Psychiatric disorders in adolescents are an important social problem which is relevant to almost all healthcare professionals. According to the results of The National Comorbidity Survey-Adolescent Supplement (NCS-A), the lifetime prevalence of anxiety, behavior, mood, and substance use disorders among adolescents was 31.9%, 19.1%, 14.3%, and 11.4%, respectively. Approximately 40% of participants in this survey with one class of disorder also met criteria for another class of lifetime disorder. Comorbidity is increasingly recognized as a key feature of mental disorders among adolescents. Female adolescents are more likely than males to have mood and anxiety disorders, but less likely to have behavioral and substance use disorders. Regretfully, medical professionals are not sufficiently trained about adolescent psychiatric disorders. For example, primary care providers correctly identify less than a fourth of youth with a depressive or anxiety disorder. Also, many clinicians underestimate the importance of the problem of adolescent psychiatric illnesses and suicidal behavior. Lack of skilled medical providers impedes the delivery of needed services to adolescents with mental health issues. This coupled with a lag in the ability of primary health care services to incorporate psychiatric interventions, and a failure of public health initiatives to pay attention to adolescent mental health problems has led to continuing gaps in care over decades despite the public pronouncements of needs. In this book you will find relevant information for health professionals, since we believe that the mental health of adolescents is essential for sustaining healthy and productive societies.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action.

A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH."

Aggressive behavior among children and adolescents has confounded parents and perplexed professionals-especially those tasked with its treatment and prevention-for countless years. As baffling as these behaviors are, however, recent advances in neuroscience focusing on brain development have helped to make increasing sense of their complexity.

""

Focusing on their most prevalent forms, Oppositional Defiant Disorder and Conduct Disorder, "Disruptive Behavior Disorders" advances the understanding of DBD on a number of significant fronts. Its neurodevelopmental emphasis within an ecological approach offers links between brain structure and function and critical environmental influences and the development of these specific disorders. The book's findings and theories help to differentiate DBD within the contexts of normal development, non-pathological misbehavior and non-DBD forms of pathology. Throughout these chapters are myriad implications for accurate identification, effective intervention and future cross-disciplinary study.

Key issues covered include:

Gene-environment interaction models.Neurobiological processes and brain functions.Callous-unemotional traits and developmental pathways.Relationships between gender and DBD.Multiple pathways of familial transmission.

"Disruptive Behavior Disorders" is a groundbreaking resource for researchers, scientist-practitioners and graduate students in clinical child and school psychology, psychiatry, educational psychology, prevention science, child mental health care, developmental psychology and social work.

Volume I of Theory and Research in Behavioral Pediatrics focused on issues of early human development, with special emphasis given to assessment of the preterm infant and to factors inftuencing the organization of the caregiver infant relationship. Chapters in Volume 2 cover a broader range of topics and encompass a wider age span. Chapter I provides a historical review of the relationship between developmental psychology and pediatrics. The authors, Barbara R. Tinsley and Ross D. Parke, discuss differences between behavioral pediatrics and pediatric psychology and note that interdiscipli nary collaboration in research and application has increased steadily in re cent years. However, if similar collaborative efforts are to occur in education and training of pediatricians and developmental psychologists, it will be necessary to determine just what each discipline hopes to gain from such collaborative efforts. Tinsley and Parke report the results of anational survey designed to determine the areas of developmental psychology that pediatricians perceive to be of potential benefit to them in their delivery of pediatric care. Results of the survey suggest that there are many ways in which developmental psychology could be in corpora ted into the pediatric curriculum. In many respects, Chapter 2 sets the stage for the remaining chapters. Nancy A. Carlson and Thomas Z.

One of the founders of the field of pediatric rheumatology, Dr. Jerry C. Jacobs, comprehensively discusses the care of children with rheumatic diseases and musculoskeletal disorders in this clinical reference. The author has completely revised and updated the text and references. A significant portion of the book is devoted to differential diagnosis; in fact, one of the book's strongest points is the detailed, illustrated description of the physical examination of joints in children. From the reviews of the first edition: "The section on the differential diagnosis of arthritis is the most comprehensive treatise of the subject that I have seen." #New England Journal of Medicine#1 "This is a book that one can pick up and read sections of and go back to again and again, and as such should be readily available wherever people are caring for children with joint complaints." #British Medical Journal#2 "Photographs, both clinical and pathological, radiographs, tables and graphs appear on almost every page and the layout is good so that the text is attractive as well as readable." #British Journal of Rheumatology#3 "...deals with all the facets of rheumatism or arthritis likely to be met with in the clinic. ...Above all the book is user friendly: very comprehensive index sections facilitate access to material, and the provision of many lists and summary tables helps in the location and clarification of information. ...The whole results in a book that is pleasant and surprisingly easy to read ...it would form an ideal library copy, both for selective reading and reference, and should be read by all paediatric rheumatologists." #The Lancet#4

