0
Your cart

Your cart is empty

Browse All departments
Price
  • R0 - R50 (1)
  • R50 - R100 (3)
  • R100 - R250 (175)
  • R250 - R500 (274)
  • R500+ (2,294)
  • -
Status
Format
Author / Contributor
Publisher

Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > General

Circadian Clock - Regulations, Genetic and External Factors (Paperback): Nathaniel Hayes Circadian Clock - Regulations, Genetic and External Factors (Paperback)
Nathaniel Hayes
R2,046 Discovery Miles 20 460 Ships in 10 - 15 working days

In this collection, the authors review temporal control of tissue homeostasis and repair by the circadian system. The molecular regulation of circadian timing has been well-characterized in several species as a highly conserved transcriptional feedback loop that maintains roughly 24-hour cellular periodicity. A current challenge is determining how the outputs of the master clock affect peripheral oscillators and numerous biological processes. A subsequent study seeks a more detailed understanding of the physiology and molecular mechanism underlying circadian changes in the plasma of glucose, which might allow for the identification of novel targets for the developing therapeutic approached to the diabetes and obesity diseases. Procambarus acanthophorus, a burrower crayfish, follows a nocturnal circadian rhythm due to the way it spends long periods of time building tunnels to reach the water table during the dry season. Therefore, it follows that this species must have a close relationship with soil. The authors suggest that soil might be an ecological factor with high perceived value, influencing ecological aspects, and physiological functions such as growth, reproduction, and organization of the circadian system. The genes involved in the maintenance of circadian rhythm and its impact on the immunological system are described as disruption of the circadian rhythm leads to significant alterations of the organism and is associated with several biological responses. In the concluding review, some of the most useful characteristics of zebrafish for studying the molecular, cellular, and behavioral aspects of the circadian clock system are described. Zebrafish have been established as an attractive vertebrate model for the examination of light signaling pathways and their impact on the cellular clock because zebrafish cellular clocks have an unusual attribute of being directly light responsive. Additionally, the molecular components of the mammalian and zebrafish cellular clocks are highly similar.

Handbook of Transcription Factor NF-kappaB (Hardcover): Sankar Ghosh Handbook of Transcription Factor NF-kappaB (Hardcover)
Sankar Ghosh
R4,336 Discovery Miles 43 360 Ships in 10 - 15 working days

Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is proving to be the most protean of all transcription factors. It has been shown to function in most cell types as a key regulator of a number of inducible genes. Research on the responsibilities and resulting pathologies of NF-kB has been prolific, but until now there has been no consolidated, multidisciplinary reference.
Providing contributions from leading authorities involved with seminal discoveries on the subject, Handbook of Transcription Factor NF-kappaB is an entry point to understanding the broad role of this widely studied factor. Beginning with a summary, the authors introduce the uninitiated reader to the complexities of the NF-kB system. They explain how a multitude of extracellular and intercellular signals integrated at the level of this transcription factor have led to fundamental insights about many aspects of gene regulation and signal transduction.
The chapters delve into specific research aspects concerning the function and regulation of NF-kB in a number of biological systems. They discuss inflammation, innate and adaptive immunity, liver integrity, and nervous system development, as well as the formation of hair, skin, teeth, and many other aspects of the developing vertebrate body. The pathological effects of excess NF-kB activity are addressed in chapters on diseases related to chronic inflammation, such as heartdisease, muscular dystrophy, cancer, and tumor proliferation, as well as diseases caused by inherent deficiencies in NF-kB. The text culminates in a discussion of current efforts to develop therapies aimed at inhibiting the aberrant activity of NF-kB in different diseases.

