Winner of the 2000 William H. Welch Medal given by the American Association for the History of Medicine. At the heart of medical history is a deep enigma. The true structure and workings of the human body are, we casually assume, everywhere the same, a universal reality. But then we look into the past, and our sense of reality wavers: accounts of the body in diverse medical traditions often seem to describe mutually alien, almost unrelated worlds. "The Expressiveness of the Body" meditates on the contrasts between the human body described in classical Greek medicine and the body as envisaged by physicians in ancient China. It asks how this most basic of human realities came to be conceived by two sophisticated civilizations in radically diverging ways. And it seeks answers in fresh and unexpected topics, such as the history of tactile knowledge, the relationship between ways of seeing and ways of listening, and the evolution of bloodletting.

Principally based on dissections of hundreds of un-embalmed human cadavers over the past decade, Functional Atlas of the Human Fascial System presents a new vision of the human fascial system using anatomical and histological photographs along with microscopic analysis and biomechanical evaluation. Prof. Carla Stecco - orthopaedic surgeon and professor of anatomy and sport activities - brings together the research of a multi-specialist team of researchers and clinicians consisting of anatomists, biomechanical engineers, physiotherapists, osteopaths and plastic surgeons. In this Atlas Prof. Stecco presents for the first time a global view of fasciae and the actual connections that describe the myofascial kinetic chains. These descriptions help to explain how fascia plays a part in myofascial dysfunction and disease as well as how it may alter muscle function and disturb proprioceptive input. Prof. Stecco also highlights the continuity of the fascial planes, explaining the function of the fasciae and their connection between muscles, nerves and blood vessels. This understanding will help guide the practitioner in selecting the proper technique for a specific fascial problem with a view to enhancing manual therapy methods. Functional Atlas of the Human Fascial System opens with the first chapter classifying connective tissue and explaining its composition in terms of percentages of fibres, cells and extracellular matrix. The second chapter goes on to describe the general characteristics of the superficial fascia from a macroscopic and microscopic point of view; while the third analyzes the deep fascia in the same manner. The subsequent five chapters describe the fasciae from a topographical perspective. In this part of the Atlas, common anatomical terminology is used throughout to refer to the various fasciae but it also stresses the continuity of fasciae between the different bodily regions. Over 300 unique photographs which show fascia on fresh (not embalmed) cadavers Demonstrates the composition, form and function of the fascial system Highlights the role of the deep fascia for proprioception and peripheral motor coordination Companion website - www.atlasfascial.com - with videos showing how fascia connects with ligaments

Bundle includes: 9781119576488 Fundamentals of Anatomy and Physiology: For Nursing and Healthcare Students, 3rd Edition A concise yet comprehensive introduction to the structure and function of the human body. Written with the needs of nursing and healthcare students in mind, this best-selling textbook incorporates clinical examples and scenarios throughout to illustrate how the topics covered are applied in practice. Hundreds of full-colour illustrations complement numerous case studies encompassing all fields of nursing practice, alongside learning outcomes, self-assessment tests and other effective learning tools. 9781119699491 Fundamentals of Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students, 4th Edition A highly visual and accessible introduction to pathophysiology for nursing and healthcare students, including brand-new content on homeostasis, a systematic approach to assessment, and key terminology. The book features links to clinical observations, vital signs to observe, investigation boxes, clinical red flags, medication alerts, and the latest, contemporary evidence for care management, including National Early Warning Score 2 (NEWS2).

The Ross & Wilson Pocket Reference Guide to Anatomy and Physiology is an exciting new resource which offers over 250 anatomical entries carefully selected for their biological importance and/or clinical relevance. Each piece of carefully crafted artwork is accompanied by helpful summary notes describing key aspects of the relevant anatomy, physiology and clinical application to aid readers with their understanding of the human body. The volume also comes with a helpful online self-assessment program which presents a range of interactive exercises designed to stimulate critical thinking and information recall. Perfect for learning and consolidating knowledge while 'on the go', Ross & Wilson Pocket Reference Guide to Anatomy and Physiology will be ideal for students of nursing and allied health professions, paramedical science, operating department practice, complementary therapy and massage therapy, as well as trainee Health Care Assistants and those studying A' level or BTEC (or equivalent) human biology. Summarizes essential facts from the world's favourite human biology textbook! Presents over 250 key anatomical structures together with 'quick reference' revision notes regarding their structure, function and clinical relevance Straightforward language and user-friendly approach provides a useful, up-to-date aide-memoire in a helpful, easy-to-carry format Helpful website provides a range of self-assessment exercises on anatomy and physiology to help consolidate learning

