Fermentation: A Practical Approach is a collection of methods and techniques covering the setting up and use of fermentation units in academic research and industrial laboratories. The emphasis is on the breadth of usage of small-scale fermenters and the interdisciplinary nature of fermentation itself. The topics covered include fermentation modelling, sterilization, and instrumentation. This area of research has many important industrial applications, as evidenced by the affiliations of the authors (Hoechst, ICI, Beecham Pharmaceuticals).

Many students find it daunting to move from studying environmental science, to designing and implementing their own research proposals. This book provides a practical introduction to help develop scientific thinking, aimed at undergraduate and new graduate students in the earth and environmental sciences. Students are guided through the steps of scientific thinking using published scientific literature and real environmental data. The book starts with advice on how to effectively read scientific papers, before outlining how to articulate testable questions and answer them using basic data analysis. The Mauna Loa CO2 dataset is used to demonstrate how to read metadata, prepare data, generate effective graphs and identify dominant cycles on various timescales. Practical, question-driven examples are explored to explain running averages, anomalies, correlations and simple linear models. The final chapter provides a framework for writing persuasive research proposals, making this an essential guide for students embarking on their first research project.

Many students find it daunting to move from studying environmental science, to designing and implementing their own research proposals. This book provides a practical introduction to help develop scientific thinking, aimed at undergraduate and new graduate students in the earth and environmental sciences. Students are guided through the steps of scientific thinking using published scientific literature and real environmental data. The book starts with advice on how to effectively read scientific papers, before outlining how to articulate testable questions and answer them using basic data analysis. The Mauna Loa CO2 dataset is used to demonstrate how to read metadata, prepare data, generate effective graphs and identify dominant cycles on various timescales. Practical, question-driven examples are explored to explain running averages, anomalies, correlations and simple linear models. The final chapter provides a framework for writing persuasive research proposals, making this an essential guide for students embarking on their first research project.

This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.

This book focuses on the use of novel electron microscopy techniques to further our understanding of the physics behind electron-light interactions. It introduces and discusses the methodologies for advancing the field of electron microscopy towards a better control of electron dynamics with significantly improved temporal resolutions, and explores the burgeoning field of nanooptics - the physics of light-matter interaction at the nanoscale - whose practical applications transcend numerous fields such as energy conversion, control of chemical reactions, optically induced phase transitions, quantum cryptography, and data processing. In addition to describing analytical and numerical techniques for exploring the theoretical basis of electron-light interactions, the book showcases a number of relevant case studies, such as optical modes in gold tapers probed by electron beams and investigations of optical excitations in the topological insulator Bi2Se3. The experiments featured provide an impetus to develop more relevant theoretical models, benchmark current approximations, and even more characterization tools based on coherent electron-light interactions.

This book covers the most useful experimental methods for all types of solubility measurements. The importance of solubility phenomena has been long recognized throughout science. For example, in medicine, the solubility of gases in liquids forms the basis of life itself; in the environment, solubility phenomena influence the weathering of rocks, the creation of soils, the composition of natural water bodies and the behaviour and fate of many chemicals. However, until now, no systematic critical presentation of the methods for obtaining solubilities has been given.

The book is divided into five sections: the first addresses the fundamental thermodynamic and kinetic background necessary for a full understanding of solubility phenomena. The next three sections cover the major types of solubility determinations according to the physical state of the solute: gases, liquids and solids; whilst the final section deals with those technologically important areas whose traditions are sufficiently different to justify their separate presentation.

Each chapter aims to be comprehensive but not encyclopaedic, with coverage of the reliable methods in the particular area. Illustrations have been included to enable the novice investigator quickly develop apparatus of their own. Where appropriate, contributors have included sets of data to enable workers to properly assess the quality of their apparatus, technique and data.

