In 2003 the German Research Foundation established a new priority programme on the subject of "Imaging Measurement Methods for Flow Analysis" (SPP 1147). This research programme was based on the fact that experimental ?ow analysis, in addition to theory and numerics, has always played a predominant part both in ?ow research and in other areas of industrial practice. At the time, however, c- parisons with numerical tools (such as Computational Fluid Dynamics), which were increasingly used in research and practical applications, soon made it clear that there are relatively few experimental procedures which can keep up with state-of-the-art numerical methods in respect of their informative value, e.g. with regard to visu- spatial analysis or the dynamics of ?ow ?elds. The priority programme "Imaging Measurement Methods for Flow Analysis" was to help close this development gap. Hence the project was to focus on the investigation of ef?cient measurement me- ods to analyse complex spatial ?ow ?elds. Speci?c cooperations with computer sciences and especially measurement physics were to advance ?ow measurement techniques to a widely renowned key technology, exceeding the classical ?elds of ?uid mechanics by a long chalk.

This volume is published as the proceedings of the third Russian-German - vanced Research Workshop on Computational Science and High Performance Computing in Novosibirsk, Russia, in July 2007. The contributions of these proceedings were provided and edited by the - thors, chosen after a careful selection and reviewing. The workshop was organized by the High Performance Computing Center Stuttgart(Stuttgart,Germany)andtheInstituteofComputationalTechnologies SBRAS(Novosibirsk,Russia)intheframeworkofactivitiesoftheGerman-Russian CenterforComputationalTechnologiesandHighPerformanceComputing. Thee event is held biannually and has already become a good tradition for German and Russian scientists. The ?rst Workshop took place in September 2003 in Novosibirskand the second Workshopwas hosted by Stuttgart in March 2005. Both workshops gave the possibility of sharing and discussing the latest results and developing further scienti?c contacts in the ?eld of computational science and high performance computing. The topics of the current workshop include software and hardware for high performancecomputation,numericalmodellingingeophysicsandcomputational ?uid dynamics, mathematical modelling of tsunami waves, simulation of fuel cellsandmodern? breopticsdevices,numericalmodellingincryptographypr- lems andaeroacoustics,interval analysis,toolsfor Gridapplications,researchon service-oriented architecture (SOA) and telemedicine technologies. Theparticipationofrepresentativesofmajorresearchorganizationsengagedin the solution of the most complex problems of mathematical modelling, devel- ment of new algorithms,programsandkey elementsof informationtechnologies, elaboration and implementation of software and hardware for high performance computing systems,provideda highlevelof competenceofthe workshop. Among the German participants were the heads and leading specialists of the HighPerformanceComputingCenterStuttgart(HLRS)(UniversityofStuttgart), NECHighPerformanceComputingEuropeGmbH,SectionofAppliedMathem- ics(UniversityofFreiburgi.Br.),InstituteofAerodynamics(RWTHAachen),- gionalComputingCenterErlangen(RRZE(UniversityofErlangen-Nuremberg), Center for High Performance Computing (ZHR) (Dresden University of Technology).

The aerospace industry increasingly relies on advanced numerical simulation tools in the early design phase. This volume provides the results of a German initiative which combines many of the CFD development activities from the German Aerospace Center (DLR), universities, and aircraft industry. Numerical algorithms for structured and hybrid Navier-Stokes solvers are presented in detail. The capabilities of the software for complex industrial applications are demonstrated.

HYDRODYNAMIC PROPULSION AND ITS OPTIMIZATION ANALYTIC THEORY Hydrodynamic propulsion has been of major interest ever since craft took to the water. In the course of time, many attempts have been made to invent, develop, or to improve hydrodynamic propulsion devices. Remarkable achievements in this field were made essentially by experienced individuals, who were in need of reliable propulsion units such as paddle wheels, sculling devices, screw propellers, and of course, sails. The problem of minimizing the amount of input energy for a prescribed effective output was first investigated seriously at the beginning of this century. In 1919, BETZ presented a paper on air-screw propellers with minimum consumption of energy which could be applied to ship-screw propellers also. Next, attempts were made to optimize hydrodynamic propulsion units. Ensuing investigations concerned the optimization of the hydrodynamic system: ship-propeller. The first simple theory of ship propulsion which was presented considered more or less only thrust augmentation, wake processing and modification of propeller characteristics when operating behind the ships hull. This theory has been little improved meanwhile and is still useful, particularly with regard to practical ship design and for evaluating results of ship model tests. However, this theory is not adequate for optimization procedures necessary for high-technology propulsion, particularly for ship propellers utilizing propulsion improving devices such as tip end plates or tip fins at the propeller blades, spoilers in front of the propeller, asymmetrical stern etc.

