This essential laboratory handbook dispels the mystery surrounding organocopper compounds and offers expert guidance on how to overcome the many problems associated with their use. Authored by leading researchers, the book features clear, practical descriptions of key procedures used in the preparation and application of these highly specific reagents. In addition, the book contains a succinct historical overview of the field's development. Beginning and established researchers alike will find Organocopper Reagents: A Practical Approach an invaluable source of information on an exciting, fast-growing field.

An ideal introduction to this fast growing area, this Primer describes the many computational methods currently used by practising chemists. The authors describe the various techniques available, and how they can be applied to single molecules, to assemblies of molecules, and to molecules undergoing reaction. An introductory chapter outlines hardware and software options, as well as investigating some applications and developments. Subsequent chapters cover quantum mechanics, molecular mechanics, statistical mechanics, the modelling of biomolecules, and drug design.

Plant cell culture techniques are being increasingly used in basic research and for plant exploitation in industry (genetic engineering, micropropagation). In this book, internationally recognized experts describe the techniques in use in their laboratories for isolating and manipulating cell cultures, and their central importance in plant biotechnology.

Die nichtinvasive Erfassung des arteriellen Pulswellensignals erlaubt Pulsmessung, Pulsoximetrie bis hin zu Gefassrisikobewertung direkt am Unterarm. Robert Couronne beschreibt zwei Modellsimulationen der Photonenausbreitung im Unterarmgewebe. Anhand gemessener Intensitaten verifiziert der Autor die erweiterte Lambert-Beer-Beziehung eines planaren Schichtenmodells und untersucht mithilfe eines Zylindermodells die Intensitatsverteilung entlang des Unterarmumfangs, wobei bevorzugte Ableitregionen identifiziert werden. Zum experimentellen Nachweis stellt der Autor den Prototyp eines optisch-transmissiven Mehrkanalsensorsystems vor und zeigt anhand von Probandenmessungen die technische Signalgewinnung und praktische Anwendbarkeit. Mit einem Klassifikationsverfahren kann die automatische Signalidentifikation sowie eine Qualitatsbewertung im Realzeitbetrieb erreicht werden. Die vorgestellten Verfahren sind dabei auf gangigen Mikrocontroller-Plattformen lauffahig."

The use of stable isotopes in nutritional studies is now widespread, and the technique is becoming increasingly popular. Practical applications are numerous and include: calcium and iron absorption studies, studies looking at the impacts of diet, physical activity, aging, and medical therapy and supplementation on nutrient metabolism, the measurement of energy cost of pregnancy, studies on the causes of growth faltering in infants, and investigations into childhood and adult obesity. This book is designed as a laboratory handbook of methods used to perform stable isotope studies in humans. It covers basic principles, dosage information, sample preparation procedures, analytical instrumentation, and necessary mathematical methods and provides the fundamentals to enable researchers to evaluate and establish stable isotope methods in their own laboratories.

There is an increasing need for analysts to understand and be able to quantify the performance of analytical instruments, in particular with respect to the following:
* specifying equipment for purchase
* estimating uncertainties in intrumental measurements
* quantifying and demonstrating performance quality
This text links together an understanding of performance characteristics with an appreciation of the limitations imposed by instrument design, leading to the interplay of the validation and qualification processes within quality assurance systems.
A unique framework of topics covers the major instrumental techniques of spectrophotometry, chromatography, capillary electrophoresis, and atomic emission spectroscopy. The use of over 200 questions and answers, together with cross-referencing, helps to develop a thorough understanding of the various concepts that underpin the different techniques.
This book will appeal to a broad range of professional chemists, technicians and students, weither with reference to specific analytical techniques, or within a general course of study in instrumental performance.
Analytical Techniques in the Sciences
This series of books provides coverage of all the major analytical techniques and their application in the most important areas of physical, life and materials sciences. Each text is presented in an open learning/distant learning style, in which the learning objectives are clearly identified. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions.