Frog Coloring Book - 30 Simple Frog Line Drawing Coloring Pages (Paperback): Crystal Coloring Books Frog Coloring Book - 30 Simple Frog Line Drawing Coloring Pages (Paperback)
Crystal Coloring Books
R167 Discovery Miles 1 670 Ships in 7 - 11 working days
A Textbook of Practical Medicine - With Particular Reference to Physiology and Pathological Anatomy: Volume 2 of a Text-Book of... A Textbook of Practical Medicine - With Particular Reference to Physiology and Pathological Anatomy: Volume 2 of a Text-Book of Practical Medicine (Paperback)
Felix Von Niemeyer, George Hoppin Humphreys, Charles Elihu Hackley
R843 Discovery Miles 8 430 Ships in 7 - 11 working days
Transactions of the Section on Surgery and Anatomy of the American Medical Association at the ... Annual Meeting; Volume 59... Transactions of the Section on Surgery and Anatomy of the American Medical Association at the ... Annual Meeting; Volume 59 (Paperback)
American Medical Association. Section On
R717 Discovery Miles 7 170 Ships in 7 - 11 working days
Atlas on the Comparative Anatomy of the Retinae of Vertebrates (Paperback): Maria S M Wai, Winnie W Y Li, David T Yew Atlas on the Comparative Anatomy of the Retinae of Vertebrates (Paperback)
Maria S M Wai, Winnie W Y Li, David T Yew
R2,683 R2,458 Discovery Miles 24 580 Save R225 (8%) Ships in 7 - 11 working days
A AND P II Lab Manual (Spiral bound): Tyler Karns A AND P II Lab Manual (Spiral bound)
Tyler Karns
R1,505 Discovery Miles 15 050 Ships in 10 - 15 working days
Speed Learning for Anatomy - Systems and Functions of the Human Body Quick and Easy (Paperback): Justina C Bachsteiner Ph D Speed Learning for Anatomy - Systems and Functions of the Human Body Quick and Easy (Paperback)
Justina C Bachsteiner Ph D
R450 Discovery Miles 4 500 Ships in 7 - 11 working days
Anatomy - Notebook (Paperback): Wild Pages Press Anatomy - Notebook (Paperback)
Wild Pages Press
R173 Discovery Miles 1 730 Ships in 7 - 11 working days
Frog Coloring Book - A Stress Relief Adult Coloring Book Containing 30 Frog Pattern Coloring Pages (Paperback): Crystal... Frog Coloring Book - A Stress Relief Adult Coloring Book Containing 30 Frog Pattern Coloring Pages (Paperback)
Crystal Coloring Books
R167 Discovery Miles 1 670 Ships in 7 - 11 working days
Basics of Human Anatomy for Students of Medical & Allied Health Sciences - General Anatomy and General Histology - Vol.1... Basics of Human Anatomy for Students of Medical & Allied Health Sciences - General Anatomy and General Histology - Vol.1 (Paperback)
Dr Najma Mobin
R252 Discovery Miles 2 520 Ships in 7 - 11 working days
Integrative Anatomy Review (Hardcover): Robert Tyler Morris Integrative Anatomy Review (Hardcover)
Robert Tyler Morris
R2,755 Discovery Miles 27 550 Ships in 7 - 11 working days
Potassium Channels in Health and Disease (Paperback): Hiroaki Kume Potassium Channels in Health and Disease (Paperback)
Hiroaki Kume
R2,423 Discovery Miles 24 230 Ships in 10 - 15 working days

Potassium ion (K+) channels are ubiquitous components and are widely distributed on the surface of the cell membrane in various tissues. There are many types of potassium ion channels (voltage-gated K+ channels, ATP-sensitive K+ channels, Ca2+-activated K+ channels, etc.), and each type of potassium ion channel has its own characteristic features concerning electrophysiology and molecular biology in each potassium ion channel. The potassium ion current across the plasma membrane is considered to have two main physiological functions, one for determining the membrane potential and the other regulating the electrical activity. Membrane hyperpolarization would reduce the excitability of the membrane by shifting the membrane potential away from the threshold for excitation and would inhibit, where it existed, calcium ion (Ca2+) influx through voltage-gated Ca2+ channels by closing the Ca2+ channel. Outward potassium ion currents activated upon depolarization would counteract the depolarizing action of inward currents carried either by sodium ion (Na+) or Ca2+. Therefore, potassium ion channels show the physiological effects in each tissue via membrane potential mediated Ca2+ dynamics (for example, excitation-contraction coupling in muscle). Potassium ion channel activity is also essentially regulated by the intracellular signal transduction pathways, such as receptors (G proteins) second messenger molecules processes in the physiological condition. On the other hand, the modification of potassium ion channel activity would be expected to have a significant effect on the excitability of various cells. Therefore, augmentation of outward potassium ion currents may be useful to treat various diseases (asthma, chronic pulmonary obstructive disease, hypertension, diabetes mellitus, glaucoma, arrhythmias, heart failure, epilepsy, etc.). Furthermore, potassium ion channels may be a target protein for the research and development of a therapeutic agent for various diseases concerning the lungs, heart, nerves, eyes, and pancreas. However, there are few books described in detail about potassium ion channels. This book will focus on the characteristics, function and regulation of several types of potassium ion channels, focusing on the role of these channels not only in terms of physical responses, but also in the aforementioned diseases.