Featuring more than 85 vibrant, fully annotated charts-19 new to this edition-this updated fourth edition of Diseases and Disorders: The World's Best Anatomical Charts is a perfect quick reference for medical and nursing students and an ideal visual aid for patient education. Printed on oversized, cardstock pages and compiled in a convenient, 10" x 12" spiral-bound volume with a laminated cover, these full-color charts created by some of the world's best medical illustrators illustrate and explain common diseases and disorders of the brain; heart; GI tract; eye and ear; endocrine, muscular, skeletal, reproductive, and respiratory systems; dental diseases; infectious diseases; healthy lifestyle issues; and cancer. Nineteen new charts cover Schizophrenia, Ovarian Cancer, Multiple Myeloma, Liver Cancer, Pancreatic Cancer, Prostate Cancer, Heart Failure, Peripheral Artery Disease, UC/Crohn's Disease, Irritable Bowel Syndrome, Age-Related Macular Degeneration, and more. All charts have been reviewed and updated. Medical terminology and easy-to-understand supporting text are printed directly on each chart. Every chart depicts an aspect of human anatomy, physiology, and disease presented in a clear, visual presentation. The book is ideal as a review resource or quick reference for studying human anatomy or for patient consultation and education.

A hands-on tool for medical students, Neuroanatomy Basics: A Clinical Guide covers key basic neuroanatomy material and the most important clinical correlations that a medical student is required to know. The book's style is simple and features an array of figures/illustrations that will show the student what he/she has just studied. It will follow a breadcrumbs approach that relies heavily on images/figures. Relying on photographic memory is quite helpful in grasping 'dry and rigid' neuroanatomy concepts; hence, the large number of figures contained in the book. Students will not have to refer to an atlas or other references in order to grasp the book's concepts. The peculiar order of sections will guide the student through the sequence of events/anatomical structures back and forth from cellular to structural levels, depending on the stimulus and response.

A concise, superbly illustrated (print + electronic) textbook that brings together a reliable, clear and up to date guide to surface anatomy and its underlying gross anatomy, combined with a practical application of ultrasound and other imaging modalities. A thorough understanding of surface anatomy remains a critical part of clinical practice, but with improved imaging technology, portable ultrasound is also fast becoming integral to routine clinical examination and effective diagnosis. This unique new text combines these two essential approaches to effectively understanding clinical anatomy and reflects latest approaches within modern medical curricula. It is tailored specifically to the needs of medical students and doctors in training and will also prove invaluable to the wide range of allied health students and professionals who need a clear understanding of visible and palpable anatomy combined with anatomy as seen on ultrasound. Concise text and high quality illustrations, photographs, CT, MRI and ultrasound scans provide a clear, integrated understanding of the anatomical basis for modern clinical practice Highly accessible and at a level appropriate for medical students and a wide range of allied health students and professionals Reflects current curriculum trend of heavily utilizing living anatomy and ultrasound to learn anatomy Supplementary video content showing live ultrasound scans and guided areas of surface anatomy to bring content to life and reflect current teaching and clinical settings An international advisory panel appointed to add expertise and ensure relevance to the variety of medical and allied health markets Inclusion of latest ultrasound image modalities Designed to complement and enhance the highly successful Gray's family of texts/atlases although also effective as a stand-alone or alongside other established anatomy resources

This is by far the most exhaustive biography on Niels Stensen, anatomist, geologist and bishop, better known as "Nicolaus Steno". We learn about the scientist's family and background in Lutheran Denmark, of his teachers at home and abroad, of his studies and travels in the Netherlands, Belgium, France, Italy, Austria, Hungary, Bohemia and Germany, of his many pioneering achievements in anatomy and geology, of his encounters with Swammerdam, Malpighi and with members of the newly established Royal Society of London and the Accademia del Cimento in Florence, and with the philosopher Spinoza. It further treats Stensen's religious conversion. The book includes the full set of Steno's anatomical and geological scientific papers in original language. The editors thoroughly translated the original Latin text to English, and included numerous footnotes on the background of this bibliographic and scientific treasure from the 17th century.

