A powerful and relatively new method for extracting detailed crystal structural information from X-ray and neutron powder diffraction data, the Rietveld method attracts a great deal of interest from researchers in physics, chemistry, materials science, and crystallography. Now available in paperback, this book comprises chapters from international researchers on all aspects of this important technique. It will be of great interest to all researchers in the fields, as well as graduate students seeking a solid introduction and comprehensive survey.

Contributors: R. A. Young (Georgia Institute of Technology, Atlanta, USA); H. M. Rietveld (Netherlands Energy Research Foundation); E. Prince (National Institute of Standards and Technology, Gaithersburg); T. M. Sabine (University of Technology, Broadway); R. J. Hill (CSIRO Divisionof Mineral Products, Port Melbourne); J. W. Richardson Jr. (Argonne National Laboratory, Argonne); R. L. Snyder (New York State College of Ceramics, USA); R. Delhez, Th. H. de Keijser, E. J. Mittemeijer, and E. J. Sonneveld (Laboratory of Metallurgy, Delft University of Technology); J. I. Langford (University of Birmingham, UK); D. Louër (Université de Rennes, France); P. Suortti (ESRF, Grenoble, Switzerland); C. Bärlocher (ETH Zentrum, Zürich); W. I. F. David (Rutherford Appleton Laboratory, UK); J. D. Jorgensen (Argonne National Laboratory, Argonne); R. B. von Dreele (Los Alamos National Laboratory, USA); F. Izumi (National Institute for Research in Inorganic Materials, Tsukuba, Japan); H. Toraya (Nagoya Institute of Technology, Asahigaoka); A. K. Cheetham (University of California, Santa Barbara, USA)

The investigation and manipulation of matter on the atomic scale have been revolutionized by scanning tunneling microscopy and related scanning probe techniques. This book is the first to provide a clear and comprehensive introduction to this subject. Beginning with the theoretical background of scanning tunneling microscopy, the design and instrumentation of practical STM and associated systems are described in detail, including topographic imaging, local tunneling barrier height measurements, tunneling spectroscopy, and local potentiometry. A treatment of the experimental techniques used in scanning force microscopy and other scanning probe techniques rounds out this section. The second part discusses representative applications of these techniques in fields such as condensed matter physics, chemistry, materials science, biology, and nanotechnology, so this book will be extremely valuable to upper-division students and researchers in these areas.

The functional anatomy of human somatosensory cortex is of both scientific and clinical interest. Scientifically, it provides insights in information processing in the human brain. Clinically, it helps to avoid neurological deficits by sparing essential brain regions during neurosurgical procedures adjacent to central fissure. In the present study the functional organization of the human somatosensory cortex was investigated with electrophysiological techniques using a combined approach of cortical stimulations and somatosensory evoked responses on electrocorticography, scalp-EEG, and magnetoencephalography. The spatiotemporal structure of the evoked response was studiedwith biophysical modeling techniqueswhich allowed identification of the three-dimensional intracerebral location, time activity, and interaction of the neuronal sources activated following peripheral somatosensory stimulation. Furthermore, the somatotopic organization ofhand and lip somatosensory cortex was investigated. The relative value of invasive (cortical stimulations and electrocorticography) and non-invasive (scalp-EEGand magnetoencephalography) was assessed. The combined use ofscalp-EEG and magnetoencephalography was useful to increase non-invasive localization accuracy. I want to thank several people who significantly contributed in completion of the present work. Univ. -Prof Dr. Luder Deecke, Chairman of the Neurological University Clinic, Vienna, Austria, supported me throughout my career at the Neurological University Clinic in Vienna since 1985. Dr. William W Sutherling, Associate Professor at the University of California, Los Angeles, who was my advisor during my stay from 1987-1989 at the Department ofNeurology, University of California, Los Angeles where most of the present work was done.

Flow cytometry is now well established in research laboratories and is gaining increasing use in clinical medicine and pathology. The technique enables multiple simultaneous light scatter and fluorescence measurements to be made at the individual cell level at very rapid rates and results in very large quantities of data being collected. Data, however, is just a series of numbers which have to be converted to information which, in turn, must be shown to have meaning. This is the most important single aspect of flow cytometry but it has received relatively little attention. One of the frequently voiced advantages of the technology is that it produces 'good statistics' because large numbers of cells have been analysed. However, it is not very often that confidence limits are placed on results, hence the reader has little or no feel for the inherent variability in the information produced. This book covers very basic number handling techniques, regression analysis, probability functions, statistical tests and methods of analysing dynamic processes. All those who use flow cytometry in their research will find this book an invaluable guide to interpreting the data produced by flow cytometers.

