This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non--commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression.* Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly* Short, concise text on this difficult topic area* Clear illustrations throughout* Written by well--known teachers in the subject* Provides insight into how to analyse the data produced from microarrays

The Oxford Handbook of the History of Physics brings together cutting-edge writing by more than twenty leading authorities on the history of physics from the seventeenth century to the present day. By presenting a wide diversity of studies in a single volume, it provides authoritative introductions to scholarly contributions that have tended to be dispersed in journals and books not easily accessible to the general reader. While the core thread remains the theories and experimental practices of physics, the Handbook contains chapters on other dimensions that have their place in any rounded history. These include the role of lecturing and textbooks in the communication of knowledge, the contribution of instrument-makers and instrument-making companies in providing for the needs of both research and lecture demonstrations, and the growing importance of the many interfaces between academic physics, industry, and the military.

There is an increasing need for analysts to understand and be able to quantify the performance of analytical instruments, in particular with respect to the following:
* specifying equipment for purchase
* estimating uncertainties in intrumental measurements
* quantifying and demonstrating performance quality
This text links together an understanding of performance characteristics with an appreciation of the limitations imposed by instrument design, leading to the interplay of the validation and qualification processes within quality assurance systems.
A unique framework of topics covers the major instrumental techniques of spectrophotometry, chromatography, capillary electrophoresis, and atomic emission spectroscopy. The use of over 200 questions and answers, together with cross-referencing, helps to develop a thorough understanding of the various concepts that underpin the different techniques.
This book will appeal to a broad range of professional chemists, technicians and students, weither with reference to specific analytical techniques, or within a general course of study in instrumental performance.
Analytical Techniques in the Sciences
This series of books provides coverage of all the major analytical techniques and their application in the most important areas of physical, life and materials sciences. Each text is presented in an open learning/distant learning style, in which the learning objectives are clearly identified. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions.

Thomas Hankins and Robert Silverman investigate an array of instruments from the seventeenth through the nineteenth century that seem at first to be marginal to science--magnetic clocks that were said to operate by the movements of sunflower seeds, magic lanterns, ocular harpsichords (machines that played different colored lights in harmonious mixtures), Aeolian harps (a form of wind chime), and other instruments of "natural magic" designed to produce wondrous effects. By looking at these and the first recording instruments, the stereoscope, and speaking machines, the authors show that "scientific instruments" first made their appearance as devices used to evoke wonder in the beholder, as in works of magic and the theater. The authors also demonstrate that these instruments, even though they were often "tricks," were seen by their inventors as more than trickery. In the view of Athanasius Kircher, for instance, the sunflower clock was not merely a hoax, but an effort to demonstrate, however fraudulently, his truly held belief that the ability of a flower to follow the sun was due to the same cosmic magnetic influence as that which moved the planets and caused the rotation of the earth. The marvels revealed in this work raise and answer questions about the connections between natural science and natural magic, the meaning of demonstration, the role of language and the senses in science, and the connections among art, music, literature, and natural science. Originally published in 1995. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Wie geht es weiter - nach der erfolgreichen Promotion? Wohin soll die medizinische Laufbahn fuhren? Dieser Leitfaden wird Ihnen bei der schwierigen Entscheidung eine wertvolle Stutze sein. Eine erfahrene Medizinjournalistin portratiert hier alle Facharztrichtungen der Ausbildungsordnung der OEsterreichischen AErztekammer - von der Anasthesie bis hin zur Zahnmedizin. Zusatzlich prasentiert sie die Additivfacher der einzelnen Sonderfacher und informiert Sie uber die neue Ausbildung zum Allgemein- bzw. Zahnmediziner. Kompakt und ubersichtlich beantwortet sie folgende Fragen: Wie gestaltet sich die Ausbildung? Welche Fahigkeiten und persoenlichen Eigenschaften sind in welchem Fach gefragt? Und: An welches Fach haben Sie bisher noch nie gedacht?