It is common for us today to associate the practice of science primarily with the act of seeing-with staring at computer screens, analyzing graphs, and presenting images. We may notice that physicians use stethoscopes to listen for disease, that biologists tune into sound recordings to understand birds, or that engineers have created Geiger tellers warning us for radiation through sound. But in the sciences overall, we think, seeing is believing. This open access book explains why, indeed, listening for knowledge plays an ambiguous, if fascinating, role in the sciences. For what purposes have scientists, engineers and physicians listened to the objects of their interest? How did they listen exactly? And why has listening often been contested as a legitimate form of access to scientific knowledge? This concise monograph combines historical and ethnographic evidence about the practices of listening on shop floors, in laboratories, field stations, hospitals, and conference halls, between the 1920s and today. It shows how scientists have used sonic skills-skills required for making, recording, storing, retrieving, and listening to sound-in ensembles: sets of instruments and techniques for particular situations of knowledge making. Yet rather than pleading for the emancipation of hearing at the expense of seeing, this essay investigates when, how, and under which conditions the ear has contributed to science dynamics, either in tandem with or without the eye.

The ultimate DIY project guide for techie dads raising kids in their own geeky image, in the spirit of "The Dangerous Book for Boys"
Today's generation of dads grew up more tech-savvy than ever. Rather than joining the Little League team, many grew up playing computer games, Dungeons and Dragons, and watching "Star Wars." Now with kids of their own, these digital-age dads are looking for fresh ways to share their love of science and technology, and help their kids develop a passion for learning and discovery.
Enter supergeek, and father of two, Ken Denmead. An engineer and editor of the incredibly popular GeekDad blog on wired.com, Ken has created the ultimate, idea-packed guide guaranteed to help dads and kids alike enjoy the magic of playtime together and tap into the infinite possibility of their imagination. With illustrations throughout, this book offers projects for all ages to suit any timeframe or budget. With Denmead's expert guidance, you and your child can:
-Fly a night-time kite ablaze with lights or launch a video camera with balloons
-Construct the "Best Slip n' Slide Ever," a guaranteed thrill ride
-Build a working lamp with LEGO bricks and CDs
-Create a customized comic strip or your own board game
-Transform any room into a spaceship
-Make geeky crafts like cyborg jack-o'-lanterns or Ethernet cuff links
Brimming with endlessly fun and futuristic tidbits on everything from gaming to gadgets, "GeekDad" helps every tech-savvy father unleash his inner kid-and bond with the next generation of brainiacs.
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The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

This book is a special edition, compiled for to the MSc Course Research Methodologies as taught at the Faculty of Aerospace Engineering at Delft University of Technology. It is a compilation of useful chapters from several sources on how to structure, set up, carry out and write up your (thesis) research to aid you in writing your research plan. Next to that it acts as a companion during your thesis research. After introducing you to the philosophy of scientific research, subsequent chapters each contribute to the different phases of your research. The book uniquely allows for the often multi- or interdisciplinary research many of you carry out, based on the established Dutch university tradition of (semi-)independent student research, creating a thread through the process for you to follow. This edition is a collection of chapters from An Introduction to Interdisciplinary Research (2016), edited by Steph Menken and Machiel Keestra, and Academic Skills for Interdisciplinary Studies. Revised edition (2019), by Koen van der Gaast, Laura Koenders and Ger Post, published by Amsterdam University Press.

A daily glass of wine prolongs life-yet alcohol can cause life-threatening cancer. Some say raising the minimum wage will decrease inequality while others say it increases unemployment. Scientists once confidently claimed that hormone replacement therapy reduced the risk of heart disease but now they equally confidently claim it raises that risk. What should we make of this endless barrage of conflicting claims? Observation and Experiment is an introduction to causal inference by one of the field's leading scholars. An award-winning professor at Wharton, Paul Rosenbaum explains key concepts and methods through lively examples that make abstract principles accessible. He draws his examples from clinical medicine, economics, public health, epidemiology, clinical psychology, and psychiatry to explain how randomized control trials are conceived and designed, how they differ from observational studies, and what techniques are available to mitigate their bias. "Carefully and precisely written...reflecting superb statistical understanding, all communicated with the skill of a master teacher." -Stephen M. Stigler, author of The Seven Pillars of Statistical Wisdom "An excellent introduction...Well-written and thoughtful...from one of causal inference's noted experts." -Journal of the American Statistical Association "Rosenbaum is a gifted expositor...an outstanding introduction to the topic for anyone who is interested in understanding the basic ideas and approaches to causal inference." -Psychometrika "A very valuable contribution...Highly recommended." -International Statistical Review