This book is designed to supply research workers in biochemistry and related fields with factual information about the compounds, reagents, and techniques they use most frequently in the laboratory. The material has been selected by practising biochemists and, in this third edition, a wide range of data is clearly displayed in an easily accessible form. Much has been deleted from earlier editions to be replaced by new material of current importance to biochemistry and molecular biology. Functional grouping of compounds has been emphasized to enable users of this book to see what compounds are available as well as find data on specific examples. Now available in paperback, this book provides a clear presentation of the type of information frequently needed in experimental work and is an invaluable laboratory companion for workers in any aspect of biochemistry. `Highly recommended as a standard reference source in biochemical research.' Journal of Histochemistry and Cytochemistry

A General History of Horology describes instruments used for the finding and measurement of time from Antiquity to the 21st century. In geographical scope it ranges from East Asia to the Americas. The instruments described are set in their technical and social contexts, and there is also discussion of the literature, the historiography and the collecting of the subject. The book features the use of case studies to represent larger topics that cannot be completely covered in a single book. The international body of authors have endeavoured to offer a fully world-wide survey accessible to students, historians, collectors, and the general reader, based on a firm understanding of the technical basis of the subject. At the same time as the work offers a synthesis of current knowledge of the subject, it also incorporates the results of some fundamental, new and original research.

Textbook of "in vivo" Imaging in Vertebrates.

Editors.

Vasilis Ntziachristos

Department of Radiology, Harvard University HMS/MGH, Charlestown, USA

Anne Leroy-Willig

U2R2M, CNRS and Universite Paris-Sud, Orsay, France

Bertrand Tavitian

Unite d'Imagerie de l'Expression des Genes, INSERM, Orsay, Franc

This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research.

Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates:

- The types of information that can be obtained with modern in vivo imaging;

-The substitution of imaging methods for more destructive histological techniques;

- The advantages conferred by in vivo imaging in building a more accurate picture of the response of tissues to stimuli over time while significantly reducing the number of animals required for such studies.

Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy.

Most chapters are written by teams of physicists and biologists, giving a balanced coherent description of each technique and its potential applications.

The book is aimed at a broad audience conducting research in areas such as biochemistry, physiology, developmental biology, oncology and pharmacology. While written primarily for those already engaged in imaging studies, it will also be of interest to scientists from other disciplines looking for an entry point into the field of in vivo imaging in small animals.

The Oxford Handbook of the History of Physics brings together cutting-edge writing by more than twenty leading authorities on the history of physics from the seventeenth century to the present day. By presenting a wide diversity of studies in a single volume, it provides authoritative introductions to scholarly contributions that have tended to be dispersed in journals and books not easily accessible to the general reader. While the core thread remains the theories and experimental practices of physics, the Handbook contains chapters on other dimensions that have their place in any rounded history. These include the role of lecturing and textbooks in the communication of knowledge, the contribution of instrument-makers and instrument-making companies in providing for the needs of both research and lecture demonstrations, and the growing importance of the many interfaces between academic physics, industry, and the military.

Team leaders should be full of ideas for new research projects and inspire a research group to achieve great results. This practical guide for team leaders, and those who aspire to become team leader, offers a unique approach to help readers develop research and become a more independent and productive investigator. Readers can learn how to recruit and develop talented team members, how to negotiate contracts and manage projects, and how to create wider visibility and publicity for their science. From human resources and project finances, legal affairs and knowledge transfer to public engagement and media performance, the book provides guidance to enhance skills and combine them with those of support staff on the road to success. With numerous valuable tips, real-life stories and practical exercises, this must-read guide provides everything needed to take responsibility for leading research teams. This title is available as Open Access via Cambridge Core.

If you're taking a basic course in classical physics, or have a healthy curiosity for the way things work in the physical world, the Illustrated Guide to Home Physics Experiments provides an ideal hands-on introduction to physics lab techniques and data analysis. With this book and a few simple (and inexpensive) tools and materials, you'll learn to conduct experiments that answer questions about our world, make demonstrations to show off physical principles, and do theoretical lab work to discover how the world works. Perfect for do-it-yourselfers, home-schooled high school students, and college students, this book will help you: Learn everything from the basics of motion all the way to particle physics - including energy, thermodynamics, magnetic fields, optics, and much more Take careful measurements of physical phenomena and conduct data analysis Build and perform physics demonstrations that are fascinating and fun Construct computer models to represent aspects of the physical world It's easy to get started. You can build most of the experiments and demonstrations in this book with ordinary household tools, using materials that you can scrounge, borrow, or get free. The most important thing is your willingness to enter the door of discovery that awaits you. The Illustrated Guide to Home Physics Experiments is your key.