From building a bridge and crafting an automaton to making a guitar and creating a crane, Science Lab is packed with activities that young readers can do at home to explore, discover, and understand the way the world works.

How do boats stay afloat? How can seals stay warm in very cold temperatures? How can you make a ball levitate? With fun, hands-on projects and experiments, this book reveals how science, technology, engineering, and maths are woven through the world around us.

Simple steps guide readers through the stages of each project, with spotlights on the key science, technology, engineering, and maths learning involved in each project along the way. "Test and tweak" panels encourage young readers to experiment and take their projects to the next level, developing their independence, initiative, and creative thinking skills.

With a focus on STEM subjects (science, technology, engineering, and maths) across school curricula to prepare children for the modern world, Science Lab will inspire and engage inquisitive young readers. It's perfect for school projects, homework help, and firing up imaginations.

The experiments in this manual are designed in a discovery format and the majority require only small quantities of reagents.

How do scientists impact society in the twenty-first century? Many scientists are increasingly interested in the impact that their research will have on the public. Scientists likewise must answer the question above when applying for funding from government agencies, particularly as part of the 'Broader Impacts' criterion of proposals to the US National Science Foundation. This book equips scientists in all disciplines to do just that, by providing an overview of the origins, history, rationale, examples, and case studies of broader impacts, primarily drawn from the author's experiences over the past five decades. Beyond including theory and evidence, it serves as a 'how to' guide for best practices for scientists. Although this book primarily uses examples from the NSF, the themes and best practices are applicable to scientists and applications around the world where funding also requires impacts and activities that benefit society.

The past six years have seen a substantial increase in the attention paid by research workers to the principles of experimental design. The Second Edition of brings this handbook up to date, while retaining the basic framework that made it so popular. Describes the most useful of the designs that have been developed with accompanying plans and an account of the experimental situations for which each design is most suitable. Examples come from diverse fields of research, with an emphasis on biology and agriculture, two of the authors' specialties. New chapters have been added: one discusses the fractional replication of experiments. A second is concerned with experiments of the factorial type that present new methods and designs in which the factors represent quantitative variables measured on a continuous scale. Other new material includes an introductory account of experimental strategies for finding the levels at which the factors must be set in order to obtain maximum response and coverage of new incomplete block designs.

Die Fort- und Weiterbildungskurse der ASG-Fellows sind seit uber 10 Jahren ein Fortbildungsprogramm und mit jeweils 5-6 Schwerpunktthemen fester Bestandteil des Kongresses der DGOT. Die Fortbildungskurse richten sich an angehende Facharzte fur Orthopadie, aber auch an erfahrene Orthopaden in Praxis und Klinik, die von bestausgewiesenen Wissenschaftlern eine kompetente UEbersicht uber Neues zu aktuellen und modernen Krankheitsbildern erfahren und Strategien in Diagnostik und Therapie dargestellt bekommen. Die verschiedenen UEbersichtsreferate sind topographisch jeweils in einem Band zusammengefasst.

Proven and tested guidelines for designing ideal labs for scientific investigations

Now in its "Fourth Edition, Guidelines for Laboratory Design "continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.

"Guidelines for Laboratory Design" features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in: Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modulesPart IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labsPart II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labsPart III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storeroomsPart IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservationPart V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainability

The final part of the book features five appendices filled with commonly needed data and reference materials.

This "Fourth Edition" is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.

Millionen von Medizin-Seiten im Internet machen den Durchblick schwer. Als kompakter, praxisbezogener Wegweiser durch diesen Informationsdschungel hilft das Buch Medizinern, das Internet optimal fur sich zu nutzen. Es erklart schrittweise den Umgang mit Daten und Datenbanken, bewertet die wichtigsten Internetadressen und informiert uber interessante Websites. Wer sich fur eine eigene Praxis-Homepage, Praxis-Netze oder telemedizinische Anwendungen interessiert, findet hier verstandliche Informationen und Anleitungen.

