In recent years the inferior olive and its projection to the cerebellum have attracted considerable interest. Numerous experimental anatomic and electrophysiologic studies have been undertaken, and much new information has been brought forward. Many apparently discordant observations have been reported however, and on many points the data obtained by the use of different methbds and approaches appear to be diffi cult to reconcile. Much of the interest in the olivocerebellar projection concerns the topographical localization within the projection. Particularly as a result of research in recent years the pattern of localization has turned out to be far more complex than previously be lieved. It was found useful, therefore, to attempt a review of the subject in the hope that a critical analysis of available observations might make it possible to obtain an integrated picture of the olivocerebellar projection and perhaps fmd some basic principles in the organization of this fiber system. As will be seen, our attempt has been only partly successful. There are still riddles that remain to be solved. In the present review attention will be focused on problems related to the locali zation within the olivocerebellar projection, particularly its anatomic aspects. An extensive review of the physiology of the inferior olive has been published recently by Armstrong (1974), who considers some anatomicophysiologic correlations as well. Physiologic fmdings will be referred to here mainly in relation to our main theme."

Of all the classes in the animal kingdom, birds represent the best known. There are in total about 8600 living species, and the systematic study of this class is more or less complete. Extensive observations - to a large extent by amateur ornithologists - with respect to geographical distribution, life cycles, demands on and adaptations to the environment, breeding habits, migration, and so forth have contributed towards basic and more widely relevant knowledge, e. g., in the areas of ethology, ecology, and evo lution and also in social biology (Hilprecht 1970; Farner and King 1971). Together, all these aspects are affected by the reproductive biology of birds, and studies have therefore been carried out for many years with special emphasis on this subject. How ever, until now this emphasis in avian reproductive biology has been physiological and in particular endocrinological (Murton and Westwood 1977; Roosen-Runge 1977). The morphology of the gonads has been treated in far less detail, and has been confined to a comparatively small number of species, compared with other classes of vertebrates. Reproduction is the section in the life cycle of an animal which is most dependent upon environmental conditions. Reproduction therefore usually takes place at a par ticular time, when stress for the adult animals is at its lowest and the chances of sur vival for the newborn are at their highest, i. e."

The afferent connections of the cerebellar cortex of the cat have been extensively in- vestigated by Alf Brodal and his collaborators using retrograde degeneration methods. These experiments (reviewed in Larsell and Jansen 1972) established that cerebellar corti- cal afferents arise from widespread areas of the brain stem and spinal cord. Brain stem nuclei shown to provide input to the cerebellar cortex included the pontine nuclei, the medial and descending vestibular nuclei, vestibular cell group x, the lateral reticular nucleus, the perihypoglossal nuclei, the paramedian reticular nucleus, the inferior olive, and the external cuneate nucleus. In addition, the red nucleus and certain of the raphe nuclei were thought to send fibers to the intracerebellar nuclei, but not to the cortex. With the advent of the horseradish peroxidase (HRP) technique, new information on the distribution and organization of cerebellar cortical afferents has recently be- come available. Thus Gould and Graybiel (1976) demonstrated that afferents to the cat cerebellar cortex arise from a previously undescribed lateral tegmental cell group at the level of the isthmus and from the intracerebellar nuclei, as well as from the classic precerebellar nuclei. Moreover, these studies showed that fibers from the vestibular nuclei, previously thought to be distributed only to the flocculonodular lobe and uvula, reach widespread areas of the cerebellar cortex. Experiments by other investi- gators have established that the cerebellar cortex of the cat receives afferents from cer- tain of the raphe nuclei (Shinnar et al. 1975; Taber Pierce et al.