Four years ago the National Institutes of Child Health and Human Development (NICHD) brought together a group of scientists to Belmont, Maryland to examine the status of human milk banking. During those deliberations, the idea was generated to organize a series of research conferences concerning human lactation and the composition and biological effects of human milk. The first one, organized by Robert G. Jensen from the University of Connecticut and Margaret C. Neville from the University of Colorado, dealt with methodologic issues. An additional meeting to explore the effects of maternal and environmental factors upon human lactation and the composition of human milk was organized by Margit Hamosh from Georgetown University and me, and was held in January, 1986 in Oaxaca, Mexico. Those meetings provided the foundation for the design of the present conference, 'The Effects of Human Milk Upon the Recipient Infant'. In addition to a grant from the NICHD, the conference was generously supported by Milupa AG from the Federal Republic of Germany; Wyeth Limited and Mead Johnson of Canada; and Ross Laboratories, Heinz USA, the Mead Johnson Nutritional Group, Wyeth International Limited, Gerber Products Company, the La Leche League International, Glaxo Incorporated and Sandoz Pharmaceutical Corporation from the United States.

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing's sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail. The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation. Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma. Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

As we move into the 21st century it is becoming increasingly difficult to offer appropriate introductory clinical experiences for medical students. Many schools offer clinical experiences in the first year of medical school, when the learner has little background in the traditions and origins of the doctor-patient interaction. Others begin this process in the second year, after a professional language base has been established, but concise educational materials are scarce that integrate the meaning of the privileged clinical encounter with the process and content of interviewing and examining patients. In the tertiary hospitals, where most medical schools are based, the educators must provide an orienta tion to the clinical encounter, an intensely personal experience, in the midst of glittering technological marvels that easily distract both the novice physician and the wizened teacher. Understanding the context and historical basis for the privilege of interviewing and examining another person about intimate matters relating to health and disease is essential to this process. Considering these factors, this textbook is written to assist medical educators and medical students involved in early clinical training. As the demand for "high-tech" medicine has accelerated, so has the public concern over the loss of "high-touch" or compassionate, humane interactions with physicians. Physicians are perceived as more concerned with readouts from machines and fiberoptic views of the patient than with understanding and car ing about the people we have labeled as patients."

This book describes key knowledge concepts, skills and up-to-date algorithms pertaining to common emergencies that can take place in a pediatric office, including: seizures, anaphylaxis and shock, and diabetic ketoacidosis. The authors supported by peer review from top specialists in Pediatric Emergency Medicine at the Baylor College of Medicine offer the first comprehensive educational resource on pediatric office emergency preparedness devoted exclusively to the practicing primary care health care provider and his/her team. During emergencies, providers and their staff are called on to work efficiently as a "code-team" which is a source of considerable apprehension for many primary care pediatricians. This unique reference guide contains a wealth of information and resources in a compact and practical form. It presents the most important knowledge, skills, office resources and team interactions required by practitioners to successfully treat pediatric emergencies in the office.