This open access book brings out the state of the art on how informatics-based tools are used and expected to be used in nanomaterials research. There has been great progress in the area in which "big-data" generated by experiments or computations are fully utilized to accelerate discovery of new materials, key factors, and design rules. Data-intensive approaches play indispensable roles in advanced materials characterization. "Materials informatics" is the central paradigm in the new trend. "Nanoinformatics" is its essential subset, which focuses on nanostructures of materials such as surfaces, interfaces, dopants, and point defects, playing a critical role in determining materials properties. There have been significant advances in experimental and computational techniques to characterize individual atoms in nanostructures and to gain quantitative information. The collaboration of researchers in materials science and information science is growing actively and is creating a new trend in materials science and engineering.

The areas of speciation analysis have being undergoing a continual evolution and development for the last 20 years. A fundamental tool for speciation analysis has been the combination of a chromatographic separation technique with atomic spectrometry, permitting a sensitive and specific detection of the target element. Recent impressive progress toward lower detection limits in ICP-MS, toward higher resolution in separation techniques, especially capillary electrophoresis and electro-chromatography, and toward higher sensitivity in electrospray mass spectrometry for molecule-specific detection at trace levels in complex matrices has allowed new frontiers to be crossed.

This first volume of The Handbook of Elemental Speciation, brings together a collection of chapters covering comprehensively different aspects of procedures for speciation analysis at the different levels starting from sample collection and storage, through sample preparation approaches to render the species chromatographable, principles of separation techniques used in speciation analysis, to the element specific detection. This already very broad coverage of analytical techniques is completed by electrochemical methods, biosensors for metal ions, radioisotope techniques and direct solid speciation techniques. Special concern is given to quality assurance and risk assessment, and speciation-relevant legislation.

Each chapter is a stand-alone reference covering a given facet of elemental speciation analysis written by an expert in a given field with the volume as a whole providing an excellent introductory text and reference handbook for analytical chemists in academia, government laboratories and industry, regulatory managers, biochemists, toxicologists, clinicians, environmental scientists, and students of these disciplines.

The second volume will present in detail a summary of each key element determined by speciation methods, and its detection and measurement within the four key areas of the environment, food, occupation and clinical health. .

Computational Methods in Physics, Chemistry ahd Biology offers an accessible introducton to key computational techniques used within science, including quantum mechanics, dynamics, evolutionary methods and molecular dynamics. Assuming only a limited background in computational methods, this book provides the reader with a series of comprehensive examples, problems and practical-based tasks from the basics through to more complex ideas and techniques.

Beginning with an introduction to a numerical solution of Schrö dinger's Equation the text moves on to discuss pertubation theory, variational calculations, diffusion, dynamics, Monte Carlo simulations and genetic algorithms. Aimed at those new to the field, the book will enable the reader to develop and implement computational methods for the solutions of a range of problems in science.

Features:

• An accessible introduction covering a range of essential techniques applicable to key problems
• Numerous examples, problems and practical-based exercises.
• A supplementary website including solutions

REVIEWS IN COMPUTATIONAL CHEMISTRY

Kenny B. Lipkowitz, Raima Larter, and Thomas R. Cundari

This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. TOPICS COVERED IN Volume 21 iNCLUDE AB INITIO QUANTUM SIMULATION IN SOLID STATE CHEMISTRY; MOLECULAR QUANTUM SIMILARITY; ENUMERATING MOLECULES; VARIABLE SELECTION; BIOMOLECULAR APPLICATIONS OF POISSON-BOLTZMANN METHODS; AND DATA SOURCES AND COMPUTATIONAL APPROACHES FOR GENERATING MODELS OF GENE REGULATORY NETWORKS.