Thomas Hankins and Robert Silverman investigate an array of instruments from the seventeenth through the nineteenth century that seem at first to be marginal to science--magnetic clocks that were said to operate by the movements of sunflower seeds, magic lanterns, ocular harpsichords (machines that played different colored lights in harmonious mixtures), Aeolian harps (a form of wind chime), and other instruments of "natural magic" designed to produce wondrous effects. By looking at these and the first recording instruments, the stereoscope, and speaking machines, the authors show that "scientific instruments" first made their appearance as devices used to evoke wonder in the beholder, as in works of magic and the theater. The authors also demonstrate that these instruments, even though they were often "tricks," were seen by their inventors as more than trickery. In the view of Athanasius Kircher, for instance, the sunflower clock was not merely a hoax, but an effort to demonstrate, however fraudulently, his truly held belief that the ability of a flower to follow the sun was due to the same cosmic magnetic influence as that which moved the planets and caused the rotation of the earth. The marvels revealed in this work raise and answer questions about the connections between natural science and natural magic, the meaning of demonstration, the role of language and the senses in science, and the connections among art, music, literature, and natural science. Originally published in 1995. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Wie geht es weiter - nach der erfolgreichen Promotion? Wohin soll die medizinische Laufbahn fuhren? Dieser Leitfaden wird Ihnen bei der schwierigen Entscheidung eine wertvolle Stutze sein. Eine erfahrene Medizinjournalistin portratiert hier alle Facharztrichtungen der Ausbildungsordnung der OEsterreichischen AErztekammer - von der Anasthesie bis hin zur Zahnmedizin. Zusatzlich prasentiert sie die Additivfacher der einzelnen Sonderfacher und informiert Sie uber die neue Ausbildung zum Allgemein- bzw. Zahnmediziner. Kompakt und ubersichtlich beantwortet sie folgende Fragen: Wie gestaltet sich die Ausbildung? Welche Fahigkeiten und persoenlichen Eigenschaften sind in welchem Fach gefragt? Und: An welches Fach haben Sie bisher noch nie gedacht?

This book should be on the shelf of every practising statistician who designs experiments. Good design considers units and treatments first, and then allocates treatments to units. It does not choose from a menu of named designs. This approach requires a notation for units that does not depend on the treatments applied. Most structure on the set of observational units, or on the set of treatments, can be defined by factors. This book develops a coherent framework for thinking about factors and their relationships, including the use of Hasse diagrams. These are used to elucidate structure, calculate degrees of freedom and allocate treatment subspaces to appropriate strata. Based on a one-term course the author has taught since 1989, the book is ideal for advanced undergraduate and beginning graduate courses. Examples, exercises and discussion questions are drawn from a wide range of real applications: from drug development, to agriculture, to manufacturing.

How do scientists impact society in the twenty-first century? Many scientists are increasingly interested in the impact that their research will have on the public. Scientists likewise must answer the question above when applying for funding from government agencies, particularly as part of the 'Broader Impacts' criterion of proposals to the US National Science Foundation. This book equips scientists in all disciplines to do just that, by providing an overview of the origins, history, rationale, examples, and case studies of broader impacts, primarily drawn from the author's experiences over the past five decades. Beyond including theory and evidence, it serves as a 'how to' guide for best practices for scientists. Although this book primarily uses examples from the NSF, the themes and best practices are applicable to scientists and applications around the world where funding also requires impacts and activities that benefit society.

This monograph describes the theoretical bases and experimental prerequisites for methods such as spin fluorescence, triplet, Mo ssbauer, photochromic and electron-density labeling, including the procedures used to obtain specifically modified proteins, enzymes, biomembranes, nucleic acids, and other biological molecules. The fundamentals of the physical theory behind each technique is explained and details are given of how to interpret the experimental data obtained. Special sections deal with critical reviews of recent data on the structure, molecular dynamics and conformational transitions of biological molecules. Each section concludes with a discussion of the results obtained from these techniques in connection with various problems of enzyme catalysis, electron transfer, molecular biophysics and molecular biology. The uses that labeling techniques can be put to for the investigation of whole cells and tissues are also discussed.

The past six years have seen a substantial increase in the attention paid by research workers to the principles of experimental design. The Second Edition of brings this handbook up to date, while retaining the basic framework that made it so popular. Describes the most useful of the designs that have been developed with accompanying plans and an account of the experimental situations for which each design is most suitable. Examples come from diverse fields of research, with an emphasis on biology and agriculture, two of the authors' specialties. New chapters have been added: one discusses the fractional replication of experiments. A second is concerned with experiments of the factorial type that present new methods and designs in which the factors represent quantitative variables measured on a continuous scale. Other new material includes an introductory account of experimental strategies for finding the levels at which the factors must be set in order to obtain maximum response and coverage of new incomplete block designs.

Maximize your skills and understanding with EXPERIMENTS IN GENERAL CHEMISTRY: INQUIRY AND SKILL BUILDING, Third Edition. The manual's 31 experiments include Skill Building, Guided Inquiry, and Open Inquiry experiments to provide maximum lab experience in the minimum amount of lab time. Each experiment includes prelab questions to help you prepare for the lab ahead of time and post-lab questions that lead you from data analysis to concept development to reinforce the core concepts of the lab.