Authored by "a superb clinician and award-winning teacher,"* Near Misses in Pediatric Anesthesiology, Second Edition is a thorough updating and significant expansion of this popular case book in the newest anesthesiology subspecialty to be approved by the American Board of Medical Specialties. The book comprises 87 true-story clinical "near misses," including 40 cases that are brand new. Recommendations, references, and discussion accompany each case. The cases provide an ideal basis for problem-centered learning and also model how to learn from experience and to maintain professionalism during the lifelong development of clinical expertise. Dr. Brock-Utne's latest case book provides a pediatric complement to his bestselling Case Studies of Near Misses in Clinical Anesthesia (Springer, 2012) and Clinical Anesthesia: Near Misses and Lessons Learned (Springer, 2008) . * Jay B. Brodsky, MD, from the Foreword.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Hyperbilirubinemia of the neonate and the related risk of brain damage with conseguent important alterations in motor development, particularly in sick preterm babies, remains a major problem in nurseries throughout the world. Since its introduction in the 1950's phototherapy has been used for reducing serum bilirubin concentrations in the newborn with hyperbilirubinemia; however, only recently the photoprocesses invoked by light on various substrates including bilirubin have been clari fied in sufficient detail. Light treatment actually exemplifies the intimate relationship between the clinical and basic sciences: the better understanding of the mechanism of phototherapy as a result of investigations initiated in the laboratory has been extended to the bedside as new types of lamps or new schedules of treatment. As a consequence, phototherapy of hyperbilirubinemia has emerged as a well-established branch of photomedicine, based on molecular photo biology, scientific method, and creative use of physics and sophis ticated electrooptical capabilities. The collaboration and exchange of information between workers in different basic and clinical di sciplines is likely to stimulate a further optimization of photo therapy. The purpose of this monograph is to discuss some of the new aspects of bilirubin metabolism and phototherapeutic treatment. Bilirubin conjugation in the fetal and early neonatal life, the mechanism of bilirubin entry into the brain, the measurements of bilirubin concentration in the skin and serum bilirubin binding capacity are discussed by a number of prominent neonatologists."

Discrimination of self from nonself is the major function of the immune system and understanding the mechanism(s) involved a main employer of immunologists. Hence, the age-old puzzle of why a fetus that contains a panel of major histocompatibility (MHC) antigens derived from its mother and its father is not rejected (spontaneously aborted) by lymphocytes from its mother who should theoretically recognize foreign MHC molecules from the father has remained of great interest. This dilemma has enticed immunologists and developmental biologists for many years. This volume was created to present the information currently on hand in this subject to the scientific public. The guest editor, Professor Lars Olding, has a long and distinguished history of contributions in this field, having been one of the main propo nents of the argument that lymphocytes from the fetus play an active role in this process by suppressing lymphocytes from the mother from proliferating and thereby acting as killer cells. His work has defined the phenomenon and identified suppressor molecules (factors) involved in the process. In a different but related chapter, Margareta Unander extends such observations to the clinical study of women with repeated "habitual" mIS carriages."

This volume offers a theoretical and practical overview of the ethics of pediatric medicine. It serves as a fundamental handbook and resource for pediatricians, nurses, residents in training, graduate students, and practitioners of ethics and healthcare policy. Written by a team of leading experts, Pediatric Bioethics addresses those difficult ethical questions concerning the clinical and academic practice of pediatrics, including an approach to recognizing boundaries when confronted with issues such as end of life care, life-sustaining treatment, extreme prematurity, pharmacotherapy, and research. Thorny topics such as what constitutes best interests, personhood, or distributive justice and public health concerns such as immunization and newborn genetic screening are also addressed.

Increasingly, global humanitarian efforts are focusing on improving the lives of children. And among the developing world, the African nations are particularly affected by extreme weather conditions, devastating pandemics, and armed conflict. Neurocognitive science offers significant avenues toward bringing needed aid to the continent while creating a template for helping children worldwide.

The studies in "Neuropsychology of Children in Africa" clearly illustrate how the brain develops and adjusts in the face of adversity. Contributors span assessment approaches and public health risk factors, and represent established topics and emerging lines of research, including biocultural constructs and genomic technologies. Together, these chapters argue for methodology that is culturally sensitive, scientifically rigorous, consistent, and sustainable. And although the focus is pediatric, the book takes a lifespan approach to prevention and intervention, modeling a universal framework for understanding neurocognitive development. Included in the coverage:

Assessment of very young children in Africa in the context of HIV.Psychosocial aspects of malnutrition among African children.Assessment of neuropsychological outcomes in pediatric severe malaria.Neurodisability screening using the Ten Questions questionnaire.The neuropsychology of sickle cell disease in West African children.Computerized Cognitive Rehabilitation Therapy for African children.

As a guide to current findings or a springboard for new studies, "Neuropsychology of Children in Africa" is a necessary reference for researchers, policymakers, and diverse professionals in global aid organizations, and across the discipline.

"

Pediatric Urology: Evidence for Optimal Patient Management provides pediatric urologists the information needed for state-of-the-art patient care. Chapters are organized around pertinent clinical questions within major areas of pediatric urology, answered using the best available data while also reporting areas for which there is poor evidence. The text includes randomized controlled trials and prospective observational studies, tables that summarize important studies, and figures that illustrate algorithms with best options for management and their expected results. With an easy to use format not found in other volumes, Pediatric Urology: Evidence for Optimal Patient Management is an indispensible and unique resource for experienced pediatric urologists, pediatric surgeons, general urologists with an interest in pediatric urology, as well as fellows and residents in training.

