This work is not an anatomical atlas nor textbook (like that of McAlpine and Anderson) nor an angiographical atlas (like that of Vlodaver et al.); it is a short and comprehensive survey of the many variations of the intrinsic cardiac vessels. The reader's attention is focused on the numerous structural details and peculiarities of the human coronary arteries. The many unique features have been revealed by meticulous dissection and present an excellent documentation. All in all, this study represents an up-to-date review of morphology of the coronary arteries.

The alternation between urine retention and discharge several times daily from a nappy to the cessation ofall vital functions only becomes the subject baby's first wet of greater attention if the harmony of the structure and function of the bladder is disturbed. Functional disturbances of the lower urinary tract are not only of great socio-economic importance, but are also a considerable personal burden for the patient. Hence urinary incontinence is rightly classified as a severelydisabling illness (Hauri 1985). Opinions still differ regarding the morphological basis ofurinary continence.The Terminologia Anatomica (1998) defines a musculus sphincter urethrae internus (in- ternal urethral sphincter) and a musculus sphincter urethrae externus (external ure- thral sphincter),which in the older nomenclature were known as musculus sphincter vesicae and musculussphincterurethrae,respectively.The internal urethral sphincter isascribed apurelyinvoluntaryandthe externalurethralsphincterapurelyvoluntary innervation. The significance of the musculature of the pelvic floor for maintaining urinarycontinence has notyetbeen ascertained. Duringnumerous urologicaloperations (forinstancetransurethralresectionofthe prostate and bladder neck incisions), the only involuntarily innervated sphincter at the collum vesicae,the internalurethralsphincter,is partiallyorcompletelydestroyed (Fig. 27C,D).All the patients remain continent as long as the externalurethral sphinc- ter remains intact.Howcan apurelyvoluntarilyinnervated sphincterlikethe external urethral sphincter ensureconstant continence in such cases? Improving the continence rate after radical surgery is a key topic of urological research. The incontinence rate after radical prostatectomy is still between 8.1% (third-degree incontinence) and41.4% (first- to second-degree incontinence; Rudyet al. 1984; Igel et a1.1987; Schroderand Ouden 1992).

In the medical imaging field, clinicians and researchers are increasingly moving from the qualitative assessment of printed images to the quantitative evaluation of digital images since the quantitative techniques often improve diagnostic accuracy and complement clinical assessments by providing objective criteria. Despite this growing interest, the field lacks a comprehensive body of knowledge. Filling the need for a complete manual on these novel techniques, Quantifying Morphology and Physiology of the Human Body Using MRI presents a wide range of quantitative MRI techniques to study the morphology and physiology of the whole body, from the brain to musculoskeletal systems. Illustrating the growing importance of quantitative MRI, the book delivers an indispensable reference for readers who would like to explore in vivo MRI techniques to quantify changes in the morphology and physiology of tissues caused by various disease mechanisms. With internationally renowned experts sharing their insight on the latest developments, the book goes beyond conventional MRI contrast mechanisms to include new techniques that measure electromagnetic and mechanical properties of tissues. Each chapter offers comprehensive information on data acquisition, processing, and analysis techniques as well as clinical applications. The text organizes the techniques based on their primary use either in the brain or the body. Some of the techniques, such as diffusion-weighted imaging and diffusion tensor imaging, span several application areas, including brain imaging, cancer imaging, and musculoskeletal imaging. The book also covers up-and-coming quantitative techniques that explore tissue properties other than the presence of protons (or other MRI-observable nuclei) and their interactions with their environment. These novel techniques provide unique information about the electromagnetic and mechanical properties of tissues and introd

The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate. Elucidating the relationship between their molecular and cellular effects and behavioural significance has been challenging, but in the past 5-10 years, improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. Dopamine-Glutamate Interactions in the Basal Ganglia synthesizes this recent research from the level of receptor molecules all the way to complex behaviours and disease. Current insights from research on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia are presented against a historical perspective. The book also discusses compromised dopamine-glutamate interaction in disorders of basal ganglia function, including Parkinson's disease, Huntington's disease, and drug addiction.

