This book explores the non-interventional aspects of interventional pulmonology, focusing on diseases of the central airways. As the field of bronchology and interventional pulmonology expands, newer conditions involving the central airways are being recognized with increasing frequency. Current literature has mainly focused on technical aspects of the subspecialty, but this book illuminates what else interventional pulmonology has to offer the pulmonologist, including diagnosis and alternate therapeutic options. Diseases of the Central Airways: A Clinical Guide presents techniques for the diagnoses, management and treatment of patients with intriguing central airway conditions such as: black bronchoscopy, tracheobronchomalacia, endobronchial tuberculosis, and tracheobronchopathia osteochondroplastica. In-depth chapters are written by international experts and are up-to-date and comprehensive reviews. This important new book will contribute significantly to the welfare of patients with lung ailments of the central airways.

Statistical investigation into technology not only provides a better understanding of the intrinsic features of the technology (analysis), but also leads to an improved design of the technology (synthesis). Physical principles and mathematical procedures of medical imaging technologies have been extensively studied during past decades. However, less work has been done on the statistical aspects of these techniques. Statistics of Medical Imaging fills this gap and provides a theoretical framework for statistical investigation into medical imaging technologies. Features Describes physical principles and mathematical procedures of two medical imaging techniques: X-ray CT and MRI Presents statistical properties of imaging data (measurements) at each stage in the imaging processes of X-ray CT and MRI Demonstrates image reconstruction as a transform from a set of random variables (imaging data) to another set of random variables (image data) Presents statistical properties of image data (pixel intensities) at three levels: a single pixel, any two pixels, and a group of pixels (a region) Provides two stochastic models for X-ray CT and MR image in terms of their statistics and two model-based statistical image analysis methods Evaluates statistical image analysis methods in terms of their detection, estimation, and classification performances Indicates that X-ray CT, MRI, PET and SPECT belong to a category of imaging: the non-diffraction computed tomography Rather than offering detailed descriptions of statistics of basic imaging protocols of X-ray CT and MRI, this book provides a method to conduct similar statistical investigations into more complicated imaging protocols.

The book has two intentions. First, it assembles the latest research in the field of medical imaging technology in one place. Detailed descriptions of current state-of-the-art medical imaging systems (comprised of x-ray CT, MRI, ultrasound, and nuclear medicine) and data processing techniques are discussed. Information is provided that will give interested engineers and scientists a solid foundation from which to build with additional resources. Secondly, it exposes the reader to myriad applications that medical imaging technology has enabled.

This issue of MRI Clinics of North America focuses on Imaging of Brain Tumors, and is edited by Dr. Rivka Colen. Articles will include: Multiparametric Imaging Analysis: MR Spectroscopy; Genomics and MicroRNAs in Glioma; Metabolomics and Hyperpolarization MRI in Brain Tumors; Imaging Genomics in Glioma; Radiomics and Big Data in Imaging; RANO Criteria and Clinical Endpoints; Gliomas: The New WHO Brain Tumor Pathological/Molecular Classification and Clinical and Radiographic Classifications; Liposomal Contrast Agents and Nanoparticles in Brain Tumor Imaging; Multiparametric Imaging Analysis: Perfusion, and more!

This issue of PET Clinics focuses on Molecular Imaging and Precision Medicine, Part 1, and is edited by Dr. Rathan Subramaniam. Articles will include: What is Precision Medicine?; Molecular Imaging and Precision Medicine in Head and Neck Cancer; Therapy Response Assessment using Molecular Imaging and Precision Medicine; Molecular Imaging and Precision Medicine in Breast Cancer; Molecular Imaging and Precision Medicine in Dementia and Movement Disorders; Molecular Imaging and Precision Medicine in Prostate Cancer; Molecular Imaging and Precision Medicine in Lymphoma; Radionucleide Therapies in Molecular Imaging and Precision Medicine, PET based Precision Medicine in Thyroid Carcinoma; Molecular Imaging and Precision Medicine in Lung Cancer, and more!

This issue of MRI Clinics of North America focuses on Imaging of the PET/MR Imaging, and articles will include: Principles of PET/MR Imaging; Attenuation Correction of PET/MR Imaging; MR-Derived Improvements in PET Imaging; Neurological Applications of PET/MR; Oncological Applications of PET/MR Imaging on the Head and Neck; Oncological Applications of PET/MR Imaging on GYN/GU; PET/MR Imaging of Multiple Myeloma; Pediatric Nuances of PET/MR Imaging; Cardiac Applications of PET/MR Imaging; Logistics and Practical Considerations of MR Coils for PET/MR; Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment; Practical Clinical Considerations of PET/MR; Incremental value of FDG PET/MR in Assessment of Rectal Cancer, and more!

Written by a leading scholar in mathematics, this monograph discusses the Radon transform. This topic has wide ranging applications, in particular X-ray technology, partial differential equations, nuclear magnetic resonance scanning, and tomography.

This issue of Radiologic Clinics of North America focuses on Genitourinary Imaging, and is edited by Dr. Andrew B. Rosenkrantz. Articles will include: Renal Stone Imaging; Imaging of Solid Renal Masses; Imaging of Cystic Renal Masses; Practical Adrenal Imaging; Dual-energy CT in Genitourinary Imaging; Imaging Genitourinary Trauma; Upper and Lower Tract Urothelial Imaging; Pediatric Genitourinary Imaging; Prostate MR Imaging; The Evidence For and Against Corticosteroid Prophylaxis in At-Risk Patients; Image-guided Renal Interventions; Diffusion-Weighted Genitourinary Imaging; and more!