Human Anatomy (Paperback): Introbooks Human Anatomy (Paperback)
Introbooks
R140 Discovery Miles 1 400 Ships in 7 - 11 working days
Human Atlas of Topographical and Functional Anatomy - The Nervous System and Analyzers (Paperback): Mircea Ifrim Human Atlas of Topographical and Functional Anatomy - The Nervous System and Analyzers (Paperback)
Mircea Ifrim
R1,953 Discovery Miles 19 530 Ships in 7 - 11 working days
Anatomy - Notebook (Paperback): Wild Pages Press Anatomy - Notebook (Paperback)
Wild Pages Press
R173 Discovery Miles 1 730 Ships in 7 - 11 working days
Atlas of Human Anatomy (Paperback): Mark T. Nielsen, Shawn D. Miller Atlas of Human Anatomy (Paperback)
Mark T. Nielsen, Shawn D. Miller
R2,229 Discovery Miles 22 290 Ships in 10 - 15 working days

This book will motivate and engage health professionals to learn the essentials of anatomy and physiology through its visual approach and special pedagogy. The condensed content covers the basics without extensive detail. Core concepts are presented visually to enable them to gain a better understanding of the material. Process diagrams are integrated throughout the chapters to guide health professionals through the material.

Anatomy Coloring Workbook, 4th Edition - An Easier and Better Way to Learn Anatomy (Paperback, 4th Revised edition): The... Anatomy Coloring Workbook, 4th Edition - An Easier and Better Way to Learn Anatomy (Paperback, 4th Revised edition)
The Princeton Review
R561 R411 Discovery Miles 4 110 Save R150 (27%) Ships in 10 - 15 working days
Clinical Correlates in Anatomy and Physiology (Hardcover): Mary Katherine Lockwood Clinical Correlates in Anatomy and Physiology (Hardcover)
Mary Katherine Lockwood
R2,099 Discovery Miles 20 990 Ships in 7 - 11 working days
Human Anatomy Notebook (Paperback): Wild Pages Press Human Anatomy Notebook (Paperback)
Wild Pages Press
R173 Discovery Miles 1 730 Ships in 7 - 11 working days
Bein Und Statik (German, Hardcover, 2nd 2., Neubearb. Aufl. 1972. Sonderausgabe ed.): Johannes Lang, W. Wachsmuth Bein Und Statik (German, Hardcover, 2nd 2., Neubearb. Aufl. 1972. Sonderausgabe ed.)
Johannes Lang, W. Wachsmuth
R3,105 R2,795 Discovery Miles 27 950 Save R310 (10%) Ships in 10 - 15 working days

Der "Lanz/Wachsmuth" ist ein Begriff - als opulent ausgestattete Darstellung der menschlichen Anatomie, als Brucke zwischen anatomischem Wissen und klinischem Handeln, als unerschopfliche Informationsquelle zu den subtilsten Details.

Mit der unveranderten Sonderausgabe, die 7 Bande aus den Jahren 1955 bis 1993 umfasst, wird der "Lanz/Wachsmuth" wieder einem breiten Interessentenkreis zuganglich gemacht.

Durch die Qualitat der Abbildungen, den Detailreichtum der Beschreibungen, den konsequenten klinischen Bezug, das ausfuhrliche Eingehen auf Verlaufsvarianten von Gefassen und Nerven und auf Normvarianten bleibt der "Lanz/Wachsmuth" auch im 21. Jahrhundert ein zeitlos aktuelles Werk."