FROM REVIEWS OF THE SERIES

"Reviews in Computational Chemistry remains the most valuable reference to methods and techniques in computational chemistry."
--JOURNAL OF MOLECULAR GRAPHICS AND MODELLING

"One cannot generally do better than to try to find an appropriate article in the highly successful Reviews in Computational Chemistry. The basic philosophy of the editors seems to be to help the authors produce chapters that are complete, accurate, clear, and accessible to experimentalists (in particular) and other nonspecialists (in general)."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparing and contrasting the reality of subjectivity in the work of history’s great scientists and the modern Bayesian approach to statistical analysis

Scientists and researchers are taught to analyze their data from an objective point of view, allowing the data to speak for themselves rather than assigning them meaning based on expectations or opinions. But scientists have never behaved fully objectively. Throughout history, some of our greatest scientific minds have relied on intuition, hunches, and personal beliefs to make sense of empirical data–and these subjective influences have often aided in humanity’s greatest scientific achievements. The authors argue that subjectivity has not only played a significant role in the advancement of science, but that science will advance more rapidly if the modern methods of Bayesian statistical analysis replace some of the classical twentieth-century methods that have traditionally been taught.

To accomplish this goal, the authors examine the lives and work of history’s great scientists and show that even the most successful have sometimes misrepresented findings or been influenced by their own preconceived notions of religion, metaphysics, and the occult, or the personal beliefs of their mentors. Contrary to popular belief, our greatest scientific thinkers approached their data with a combination of subjectivity and empiricism, and thus informally achieved what is more formally accomplished by the modern Bayesian approach to data analysis.

Yet we are still taught that science is purely objective. This innovative book dispels that myth using historical accounts and biographical sketches of more than a dozen great scientists, including Aristotle, Galileo Galilei, Johannes Kepler, William Harvey, Sir Isaac Newton, Antoine Levoisier, Alexander von Humboldt, Michael Faraday, Charles Darwin, Louis Pasteur, Gregor Mendel, Sigmund Freud, Marie Curie, Robert Millikan, Albert Einstein, Sir Cyril Burt, and Margaret Mead. Also included is a detailed treatment of the modern Bayesian approach to data analysis. Up-to-date references to the Bayesian theoretical and applied literature, as well as reference lists of the primary sources of the principal works of all the scientists discussed, round out this comprehensive treatment of the subject.

Readers will benefit from this cogent and enlightening view of the history of subjectivity in science and the authors’ alternative vision of how the Bayesian approach should be used to further the cause of science and learning well into the twenty-first century.

Team leaders should be full of ideas for new research projects and inspire a research group to achieve great results. This practical guide for team leaders, and those who aspire to become team leader, offers a unique approach to help readers develop research and become a more independent and productive investigator. Readers can learn how to recruit and develop talented team members, how to negotiate contracts and manage projects, and how to create wider visibility and publicity for their science. From human resources and project finances, legal affairs and knowledge transfer to public engagement and media performance, the book provides guidance to enhance skills and combine them with those of support staff on the road to success. With numerous valuable tips, real-life stories and practical exercises, this must-read guide provides everything needed to take responsibility for leading research teams. This title is available as Open Access via Cambridge Core.

