Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter "Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses" is available open access under a CC BY 4.0 license via link.springer.com.

This book presents the state of the art in designing high-performance algorithms that combine simulation and optimization in order to solve complex optimization problems in science and industry, problems that involve time-consuming simulations and expensive multi-objective function evaluations. As traditional optimization approaches are not applicable per se, combinations of computational intelligence, machine learning, and high-performance computing methods are popular solutions. But finding a suitable method is a challenging task, because numerous approaches have been proposed in this highly dynamic field of research. That's where this book comes in: It covers both theory and practice, drawing on the real-world insights gained by the contributing authors, all of whom are leading researchers. Given its scope, if offers a comprehensive reference guide for researchers, practitioners, and advanced-level students interested in using computational intelligence and machine learning to solve expensive optimization problems.

Marking the 30th anniversary of the European Conference on Modelling and Simulation (ECMS), this inspirational text/reference reviews significant advances in the field of modelling and simulation, as well as key applications of simulation in other disciplines. The broad-ranging volume presents contributions from a varied selection of distinguished experts chosen from high-impact keynote speakers and best paper winners from the conference, including a Nobel Prize recipient, and the first president of the European Council for Modelling and Simulation (also abbreviated to ECMS). This authoritative book will be of great value to all researchers working in the field of modelling and simulation, in addition to scientists from other disciplines who make use of modelling and simulation approaches in their work.

This book is devoted to the most used methodologies for performance evaluation: simulation using specialized software and mathematical modeling. An important part is dedicated to the simulation, particularly in its theoretical framework and the precautions to be taken in the implementation of the experimental procedure. These principles are illustrated by concrete examples achieved through operational simulation languages (OMNeT ++, OPNET). Presented under the complementary approach, the mathematical method is essential for the simulation. Both methodologies based largely on the theory of probability and statistics in general and particularly Markov processes, a reminder of the basic results is also available.

Computational Approaches in Physics reviews computational schemes which are used in the simulations of physical systems. These range from very accurate ab initio techniques up to coarse-grained and mesoscopic schemes. The choice of the method is based on the desired accuracy and computational efficiency. A bottom-up approach is used to present the various simulation methods used in Physics, starting from the lower level and the most accurate methods, up to particle-based ones. The book outlines the basic theory underlying each technique and its complexity, addresses the computational implications and issues in the implementation, as well as present representative examples. A link to the most common computational codes, commercial or open source is listed in each chapter. The strengths and deficiencies of the variety of techniques discussed in this book are presented in detail and visualization tools commonly used to make the simulation data more comprehensive are also discussed. In the end, specific techniques are used as bridges across different disciplines. To this end, examples of different systems tackled with the same methods are presented. The appendices include elements of physical theory which are prerequisites in understanding the simulation methods.

Parallel CFD 2000, the Twelfth in an International series of meetings featuring computational fluid dynamics research on parallel computers, was held May 22-25, 2000 in Trondheim, Norway.
Following the trend of the past conferences, areas such as numerical schemes and algorithms, tools and environments, load balancing, as well as interdisciplinary topics and various kinds of industrial applications were all well represented in the work presented. In addition, for the first time in the Parallel CFD conference series, the organizing committee chose to draw special attention to certain subject areas by organizing a number of special sessions.
We feel the emphasis of the papers presented at the conference reflect the direction of the research within parallel CFD at the beginning of the new millennium. It seems to be a clear tendency towards increased industrial exploitation of parallel CFD. Several presentations also demonstrated how new insight is being achieved from complex simulations, and how powerful parallel computers now make it possible to use CFD within a broader interdisciplinary setting.
Obviously, successful application of parallel CFD still rests on the underlying fundamental principles. Therefore, numerical algorithms, development tools, and parallelization techniques are still as important as when parallel CFD was in is infancy. Furthermore, the novel concepts of affordable parallel computing as well as metacomputing show that exciting developments are still taking place.
As is often pointed out however, the real power of parallel CFD comes from the combination of all the disciplines involved: Physics, mathematics, and computer science. This is probably one of the principal reasons for the continued popularity of the Parallel CFD Conferences series, as well as the inspiration behind much of the excellent work carried out on the subject. We hope that the papers in this book, both on an individual basis and as a whole, will contribute to that inspiration. Further details of Parallel CFD'99, as well as other conferences in this series, are available at http: //www.parcfd.org

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales - including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces - bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

The present book provides guidance to understanding complicated coupled processes based on the experimental data available and implementation of developed algorithms in numerical codes. Results of selected test cases in the fields of closed-form solutions (e.g., deformation processes), single processes (such as groundwater flow) as well as coupled processes are presented. It is part of the OpenGeoSys initiative - an open source project to share knowledge and experience in environmental analysis and scientific computation with the community.