Studies on cell kinetics in untreated animals have for the most part been done on or gans in which many proliferating cells can be found. In general the proliferating cells have been identified either in histologic sections as mitoses or by autoradiography as labeled interphase cells following the injection of a labeled precursor of DNA, such as 3H_ or 14C-thymidine (TdR). A great many proliferating cells can be observed in the rat and mouse brain during the embryonic period and for a short time after birth, and many studies on cell kinetics have been performed for this phase of life. By contrast, very few proliferating cells are found in the brain of adult rodents (except for the subependymallayer, see below). As a result, only isolated studies have been done on cell kinetics during this period. Al though there is an increase in proliferating cells in adult animals which had been pre treated (e g. , by wounding, X-irradiation, viral infection, withdrawal of water), this proliferation too has not been investigated in detail. A number of studies have been done since 1959 on the proliferation of cells in the sub ependymal layer of the lateral ventricles of the forebrain. This cell type is well suited for such investigations because mitoses can be found there even in animals which are quite old. Since the studies ofLe blond and co-workers (Walker and Leblond 1958 ;Messier et al.

References ............................... 76 Subject Index ............................. 93 VIII Acknowledgments This study was funded by the Deutsche Forschungsgemeinschaft. I am indebted to Prof. Dr. W. Schlote for helpful advice and numerous discussions. I am also grateful to Dr. G. Kurz-Isler for her generous help in problems dealing with electron microscopy and to Mrs. B. Sabrowski for her careful preparation of the manuscript. The careful translation of T.C. Telger is gratefully acknowledged. The translation was financially supported by the Erwin Riesch Foundation. IX 1 Introduction One of the basic principles underlying the efficiency and adaptability of cellular meta bolism is the structural compartmentalization of the cell. Only through compartmenta lization can reaction components be kept apart prior to their reaction, isolated from other "reaction spaces" during the course of their reaction, and the reaction products incorporated into designated structures or transported to remote parts of the cell. Thus, the partitioning of the cellular substance into countless membranous spaces corresponds to the spatial segregation of reaction components, and the dynamics of intracellular membrane systems is an expression of ever-changing equilibrium condi tions and the continuous formation of new reaction spaces. It has been shown with some certainty that many of the processes in membrane dynamics can take place only with the aid of contractile proteins such as actin, myosin, and tubulin."

The earliest mention of a cell sheath enveloping the body of the neurons in sensory ganglia is probably the following description by Valentin: "Sowohl die Kugeln der Be- legungsformation 1 , als die Primitivfasem, werden von eigenthi. imlichen, sie isolirenden Scheiden umgeben, welche aile Stufen der Dicke von einer fast gar nicht mehr wahr- nehrnbaren Zartheit bis zu einer ziemlich bedeutenden Starke durchlaufen. Diese Hill- len sind aber immer zellgewebeartiger Natur" (1836, p 162). In some illustrations of the above mentioned paper the nuclei of the satellite cells adjacent to the surface of the nerve cell body, both in the trigeminal ganglion and in the ganglia of the vegeta- tive nervous system, are clearly shown (Fig. lA). The author, however, miSinterpreted these nuclei as pigment granules (Pigmentkorperchen). A little later, Remak (1838) denied the existence of the perineuronal cell sheath. This prompted a ready reply from Valentin (1839), who offered a more detailed description of the perineuronal cell sheath, illustrated it with new drawings (Fig. IB), and gave a correct interpreta- tion of the nuclei. In fact, he wrote: Fig. lA-B. Nerve cell bodies of sympathetic ganglia with the nuclei of the satellite cells on the neuronal surface. Redrawn from Valentin; A, 1836; B, 1839.

A vascular system consists of a supplying arterial and a draining venous part which are connected by a terminal vascular network. The arterial segment can be characterized according to the structural features of the vessel wall. However, it is sometimes diffi- cult to distinguish the capillary from the postcapillary vessels on the basis of structural features alone. On the other hand, physiologic qualities such as permeability can hard- ly be associated with an equivalent histologic pattern of the vessel wall (lllig 1961; Rhodin 1967, 1968; Hauck 1971; Westergaard 1974). A defmition of a vascular seg- ment based on biologic significance should combine morphological and functional qualities of the vessel walls. During the ontogeny of the mammalian organism a variety of vascular patterns (e. g. , distribution of arteries and veins, arrangement of the capillaries) has been formed typical of each organ (Wolff et al. 1975; Baez 1977). The capillaries connect the feed- ing arterioles and the collecting venules in two different ways according to the branch- ing pattern of the terminal vessels (Hauck 1975, Wolff et al. , 1975). The arterioles and venules are directly connected by capillary segments. Consequently a terminal vessel called arteriovenous (a-v) capillary results, or a closely meshed capillary network is de- veloped which connects arterioles and venules by a variable number of small capillary branches arranged parallel to the preexisting a-v capillary.

