Making big science topics just the right size for little readers as we explore the human body. Did you know that your body is two-thirds water? Or that it takes two days for food to go right through your body? The human body is pretty amazing, and we'd like to tell you why... So sit back, and let expert scientist and CBeebies writer Emily Dodd tell you all about the human body. With bite-sized text, facts to make you say 'WOW', and easy-to-understand explanations, big science topics are now just the right size for readers 4 years plus. Brilliantly illustrated by Chorkung, this is the perfect little book for readers who are just discovering all the AMAZING STUFF in the world around them.

Dieses Lehrbuch erfasst examensgerecht alle Teilgebiete der Anatomie: makroskopische Anatomie einschliesslich Topographie, Embryologie, Histologie mit integrierter Zytologie und mikroskopischer Anatomie. Es ist lerngerecht und klinikorientiert durch: Stoffauswahl und Gliederung unter klinischen Gesichtspunkten - "Wie du dem Menschen gegenuberstehst." Aufbau nach dem Modul-Prinzip mit Lernzielen und kurzen Zusammenfassungen - facherubergreifende und funktionelle Aspekte - klinische Hinweise.

Das Werk ist eng mit einem internetbasierten Lernprogramm verbunden (e-learning), das das Buch um einen Atlas der Histologie und der mikroskopischen Anatomie erweitert. Makroskopisch-anatomische Animationen zu ausgewahlten Kapiteln machen Spass und fordern die Lerneffizienz."

Written for yogis of all levels, 'The Anatomy of Yoga Coloring Book' perfectly bridges the gap between anatomy textbook, yoga compendium, and interactive revision tool. The human body is a complex and fascinating machine. Author Jo Ann Staugaard-Jones illustrates just how clever it is by first breaking it down in to its component parts, and then putting it back together in its full glory within the context of yoga movement. Starting with a comprehensive examination of the nervous system, anatomical movement, and all the body systems, the book then truly comes to life as Staugaard-Jones presents over 50 popular asanas describing with color and artistry which muscles are being strengthened (contracting), which are being stretched (lengthened), and which muscles are working as stabilizers to support the pose. Test your knowledge as you color intricate black and white drawings of each asana The seven categories of asanas are presented with prompts to color relevant structures and functions, insightful technique tips, and anatomical nuggets that will enhance your understanding of the science behind your practice. You will learn not only the benefits of each pose but also the contraindications, relevant terminology, and how to vary poses where necessary. The healing heart of yoga What sets this book apart from others is its inclusion of the subtler realm of yoga - that which is referred to as 'energetic anatomy'. Understanding the unseen energies of the body in terms of fascia, bandhas, nadis, and chakras will take you beyond just muscle and joint mechanics, alignment and technique, and connect you more profoundly to the yogic way of life.

This is by far the most exhaustive biography on Niels Stensen, anatomist, geologist and bishop, better known as "Nicolaus Steno". We learn about the scientist's family and background in Lutheran Denmark, of his teachers at home and abroad, of his studies and travels in the Netherlands, Belgium, France, Italy, Austria, Hungary, Bohemia and Germany, of his many pioneering achievements in anatomy and geology, of his encounters with Swammerdam, Malpighi and with members of the newly established Royal Society of London and the Accademia del Cimento in Florence, and with the philosopher Spinoza. It further treats Stensen's religious conversion. The book includes the full set of Steno's anatomical and geological scientific papers in original language. The editors thoroughly translated the original Latin text to English, and included numerous footnotes on the background of this bibliographic and scientific treasure from the 17th century.