The ultimate DIY project guide for techie dads raising kids in their own geeky image, in the spirit of "The Dangerous Book for Boys"
Today's generation of dads grew up more tech-savvy than ever. Rather than joining the Little League team, many grew up playing computer games, Dungeons and Dragons, and watching "Star Wars." Now with kids of their own, these digital-age dads are looking for fresh ways to share their love of science and technology, and help their kids develop a passion for learning and discovery.
Enter supergeek, and father of two, Ken Denmead. An engineer and editor of the incredibly popular GeekDad blog on wired.com, Ken has created the ultimate, idea-packed guide guaranteed to help dads and kids alike enjoy the magic of playtime together and tap into the infinite possibility of their imagination. With illustrations throughout, this book offers projects for all ages to suit any timeframe or budget. With Denmead's expert guidance, you and your child can:
-Fly a night-time kite ablaze with lights or launch a video camera with balloons
-Construct the "Best Slip n' Slide Ever," a guaranteed thrill ride
-Build a working lamp with LEGO bricks and CDs
-Create a customized comic strip or your own board game
-Transform any room into a spaceship
-Make geeky crafts like cyborg jack-o'-lanterns or Ethernet cuff links
Brimming with endlessly fun and futuristic tidbits on everything from gaming to gadgets, "GeekDad" helps every tech-savvy father unleash his inner kid-and bond with the next generation of brainiacs.
Watch a Video

Demography is everywhere in our lives: from birth to death. Indeed, the universal currencies of survival, development, reproduction, and recruitment shape the performance of all species, from microbes to humans. The number of techniques for demographic data acquisition and analyses across the entire tree of life (microbes, fungi, plants, and animals) has drastically increased in recent decades. These developments have been partially facilitated by the advent of technologies such as GIS and drones, as well as analytical methods including Bayesian statistics and high-throughput molecular analyses. However, despite the universality of demography and the significant research potential that could emerge from unifying: (i) questions across taxa, (ii) data collection protocols, and (iii) analytical tools, demographic methods to date have remained taxonomically siloed and methodologically disintegrated. This is the first book to attempt a truly unified approach to demography and population ecology in order to address a wide range of questions in ecology, evolution, and conservation biology across the entire spectrum of life. This novel book provides the reader with the fundamentals of data collection, model construction, analyses, and interpretation across a wide repertoire of demographic techniques and protocols. It introduces the novice demographer to a broad range of demographic methods, including abundance-based models, life tables, matrix population models, integral projection models, integrated population models, individual based models, and more. Through the careful integration of data collection methods, analytical approaches, and applications, clearly guided throughout with fully reproducible R scripts, the book provides an up-to-date and authoritative overview of the most popular and effective demographic tools. Demographic Methods across the Tree of Life is aimed at graduate students and professional researchers in the fields of demography, ecology, animal behaviour, genetics, evolutionary biology, mathematical biology, and wildlife management.

The global loss of biodiversity is occurring at an unprecedented pace. Despite the considerable effort devoted to conservation science and management, we still lack even the most basic data on the distribution and density of the majority of plant and animal species, which in turn hampers our efforts to study changes over time. In addition, we often lack behavioural data from the very animals most influenced by environmental changes; this is largely due to the financial and logistical limitations associated with gathering scientific data on species that are cryptic, widely distributed, range over large areas, or negatively influenced by human presence. To overcome these limitations, conservationists are increasingly employing technology to facilitate such data collection. Innovative solutions have been driven by dramatic advances in the conservation-technology interface. The use of camera traps, acoustic sensors, satellite data, drones, and computer algorithms to analyse the large datasets collected are all becoming increasingly widespread. Although specialist books are available on some of these individual technologies, this is the first comprehensive text to describe the breadth of available technology for conservation and to evaluate its varied applications, bringing together a team of international experts using a diverse range of approaches. Conservation Technology is suitable for graduate level students, professional researchers, practitioners and field managers in the fields of ecology and conservation biology.