This book offers a timely overview of fuzzy and rough set theories and methods. Based on selected contributions presented at the International Symposium on Fuzzy and Rough Sets, ISFUROS 2017, held in Varadero, Cuba, on October 24-26, 2017, the book also covers related approaches, such as hybrid rough-fuzzy sets and hybrid fuzzy-rough sets and granular computing, as well as a number of applications, from big data analytics, to business intelligence, security, robotics, logistics, wireless sensor networks and many more. It is intended as a source of inspiration for PhD students and researchers in the field, fostering not only new ideas but also collaboration between young researchers and institutions and established ones.

This contributed volume, written by leading international researchers, reviews the latest developments of genetic programming (GP) and its key applications in solving current real world problems, such as energy conversion and management, financial analysis, engineering modeling and design, and software engineering, to name a few. Inspired by natural evolution, the use of GP has expanded significantly in the last decade in almost every area of science and engineering. Exploring applications in a variety of fields, the information in this volume can help optimize computer programs throughout the sciences. Taking a hands-on approach, this book provides an invaluable reference to practitioners, providing the necessary details required for a successful application of GP and its branches to challenging problems ranging from drought prediction to trading volatility. It also demonstrates the evolution of GP through major developments in GP studies and applications. It is suitable for advanced students who wish to use relevant book chapters as a basis to pursue further research in these areas, as well as experienced practitioners looking to apply GP to new areas. The book also offers valuable supplementary material for design courses and computation in engineering.

The "2019 DigitalFUTURES - The 1st International Conference on Computational Design and Robotic Fabrication (CDRF 2019)" provides an international platform for advanced scientific research papers on the digital technology of architectural design and construction. The themes of the papers include, but are not limited to, architectural theories, tools, methods and procedures in material intelligence, data intelligence; computational intelligence, and robotic intelligence.

This book integrates current advances in biology, economics of information and linguistics research through applications using agent-based modeling and social network analysis to develop scenarios of communication and language emergence in the social aspects of biological communications. The book presents a model of communication emergence that can be applied both to human and non-human living organism networks. The model is based on economic concepts and individual behavior fundamental for the study of trust and reputation networks in social science, particularly in economics; it is also based on the theory of the emergence of norms and historical path dependence that has been influential in institutional economics. Also included are mathematical models and code for agent-based models to explore various scenarios of language evolution, as well as a computer application that explores language and communication in biological versus social organisms, and the emergence of various meanings and grammars in human networks. Emergence of Communication in Socio-Biological Networks offers both a completely novel approach to communication emergence and language evolution and provides a path for the reader to explore various scenarios of language and communication that are not constrained to the human networks alone. By illustrating how computational social science and the complex systems approach can incorporate multiple disciplines and offer an integrated theory-model approach to the evolution of language, the book will be of interest to researchers working with computational linguistics, mathematical linguistics, and complex systems.

This book introduces readers to the most advanced research results on Design for Manufacturability (DFM) with multiple patterning lithography (MPL) and electron beam lithography (EBL). The authors describe in detail a set of algorithms/methodologies to resolve issues in modern design for manufacturability problems with advanced lithography. Unlike books that discuss DFM from the product level or physical manufacturing level, this book describes DFM solutions from a circuit design level, such that most of the critical problems can be formulated and solved through combinatorial algorithms.

Evolutionary models (e.g genetic algorithms, artificial life) are emerging as an important new tool for geographic information systems for a number of reasons. First, they are highly appropriate for modelling geographic phenomena; second, geographical problems are often spatially separate (broken down into logical or regional problems), and evolutionary algorithms can exploit this structure; and finally, the ability to store, mainipulate, and visualize spatial data has increased to the point that space-time attribute databases can be easily handled. This book is proposed to serve as a guide to the evolutionary modelling of spatial phenomena.