Motility is a fundamental property of living systems, from the cytoplasmic streaming of unicellular organisms to the most highly differentiated and de veloped contractile system of higher organisms, striated muscle. Although of motility have a long and in scientific investigations into the mechanisms teresting history, the knowledge of molecular processes, especially in the area of regulation of control of motility, has been developing at an ever more rapid pace with the utilization of multidisciplinary approaches from physiology, cell biology, genetics, biochemistry, pharmacology, and biophysics. In Volume 3, Cell and Muscle Motility continues the same philosophy as that of the preceding volumes. The essays are meant to focus on topics of current interest, to be critical rather than exhaustive, and to indicate the current trends of research efforts. The series is intended to foster an in terchange of concepts among various workers in a variety of disciplines and to serve as a reference for students and workers who wish to familiarize them selves with the most current progress in motility. Robert M. Dowben Jerry W. Shay Dallas vii Contents Chapter 1 Intermediate Filaments in Striated Muscle: A Review of Structural Studies in Embryonic and Adult Skelttal and Cardiac Muscle Maureen C. Price and Joseph W. Sanger 1. Introduction ................................................ ."

This book was not written for contemporary scientists with a major interest in cell biology. Rather, it was prepared for the serious and inquiring student who mayor may not have had an extensive background in the sciences but who is interested in exploring or reviewing in depth the current body of knowledge about cellular structure and function. We have tried to convey a sense of the expectant excitement that characterizes the modem-day cellular biologist and we regret any scientific jargon that may have crept into the text as a result of this effort. We have selected and assimilated experiments done by numerous scien tists and have used them to explain how cells work. In doing this, we have concentrated on animal cells because we know more about them. We have come to a deeper appreciation, while preparing this book, of the limitations in understanding the inner workings of the cell and have come to realize more than ever that we are, in these matters, still "looking through a glass darkly. " An explosively increasing body of knowledge about the cell and its organelles has become available through the diligent work of numerous biologists. Thus it is impractical to attempt to credit each of these scientists for all of their important contributions: The listed references are neither exhaustive nor are they necessarily the first report of a finding."

The Color Atlas of "Xenopus laevis" Histology provides the first central source on the microscopic anatomy of cells, tissues, and major organs of the adult South African clawed frog, Xenopus laevis. For many years, X. laevis has been a highly popular experimental animal model in many areas of research. The recent development of transgenic Xenopus technology offers the promise that this animal model will be utilized more than ever before. The purpose of this book is to provide the active researcher with a central source of high quality light microscopic color images of the tissues of X. laevis, to aid in the identification of the cells and tissues of interest.

Major features of this atlas include:

*277 large, colorful, high resolution light microscopic images of cells, structures, tissues and organs;
*Clear, detailed labeling of important structures in all images;
*Concise, easy-to-read descriptions of histological organization and functions;
*Colorful three-dimensional illustrations that simplify complex structure;
*Detailed presentation of cranial structures and organization;
*Easy-to-use cross-referenced index;
*Bundled CD/ROM containing all images for easy downloading.

Looking for the resource to help your students fully understand and retain critical knowledge of sectional anatomy? Allow us to introduce this new edition of" Introduction to""Sectional Anatomy." Focusing on presenting this highly visual an dynamic topic in a way that makes it engaging and accessible to students, "Introduction to Sectional Anatomy"begins with key terminology and concepts and then moves through the body from head to toe. This new edition has been completely updated to include the most current imaging modalities, including ultrasound, MR, and PET/CT, so your students are fully equipped for what they will encounter in practice. Here's what you can expect to find inside "Introduction to Sectional Anatomy," Third Edition...""- A design that makes it easy for students to compare images from several patients- Clinical cases demonstrating how knowledge of sectional anatomy is applied in practice- Chapter objectives that help students study more efficiently- Clinical application questions at the end of each chapter that review students' understanding of essential concepts

