Nanoscale Imaging and Characterisation of Amyloid- (Paperback, Softcover reprint of the original 1st ed. 2016)

This thesis presents a method for reliably and robustly producing samples of amyloid- (A ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide's nanomechanical, elastic, thermal or spectroscopical properties. Amyloid- (A ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	June 2018
First published:	2016
Authors:	Claire Louisa Tinker-Mill
Dimensions:	235 x 155 x 9mm (L x W x T)
Format:	Paperback
Pages:	149
Edition:	Softcover reprint of the original 1st ed. 2016
ISBN-13:	978-3-319-81907-5
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Professional & Technical > Technology: general issues > Nanotechnology Books > Science & Mathematics > Physics > Classical mechanics > Fluid mechanics Books > Science & Mathematics > Physics > States of matter > Condensed matter physics (liquids & solids) Books > Science & Mathematics > Chemistry > Analytical chemistry > Qualitative analytical chemistry > Chemical spectroscopy, spectrochemistry > General
LSN:	3-319-81907-0
Barcode:	9783319819075

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