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Optical Whispering Gallery Modes for Biosensing - From Physical Principles to Applications (Hardcover, 2nd ed. 2022)
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Optical Whispering Gallery Modes for Biosensing - From Physical Principles to Applications (Hardcover, 2nd ed. 2022)
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This interdisciplinary book covers the fundamentals of optical
whispering gallery mode (WGM) microcavities, light-matter
interaction, and biomolecular structure with a focus on
applications in biosensing. Novel biosensors based on the
hybridization of WGM microcavities and localized surface plasmon
resonances (LSPRs) in metal nanoparticles have emerged as the most
sensitive microsystem biodetection technology that boasts single
molecule detection capability without the need for amplification
and labeling of the analyte. The book provides an ample survey of
the physical mechanisms of WGMs and LSPRs for detecting affinity,
concentration, size, shape and orientation of biomarkers, while
informing the reader about different classes of biomolecules, their
optical properties and their importance in label-free clinical
diagnostics. This expanded and updated second edition features a
new chapter that introduces the reader to advanced in vivo
biosensing techniques using WGM microcavities, looking at
photothermal sensing, methods for trapping neutral atoms around WGM
microcavities, and practical aspects of optoplasmonic sensing. The
second Edition now provides a comprehensive introduction to the use
of WGM microcavities in physical sensing which includes
measurements with frequency combs, macro and micro (one atom)
lasers, gyroscopes, optomechanical and parity-time-symmetric sensor
devices. Chapter-end problems round out this comprehensive and
fundamental textbook, inspiring a host of up-and-coming physicists,
bioengineers, and medical professionals to make their own
breakthroughs in this blossoming new field. This textbook can be
used for both introductory and advanced courses about the modern
optics of optical microcavities.
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