This beautifully illustrated volume brings to life all the excitement and challenge of the study of human anatomy and physiology in one stunning resource! Characterised by its friendly and accessible writing style, each chapter of Anatomy & Physiology, Adapted International Edition, comes with a range of helpful learning features such as Study Hints, Chapter Outlines, Language of Science and Medicine lists, Case Studies, Chapter Summaries and Review- and Critical Thinking Questions. The volume also boasts over 1400 images together with the unique underlying themes entitled the 'Big Picture' and 'Cycle of Life', which serve to emphasize the importance of the interrelationship between systems of the body and how these systems are influenced, in turn, by development and aging. Alongside this emphasis on interdependence and change, comes a focus on homeostasis, which enables the reader to see how the healthy body is one that is carefully tuned and that disease can readily occur when internal balance is disrupted. Anatomy and Physiology, Adapted International Edition, has been fully updated to make full reference European healthcare systems, including drugs, relevant investigations and local treatment protocols. The also book comes with an extensive website facility and accompanying Brief Atlas of the Human Body and Quick Guide to the Language of Science and Medicine. Anatomy & Physiology, Adapted International Edition, will be ideal for students of nursing and allied health professions, biomedical and paramedical science, operating department practice, complementary therapy and massage therapy, as well as anyone studying BTEC (or equivalent) human biology. Please refer to the individual product pages for the duration of access to these products. Unique 'Clear View of the Human Body' allows the reader to build up a view of the body layer by layer Clear, conversational writing style helps demystify the complexities of human biology Content presented in digestible 'chunks' to aid reading and retention of facts Consistent unifying themes, such as the 'Big Picture' and 'Cycle of Life' features, help readers understand the interrelation of body systems and how they are influenced by age and development Accompanying Brief Atlas of the Human Body offers more than 100 full-colour transparencies and supplemental images that cover body parts, organs, cross sections, radiography images, and histology slides Quick Guide to the Language of Science and Medicine contains medical terminology and scientific terms, along with pronunciations, definitions, and word part breakdowns for terms highlighted in the text Numerous feature boxes such as Language of Science and Language of Medicine, Mechanisms of Disease, Health Matters, Diagnostic Study, FYI, and Sport and Fitness provide interesting and important side considerations to the main text More than 1,400 full-colour photographs and spectacular drawings illustrate the most current scientific knowledge and help bring difficult concepts to life Quick Check Questions within each chapter help reinforce learning by prompting readers to review what they just read Chapter outlines, chapter objectives and study tips begin each chapter Outline summaries, review questions, critical thinking questions, and case studies are included at the end of each chapter Study Hints found throughout the text give practical advice to students about mnemonics or other helpful means of understanding or recall Connect IT! features link to additional content online to facilitate wider study Helpful Glossary and Anatomical Directions Ideal for students who are new to the subject, or returning to study after a period of absence, and for anyone whose first language is not English

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine. Radiotherapy is an important part of modern multimodal cancer treatment, and the past several years have witnessed not only substantial improvements in radiation techniques and the use of new beam qualities, but also major strides in our understanding of molecular tumor biology and tumor radiation response. Against this backdrop, the book highlights recent efforts to identify reasonable and clinically applicable biomarkers using broad-spectrum tissue microarrays and high-throughput systems biology approaches like genomics and epigenomics. In particular, it describes in detail how such molecular information is now being exploited for diagnostic imaging and imaging throughout treatment using the example of positron emission tomography. By discussing all these issues in the context of modern radiation oncology, the book provides a broad, up-to-date overview of the molecular aspects of radiation oncology that will hopefully foster its further optimization.

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

This volume presents detailed laboratory protocols for in vitro synthesis of mRNA with favorable properties, its introduction into cells by a variety of techniques, and the measurement of physiological and clinical consequences such as protein replacement and cancer immunotherapy. Synthetic techniques are described for structural features in mRNA that provide investigational tools such as fluorescence emission, click chemistry, photo-chemical crosslinking, and that produce mRNA with increased stability in the cell, increased translational efficiency, and reduced activation of the innate immune response. Protocols are described for clinical applications such as large-scale transfection of dendritic cells, production of GMP-grade mRNA, redirecting T cell specificity, and use of molecular adjuvants for RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences is a valuable and cutting-edge resource for both laboratory investigators and clinicians interested in this powerful and rapidly evolving technology.