The global loss of biodiversity is occurring at an unprecedented pace. Despite the considerable effort devoted to conservation science and management, we still lack even the most basic data on the distribution and density of the majority of plant and animal species, which in turn hampers our efforts to study changes over time. In addition, we often lack behavioural data from the very animals most influenced by environmental changes; this is largely due to the financial and logistical limitations associated with gathering scientific data on species that are cryptic, widely distributed, range over large areas, or negatively influenced by human presence. To overcome these limitations, conservationists are increasingly employing technology to facilitate such data collection. Innovative solutions have been driven by dramatic advances in the conservation-technology interface. The use of camera traps, acoustic sensors, satellite data, drones, and computer algorithms to analyse the large datasets collected are all becoming increasingly widespread. Although specialist books are available on some of these individual technologies, this is the first comprehensive text to describe the breadth of available technology for conservation and to evaluate its varied applications, bringing together a team of international experts using a diverse range of approaches. Conservation Technology is suitable for graduate level students, professional researchers, practitioners and field managers in the fields of ecology and conservation biology.

Over the past decade, advances in the field of close-range photogrammetry have been rapid and the era of digital photogrammetry is well on its way. This book provides a complete account of the subject with contributions from international experts.;The methodology, algorithms, techniques and equipment necessary to achieve real-time digital photogrammetric solutions are presented, together with contemporary aspects of close-range photogrammetry. Advances in the theory are presented as are a range of important applications of photogrammetry which illustrate the flexibility and comprehensive nature of these techniques of three-dimensional measurement.

Volume 26 Reviews In Computational Chemistry

Kenny B. Lipkowitz and Thomas R. Cundari Donald B. Boyd, Editor Emeritus

This book series contains pedagogically driven reviews of computational methods for the novice molecular modeler as well as for the expert computational scientist. Topics covered in this volume include computational methods needed to compute interactions accurately, quantum mechanical methods used for computing weakly bound clusters, computing excited state properties with time-dependent density functional theory, and methods for computing quantum phase transitions. Also covered are real-space and multi-grid methods, hybrid methods for atomic level simulations spanning multiple time scales and multiple length scales, techniques used for extending time scales in atomic level simulations, and strategies for simulating ionic liquids.

From Reviews Of The Series

"Reviews in Computational Chemistry remains the most valuable reference to methods and techniques in computational chemistry."
--Journal Of Molecular Graphics And Modelling

"One cannot generally do better than to try to find an appropriate article in the highly successful Reviews in Computational Chemistry. The basic philosophy of the editors seems to be to help the authors produce chapters that are complete, accurate, clear, and accessible to experimentalists (in particular) and other nonspecialists (in general)."
--Journal Of The American Chemical Society

Experiments, surveys, measurements, and observations all generate data. These data can provide useful insights for solving problems, guiding decisions, and formulating strategy. Progressing from relatively unprocessed data to insight, and doing so efficiently, reliably, and confidently, does not come easily, and yet gaining insights from data is a fundamental skill for science as well as many other fields and often overlooked in most textbooks of statistics and data analysis. This accessible and engaging book provides readers with the knowledge, experience, and confidence to work with data and unlock essential information (insights) from data summaries and visualisations. Based on a proven and successful undergraduate course structure, it charts the journey from initial question, through data preparation, import, cleaning, tidying, checking, double-checking, manipulation, and final visualization. These basic skills are sufficient to gain useful insights from data without the need for any statistics; there is enough to learn about even before delving into that world! The book focuses on gaining insights from data via visualisations and summaries. The journey from raw data to insights is clearly illustrated by means of a comprehensive Workflow Demonstration in the book featuring data collected in a real-life study and applicable to many types of question, study, and data. Along the way, readers discover how to efficiently and intuitively use R, RStudio, and tidyverse software, learning from the detailed descriptions of each step in the instructional journey to progress from the raw data to creating elegant and informative visualisations that reveal answers to the initial questions posed. There are an additional three demonstrations online! Insights from Data with R is suitable for undergraduate students and their instructors in the life and environmental sciences seeking to harness the power of R, RStudio, and tidyverse software to master the valuable and prerequisite skills of working with and gaining insights from data.