Drag Reduction of Turbulent Flows by Additives is the first treatment of the subject in book form. The treatment is extremely broad, ranging from physicochemical to hydromechanical aspects. The book shows how fibres, polymer molecules or surfactants at very dilute concentrations can reduce the drag of turbulent flow, leading to energy savings. The dilute solutions are considered in terms of the physical chemistry and rheology, and the properties of turbulent flows are presented in sufficient detail to explain the various interaction mechanisms. Audience: Those active in fundamental research on turbulence and those seeking to apply the effects described. Fluid mechanical engineers, rheologists, those interested in energy saving methods, or in any other application in which the flow rate in turbulent flow should be increased.

Large Eddy Simulation is a relatively new and still evolving computatio nal strategy for predicting turbulent flows. It is now widely used in research to elucidate fundamental interactions in physics of turbulence, to predict phe nomena which are closely linked to the unsteady features of turbulence and to create data bases against which statistical closure models can be asses sed. However, its applicability to complex industrial flows, to which statisti cal models are applied routinely, has not been established with any degree of confidence. There is, in particular, a question mark against the prospect of LES becoming an economically tenable alternative to Reynolds-averaged N avier-Stokes methods at practically high Reynolds numbers and in complex geometries. Aerospace flows pose particularly challenging problems to LES, because of the high Reynolds numbers involved, the need to resolve accura tely small-scale features in the thin and often transitional boundary layers developing on aerodynamic surfaces. When the flow also contains a separated region - due to high incidence, say - the range and disparity of the influen tial scales to be resolved is enormous, and this substantially aggravates the problems of resolution and cost. It is just this combination of circumstances that has been at the heart of the project LESFOIL to which this book is devoted. The project combined the efforts, resources and expertise of 9 partner organisations, 4 universities, 3 industrial companies and 2 research institu tes."

This volume contains selected presentations of the "EUROMECH Colloquium 412 on LES of complex transitional and turbulent flows" held at the Munich University of Technology from 4 to 6 October 2000.

The articles focus on new developments in the field of large-eddy simulation of complex flows and are related to the topics: modelling and analysis of subgrid scales, numerical issues in LES cartesian grids for complex geometries, curvilinear and non-structured grids for complex geometries. DES and RANS-LES coupling, aircraft wake vortices, combustion and magnetohydrodynamics.

Progress has been made not only in understanding and modelling the dynamics of unresolved scales, but also in designing means that prevent the contamination of LES predictions by discretization errors. Progress is reported as well on the use of cartesian and curvilinear coordinates to compute flow in and around complex geometries and in the field of LES with unstructured grids. A chapter is dedicated to the detached-eddy simulation technique and its recent achievements and to the promising technique of coupling RANS and LES solutions in order to push the resolution-based Reynolds number limit of wall-resolving LES to higher values.

Complexity due to physical mechanisms links the last two chapters. It is shown that LES constitutes the tool to analyse the physics of aircraft wake vortices during landing and takeoff. Its thorough understanding is a prerequisite for reliable predictions of the distance between consecutive landing airplanes. Subgrid combustion modelling for LES of single and two-phase reacting flows is demonstrated to have the potential to deal with finite-rate kinetics in high Reynolds number flows of full-scale gas turbine engines. Fluctuating magnetic fields are more reliably predicted by LES when tensor-diffusivity rather than gradient-diffusion models are used. An encouraging result in the context of turbulence control by magnetic fields.

Research into the fascinating properties and applications of magnetic fluids - also called ferrofluids - is rapidly growing, making it necessary to provide, at regular intervals, a coherent and tutorial account of the combined theoretical and experimental advances in the field.

This volume is an outgrow of seven years of research by some 30 interdisciplinary groups of scientists: theoretical physicists describing the behaviour of such complex fluids, chemical engineers synthesizing nanosize magnetic particles, experimentalist measuring the fluid properties and mechanical engineers exploring the many applications such fluids offer, in turn providing application-guided feedback to the modellers and requests for the preparation of new fluid types to chemists, in particular those providing optimum response to given magnetic field configurations.