In the past decennia nonhuman primates have been increasingly used for research purposes in various scientific fields. Much interest has been focused on this group of animals in general and on the rhesus monkey in particular because of its close phylo genetic relationship with man. In some fields of research, however, such as embryology and microscopic anatomy, much less attention has been paid to nonhuman primates, probably because of the expense involved in the collection of the extensive material needed. On the other hand, teratological and experimental embryologic studies must be based upon a thorough knowledge of the normal ontogenesis since only in that way can a reliable distinction be made between normal and abnormal or induced develop ment. Each ontogenetic study essentially consists of a comparison of different deve lopmental stages. In most reports dealing with the development of individual organs or their subunits the material used is classified according to the estimated age or the length of the embryos. These criteria, however, are not valid, since considerable varia tion in developmental stage occurs between animals of the same age even between littermates and between animals of the same length. Therefore a method is needed for assigning embryos to successive developmental stages that are defmed on the basis of extemal and internal characteristics. This type of classification was elaborated by Stree ter (1942, 1945, 1948,1951), who arranged human embryos into developmental hori zons numbered XI through XXIII."

Wilhelm His, one of the founders of developmental neurobiology, was convinced "that the processes of generation and development obey fundamental and simple laws and submit to the general laws of nature" (His 1901). Therefore, we should be able to find immediate conditions, dependencies and rules determining the de velopment of an organic form. With this in mind, His (1874) defined the task of embryology as follows: "Developmental biology is essentially a physiological science; it has not only to describe how each individual form develops from the egg, it has to derive this development in such a way that each developmental stage together with all its specialities appears as a necessary consequence of the immediately pre ceding stage . . . Only if developmental biology has given a perfect physiological deriva tion for any given form, has it the right to say that it has explained this individual form. " The ultimate aim of a physiological derivation would be that laws of growth valid for organic ,beings can be expressed as mathematical formulae (His 1874). To exemplify this, he formulated a universal and purely formal law of growth in mathematical terms making the comment: "I now suggest that the body form follows immediately from germinal growth and can be derived from the given germinal form according to the laws of growth. My interest is, therefore, firstly to detect the law of growth empirically and secondly to derive consecutive forms of the developing or ganism by applying this law.

Anatomy to most people is a subject which suggests the cutting up of dead bodies (the word literally means cutting up). In addition it is generally known that Vesalius published a book in 1543 in which much of the human body was described in detail and more or less accurately. A subject which is dead and ancient fre quently has little appeal especially if it appears to involve learning a large amount of factual information. For many years anatomy has had to struggle with these disadvantages and at times one has had the impression that there is almost a conspiracy on the part of everyone to suggest that anatomy is unnecessary. There is no doubt, however that a knowledge of the structures of the body, for that is what anatomy is, whether it is what can be seen with the naked eye or with different kinds of microscope, is an essential preliminary and corollary to the understanding of the functions of the body. It was no historical accident that Vesalius, the anatomist, preceded Harvey, the physiologist. No apology need be made for trying to present the basic facts of anatomy to anyone interested in the human body and to members of any profession which will have to cope with the physical and mental problems of children, men and women in health and in sickness. It is not intended that the reader should know every thing contained in this book."

Although a human embryo possesses so much grace that the untutored spectator can only admire it in awe, this minute and humble embryo is still almost unknown to many. For some, it seems to belong to the animal kingdom only; others see in it man in his most primordial and elementary aspect. The early life of man thus has become a problem. The development of man as individual (individual development) begins with fertilization. The following pages, therefore, concentrate above all on the develop- ment from the ovum to the embryo. The description given below of the ontogenesis of the human embryo and its early functions has been completely documented by our human-embryological collection. Numerous original pho- tographs and systematically revised drawings were pub- lished in 1973 under the title Die praenatalen Organsys- teme des Menschen (The Prenatal Organ Systems of Man); the supplementary scientific commentaries were published in 1977 in Biokinetics and Biodynamics of Human Differentiations. A complete series of portrait illustrations is located at the Science Centre in Toronto, Canada.