This seminal study of human bone forms Dr. Mees reveals the skeleton as an articulate work of art. But who is the artist? Using a blend of phenomenological observations and artistic intuition, the author carefully explores the anatomical facts of the human skeleton, with the beauty of many bones are impressively described and illustrated through numerous parallel photographs and illustrations.

Motility is a fundamental property of living systems, from the cytoplasmic streaming of unicellular organisms to the most highly differentiated and de veloped contractile system of higher organisms, striated muscle. Although of motility have a long and in scientific investigations into the mechanisms teresting history, the knowledge of molecular processes, especially in the area of regulation of control of motility, has been developing at an ever more rapid pace with the utilization of multidisciplinary approaches from physiology, cell biology, genetics, biochemistry, pharmacology, and biophysics. In Volume 3, Cell and Muscle Motility continues the same philosophy as that of the preceding volumes. The essays are meant to focus on topics of current interest, to be critical rather than exhaustive, and to indicate the current trends of research efforts. The series is intended to foster an in terchange of concepts among various workers in a variety of disciplines and to serve as a reference for students and workers who wish to familiarize them selves with the most current progress in motility. Robert M. Dowben Jerry W. Shay Dallas vii Contents Chapter 1 Intermediate Filaments in Striated Muscle: A Review of Structural Studies in Embryonic and Adult Skelttal and Cardiac Muscle Maureen C. Price and Joseph W. Sanger 1. Introduction ................................................ ."

This book was not written for contemporary scientists with a major interest in cell biology. Rather, it was prepared for the serious and inquiring student who mayor may not have had an extensive background in the sciences but who is interested in exploring or reviewing in depth the current body of knowledge about cellular structure and function. We have tried to convey a sense of the expectant excitement that characterizes the modem-day cellular biologist and we regret any scientific jargon that may have crept into the text as a result of this effort. We have selected and assimilated experiments done by numerous scien tists and have used them to explain how cells work. In doing this, we have concentrated on animal cells because we know more about them. We have come to a deeper appreciation, while preparing this book, of the limitations in understanding the inner workings of the cell and have come to realize more than ever that we are, in these matters, still "looking through a glass darkly. " An explosively increasing body of knowledge about the cell and its organelles has become available through the diligent work of numerous biologists. Thus it is impractical to attempt to credit each of these scientists for all of their important contributions: The listed references are neither exhaustive nor are they necessarily the first report of a finding."

The Color Atlas of "Xenopus laevis" Histology provides the first central source on the microscopic anatomy of cells, tissues, and major organs of the adult South African clawed frog, Xenopus laevis. For many years, X. laevis has been a highly popular experimental animal model in many areas of research. The recent development of transgenic Xenopus technology offers the promise that this animal model will be utilized more than ever before. The purpose of this book is to provide the active researcher with a central source of high quality light microscopic color images of the tissues of X. laevis, to aid in the identification of the cells and tissues of interest.

Major features of this atlas include:

*277 large, colorful, high resolution light microscopic images of cells, structures, tissues and organs;
*Clear, detailed labeling of important structures in all images;
*Concise, easy-to-read descriptions of histological organization and functions;
*Colorful three-dimensional illustrations that simplify complex structure;
*Detailed presentation of cranial structures and organization;
*Easy-to-use cross-referenced index;
*Bundled CD/ROM containing all images for easy downloading.