Kopf - Teil B, Gehirn- Und Augenschadel (German, Hardcover, 1. Aufl. 1979. Sonderausgabe 2003 ed.): Johannes Lang Kopf - Teil B, Gehirn- Und Augenschadel (German, Hardcover, 1. Aufl. 1979. Sonderausgabe 2003 ed.)
Johannes Lang
R3,741 R3,367 Discovery Miles 33 670 Save R374 (10%) Ships in 10 - 15 working days

Der "Lanz/Wachsmuth" ist ein Begriff - als opulent ausgestattete Darstellung der menschlichen Anatomie, als Brucke zwischen anatomischem Wissen und klinischem Handeln, als unerschopfliche Informationsquelle zu den subtilsten Details.

Mit der unveranderten Sonderausgabe, die 7 Bande aus den Jahren 1955 bis 1993 umfasst, wird der "Lanz/Wachsmuth" wieder einem breiten Interessentenkreis zuganglich gemacht.

Durch die Qualitat der Abbildungen, den Detailreichtum der Beschreibungen, den konsequenten klinischen Bezug, das ausfuhrliche Eingehen auf Verlaufsvarianten von Gefassen und Nerven und auf Normvarianten bleibt der "Lanz/Wachsmuth" auch im 21. Jahrhundert ein zeitlos aktuelles Werk."

The Anatomy Coloring Book (Paperback): Jeffrey Harper The Anatomy Coloring Book (Paperback)
Jeffrey Harper
R205 Discovery Miles 2 050 Ships in 7 - 11 working days
The A to Z of the Major Organs (Paperback, 2nd Revised edition): Amanda Neill The A to Z of the Major Organs (Paperback, 2nd Revised edition)
Amanda Neill
R509 Discovery Miles 5 090 Ships in 10 - 15 working days
Commemorations And Memorials: Exploring The Human Face Of Anatomy (Hardcover): Goran Strkalj, Nalini Pather Commemorations And Memorials: Exploring The Human Face Of Anatomy (Hardcover)
Goran Strkalj, Nalini Pather
R2,312 R2,157 Discovery Miles 21 570 Save R155 (7%) Ships in 10 - 15 working days

A major component of many modern human anatomy programs is commemorating people who have donated their body for education and research. In addition, some institutions have also organized memorial places to honor the body donors. This book is an edited volume which explores the phenomena of commemorations and memorials in anatomy. It includes both descriptive papers focusing on the content of the ceremonies and theoretical papers contextualizing and examining these within the broader ethical, scientific, medical and educational frameworks. Building up on the idea of a community of practice, the main objective of the volume is to enhance the exchange of ideas and sharing of experiences. The concepts of 'commemoration' and 'memorial' in anatomy programs are presented as emerging. They are seen as phenomena that will continue to evolve and ramify within different cultural and educational contexts, and this volume is expected to facilitate these processes. Indeed, meager literature on the topic indicates potentially enormous practical value in sharing and combining practices from different cultural and teaching/research traditions.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Sobotta Atlas of Anatomy, Vol.1, 16th…
Friedrich Paulsen, Jens Waschke Hardcover R1,520 R1,289 Discovery Miles 12 890
The Concise Book of Muscles Fourth…
Chris Jarmey Paperback  (1)
R616 R503 Discovery Miles 5 030
Anatomy and Physiology - Adapted…
Kevin T. Patton, Gary A. Thibodeau, … Hardcover R1,777 R1,664 Discovery Miles 16 640
An Introductory Guide to Anatomy…
Louise Tucker Paperback R547 R510 Discovery Miles 5 100
Lippincott Atlas of Anatomy
Thomas R. Gest Paperback R1,405 R1,289 Discovery Miles 12 890
Neuroanatomy Atlas in Clinical Context…
Duane E. Haines Paperback R1,361 R1,142 Discovery Miles 11 420
Sobotta Dissection Atlas - Bilingual…
Friedrich Paulsen, Jens Waschke Spiral bound R1,218 R1,140 Discovery Miles 11 400
Tortora's Principles of Anatomy and…
Gerard J. Tortora, Bryan H. Derrickson Paperback R1,669 R1,533 Discovery Miles 15 330
Not available
Geillustreerde gids tot die menslike…
Collectif Quebec-Amerique Paperback R120 Discovery Miles 1 200

 

Partners