This highly regarded text is one of the most comprehensive reference works available on the topographical, functional and radiographic anatomy of the lumbosacral spine. Fully updated in this sixth edition, Clinical and Radiological Anatomy of the Lumbar Spine walks the reader through the structure, function and common disorders of the lumbar spine. It covers the basic anatomy of lumbar components, how the spine changes with age, clinical problems, and imaging. Internationally renowned author Nikolai Bogduk's thorough referencing and clear text bridge the gap between science and clinical presentation to provide practical, validated and clinically relevant information that will be invaluable for students and clinicians alike. Clearly written and accessible - brings the science to life Thoroughly and comprehensively referenced - can be used as a starting point for research High quality illustrations to support understanding Highly relevant to undergraduate and postgraduate courses in physiotherapy, pain medicine, chiropractic, and rehabilitation medicine New understanding of the causes and pathology of back pain Additional references reflect current literature New, colour illustrations of nerves Expanded radiographic anatomy chapter

From New York Times bestselling author Sam Kean comes more incredible stories of science, history, language, and music, as told by our own DNA.
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There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.
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This book is the first modern history of medieval European anatomical images. Richly illustrated, it explores the many ways in which medieval surgeons, doctors, monks and artists understood and depicted human anatomy. Taylor McCall refutes the common misconception that Renaissance artists and anatomists such as Leonardo da Vinci and Andreas Vesalius were the ‘fathers’ of anatomy, and the first to perform scientific human dissection; on the contrary, she proves these Renaissance figures drew upon centuries of visual and written tradition in their works. This interdisciplinary book will appeal to general audiences interested in the history of the body and medical professionals curious about the history of their discipline, as well as historians of art, medicine and medieval culture.

According to the classical theory of functional structure of bone which was developed by J. Wolff (1884, 1892) and W. Roux (1895) following the investigations of the functional architecture of the substantia spongiosa by H. von Meyer (1867), bone is "functionally" laid down in gross form as well as in minute architecture in accordance with the "maximum-minimum-law." As a result of functional adaptation, a maximum of efficiency is achieved with a minimum of material (Kummer, 1962a). In this sense functional adaptation is a reaction of adaptation of the idiotype-within the bounds of the reaction norm-to a changed internal environment, that is in this case an adaptation to changed mechanical stresses. 1. The Formation of the Normal Femur Shape The heredity basis of shape characteristics of human femora is really unknown. Identical twins show a significant lower variability of length of femur than binovular twins. Population variability of length of femur due to heritability may exceed twice the variability due to environmental factors (Knussmann, 1968). A significant part of the total variation of femur shape characteristics remains therefore unexplained supposing that the sources of variation due to heritability and environmental factors are also nearly the same for the other traits.

The prime purpose of this paper is to look at the region of brain which many authors call 'paleocortex' and to ask how much of the area it embraces can be described properly as cortex. Before this can be considered it is necessary to have some idea of what constitutes a cortex. Therefore, in the first part of the paper the criteria used in constructing classifications of cortex are looked into. Also considered is the meaning of classifications such as 'paleocortex'. Is it relevant to define cortex in this way? How does this view correlate with a functional approach? The second purpose of this paper, of equal importance to the first, is to review terminology. Each area of' paleocortex' has a review introduction that endeavoors to cut through the existing jungle of terms and usage and to provide a clear account of the area in question, prior to examining its standing as cortex. The term 'paleocortex' is in common use and for this reason it is worth close examination. Kappers (1909) first created the term to supplement the earlier division of cortex-into archicortex and neocortex-introduced by Elliot Smith. Kappers applied the term to the mantle layer of the most primitive vertebrates (cyclostomes and selachians), the whole of which receives secondary olfactory fibres.