Die Fort- und Weiterbildungskurse der ASG-Fellows sind seit uber 10 Jahren ein Fortbildungsprogramm und mit jeweils 5-6 Schwerpunktthemen fester Bestandteil des Kongresses der DGOT. Die Fortbildungskurse richten sich an angehende Facharzte fur Orthopadie, aber auch an erfahrene Orthopaden in Praxis und Klinik, die von bestausgewiesenen Wissenschaftlern eine kompetente UEbersicht uber Neues zu aktuellen und modernen Krankheitsbildern erfahren und Strategien in Diagnostik und Therapie dargestellt bekommen. Die verschiedenen UEbersichtsreferate sind topographisch jeweils in einem Band zusammengefasst.

As careers in science have become increasingly demanding, they require much more than a keen scientific mind and practical ability. If you are considering a career in research, have already embarked on your career and want to succeed, are uncertain which route to take or advise, train or supervise scientists, this book offers some helpful advice. Nancy Rothwell, a senior scientist with extensive experience training scientists and communicating with the public, covers topics ranging from choosing a PhD or postdoctoral position, successful interviews and preparing your cv to managing your supervisor; how to give successful talks, publish high quality papers and become known within your field. Broader aspects of science which are so important today are also covered, including ethics and fraud, intellectual property and exploitation and disseminating science to the public.

This book is the first synthesis of the practice and the philosophy of the scientific method. It offers scientists a deeper understanding of the underpinnings of the scientific method, thereby leading to more productive research and experimentation. It also provides a greater perspective on the rationality of the scientific approach and its role in society. Topics relevant to a variety of disciplines are treated, and clarifying figures, case studies, and chapter summaries enhance the pedagogy.

Proven and tested guidelines for designing ideal labs for scientific investigations

Now in its "Fourth Edition, Guidelines for Laboratory Design "continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.

"Guidelines for Laboratory Design" features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in: Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modulesPart IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labsPart II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labsPart III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storeroomsPart IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservationPart V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainability

The final part of the book features five appendices filled with commonly needed data and reference materials.

This "Fourth Edition" is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.

Millionen von Medizin-Seiten im Internet machen den Durchblick schwer. Als kompakter, praxisbezogener Wegweiser durch diesen Informationsdschungel hilft das Buch Medizinern, das Internet optimal fur sich zu nutzen. Es erklart schrittweise den Umgang mit Daten und Datenbanken, bewertet die wichtigsten Internetadressen und informiert uber interessante Websites. Wer sich fur eine eigene Praxis-Homepage, Praxis-Netze oder telemedizinische Anwendungen interessiert, findet hier verstandliche Informationen und Anleitungen.

This classic companion to undergraduate practical work in physics describes the purposeful, critical approach that should be made to all physics experiments. It covers the statistical treatment of data and experimental methods, and gives advice on keeping efficient records, calculations, and scientific writing. The new edition features treatment of the c2 distribution, a section on atomic clocks, worked examples based on spreadsheets, and additional exercises. Existing examples and references have been brought up to date. The text is liberally illustrated with examples and exercises, with solutions to the latter. Although intended for undergraduates, Practical Physics will be of interest to researchers, not only in physics, but in other sciences as well.

This textbook provides a comprehensive introduction to the theory and practice of validated numerics, an emerging new field that combines the strengths of scientific computing and pure mathematics. In numerous fields ranging from pharmaceutics and engineering to weather prediction and robotics, fast and precise computations are essential. Based on the theory of set-valued analysis, a new suite of numerical methods is developed, producing efficient and reliable solvers for numerous problems in nonlinear analysis. Validated numerics yields rigorous computations that can find all possible solutions to a problem while taking into account all possible sources of error--fast, and with guaranteed accuracy.

"Validated Numerics" offers a self-contained primer on the subject, guiding readers from the basics to more advanced concepts and techniques. This book is an essential resource for those entering this fast-developing field, and it is also the ideal textbook for graduate students and advanced undergraduates needing an accessible introduction to the subject. "Validated Numerics" features many examples, exercises, and computer labs using MATLAB/C++, as well as detailed appendixes and an extensive bibliography for further reading.Provides a comprehensive, self-contained introduction to validated numerics Requires no advanced mathematics or programming skills Features many examples, exercises, and computer labs Includes code snippets that illustrate implementation Suitable as a textbook for graduate students and advanced undergraduates

The first book of its kind on marrow stromal cells, and written by leading experts in the field, this concise handbook aims to provide all that is needed to those new to this relatively young area of research. It provides a historical perspective and a summary of present knowledge of the marrow stromal lineages which are currently best understood. Detailed protocols for the isolation, culture and characterization of marrow stromal cell types from human and other animal species are given. The breadth and depth of the subject matter included makes the book equally suitable for new researchers and the more experienced investigator in this rapidly expanding field, including clinicians and bioscientists.

The Works of Archimedes: Edited in Modern Notation With Introductory Chapters Authored by T.L. Heath Sc.D.