Looking for the resource to help your students fully understand and retain critical knowledge of sectional anatomy? Allow us to introduce this new edition of" Introduction to""Sectional Anatomy." Focusing on presenting this highly visual an dynamic topic in a way that makes it engaging and accessible to students, "Introduction to Sectional Anatomy"begins with key terminology and concepts and then moves through the body from head to toe. This new edition has been completely updated to include the most current imaging modalities, including ultrasound, MR, and PET/CT, so your students are fully equipped for what they will encounter in practice. Here's what you can expect to find inside "Introduction to Sectional Anatomy," Third Edition...""- A design that makes it easy for students to compare images from several patients- Clinical cases demonstrating how knowledge of sectional anatomy is applied in practice- Chapter objectives that help students study more efficiently- Clinical application questions at the end of each chapter that review students' understanding of essential concepts

This beautifully illustrated volume brings to life all the excitement and challenge of the study of human anatomy and physiology in one stunning resource! Characterised by its friendly and accessible writing style, each chapter of Anatomy & Physiology, Adapted International Edition, comes with a range of helpful learning features such as Study Hints, Chapter Outlines, Language of Science and Medicine lists, Case Studies, Chapter Summaries and Review- and Critical Thinking Questions. The volume also boasts over 1400 images together with the unique underlying themes entitled the 'Big Picture' and 'Cycle of Life', which serve to emphasize the importance of the interrelationship between systems of the body and how these systems are influenced, in turn, by development and aging. Alongside this emphasis on interdependence and change, comes a focus on homeostasis, which enables the reader to see how the healthy body is one that is carefully tuned and that disease can readily occur when internal balance is disrupted. Anatomy and Physiology, Adapted International Edition, has been fully updated to make full reference European healthcare systems, including drugs, relevant investigations and local treatment protocols. The also book comes with an extensive website facility and accompanying Brief Atlas of the Human Body and Quick Guide to the Language of Science and Medicine. Anatomy & Physiology, Adapted International Edition, will be ideal for students of nursing and allied health professions, biomedical and paramedical science, operating department practice, complementary therapy and massage therapy, as well as anyone studying BTEC (or equivalent) human biology. Please refer to the individual product pages for the duration of access to these products. Unique 'Clear View of the Human Body' allows the reader to build up a view of the body layer by layer Clear, conversational writing style helps demystify the complexities of human biology Content presented in digestible 'chunks' to aid reading and retention of facts Consistent unifying themes, such as the 'Big Picture' and 'Cycle of Life' features, help readers understand the interrelation of body systems and how they are influenced by age and development Accompanying Brief Atlas of the Human Body offers more than 100 full-colour transparencies and supplemental images that cover body parts, organs, cross sections, radiography images, and histology slides Quick Guide to the Language of Science and Medicine contains medical terminology and scientific terms, along with pronunciations, definitions, and word part breakdowns for terms highlighted in the text Numerous feature boxes such as Language of Science and Language of Medicine, Mechanisms of Disease, Health Matters, Diagnostic Study, FYI, and Sport and Fitness provide interesting and important side considerations to the main text More than 1,400 full-colour photographs and spectacular drawings illustrate the most current scientific knowledge and help bring difficult concepts to life Quick Check Questions within each chapter help reinforce learning by prompting readers to review what they just read Chapter outlines, chapter objectives and study tips begin each chapter Outline summaries, review questions, critical thinking questions, and case studies are included at the end of each chapter Study Hints found throughout the text give practical advice to students about mnemonics or other helpful means of understanding or recall Connect IT! features link to additional content online to facilitate wider study Helpful Glossary and Anatomical Directions Ideal for students who are new to the subject, or returning to study after a period of absence, and for anyone whose first language is not English

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine. Radiotherapy is an important part of modern multimodal cancer treatment, and the past several years have witnessed not only substantial improvements in radiation techniques and the use of new beam qualities, but also major strides in our understanding of molecular tumor biology and tumor radiation response. Against this backdrop, the book highlights recent efforts to identify reasonable and clinically applicable biomarkers using broad-spectrum tissue microarrays and high-throughput systems biology approaches like genomics and epigenomics. In particular, it describes in detail how such molecular information is now being exploited for diagnostic imaging and imaging throughout treatment using the example of positron emission tomography. By discussing all these issues in the context of modern radiation oncology, the book provides a broad, up-to-date overview of the molecular aspects of radiation oncology that will hopefully foster its further optimization.