Acquire the 21st-century skills to succeed in A&P with a leading text in the field. Human Anatomy & Physiology, 12th edition by best-selling authors Elaine Marieb and Katja Hoehn is one of the leading texts in the field, aimed not only to support your learning every step of the way but also to motivate and inspire you as a future scientist in the field. An ideal learning resource both for novice and expert students, this text will equip you with the most up to date, 21st-century skills to succeed in A&P and beyond. Well-known for its engaging, conversational writing style, easy-to-follow figures, and unique clinical insights, this editioncontinues its tradition of innovation, with an array of compelling multimedia tools and visual presentations, along with questions and clinical case studies to cement your understanding of the topics. With this text you can: Master the challenging A&P terminology Practice your critical thinking and problem-solving skills Apply your knowledge to clinical scenarios Gain the knowledge required for entry into nursing, allied health, and exercise science programs. Personalise your learning experience and improve results with Mastering (R) A&P. Mastering provides access to trusted content using customisable tools, features, and assessments built for today's digital learners. Pearson Mastering (R) A&P is not included. If you would like to purchase both the physical text and Mastering A&P, search for: 9781292421957 Human Anatomy & Physiology, Global Edition, 12th edition with Mastering Biology The bundle consists of: 9781292421803 Human Anatomy & Physiology, Global Edition, 12th Edition 9781292421797 Pearson Mastering A&P- Instant Access - for Human Anatomy & Physiology, Global Edition 9781292421742 Pearson Mastering A&P with Pearson eText - Instant Access - for Human Anatomy & Physiology, Global Edition Mastering A&P should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson representative for more information.

The studies presented in this monograph concentrate on the glycoconjugate characterisation of the mouse and human GALT and on the overlying follicle-associated epithelium (FAE), in order to identify their cell-specific carbohydrate residues.

5 Function of Splenic Compartments . . . . . . . . . . . . . . . 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens . . . . . . . . . . . . . . . . . . . . . . . . . 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS . . . . . . . . . . . . . . . . . . . . 46 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 5. 1. 3 Formation of Germinal Centres . . . . . . . . . . . . . . . . . . . 50 5. 1. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens . . . . . . . . 57 5. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Function of the Red Pulp . . . . . . . . . . . . . . . . . . . . . . . . . 59 5. 3 5. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses . . . . . . . . . . . . . . . 61 5. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells . . . . . . . . . . . . . . . . . . . . . . . . 62 5. 5. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 6 Recirculation of Lymphocytes Through the Spleen . . 65 6. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments . . . . . . 69 7. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Unsolved Problems of Human Splenic Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. . . . . . . . . . . . . . . . . 73 . . . . 8. 1. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 8.

Preparatory work for this monograph started in 1988 and 1989. The motive was provided by certain incongruities in the illustra- tion of descensus testis for the chapter "Entwicklung der Genital- organe" in the book Humanembryologie. The evoked discussion was reason enough for our own re- search on the phenomenon and uncertainties of testicular des- cent in human. The basis ofthese investigations was the collection of human embryos founded by Prof. Hinrichsen in 1970 at the Department of Anatomy and Embryology, Ruhr-University Bo- chum. The preparation of the material used in this paper has been done with the help of many staff members of our department to whom we feel obliged. We are especially indebted to Prof. Hin- richsen who prepared the foetuses and took the first steps of this project. We wish also to acknowledge Dr. Heinz Jiirgen Jacob for careful fixation and microdissection of specimens intended for scanning electron microscopy. Weare also grateful to Mrs. Vera Mannheim for her involvement and her sensitivity in making scanning electron micrographs, and Mrs. Antje Jaeger for provid- ing an expert and skilful photographic technique especially in the setting up of micrographs. Our thanks are also due to Mrs. Marion Kohn for skilful technical assistance and to all those technical assistants who worked in our department during the past 25 years and who were engaged in providing the serial sec- tions. The English text has been thoroughly revised by Prof. Dr.