This volume details methods on several aspects of circadian research. Chapters guide readers through the latest techniques and a wide variety of daily rhythmic processes, model organisms, circadian rhythms in the SCN and in peripheral organs, and describing in vitro systems and in silico methods. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Circadian Regulation: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field. Chapters 3, 4, 8, and 17 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Prudent Practices in the Laboratory-the book that has served for decades as the standard for chemical laboratory safety practice-now features updates and new topics. This revised edition has an expanded chapter on chemical management and delves into new areas, such as nanotechnology, laboratory security, and emergency planning. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices in the Laboratory provides guidance on planning procedures for the handling, storage, and disposal of chemicals. The book offers prudent practices designed to promote safety and includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices in the Laboratory will continue to serve as the leading source of chemical safety guidelines for people working with laboratory chemicals: research chemists, technicians, safety officers, educators, and students. Table of Contents Front Matter 1 The Culture of Laboratory Safety 2 Environmental Health and Safety Management System 3 Emergency Planning 4 Evaluating Hazards and Assessing Risks in the Laboratory 5 Management of Chemicals 6 Working with Chemicals 7 Working with Laboratory Equipment 8 Management of Waste 9 Laboratory Facilities 10 Laboratory Security 11 Safety Laws and Standards Pertinent to Laboratories Bibliography APPENDIXES Appendix A: OSHA Laboratory Standard Appendix B: Statement of Task Appendix C: Committee Member Biographies Index

Dealing with the intermolecular Diels-Alder reaction, this book focuses on one of the reactants, the diene. The first chapter deals with the fundamental principles of the reaction. The remaining five chapters describe the salient features of the different classes of dienes and report a great deal of tabulated data and literary references. In the tables, the dienes and dienophiles are ordered in such a way that the reader can easily find the dienophile and the cycloaddition reactions which are of interest to him or her. The book should be a valuable tool for students and for academic and industrial researchers working in the field of organic synthesis.

Passive acoustic monitoring is increasingly used by the scientific community to study, survey and census marine mammals, especially cetaceans, many of which are easier to hear than to see. PAM is also used to support efforts to mitigate potential negative effects of human activities such as ship traffic, military and civilian sonar and offshore exploration. Walter Zimmer provides an integrated approach to PAM, combining physical principles, discussion of technical tools and application-oriented concepts of operations. Additionally, relevant information and tools necessary to assess existing and future PAM systems are presented, with Matlab code used to generate figures and results so readers can reproduce data and modify code to analyse the impact of changes. This allows the principles to be studied whilst discovering potential difficulties and side effects. Aimed at graduate students and researchers, the book provides all information and tools necessary to gain a comprehensive understanding of this interdisciplinary subject.

Originally published in 1941, this book seeks to inform the scientific community of the possible uses of photography in research or teaching. Lawrence gives an account of the possibilities and limitations of the medium for the scientific reader as well as for the 'serious amateur', explains the various mechanisms of the camera and gives some suggestions for scientific applications, such as high-speed photography. This book will be of value to anyone with an interest in photography or the history of science.

Organic synthesis is a vibrant and rapidly evolving field; we can now cyclize amines directly onto alkenes. Like its predecessors, this reference leads readers quickly to the field's more important recent developments. Two years of Douglass F. Taber's popular weekly online column, "Organic Chemistry Highlights", as featured on the organic-chemistry.org website, are consolidated here, with cumulative indices of all three volumes in this series. Important topics that are covered range from powerful new methods for C-C bond construction to asymmetric organocatalysis and direct C-H functionalization. This go-to reference focuses on the most important recent developments in organic synthesis, and includes a succinct analysis of the significance and applicability of each new synthetic method.

The fundamental principles of the scientific method are essential for enhancing perspective, increasing productivity, and stimulating innovation. These principles include deductive and inductive logic, probability, parsimony and hypothesis testing, as well as science's presuppositions, limitations, ethics and bold claims of rationality and truth. The examples and case studies drawn upon in this book span the physical, biological and social sciences; include applications in agriculture, engineering and medicine; and also explore science's interrelationships with disciplines in the humanities such as philosophy and law. Informed by position papers on science from the American Association for the Advancement of Science, National Academy of Sciences and National Science Foundation, this book aligns with a distinctively mainstream vision of science. It is an ideal resource for anyone undertaking a systematic study of scientific method for the first time, from undergraduates to professionals in both the sciences and the humanities.