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

This volume presents detailed laboratory protocols for in vitro synthesis of mRNA with favorable properties, its introduction into cells by a variety of techniques, and the measurement of physiological and clinical consequences such as protein replacement and cancer immunotherapy. Synthetic techniques are described for structural features in mRNA that provide investigational tools such as fluorescence emission, click chemistry, photo-chemical crosslinking, and that produce mRNA with increased stability in the cell, increased translational efficiency, and reduced activation of the innate immune response. Protocols are described for clinical applications such as large-scale transfection of dendritic cells, production of GMP-grade mRNA, redirecting T cell specificity, and use of molecular adjuvants for RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences is a valuable and cutting-edge resource for both laboratory investigators and clinicians interested in this powerful and rapidly evolving technology.

The annual meeting of the European Tissue Culture ., Society was held at the Castle of Zinkovy in Czechoslovakia from May 7-10,1969. Included as part of this meeting was a symposium on "Aging in Cell and Tissue Culture." This volume contains the papers presented at that symposium. The use of cell and tissue culture techniques to study the mechanism of aging is not new. For example, it has long been known that age-associated changes which occur in plasma can inhibit cell proliferation in vitro; also that the time lapse prior to cell migration from ex planted tissue fragments increases with increasing age. These are both examples of the expression in vitro of aging in vivo. More recently, attention has been focused on the occurrence of senescence in vitro. These investi gations have included studies of alterations in non dividing cell cultures, and to a somewhat greater extent, of age-related changes in the proliferative capacity of cells in vitro. For example, cells derived from human fetal lung retain many properties of normal cells including a stable normal diploid karyotype and these cultures have been shown to have a limited life-span in vitro. In addi tion, cultures derived from human adult lung show the same normal characteristics and appear to have a shorter life span than cells derived from fetal lung."

Presently, the need for methods involving separation, identification, and characterization of different kinds of cells is amply realized among immu nologists, hematologists, cell biologists, clinical pathologists, and cancer researchers. Unless cells exhibiting different functions and stages of differ entiation are separated from one another, it will be exceedingly difficult to study some of the molecular mechanisms involved in cell recognition, spe cialization, interactions, cytotoxicity, and transformation. Clinical diagno sis of diseased states and use of isolated cells for therapeutic (e. g., immu notherapy) or survival (e. g, transfusion) purposes are some of the pressing areas where immediate practical benefits can be obtained by applying cell separation techniques. However, the development of such useful methods is still in its infancy. A number of good techniques exist based either on the physical or biological properties of the cells, and these have produced some valuable results. Still others are to be discovered. Therefore, the purpose of this open-ended treatise is to acquaint the reader with some of the basic principles, instrumentation, and procedures presently in practice at various laboratories around the world and to present some typical applications of each technique to particular biological problems."

The study of life is the study of tier upon tier of interlocking homeostatic mechanisms, and the main theme of this book concerns that part of the system that ensures cellular and tissue homeostasis and thus maintains tissue mass, tissue structure and tissue function in the adult mammal. The functional existence of any adult tissue depends on the continuing control of the states of differentiation of its cells. Just as in an embryo, where cellular differentiation is initiated and controlled by the genetic responses of the cells to specific messenger molecules, so also throughout the whole of adult life does the genetic activity of the tissue cells continue to be regulated by similarly specific messenger molecules. The process of differentiation does not cease in the embryo but remains as the essential factor which ensures not only the function but also the continuing existence of the adult tissues. Thus the first problem considered here, the methods of control of cell production, cell function and cell death, is discussed in terms of the nature and mode of action of those messenger molecules which, from moment to moment, determine the states of differentiation of the tissue cells. Some of these messenger molecules are synthesized in adjacent tissues while others are synthesized within the responding tissues themselves.

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker H2AX: from bench science to clinical trials What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children's exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive "liquid biopsy" procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.