What is the function of the mammillary body? Which information is passed through the cuneate fasciculus or the internal arcuate fibers? Which hormones are produced by the paraventricular hypothalamic nucleus? Which nerves and vessels run through the jugular foramen? Which parts of the body are innervated by the accessory nerve? Which cortical regions are affected by a dysfunction of the central sulcus artery?These are frequently asked questions to which a short and precise answer is seldom found in textbooks or other scientific works. These questions - and more - are now answered in the long-awaited Dictionary of Human Neuroanatomy. It will be a useful companion for everyone looking for precise and functional definitions of terms in the field of neuroanatomy, and is absolutely essential for those studying neuroanatomy, and for quick reference.

The objective of the present work is to review the existing literature on joint incongruity, cellular mechano-transduction, and computer simulations of mechano-adaptive bone remodelling, and to quantitatively assess the effect of incongruity on load transmission and subchondral mineralisation. Idealised computer models of incongruous joints and a specific anatomically based model of the humero-ulnar joint articulation were analysed with the finite element method, and the results directly compared with experimental and morphological data.

Since the 1980s, ankle arthroplasty has been considered a dubious treatment for painful and degenerated joints. Many of the concerns that existed previously have been solved today. Prosthetic replacement of other joints also took a long time before reaching their present successful status. This is the first book to deal with ankle arthroplasty. International experts have given their opinion on (i) the kinematics of the ankle; (ii) the basics of replacing the ankle joint; and (iii) the current status of several modern ankle-prosthesis designs. A better understanding of the ankle kinematics, alignment techniques and biological stabilisation and the results of newer designs have changed the former attitude worldwide. The content of this book bears evidence for this change in opinion.

This chart shows posterior view of the pharynx and shows sagittal section, deep side view, and tonsils. Illustrations provide various views of the larynx: anterior, posterior, side, cut-away side, top, and sagittal section. The chart also shows laryngeal function, including phonation, inspiration, and deep inspiration.

This is an overview of human physiology and anatomy, including health and hygiene. A resource for Steiner-Waldorf teachers of Classes 7 and 8 (age 12-14).

Investigations on anatomical specimens have demonstrated that the subchondral mineralization does indeed show regular distribution patterns from which conclusions about the mechanical situation within an individual joint may be drawn. Since radiographical densitometry and histological methods are only available for determining the adaptive reaction of the bone to the mechanical situation in a joint after death, the information obtained applies only to an end situation and tells us nothing about the development of the changes with time. Furthermore, investigations carried out on human specimens by radiographical densitometry mostly apply to samples of a particular age, since such specimens can be acquired only from departments of pathology, forensic medicine or anatomy.

Glomerular flltration represents one of the basic mechanisms in the function of an organism. Our understanding of this process is still quite fragmentary. Regulation of blood flow and pressure, together with regulation of the ultraflltration coefficient (which is an attribute of the flltration barrier), are the two fundamental mechanisms accounting for maintenance and adaptability of glomerular flltration. Regulation of glomerular blood flow is generally considered to result from an interplay between afferent and efferent glomerular arterioles, and much progress has been made recently in understanding this interplay (Navar et al. 1996). The present study provides a detailed structural description of the glomerular vascular pole of rat. The results of this study appear to be relevant for several open questions of glomerular function. First, the interaction between afferent and efferent arterioles in regulating glomerular blood is generally understood to occur between the preglomerular and the postglomerular portions of these vessels. As shown in the present study, the structural elaborations of these arterioles and the spatial relationships between them within the glomerular hilum strongly suggest an interplay also at this site. Moreover, the current understanding of glomerular blood flow regulation by tuning the interplay between afferent and efferent arterioles is exclusively based on signals whose regulatory loops are established in follow-up events outside the glomerulus (tubuloglomerular balance, tubuloglomerular feedback).