Special Details: Equipment Testing Procedure. Softcover Member and other discounts do not apply to this title.

Scientists' views on what makes an experiment successful have developed dramatically throughout history. Different criteria for proper experimentation were privileged at different times, entirely new criteria for securing experimental results emerged, and the meaning of commitment to experimentation altered. In About Method, Schickore captures this complex trajectory of change from 1660 to the twentieth century through the history of snake venom research. As experiments with poisonous snakes and venom were both challenging and controversial, the experimenters produced very detailed accounts of their investigations, which go back three hundred years-making venom research uniquely suited for such a long-term study. By analyzing key episodes in the transformation of venom research, Schickore is able to draw out the factors that have shaped methods discourse in science. About Method shows that methodological advancement throughout history has not been simply a steady progression toward better, more sophisticated and improved methodologies of experimentation. Rather, it was a progression in awareness of the obstacles and limitations that scientists face in developing strategies to probe the myriad unknown complexities of nature. The first long-term history of this development and of snake venom research, About Method offers a major contribution to integrated history and philosophy of science.

This textbook provides a comprehensive introduction to the theory and practice of validated numerics, an emerging new field that combines the strengths of scientific computing and pure mathematics. In numerous fields ranging from pharmaceutics and engineering to weather prediction and robotics, fast and precise computations are essential. Based on the theory of set-valued analysis, a new suite of numerical methods is developed, producing efficient and reliable solvers for numerous problems in nonlinear analysis. Validated numerics yields rigorous computations that can find all possible solutions to a problem while taking into account all possible sources of error--fast, and with guaranteed accuracy.

"Validated Numerics" offers a self-contained primer on the subject, guiding readers from the basics to more advanced concepts and techniques. This book is an essential resource for those entering this fast-developing field, and it is also the ideal textbook for graduate students and advanced undergraduates needing an accessible introduction to the subject. "Validated Numerics" features many examples, exercises, and computer labs using MATLAB/C++, as well as detailed appendixes and an extensive bibliography for further reading.Provides a comprehensive, self-contained introduction to validated numerics Requires no advanced mathematics or programming skills Features many examples, exercises, and computer labs Includes code snippets that illustrate implementation Suitable as a textbook for graduate students and advanced undergraduates

The Works of Archimedes: Edited in Modern Notation With Introductory Chapters Authored by T.L. Heath Sc.D.

What can you learn about your world in just a moment? Have you ever wondered why the sky is blue? Or whether dogs can read our facial expressions? Don Glass and experts in their fields answer these questions and many more. Written for readers of all ages with no background in science required, How the World Looks to a Bee is the perfect armchair companion for curious people who want to know more about the science of everyday life but have only a moment to spare. With intriguing everyday phenomena as a starting point, this entertaining collection uses short tutorials and quick and simple experiments to invite readers to test the science for themselves. These fascinating and topical science stories are sure to delight the curious child in all of us.