Moreover, recent developments towards biomedical applications widens this spectrum to include medicine and pharmacology.

Consisting of six large chapters on synthesis and characterization, thermo- and electrodynamics, surface instabilities, structure and rheology, biomedical applications as well as engineering and technical applications, this work is both a unique source of reference for anyone working in the field and a suitable introduction for newcomers to the field.

An exciting new direction in hydrodynamic stability theory and the transition to turbulence is concerned with the role of disconnected states or finite amplitude solutions in the evolution of disorder in fluid flows. This volume contains refereed papers presented at the IUTAM/LMS sponsored symposium on "Non-Uniqueness of Solutions to the Navier-Stokes equations and their Connection with Laminar-Turbulent Transition" held in Bristol 2004. Theoreticians and experimentalists gathered to discuss developments in understanding both the onset and collapse of disordered motion in shear flows such as those found in pipes and channels.

The central objective of the symposium was to discuss the increasing amount of experimental and numerical evidence for finite amplitude solutions to the Navier-Stokes equations and to set the work into a modern theoretical context. The participants included many of the leading authorities in the subject and this volume captures much of the flavour of the resulting stimulating and lively discussions.

Knowledge of added body masses that interact with fluid is necessary in various research and applied tasks of hydro- and aeromechanics: steady and unsteady motion of rigid bodies, total vibration of bodies in fluid, local vibration of the external plating of different structures. This reference book contains data on added masses of ships and various ship and marine engineering structures. Also theoretical and experimental methods for determining added masses of these objects are described. A major part of the material is presented in the format of final formulas and plots which are ready for practical use.

The book summarises all key material that was published in both Russian and English-language literature.

This volume is intended for technical specialists of shipbuilding and related industries.

The author is one of the leading Russian experts in the area of ship hydrodynamics.

The active field of multi-phase flow has undergone fundamental changes in the last decade. Many salient complex interfacial dynamics of such flows are now understood at a basic level with precise mathematical and quantitative characterization. This is quite a departure from the traditional empirical approach. At an IUTAM Symposium at Notre Dame, in 1999, some of the leading researchers in the field gathered to review the progress thus far and to contemplate future directions. Their reports are summarized in this Proceedings. Topics covered include solitary wave dynamics on viscous film flows, sheet formation and drop entrainment in stratified flow, wetting and dewetting dynamics, self-similar drop formation dynamics, waves in bubbly and suspension flow, and bubble dynamics. It is a unique and essential reference for applied mathematicians, physicists, research engineers, and graduate students to keep abreast of the latest theoretical and numerical developments that promise to transform multi-phase flow research.

The study of incompressible ?ows is vital to many areas of science and te- nology. This includes most of the ?uid dynamics that one ?nds in everyday life from the ?ow of air in a room to most weather phenomena. Inundertakingthesimulationofincompressible?uid?ows, oneoftentakes many issues for granted. As these ?ows become more realistic, the problems encountered become more vexing from a computational point-of-view. These range from the benign to the profound. At once, one must contend with the basic character of incompressible ?ows where sound waves have been analytically removed from the ?ow. As a consequence vortical ?ows have been analytically "preconditioned," but the ?ow has a certain non-physical character (sound waves of in?nite velocity). At low speeds the ?ow will be deterministic and ordered, i.e., laminar. Laminar ?ows are governed by a balance between the inertial and viscous forces in the ?ow that provides the stability. Flows are often characterized by a dimensionless number known as the Reynolds number, which is the ratio of inertial to viscous forces in a ?ow. Laminar ?ows correspond to smaller Reynolds numbers. Even though laminar ?ows are organized in an orderly manner, the ?ows may exhibit instabilities and bifurcation phenomena which may eventually lead to transition and turbulence. Numerical modelling of suchphenomenarequireshighaccuracyandmostimportantlytogaingreater insight into the relationship of the numerical methods with the ?ow physics.

This book covers the whole range of today 's technology for pneumatic drives. It details drives for factory automation and automotive applications as well as describes the technology for the process industry like positioners or spring-and-diaphragm. In addition, the book examines several control strategies like binary mode cylinder drives or position controlled drives and computer aided analysis of complex systems.