Fundamentals of Clinical Practice, Second Edition presents medical students with a comprehensive guide to the social ramifications of a physician's work, and more experienced practitioners with the tools to augment their own patient-centered techniques.

Over the past two decades, the assessment of Attention-Deficit/Hyperactivity Disorder (AD/HD) has evolved into a sophisticated balance of science and clinical judgement essential for arriving at reliable and valid diagnostic de- sions. Because of the precarious mix of clinical and empirical skill needed to evaluate children with this disorder, diagnostic practice in this area has been found wanting by many critics. In fact, a 1998 National Institutes of Health consensus panel concluded that "existing diagnostic treatment practices ... point to the need for improved awareness by the health service sector conce- ing an appropriate assessment, treatment, and follow-up. A more consistent set of diagnostic procedures and practice guidelines is of utmost importance" (p. 21). Drs. Arthur D. Anastopoulos and Terri L. Shelton have designed a book that addresses this need. A number of themes are highlighted throughout the text. Perhaps the most important is that the assessment guidelines set forth in this book represent a balance between science and practice. The authors account for the realities of clinical practice in an age of managed care while challenging clinicians to heed the lessons of empirical research. Although the use of empirically based asse- ment procedures may at times fly in the face of cost constraints (e. g. , systematic evaluation of medication effects), the authors present a strong argument for them. Further, they call upon their vast clinical experience to provide concrete suggestions for translating research findings into effective evaluations.

Sexual Orientation in Child and Adolescent Health Care serves as a resource for child health care professionals including pediatricians, family physicians, nurses, pediatric psychologists, child and adolescent psychiatrists, and social workers. The issues of sexuality and sexual orientation now generate great interest among those who treat children. This volume describes the effects of stigmatization on non-heterosexual physicians, patients, and students, and discusses a variety of clinically relevant topics including the development of sexual orientations, children of gay or lesbian parents, young children with gender atypical behavior, and the healthcare needs of gay and lesbian adolescents. The last two chapters describe methods for improvement in medical education and medical care, and provide extensive resources available to professionals and consumers.

As the pastPresident ofthe Israel Society forAutism, it gives me great pleasure to c- gratulate Professor Schopler and his colleagues on the publication of their new book concerning the relationship between scientific research and treatment. When we in Israel began our specifically structured education program for young children with autism, our work was based on slim to scarceknow-how andinformation, and with no experience whatsoever. Whatever information we could gather was mostly from psychological educational centers in the U.S. One of the most important and significant connections was established between the TEACCH program of North Carolina, led and conducted by the two important scholars, Professor Eric Schopler and Professor Lee Marcus, and our Israel Society for Autism. During our many encounters, seminars, and conferences, we profited enormously from all their accumulated expertise and scientific research, while perhaps it was also an important experience for them to see how a young society with very limited means was eventually shaping its educational program and arriving at some excellent results. We, ofcourse, have the highest esteem for Governor Hunt who has been following this program with so much attention and support, and we still remember his visit to Israel with distinguished representatives of the TEACCH Program. I wish the new book every success. I know it will be an enormous contribution to all those who must cope with a difficult and painful issue-autism-for whom there is no end to the need for research and continuously improving methods of care and education.

Proceedings of the 9th International Conference of the International Society for Research in Human Milk and Lactation (ISRHML), October 2-6, 1999, Bavaria, Germany. The quality of infant feeding is of major importance for child health development and well being, and breast feeding is the natural form of supplying food to the infant and is considered to be ideally adapted to the needs of both mother and child. This contributed volume therefore, brings together the research on the physiological foundations and on the biological effects of breast feeding, both short and long term. This book contains the work of scientists from over thirty countries, many of whom are leading researchers in their fields, and details papers presented by the invited speakers of the conference and short summaries of presentations of original research results.

In this volume, Kathleen Nader has compiled an articulate and comprehensive guide to the complex process of assessment in youth and adolescent trauma. There are many issues that are important to evaluating children and adolescents, and it is increasingly clear that reliance on just one type of assessment does not provide the most accurate results. From history to recent advances, this book covers a wide range of methods and measures for assessing trauma, including case examples to illustrate the integration of these different facets. Altogether, the broad scope and inclusive depth of this work make it an essential addition to the field of trauma assessment.