This book addresses the mathematical aspects of modern image processing methods, with a special emphasis on the underlying ideas and concepts. It discusses a range of modern mathematical methods used to accomplish basic imaging tasks such as denoising, deblurring, enhancing, edge detection and inpainting. In addition to elementary methods like point operations, linear and morphological methods, and methods based on multiscale representations, the book also covers more recent methods based on partial differential equations and variational methods. Review of the German Edition: The overwhelming impression of the book is that of a very professional presentation of an appropriately developed and motivated textbook for a course like an introduction to fundamentals and modern theory of mathematical image processing. Additionally, it belongs to the bookcase of any office where someone is doing research/application in image processing. It has the virtues of a good and handy reference manual. (zbMATH, reviewer: Carl H. Rohwer, Stellenbosch)

Simulation of ODE/PDE Models with MATLAB(r), OCTAVE and SCILAB shows the reader how to exploit a fuller array of numerical methods for the analysis of complex scientific and engineering systems than is conventionally employed. The book is dedicated to numerical simulation of distributed parameter systems described by mixed systems of algebraic equations, ordinary differential equations (ODEs) and partial differential equations (PDEs). Special attention is paid to the numerical method of lines (MOL), a popular approach to the solution of time-dependent PDEs, which proceeds in two basic steps: spatial discretization and time integration.

Besides conventional finite-difference and element techniques, more advanced spatial-approximation methods are examined in some detail, including nonoscillatory schemes and adaptive-grid approaches. A MOL toolbox has been developed within MATLAB(r)/OCTAVE/SCILAB. In addition to a set of spatial approximations and time integrators, this toolbox includes a collection of application examples, in specific areas, which can serve as templates for developing new programs.

Simulation of ODE/PDE Models with MATLAB(r), OCTAVE and SCILAB provides a practical introduction to some advanced computational techniques for dynamic system simulation, supported by many worked examples in the text, and a collection of codes available for download from the book s page at www.springer.com. This text is suitable for self-study by practicing scientists and engineers and as a final-year undergraduate course or at the graduate level.

This book presents comprehensive experimental, numerical, and theoretical research on projectile impact analysis, such as the rigid projectile penetration/perforation of concrete and metallic targets, and shaped-charge-formed projectile and jet penetrations. Concrete and metal materials are widely used in protective structures in both civil engineering and armored vehicles, such as military fortifications, underground shelters, infantry fighting vehicles, and tanks, which are designed to withstand intentional or accidental impact loadings caused by projectiles and fragments, and the responses of these targets under projectile impact have been a topic of discussion for several decades. Written for researchers and engineers working in the fields of protective structures and high-speed penetration mechanics, the book is also a valuable reference for senior undergraduate and postgraduate students majoring in defense engineering, terminal ballistics and other related fields.

This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.

This thesis provides a systematic and integral answer to an open problem concerning the universality of dynamic fuzzy controllers. It presents a number of novel ideas and approaches to various issues including universal function approximation, universal fuzzy models, universal fuzzy stabilization controllers, and universal fuzzy integral sliding mode controllers. The proposed control design criteria can be conveniently verified using the MATLAB toolbox. Moreover, the thesis provides a new, easy-to-use form of fuzzy variable structure control. Emphasis is given to the point that, in the context of deterministic/stochastic systems in general, the authors are in fact discussing non-affine nonlinear systems using a class of generalized T-S fuzzy models, which offer considerable potential in a wide range of applications.

This book provides the state of the art in the simulation and gaming study field by systematically collecting excellent papers presented at the 46th International Simulation and Gaming Association annual conference held in Kyoto 17-25 July 2015. Simulation and gaming has been used in a wide variety of areas ranging from early childhood education and school-age children, universities, and professional education, to policy exploration and social problem solving. Moreover, it now been drastically changing its features in the Internet Of Things (IOT) society while taking over a wide variety of aliases, such as serious games and gamification. Most of the papers on which this book's chapters are based were written by academic researchers, both up-and-coming and well known. In addition, simulation and gaming is a translational system science going from theory to clinical cross-disciplinary topics. With this book, therefore, graduate students and higher-level researchers, educators, and practitioners can become familiar with the state-of-the-art academic research on simulation and gaming in the network society of the twenty-first century.