Besides turbulence, there is hardly any other scientific topic which has been considered a prominent scientific challenge for such a long time. The special interest in turbulence is not only based on it being a difficult scientific problem but also on its meaning in the technical world and our daily life. This carefully edited book comprises recent basic research as well as research related to the applications of turbulence. Therefore, both leading engineers and physicists working in the field of turbulence were invited to the iTi Conference on Turbulence held in Bad Zwischenahn, Gemany 21st - 24th of September 2003. Topics discussed include, for example, scaling laws and intermittency, thermal convection, boundary layers at large Reynolds numbers, isotropic turbulence, stochastic processes, passive and active scalars, coherent structures, numerical simulations, and related subjects.

"Systems of Commercial Turbofan Engines" gives the reader information about the operation of the engine systems, its components and the terminology used throughout the industry. The engine systems are explained by the use of examples from today's engines. So the readers, from aircraft mechanics to commercial pilot, become familiar with the current technology in this field and attains a deeper knowledge of the systems of commercial turbofan engines.

To understand the operation of gas turbine engines used in aircraft, it is not enough to understand the basic operation of a gas turbine. It is also necessary to understand the operation and the design of its auxiliary systems. This book is an introduction into the systems of modern commercial aircraft gas turbine engines. It is made for the reader who is familiar with the basic operation of aircraft gas turbine engine.

In sport disciplines such as running, ice skating, bicycling and cross-country skiing the aerodynamic drag force constitutes the major obstacle to overcome. Furthermore, in ski jumping and in various activities involving a ball the aerodynamic lift force comes in addition into action.

This book describes the various sport disciplines on the basis of aerodynamic analysis and also cover the biomechanics part by illustrative performance examples. Such treatment of the underlying physical phenomena of sport activities gives a valuable supplement to existing literature on sport. The reader will also be guided to references which exist for the various topics discussed, so she or he can go into a deeper study of the particular sport activity at wish.

This book brings together the quick integral approaches and advances in the field for the prediction of stall and surge problems in the compressor. The book is useful for people involved in the flow analysis, design and testing of rotating machinery. For students, it can be used as a specialized topic of senior undergraduate or graduate study. The book can also serve as self-study material.

C Specific heat at constant pressure p D Displacement field D Diffusion coefficient d D Orifice diameter E Electric field E Electron charge F Force G Acceleration due to gravity I Current J Current flux K Conductivity k Boltzmann constant B L Atomizer geometry: length from electrode tip to orifice plane i L Atomizer geometry : length of orifice channel o P Polarization Q Flow rate/Heat flux Q Charge r Atomizer geometry : electrode tip radius p T Time T Temperature U Velocity V Voltage W Energy X Distance Nomenclature (Greek) Thermal expansion coefficient ? Permittivity ? Permutation operator ? ijk Ion mobility ? VI Nomenclature Debye length ? D ? Dynamic viscosity ? Mass density Surface tension ? T Electrical conductivity ? ? Timescale ? Vorticity Nomenclature (Subscripts) Reference state ? o Cartesian tensor notation ? ijk Volume density (? per unit volume) ? v Surface density (? per unit area) ? s Linear density (? per unit length) ? l 'critical' state ? c Bulk mean injection ? inj Nomenclature (Superscripts) Time or ensemble averaged ? Contents Contents 1 Introduction................................................................... 1 1.1 Introduction and Scope.................................................. 1 1.2 Organization.............................................................. 3 2 Electrostatics, Electrohydrodynamic Flow, Coupling and Instability.................................................................. 5 2.1 Electrostatics.............................................................. 5 2.1.1 The Coulomb Force............................................. 5 2.1.2 Permittivity...................................................... 6 2.1.3 Conductors, Insulators, Dielectrics and Polarization........ 6 2.1.4 Gauss's Law...................................................... 8 2.2 Mobility and Charge Transport........................................ 10 2.2.1 Introduction...................................................... 10

This book presents comprehensive and authoritative coverage of the wide field of concentrated vortices observed in nature and technique. The methods for research of their kinematics and dynamics are considered. Special attention is paid to the flows with helical symmetry. The authors have described models of vortex structures used for interpretation of experimental data which serve as a ground for development of theoretical and numerical approaches to vortex investigation.