Help your students maximize their study time, improve their performance on exams, and succeed in the course with this updated Study Guide to accompany Memmler's The Human Body in Health and Disease, Fourteenth? Edition. The questions in this edition have been fully updated and revised to reflect the changes within the main text and the labeling and coloring exercises are taken from the illustrations designed for the book. Filled with empowering self-study tools and learning activities for every learning style, this practical Study Guide follows the organization of the main text chapter by chapter, helping students every step of the way toward content mastery. The variety of learning activities, with three main components, are designed to facilitate student learning of all aspects of anatomy, physiology, and the effects of disease, not merely to test knowledge. Addressing the Learning Objectives: Designed to be completed as students read through each chapter, this section includes labeling, coloring, matching, and short answer exercises. Making the Connections: Completing a concept map helps students integrate information from multiple learning objectives. Testing Your Knowledge: This section utilizes multiple choice, true/false, completion, short answer, and essay questions to identify areas requiring further study. This section also includes "Practical Applications" questions which use clinical situations to test students' mastery of a subject. Answers to Study Guide questions are available on the instructor's website on thePoint site for the main text.

Anatomy Essentials For Dummies (9781119590156) was previously published as Anatomy Essentials For Dummies (9781118184219). While this version features a new Dummies cover and design, the content is the same as the prior release and should not be considered a new or updated product. The core concepts you need to ace Anatomy Perfect for those just starting out or returning to Anatomy after some time away, Anatomy Essentials For Dummies focuses on core concepts taught (and tested on!) in a typical Anatomy course. From names and technical terms to how the body works, you'll skip the suffering and score high marks at exam time with the help of Anatomy Essentials For Dummies. Designed for students who want the key concepts and a few examples--without the review, ramp-up, and anecdotal content--Anatomy Essentials For Dummies is a perfect solution for exam-cramming, homework help, and reference. A useful and handy reference to the anatomy of the human body Perfect for a refresher or a quick reference Serves as an excellent review to score higher at exam time If you have some knowledge of anatomy and want to polish your skills, Anatomy Essentials For Dummies focuses on just the core concepts you need to understand this fascinating topic.

This chart illustrates spinal nerves and cranial nerves and diagrams the portion of the thoracic spinal cord with spinal nerves. It also shows spinal cord segments, cutaneous distribution of spinal nerves, and dermal segmentation.

Originally published as part of the McMinn anatomy atlas family, McMinn's Color Atlas of Head and Neck Anatomy remains the only large format photographic atlas of the human head and neck, incorporating outstanding dissections, osteology, radiographic and surface anatomy images. It is the ideal study aid or trusted reference for the range of students and practitioners who require a detailed understanding of the head and neck, including those in dentistry, radiology and surgery. Dissections are accompanied by concise notes and commentaries, as well as orientational artworks to help readers locate the structure on the body. Dental anaesthesia information and important quick reference lists are also incorporated in appendices at the back of the book. This updated fifth edition offers increased clinical relevance and features an entirely new chapter on Imaging of the Head and Neck, reflecting the very latest modalities and techniques. It also comes with the complete, enhanced eBook for the first time. Increased clinical relevance - helps translate traditional anatomy into current clinical practice All new state-of-the-art clinical imaging - including: 3T MRI of the brain with tractography Cone-beam CT assessment of the jaws and middle ear Concise notes and commentaries for every dissection Dedicated dental section Access to complete downloadable eBook version via Expert Consult, with bonus enhancements - including: Over 180 additional figures - expands the imaging of normal and developmental structures and highlights common and clinically important variations, anomalies, defects and diseases Interactive question bank - over 150 multiple choice questions to aid exam preparation and check your understanding