Experiments, surveys, measurements, and observations all generate data. These data can provide useful insights for solving problems, guiding decisions, and formulating strategy. Progressing from relatively unprocessed data to insight, and doing so efficiently, reliably, and confidently, does not come easily, and yet gaining insights from data is a fundamental skill for science as well as many other fields and often overlooked in most textbooks of statistics and data analysis. This accessible and engaging book provides readers with the knowledge, experience, and confidence to work with data and unlock essential information (insights) from data summaries and visualisations. Based on a proven and successful undergraduate course structure, it charts the journey from initial question, through data preparation, import, cleaning, tidying, checking, double-checking, manipulation, and final visualization. These basic skills are sufficient to gain useful insights from data without the need for any statistics; there is enough to learn about even before delving into that world! The book focuses on gaining insights from data via visualisations and summaries. The journey from raw data to insights is clearly illustrated by means of a comprehensive Workflow Demonstration in the book featuring data collected in a real-life study and applicable to many types of question, study, and data. Along the way, readers discover how to efficiently and intuitively use R, RStudio, and tidyverse software, learning from the detailed descriptions of each step in the instructional journey to progress from the raw data to creating elegant and informative visualisations that reveal answers to the initial questions posed. There are an additional three demonstrations online! Insights from Data with R is suitable for undergraduate students and their instructors in the life and environmental sciences seeking to harness the power of R, RStudio, and tidyverse software to master the valuable and prerequisite skills of working with and gaining insights from data.

The modern ecologist usually works in both the field and laboratory, uses statistics and computers, and often works with ecological concepts that are model-based, if not model-driven. How do we make the field and laboratory coherent? How do we link models and data? How do we use statistics to help experimentation? How do we integrate modeling and statistics? How do we confront multiple hypotheses with data and assign degrees of belief to different hypotheses? How do we deal with time series (in which data are linked from one measurement to the next) or put multiple sources of data into one inferential framework? These are the kinds of questions asked and answered by "The Ecological Detective."

Ray Hilborn and Marc Mangel investigate ecological data much as a detective would investigate a crime scene by trying different hypotheses until a coherent picture emerges. The book is not a set of pat statistical procedures but rather an approach. The Ecological Detective makes liberal use of computer programming for the generation of hypotheses, exploration of data, and the comparison of different models. The authors' attitude is one of exploration, both statistical and graphical. The background required is minimal, so that students with an undergraduate course in statistics and ecology can profitably add this work to their tool-kit for solving ecological problems.

"BioCoder" is a quarterly newsletter for DIYbio, synthetic bio, and anything related. You ll discover: Articles about interesting projects and experiments, such as the glowing plantArticles about tools, both those you buy and those you buildVisits to DIYbio laboratoriesProfiles of key people in the communityAnnouncements of events and other items of interestSafety pointers and tips about good laboratory practiceAnything that s interesting or useful: you tell us!And "BioCoder" is free (for the time being), unless you want a dead-tree version. We d like "BioCoder" to become self supporting (maybe even profitable), but we ll worry about that after we ve got a few issues under our belt.If you d like to contribute, send email to [email protected]. Tell us what you d like to do, and we ll get you started."

Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.

BioCoder is a quarterly newsletter for DIYbio, synthetic bio, and anything related. You'll discover: Articles about interesting projects and experiments, such as the glowing plant Articles about tools, both those you buy and those you build Visits to DIYbio laboratories Profiles of key people in the community Announcements of events and other items of interest Safety pointers and tips about good laboratory practice Anything that's interesting or useful: you tell us! And BioCoder is free (for the time being), unless you want a dead-tree version. We'd like BioCoder to become self supporting (maybe even profitable), but we'll worry about that after we've got a few issues under our belt.

Featuring new experiments, a new essay, and new coverage of nanotechnology, this organic chemistry laboratory textbook offers a comprehensive treatment of laboratory techniques including small scale and some microscale methods that use standard-scale ("macroscale") glassware and equipment. The book is organized based on essays and topics of current interest and covers a large number of traditional organic reactions and syntheses, as well as experiments with a biological or health science focus. Seven introductory technique-based experiments, thirteen project-based experiments, and sections on green chemistry and biofuels spark students' interest and engage them in the learning process. Instructors may choose to offer Cengage Learning's optional Premium Website, which contains videos on basic organic laboratory techniques.

A classic brought up to date with new experiments using the latest methods.
Modern spectroscopic techniques and current research topics make this an incomparable resource for undergraduate and graduate students, presenting a fascinating approach to inorganic chemistry by providing experiments that resemble real research. As a result, students learn to think in a research-oriented fashion and to research together in a group.
The experiments have been thoroughly tested and safety instructions are included, while hazardous substances are replaced by less harmful ones. This new edition also has a special focus on environmentally friendly experiments.

* Internet exercises available on the Web.
* Topics and approach emphasize the development of scientific literacy.
* Written in a clear, easy-to-read style.
* Numerous experiments to choose from cover all topics typically covered in prep chemistry courses.
* Avoids the use of known carcinogens and toxic metal salts.
* Chemical Capsules demonstrate the relevance and importance of chemistry.