover an area of atomic spectroscopy where rapid development has occurred.

As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Nucleic Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications. Volume 33 covers literature published from June 2002 to May 2003. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Chemometrics in Analytical Spectroscopy provides students and practising analysts with a tutorial guide to the use and application of the more commonly encountered techniques used in processing and interpreting analytical spectroscopic data. In detail the book covers the basic elements of univariate and multivariate data analysis, the acquisition of digital data and signal enhancement by filtering and smoothing, feature selection and extraction, pattern recognition, exploratory data analysis by clustering, and common algorithms in use for multivariate calibration techniques. An appendix is included which serves as an introduction or refresher in matrix algebra. The extensive use of worked examples throughout gives Chemometrics in Analytical Spectroscopy special relevance in teaching and introducing chemometrics to undergraduates and post-graduates undertaking analytical science courses. It assumes only a very moderate level of mathematics, making the material far more accessible than other publications on chemometrics. The book is also ideal for analysts with little specialist background in statistics or mathematical methods, who wish to appreciate the wealth of material published in chemometrics.

Documenting critical advances in this rapidly evolving field, the Second Edition highlights the need for new applications and technologies that assist in the determination of molecular weight and molecular weight distributions of polymers in an accurate, efficient manner. This volume presents the latest findings from a international team of specialists, and will continue to inspire and extend practical applications of size exclusion chromatography (SEC). It includes six new chapters covering high-speed size exclusion chromatography, SEC of low molecular weight materials, and the extended family of techniques from two-dimensional liquid chromatography to high osmotic pressure chromatography.

Cyclodextrins can form complexes with a wide variety of organic and inorganic compounds, a property which can prove useful when trying to separate complex mixtures. This book provides an up-to-date and critical evaluation of the application of cyclodextrins in many fields of chromatography (including thin layer, gas-liquid, high performance liquid and supercritical fluid chromatography; capillary electrophoresis; and isotacophoresis). Whilst mainly practical in nature, the book also looks briefly at the theoretical background for the various techniques. Any professional working with chromatography will welcome this unique book as both a practical compilation of methods and a source of reference to the literature regarding the use and impact of cyclodextrins in chromatography.

This book provides a snapshot of the current state-of-the-art of the understanding of the fundamentals of ICPMS, instrumental development, methods development, spectral interpretation and applications. It covers a diverse range of topics including: bioanalytical applications (immunoassay, state of phosphorylation, metallo-drugs); environmental applications (drinking water, groundwater, seawater, speciation); reaction cells and collision cells (theory and applications); archaeology; laser ablation; isotope ratio analysis; and the performance, characterization and applications of multicollector instruments. Written by international contributors who emphasize their current perceptions and understanding of the subject, Plasma Source Mass Spectrometry: Applications and Emerging Technologies offers a current perspective on elemental analysis by plasma source mass spectrometry that is not to be found elsewhere. Researchers and professionals in many areas will welcome this book, particularly those in the fields of bioanalytical, environmental and geological chemistry.

Chromatography of Natural, Treated and Waste Waters is the first book to bring together information of a range of chromatographic techniques in all types of water, precipitation to sewage effluents. Organic and inorganic compounds, cations, anions and elements are all discussed. Particular attention is paid to multi compound analysis of water, and the analysis of minute traces of pollutants. Gas chromatography, high performance liquid chromatography and mass spectrometry are included, and this book is well referenced and easy to use.

eBook available with sample pages: 0203301862

This book demonstrates the usefulness of NMR spectroscopy for a wide variety of applications in environmental science and technology. The book contains a wealth of information relating to instrumentation, sample preparation, and data interpretation. It is divided into three sections discussing contaminant interaction, solution and condensed phase characterization, and nutrients and natural organic matter characterization. In addition to these in-depth chapters, an introductory overview provides the basic principles of solution and solid-state NMR spectroscopy. Each section also contains a discussion of advances in each area directly attributable to NMR spectroscopy. A final chapter suggests future directions for the deployment of this powerful technology in environmental science.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

The term magnetic resonance covers a wide range of techniques, spectroscopy, relaxation and imaging. In turn, these areas are evolving and leading to various new applications of NMR and ESR in food science and nutrition. From assessment of meat quality, through to a study of beer components and the effect of microwaves on potato texture, Magnetic Resonance in Food Science: Latest Developments provides an account of the state of the art in this lively area. Coverage includes: recent developments in magnetic resonance; human aspects of food; structure and dynamics in food; and food quality control. With contributions from international experts, this book is essential reading for academics and industrialists in food science. It is the latest in a series of titles in this area published by the RSC.

Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement.

This completely revised and extended second edition: " "Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents.Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations.Is written for all of those involved in the development and application of contrast agents in MRI.Presented in colour, it provides readers with true representation and easy interpretation of the images.

A word from the Authors:

"Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms."

"Reviews of the First Edition: "

..".attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."--Journal of the American Chemical Society..".well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."--NMR in Biomedicine

This book addresses Furnace Atomic Absorption Spectroscopy (FAAS), which has gained worldwide acceptance as an analytical technique. FAAS offers 100-1000 times better determination and detection limits than other techniques for a majority of the elements. This technique requires a small sample size, and demands less sample-preparation time than others. The handbook is a collection of thousands of references for detection and determination of various elements in agricultural products, biological and clinical samples, and metallurgical and electronic materials. Each chapter is devoted to an element or a similar group of elements. Included are instrumental setup parameters, references, and author and subject indexes. Also presented are detailed appendixes covering glossary, list of manufacturers of spectrophotometers and its accessories, list of chemical suppliers, and list of reviews and abstracts. The handbook covers topics such as heavy metals, clinical products, and trace metal analysis. This desk-top reference is meant for chemists who handle day-to-day analysis problems in laboratories in government, clinical, industrial and academic settings. It is invaluable for those involved in research in environmental science, analytical chemistry, clinical chemistry and forensic science.

Many books and reviews about scanning probe microscopies (SPM) cover the basics of their performance, novel developments, and state-of-the-art applications. Taking a different approach, Hybridizing Surface Probe Microscopies: Towards a Full Description of the Meso- and Nanoworlds encompasses the technical efforts in combining SPM with spectroscopic and optical complementary techniques that, altogether, provide a complete description of nanoscale and mesoscale systems and processes from corrosion to enzymatic reactions. The book is organized into eight chapters, following a general scheme that revolves around the two main capabilities of SPM: imaging and measuring interactions. Each chapter introduces key theoretical concepts and basic equations of the particular stand-alone technique with which the scanning probe microscopies are combined. Chapters end with the SPM-technique combination and some real-world examples in which the combination has been devised or used. Most chapters include a historical review of the techniques and numerous illustrations to support key ideas and provide the reader with intuitive understanding. To understand the limitations of any technique also means to understand how this technique works. This book has devoted a considerable amount of space in explaining the basics of each technique as they are being introduced. At the same time, it avoids explaining the particularities of each SPM-based technique and opts for a rather generalized approach. In short, the book's focus is not on what SPM can do, but rather on what SPM cannot do and, most specifically, on presenting the experimental approaches that circumvent these limitations.

This series provides an unequalled source of information on an area of chemistry that continues to grow in importance. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in the field, researchers will find this an invaluable source of information on current methods and applications. provides a critical review of the literature published up to late 2002. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Speciation analysis is a field of trace element analytical chemistry that deals with detection, identification and determination of individual chemical forms of metals and metalloids. There has been increased awareness of the importance of elemental speciation over the last 20 years and this has lead to growing demand for analytical techniques capable of providing species-specific information. Hyphenated Techniques in Speciation Analysis offers a brief but comprehensive overview of hyphenated techniques and their various applications for the determination of chemical forms of trace elements. It brings a succinct presentation of the concept of speciation analysis, gives an overview of techniques based on coupling of chromatography with element and molecule specific detection and summarises their applications in the fields of environmental and industrial chemistry, biochemistry, nutrition, toxicology and medicine. Fully referenced, Hyphenated Techniques in Speciation Analysis is an invaluable introduction to elemental speciation analysis and also provides a practising analyst with a critical overview of research carried out in the field.

Glow discharge optical emission spectroscopy (GDOES) is an essential technique for the direct analysis of bulk solids, for elemental surface analysis and for the depth profiling of thin films and industrial coatings. The technique has shown rapid growth in numbers of instruments, in breadth of applications, in improved quantification in recent years and is now a recognised technique within the ISO, with two international standards. Glow Discharge Optical Emission Spectroscopy: A Practical Guide takes the reader on a journey through instrument operation, sample preparation, analysis, and reporting results. It follows two sets of samples through the whole process of analysis, brass samples for bulk analysis, and zinc-coated steel for depth profiling. Procedures are consistent with recent ISO standards and each step is loaded with hands-on tips and theoretical insight. The book also includes unique data tables on spectral interferences, molecular bands, self-absorption and relative sputtering rates. This book is designed for those using or managing GDOES instruments and for students interested in learning the technique from a hands-on perspective. It is also an invaluable aid to those considering the purchase of a GDOES instrument, or those using GDOES results, to understand in detail how the technique works and what is involved in maintaining the instrument and achieving high quality results.