1. Einleitung 2. 2.1. Der Stand der anatomischen Wissenschaft an der Schwelle zum 16. Jahrhundert 2.2.1 Biographie 2.2.2. Leonardos urologisch-anatomische Zeichnungen 3. Das 16. Jahrhundert 3.1 Andreas Vesal 3.1.1. Biographie 3.1.2. Vesals Abb. zum Urogenitalsystem 3.1.3. Vesals Konsil uber die Behandlung einer Nierensteinerkrankung 3.2 Charles Estienne 3.2.1. Charles Estienne - Biographie 3.2.2. Die Darstellung des Urogenitaltraktes bei Charles Estienne und Estienne la Riviere 3.3 Bartholomaeus Eustachi 3.3.1 Biographie 3.3.2 Eustachis urologisch-anatomische Graphik 4. Das 17. Jahrhundert 4.1 Regnier de Graaf 4.1.1 Biographie 4.1.2 De Graafs urologisch-anatomische Abbildungen 4.2 Godefridus Bidloo 4.2.1 Biographie 4.2.2 Bidloos urologisch-anatomische Abbildungen von 1685 5. Das 18. Jahrhundert 5.1. Giovanni Domenico Santorini 5.1.1. Biographie 5.1.2. Santorinis Darstellungen zum Plexus venosus vesicoprostaticus 5.2. William Cheselden 5.2.1. Biographie 5.2.2. Cheseldens Darstellungen zum Urogenitaltrakt 5.3. Weitere urologisch-anatomische Abbildungen aus dem 18. Jahrhundert 5.3.1. Urologisch-anatomische Buntkupferdrucke 6. Das 19. Jahrhundert 6.1. Justus Christian Loder 6.1.1. Biographie 6.1.2. Loders Darstellungen zum Urogenitaltrakt 6.2. Antonio Scarpa 6.2.1. Biographie 6.2.2. Scarpas Darstellungen zum mannlichen Urogenitaltrakt 6.3. Martin Munz 6.3.1 Biographie 6.3.2. Die Lithographischen Darstellungen von Martin Munz zumUrogenitaltrakt 6.4. Marc Jean Bourgery 6.4.1. Biographie 6.4.2. Farblithographische Darstellungen des Urogenitaltraktes im Atlas von Marc Jean Bourgery 7. Die Urologie an der Schwelle zum 20. Jahrhundert 7.1. Gustav Simon 7.1.1. Biographie 7.1.2. Die erste wissenschaftlich geplante Exstirpation einer Niere durch Gustav Simon 7.2. Henry Morris 7.2.1. Biographie 7.2.2. Die erste operative Entfernung einer Nebenniere aufgrund eines Tumorleidens durch Henry Morris 1885 7.3. Bernhard Bardenheuer 7.3.1. Biographie 7.3.2. Die erste totale Blasenexstirpation aufgrund eines Tumorleidens ohne Harnleiterneuimplantation durch Bernhard Bardenheuer 1887 7.4. Karl Pawlik 7.4.1 Biographie 7.4.2. Die erste totale Blasenexstirpation mit Harnleiterneueinpflanzung bei einer Frau durch Karl Pawlik 1889 7.5. Hugh Hampton Young 7.5.1 Biographie 7.5.2. Die erste perineale radikale Prostatavesikulektomie aufgrund eines Proststakarzinoms durch H. H.Young 1904 7.6. Friedrich Voelcker 7.6.1 Biographie 7.6.2. Die Erstbeschreibung der totalen Samenblasenexstirpation auf ischiorektalem Weg durch Friedrich Voelcker 1912 8. Schlussbetrachtung

Principles of Anatomy according to the Opinion of Galen is a translation of Johann Guinter's textbook as revised and annotated by Guinter's student, Andreas Vesalius, in 1538. Despite Vesalius' fame as an anatomist, his 1538 revision has attracted almost no attention. However, this new translation shows the significant rewrites and additional information added to the original based on his own dissections. 250 newly discovered annotations by Vesalius himself, published here in full for the first time, also show his working methods and ideas. Together they offer remarkable insights into Vesalius' intellectual biography and the development of his most famous work: De humani corporis fabrica, 1543. An extensive introduction by Vivian Nutton also provides new information on Johann Guinter, and his substantial use of Vesalius' work for his own revised version of the text in 1539. Their joint production, a student textbook, is set against a background of the development of Renaissance anatomy, and of attitudes to their ancient Greek predecessor, Galen of Pergamum. This text will be of great interest to historians of science and medicine, as well as to Renaissance scholars.

This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.