Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Signaling at the Cell Surface in the Circulatory and Ventilatory Systems (Paperback, Softcover reprint of the original 1st ed. 2012)
Loot Price: R4,515
Discovery Miles 45 150
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Signaling at the Cell Surface in the Circulatory and Ventilatory Systems (Paperback, Softcover reprint of the original 1st ed. 2012)
Series: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, 3
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The volumes in this authoritative series present a
multidisciplinary approach to modeling and simulation of flows in
the cardiovascular and ventilatory systems, especially multiscale
modeling and coupled simulations. The cardiovascular and
respiratory systems are tightly coupled, as their primary function
is to supply oxygen to and remove carbon dioxide from the body's
cells. Because physiological conduits have deformable and reactive
walls, macroscopic flow behavior and prediction must be coupled to
nano- and microscopic events in a corrector scheme of regulated
mechanisms when the vessel lumen caliber varies markedly.
Therefore, investigation of flows of blood and air in physiological
conduits requires an understanding of the biology, chemistry, and
physics of these systems together with the mathematical tools to
describe their functioning. Volume 3 is devoted to the set of
mediators of the cell surface, especially ion and molecular
carriers and catalytic receptors that, once liganded and activated,
initiate signal transduction pathways. Intracellular cascades of
chemical reactions trigger the release of substances stored in
cellular organelles and/or gene transcription and protein
synthesis. Primary mediators are included in models of regulated
cellular processes, but multiple secondary signaling components are
discarded to allow simple, representative modeling and to manage
their inverse problems.
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