This book discusses the latest investigations into the electronic structure of narrow-gap semiconductors in extreme conditions, and describes in detail magnetic field and pressure measurements using two high-quality single crystals: black phosphorus (BP) and lead telluride (PbTe). The book presents two significant findings for BP and PbTe. The first is the successful demonstration of the pressure-induced transition from semiconductor to semimetal in the electronic structure of BP using magnetoresistance measurements. The second is the quantitative estimation of how well the Dirac fermion description works for electronic properties in PbTe. The overviews on BP and PbTe from the point of view of material properties help readers quickly understand the typical electronic character of narrow-gap semiconductor materials, which has recently attracted interest in topological features in condensed matter physics. Additionally the introductory review of the principles and methodology allows readers to understand the high magnetic field and pressure experiments.

Electron Paramagnetic Resonance (EPR) Volume 18 highlights major developments in this area reported in 2001 and 2002, with results being set into the context of earlier work and presented as a set of critical yet coherent overviews. The topics covered describe contrasting types of application ranging from biological areas such as EPR studies of free-radical reactions in biology and medically-related systems to experimental developments and applications involving EPR imaging the use of very high fields and time-resolved methods. Critical and up-to-the-minute reviews of advances involving the design of spin-traps advances in spin-labelling paramagnetic centres on solid surfaces exchange-coupled oligomers metalloproteins and radicals in flavoenzymes are also included. As EPR continues to find new applications in virtually all areas of modern science including physics chemistry biology and materials science this series caters not only for experts in the field but also those wishing to gain a general overview of EPR applications in a given area.

Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr

PMCommon methods of local magnetic imaging display either a high spatial resolution and relatively poor field sensitivity (MFM, Lorentz microscopy), or a relatively high field sensitivity but limited spatial resolution (scanning SQUID microscopy). Since the magnetic field of a nanoparticle or nanostructure decays rapidly with distance from the structure, the achievable spatial resolution is ultimately limited by the probe-sample separation. This thesis presents a novel method for fabricating the smallest superconducting quantum interference device (SQUID) that resides on the apex of a very sharp tip. The nanoSQUID-on-tip displays a characteristic size down to 100 nm and a field sensitivity of 10 -3 Gauss/Hz (1/2). A scanning SQUID microsope was constructed by gluing the nanoSQUID-on-tip?? to a quartz tuning-fork. This enabled the nanoSQUID to be scanned within nanometers of the sample surface, providing simultaneous images of sample topography and the magnetic field distribution. This microscope represents a significant improvement over the existing scanning SQUID techniques and is expected to be able to image the spin of a single electro

The main aim of this unique book is to introduce the student to spectroscopy in a clear manner which avoids, as far as possible, the mathematical aspects of the subject. It is thus intended for first or second year undergraduates, particularly those with minimal mathematics qualifications. After explaining the theory behind spectroscopy, the book then goes on to look at the different techniques, such as rotational, vibrational and electronic spectroscopy. It encompasses both high resolution (structural) and low resolution (analytical) spectroscopy, demonstrating their close interrelationship. The many worked problems make this book particularly appealing for independent study. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major new series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

This reference/text presents a complete and thorough examination of the latest advances in the instrumentation, evaluation, and implementation of UV technology for reliable and efficient data acquisition and analysis-providing real-world applications in expanding fields such as chemical physics, plasma science, photolithography, laser spectroscopy, astronomy, and atmospheric science, and highlighting important UV and VUV laser light generation issues. Discusses the LIF technique for studying organic molecules at low vibrational temperatures Supplemented with more than 1000 contemporary references, Ultraviolet Spectroscopy and UV Lasers is a clear and authoritative reference for spectroscopists, optical physicists and engineers; photolithography specialists; analytical chemists; biochemists; atmospheric specialists; biophysicists; astronomers; laser and solid-state laser material specialists; and an excellent text for upper-level undergraduate and graduate students in these disciplines.