}This eloquent book takes us on a spell-binding journey into the workings of our bodies in health and disease. Dr. Charles A. Pasternak captivates us with his vivid and even poetic explanations of what keeps us healthy and vital, and what tears away at our health. He possesses the gift for rendering complex topics clear and lyrical, as in the ways our molecules interact with one another to decide the fate of our heart, brain, and lungs---whether we live or die.Why does disease rear its ugly head? Why does cancer take hold in some of us and pass by others? What roles do nutrition and stress play in determining our chances for a long, fulfilling life? Can we hold our eventual demise at bay by trying novel drugs and therapies? Dr. Pasternak also explores to what extent the illnesses we sufferand even our level of intelligenceare dependent on the genes we inherit from our parents, or the food we eat, or even the environment we inhabit. The story of our bodies is a true saga that has never before been so engrossingly told. }

1. 1 Scientific Aims In recent years, there has been a definite trend away from the casuistic scientific thinking which has dominated the scientific world, at least in the field of medicobi ological research. Now, in the last decade of this century, scientists are returning to a conceptual way of thinking that characterized the beginning of this century, namely organismal thinking. The holistic concept is not a new one; it was rekindled by a small group of scientists who, in the previous two decades, have begun to warn against too great an emphasis being placed on a molecular casuistic approach as the final pursuit to science (see Duncker 1983). These thinkers were perhaps instrumental in helping to turn the tide, to instruct and encourage fellow researchers to extend their findings from the molecular and to the organismal (see Duncker 1983, 1992a, b; Duncker and Kreite 1987). Having observed the ceca of many different animals for many years and having described their morphology at different levels of study -from the macroscopic to the electron microscopy level - the need to compare and observe these morphological entities in a quantitiative way became increasingly imminent. Quantitative methodol ogy in morphology requires the use of morphometry, which in the most general terms can be described as the measurement of the forms of animals. As defined by Reith and Meyhew (1988), it is quantitative morphology, i. e., the measurement of structures by any method, including stereology."

In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.

The knowledge of the mammalian central nervous pared by Ms. Anne Dunn. I am truly grateful for system has increased dramatically during the last their contributions. decade, which has provided a major impetus for A caveat is in order for the first 5 figures in preparing the second edition of The Human Brain Chapter 10, which represent cross-sections through and Spinal Cord. For the medical profession this has different levels of the brainstem. Considering the been a revolutionary time, since modem imaging rapidly expanding reliance on in vivo imaging by the methods have provided unparalleled opportunities clinicians, figures 10-1 to 10-5 are presented with for anatomical and functional studies of the human the posterior parts of the brainstem facing down body in vivo. It is now essential for the clinician to wards, since this is the way the brainstem images have an intimate knowledge of anatomy including appear in axial MRls routinely used by neuro the functional-anatomical systems in the brain radiologists (see Chapter 5). This somewhat un and spinal cord. The new edition of this textbook conventional approach, suggested by Dr. Duane reflects this progress in the sense that almost all of Haines, is directly relevant for the transfer of basic the chapters have been rewritten and several new science information to clinical practice. All other figures have been included.

Over 400 short videos highlight the steps in a full-body human dissection in the gross anatomy lab. Each step is narrated and key structures labeled. Text of the audio is included for each video so that the narration can be appreciated without audio as well. In addition, key structures are defined and linked to a library of illustrations from the Atlas of Human Anatomy by world-renowned physician-artist Frank H. Netter, MD. The illustrations can be viewed in Test-Yourself mode to quiz your knowledge of structure names. This Retail Access Card contains a pincode that can be used to access the enhanced eBook on www.StudentConsult.com The eBook is viewable on desktop, laptop, and on phones and devices (via the Inkling app).

International experts review the molecular biology of ion channels, diseases of the central nervous system including Alzheimer's disease, the molecular biology of atherogenesis, plasma lipproteins, lipid transport, long chain fatty acid transport and metabolism, and lipoprotein receptors. Future directions and perspectives and common features in these important areas are discussed.

A new approach using comparative neuromorphology is taken in this study dealing with the organization of the efferent nuclei of cranial nerves. The authors use the cobalt labelling technique to identify neuron types and follow their presence, or absence, in different animal species. They suggest a new classification which is free from a number of controversies inherent in the classical classification. The results suggest that evolutionary changes in the center and in the innervated periphary parallel each other with increasingly complex function.