The annual meeting of the European Tissue Culture ., Society was held at the Castle of Zinkovy in Czechoslovakia from May 7-10,1969. Included as part of this meeting was a symposium on "Aging in Cell and Tissue Culture." This volume contains the papers presented at that symposium. The use of cell and tissue culture techniques to study the mechanism of aging is not new. For example, it has long been known that age-associated changes which occur in plasma can inhibit cell proliferation in vitro; also that the time lapse prior to cell migration from ex planted tissue fragments increases with increasing age. These are both examples of the expression in vitro of aging in vivo. More recently, attention has been focused on the occurrence of senescence in vitro. These investi gations have included studies of alterations in non dividing cell cultures, and to a somewhat greater extent, of age-related changes in the proliferative capacity of cells in vitro. For example, cells derived from human fetal lung retain many properties of normal cells including a stable normal diploid karyotype and these cultures have been shown to have a limited life-span in vitro. In addi tion, cultures derived from human adult lung show the same normal characteristics and appear to have a shorter life span than cells derived from fetal lung."

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker H2AX: from bench science to clinical trials What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children's exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive "liquid biopsy" procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.

This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care.

Innovative microscopic techniques, introduced during the last two decades, have contributed much to creating a new picture of the dynamic architecture of the cell, which can now be more exactly correlated with specific biochemical and physiopathological events. These developments have led to significant advances in our understanding of the physiomorphological and pathological aspects of the secretory mechanism, as well as the pharmacologic methods used to control, experimentally, the function of exocrine and endocrine glands. The integration of new ultrastructural methods such as freeze-fracture/etching, immunocytochemistry, scanning and high-voltage electron microscopy, cytoautoradiography, etc. , has proven to be of great value when applied to the study of endocrine cells and tissues. Because information on this topic has appeared in a variety of scientific and medical journals, this book: (1) reviews the results of an integrative approach presenting a comprehensive ultrastructural account of the main aspects of the field; (2) points out gaps or controversial topics in our knowledge; and (3) outlines pertinent directions for future research. The chapters, prepared by recognized authorities in the field, present traditional information on the topic in a concise manner and, with a valuable selection of original illustrations, show what the integration of new microscopic methods can contribute to the subject in terms of new concepts. This volume will be useful to cell biologists, anatomists, embryologists, histologists, pharmacologists, pathologists, and, of course, endocrinologists. It will also be of interest to students, practitioners of medicine, and to all others dealing with clinical research and diagnosis.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to provide a means and design of future cancer prevention strategies and challenges thereupon. The volume also explores various receptor drugs that are in development process with the emphasis of inhibitors used to prevent malignant gene expression. The book bridges the gap between basic science and clinical application of current knowledge of cancer and emphasizes that tumor progression and cancer metastasis are not random - treatments and cure are logical and eventual. Expertly authored and drawing from a wealth of international perspectives, Molecular Targets and Strategies in Cancer Prevention is invaluable reading for clinicians and researchers in the fields of oncology and molecular biology.

The fascinating area of Nutrigenomics describes this daily communication between diet, food and nutrients, their metabolites and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannas of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life, and our life-long "chat" with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. We are not aiming to compete with more comprehensive textbooks on molecular nutrition, evolutionary biology, genomics, gene regulation or metabolic diseases, but rather will focus on the essentials and will combine, in a compact form, elements from different disciplines. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule "a picture tells more than thousand words". The content of this book is based on the lecture course "Nutrigenomics", which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book is subdivided into three sections and twelve chapters. Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively. Besides its value as a textbook, Nutrigenomics will be a usefull reference for individuals working in biomedicine.

Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.

This volume, with contributions from the most recognized experts in preventive strategies in breast cancer, presents the accepted as well as the novel ideas that have been introduced for the prevention of breast cancer. There is no single preventive agent that can stop the incidence of breast cancer-the malignant disease most frequently diagnosed in women of all races and nationalities. Furthermore, its incidence around the globe is increasing in industrialized countries. The worldwide incidence of breast cancer has increased 30-40% since the 1970s, reaching an excess of 1,390,000 new cases and a mortality of more than 460,000 cases in 2015. Therefore, what is needed is the development of rational strategies for the prevention of this fatal disease.

This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.

This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.