Current research fields in science and technology were presented and discussed at the EKC2008, informing about the interests and directions of the scientists and engineers in EU countries and Korea. The Conference has emerged from the idea of bringing together EU and Korea to get to know each other better, especially in fields of science and technology. The focus of the conference is put on the topics: Computational Fluid Dynamics; Mechatronics and Mechanical Engineering; Information and Communications Technology; Life and Natural Sciences; Energy and Environmental Technology.

The numerical optimization of practical applications has been an issue of major importance for the last 10 years. It allows us to explore reliable non-trivial configurations, differing widely from all known solutions. The purpose of this book is to introduce the state-of-the-art concerning this issue and many complementary applications are presented.

In order to allow the application of the theory from all the three volumes also to processes in combustion engines a systematic set of internally consistent state equations for diesel fuel gas and liquid valid in broad range of changing pressure and temperature are provided also in Volume 3. Erlangen, October 2006 Nikolay Ivanov Kolev Table of contents 1 Some basics of the single-phase boundary layer theory. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1 Flow over plates, velocity profiles, share forces, heat transfer. . . . . . . . . . . . . . . . . . . . 1 1. 1. 1 Laminar flow over the one site of a plane. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1. 2 Turbulent flow parallel to plane. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1. 2 Steady state flow in pipes with circular cross sections. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1. 2. 1 Hydraulic smooth wall surface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1. 2. 2 Transition region. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 1. 2. 3 Complete rough region. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 1. 2. 4 Heat transfer to fluid in a pipe. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 1. 3 Transient flow in pipes with circular cross sections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Nomenclature. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2 Introduction to turbulence of multi-phase flows . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 2. 1 Basic ideas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 2. 2 Isotropy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 2. 3 Scales, eddy viscosity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 2. 3. 1 Small scale turbulent motion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 2. 3. 2 Large scale turbulent motion, Kolmogorov-Pandtl expression. . . . . . . . . 42 2. 4 k-eps framework. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 Nomenclature. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 3 Sources for fine resolution outside the boundary layer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 3. 1 Bulk sources. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 3. 1. 1 Deformation of the velocity field. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 3. 1. 2 Blowing and suction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

This book develops a modern presentation of Continuum Mechanics, oriented towards numerical applications in the ?elds of nonlinear analysis of solids, structures and ?uids. Kinematics of the continuum deformation, including pull-back/push-forward transformations between di erent con?gurations; stress and strain measures; objective stress rate and strain rate measures; balance principles; constitutive relations, with emphasis on elasto-plasticity of metals and variational prin- ples are developed using general curvilinear coordinates. Being tensor analysis the indispensable tool for the development of the continuum theory in general coordinates, in the appendix an overview of t- soranalysisisalsopresented. Embedded in the theoretical presentation, application examples are dev- oped to deepen the understanding of the discussed concepts. Even though the mathematical presentation of the di erent topics is quite rigorous; an e ort is made to link formal developments with engineering ph- ical intuition. This book is based on two graduate courses that the authors teach at the Engineering School of the University of Buenos Aires and it is intended for graduate engineering students majoring in mechanics and for researchers in the ?elds of applied mechanics and numerical methods. VIII Preface I am grateful to Klaus-Jurgen Bathe for introducing me to Computational Mechanics, for his enthusiasm, for his encouragement to undertake challenges and for his friendship."

Recent investigations have highlighted the similarities between turbulence in cryogenic fluids at temperatures close to absolute zero, in particular superfluid helium, and turbulence in ordinary fluids. This book contains lectures on various theoretical and experimental aspects of the problem given by experts at the advanced school "Vortices and Turbulence at Low Temperatures" held at CISM, Udine, in the summer of 2007. The lectures provide an introduction into this rapidly expanding area of research. The book is suitable to PhD students and young researchers starting their career as well as established researchers in either low temperature physics or fluid mechanics who are interested in this problem.

Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar, respiratory, skeletalandnervoussystems, aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular to the description of tumor growth. The integration of models aimed at simulating the cooperation and interrelation of different systems is an even more dif?cult task. It calls for the setting up of, for instance, interaction models for the integrated cardio-vascular system and the interplay between the central circulation and peripheral compartments, models for the mid-to-long range cardiovascular adjustments to pathological conditions (e.g., to account for surgical interventions, congenital malformations, or tumor growth), models for integration among circulation, tissue perfusion, biochemical and thermal regulation, models for parameter identi?cation and sensitivity analysis to parameter changes or data uncertainty - and many othe