2. ERFOLGREICHES SUCHEN IN DATENBANKEN 2. 1. Suchstrategien 3 2. 2. Suchbeispiele 8 2. 2. 1. LITERA TURDA TENBANKEN 9 2. 2. 1. 1. Medline 37 2. 2. 1. 2. Science Citation Index 42 2. 2. 1. 3. Spektrum der Wissenschaft 2. 2. 1. 4. VLB (=Verzeichnis lieferbarer Bucher) 44 2. 2. 2. FAKTENDATENBANKEN 49 2. 2. 2. 1. Drug Information Fulltext 61 2. 2. 2. 2. Meyler's Side Effects of Drugs 2. 2. 2. 3. Physician Data Query (PDQ) 70 87 2. 2. 2. 4. EMBL -Datenbanken 3. BIBLIOTHEKSKATALOGE 3. 1. Kataloge amerikanischer Bibliotheken 97 3. 2. Kataloge deutscher Bibliotheken 102 3. 3. Kataloge osterreichischer Bibliotheken 105 4. GALE DIRECTORY OF DA TABASES - DIE "DATENBANK DER DATENBANKEN" 110 5. ORIGINALLITERATUR INNERHALB VON 24 STUNDEN Zentralbibliothek der Medizin (KOIn) 113 6. MEDIZINISCHE DATENBANKEN 6. 1. A bledata 115 6. 2. Acubase 115 6. 3. Aesculapis Project -WHO 115 6. 4. Ageline 115 6. 5. AIDS -Database 116 6. 6. AIDS Information and Education Worldwide 116 116 6. 7. AIDSLINE 6. 8. A IDS-Newsletter-BHTD 117 VI I nhaltsverzeichnis 6. 9. AIDS-Supplement 117 6. 10. Alcohol and Alcohol Problems Science Database 117 6. 11. Alcohol Information for Clinicians and Educators Database 118 6. 12. Allied & Alternative Medicine 118 6. 13. American Journal of Diseases of Children 118 6. 14. American Medical Association Journals Online 119 6. 15. AMIA Communications Network 119 6. 16. Anatomist 119 6. 17. Arzte Zeitung 120 6. 18. Bacteriology Abstracts 120 6. 19.

This bestselling DIY handbook now features new and expanded projects, enabling ordinary folks to construct 16 awesome ballistic devices in their garage or basement workshops using inexpensive household or hardware store materials and this step-by-step guide. Clear instructions, diagrams, and photographs show how to build projects ranging from the simple match-powered rocket to the more complex tabletop catapult and the offbeat Cincinnati fire kite. The classic potato cannon has a new evil twin--the piezo-electric spud gun and the electromagnetic pipe gun has joined the company of such favorites as the tennis ball mortar. With a strong emphasis on safety, the book also gives tips on troubleshooting, explains the physics behind the projects, and profiles scientists and extraordinary experimenters such as Alfred Nobel, Robert Goddard, and Isaac Newton. This book will be indispensable for the legions of backyard toy-rocket launchers and fireworks fanatics who wish every day was the fourth of July.

Die Proceedings der 35. Jahrestagung der Gesellschaft fur Medizinische Dokumentation, Informatik und Statistik geben einen UEberblick uber die derzeit wichtigen Forschungsschwerpunkte der Epidemiologie. Dabei konnten zum ersten Mal auch Beitrage aus der ehemaligen DDR in groesserer Zahl eingebracht werden. Schwerpunkte des Proceedingsbandes bilden die Epidemiologie kardiovaskularer Erkrankungen, die Umweltepidemiologie, die Epidemiologie von Berufskrankheiten und das epidemiologische Monitoring von Krebserkrankungen und Infektionskrankheiten. Die Qualitat verfugbarer Datenquellen wird kritisch diskutiert und die Bedeutung der Epidemiologie fur eine Verbesserung der Gesundheitsberichterstattung in den alten und in den neuen Bundeslandern klargelegt. Daruber hinaus werden methodische Probleme und unterstutzende Techniken der Medizinischen Informatik angesprochen.

Der Proceedingsband enth{lt ausgew{hlte ausgew{hlte refe- rierte Aufs{tze sowohl zu innovativen Entwicklungen in den Disziplinen Biometrie und Medizinische Informatik als auch }ber den Einsatz bekannter, bew{hrter Konzepte aus diesen Fachbereichen in der Medizin. Behandelt werden spezielle Fragestellungen zu den Themen Epidemiologie, methodische Therapieforschung, Nachweis therapeutischer Oquivalenz, Dia- gnostik und Monitoring von Krankheitsprozessen, Modellierung biologischer Mechanismen, biometrische Methoden, medizini- sche Dokumentation, L-sungsans{tze f}r Informationssysteme, spezielle Hard- und Softwarel-sungen, Expertensysteme, Bild- kommunikation und Archivierung, Bilderzeugung, wissensba- sierte Bildinterpretation und 3-d Darstellungsverfahren.