Imaging of tissue blood flow (BF) distributions provides vital information for the diagnosis and therapeutic monitoring of various vascular diseases. The innovative near-infrared speckle contrast diffuse correlation tomography (scDCT) technique produces full 3D BF distributions. Many advanced features are provided over competing technologies including high sampling density, fast data acquisition, noninvasiveness, noncontact, affordability, portability, and translatability across varied subject sizes. The basic principle, instrumentation, and data analysis algorithms are presented in detail. The extensive applications are summarized such as imaging of cerebral BF (CBF) in mice, rat, and piglet animals with skull penetration into deep brain. Clinical human testing results are described by recovery of BF distributions on preterm infants (CBF) through incubator wall, and on sensitive burn tissues and mastectomy skin flaps without direct device-tissue interactions. Supporting activities outlined include integrated capability for acquiring surface curvature information, rapid 2D blood flow mapping, and optimizations via tissue-like phantoms and computer simulations. These applications and activities both highlight and guide the reader as to the expected abilities and limitations of scDCT for adapting into their own preclinical/clinical research, use in constrained environments (i.e., neonatal intensive care unit bedside), and use on vulnerable subjects and measurement sites.

Authored by a leading educator, this book teaches the fundamental mathematics and physics concepts associated with medical imaging systems. Going beyond mere description of imaging modalities, this book delves into the mechanisms of image formation and image quality common to all imaging systems: contrast mechanisms, noise, and spatial and temporal resolution, making it an important reference for medical physicists and biomedical engineering students. This is an extensively revised new edition of The Physics of Medical X-Ray Imaging by Bruce Hasegawa (Medical Physics Publishing, 1991), and includes a wide range of modalities such as X-ray CT, MRI and SPECT.

Medical students preparing for a career in clinical practice must become familiar with a wide range of diagnostic imaging techniques and image-guided interventions. They must learn to identify the indications for radiological examination and recognize the role each procedure plays in the workup, diagnosis, and therapeutic management of patients. That is why Squire's Fundamentals of Radiology has been such an important, long-standing resource for medical students, physicians, and other professionals at all stages of their careers. It teaches essential topics in the radiology curriculum and features hundreds of illustrative cases clinicians can turn to again and again in practice. In this long-awaited seventh edition, Robert Novelline provides more than 600 new high-resolution images representing the current breadth of radiological procedures: conventional x-rays, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), angiography, radioisotope scanning, positron emission tomography (PET), and molecular imaging. This edition's expanded coverage addresses dual energy CT, breast tomosynthesis, PET-MR scanning, and tractography brain imaging, along with best practices for managing patient experiences during and after examination. All new images were produced at a major teaching hospital using state-of-the-art imaging technologies. Squire's Fundamentals of Radiology is designed to be read cover to cover by students, with concepts, principles, and methods progressing in a logical, cumulative manner. It also serves as an invaluable tool for teachers and an indispensable reference for seasoned practitioners. Written by a radiologist who has trained thousands of medical students and residents, this textbook is the clear choice for excelling in the general practice of radiology.

This issue of PET Clinics focuses on PET/MRI: Clinical Applications, and is edited by Drs. Drew Torigian and Andreas Kjaer. Articles will include: PET/MRI in Prostate Cancer; PET/MRI in Vascular Disease; PET/MRI in Lymphoma; PET/MRI in Head and Neck Cancer; PET/MRI in Brain Disease; PET/MR in Cancers of GI Tract; PET/MRI in Gynecologic Cancer; Clinical PET/MRI Systems and Patient Workflow; PET/MRI in Heart Disease; PET/MR in Breast Cancer and Lung Cancer; PET/MRI in Musculoskeletal Disorders; PET/MRI in Pediatric Oncology; Clinical PET/MRI: Future Perspectives; and more!

This issue of Physical Medicine and Rehabilitation Clinics of North America will cover musculoskeletal ultrasound in the outpatient. The articles will include: Fundamental Considerations for Ultrasound-Guided Musculoskeletal Interventions, Ultrasound-Guided Shoulder Procedures, Ultrasound-Guided Elbow Procedures, Ultrasound-Guided Hand and Wrist Procedures, Ultrasound-Guided Hip Procedures Ultrasound-Guided Knee Procedures, Ultrasound-Guided Foot and Ankle Procedures, Ultrasound-Guided Spine and Pelvis Procedures and many more exciting topics!

The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results. Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.

This issue of the Neurologic Clinics is being edited by the series Consulting Editor, Dr. Randolph Evans, and will be a special issue focusing on patient case studies of a board range of neurological diseases and disorders. Topics and cases covered include, but are not limited to: cerebrovascular disease, multiple sclerosis, syncope, epilepsy, tremor, dementia, neurologic issues in pregnancy, and medicolegal cases.

This book encompasses the full breadth of the super-resolution imaging field, representing modern techniques that exceed the traditional diffraction limit, thereby opening up new applications in biomedicine. It shows readers how to use the new tools to increase resolution in sub-nanometer-scale images of living cells and tissue, which leads to new information about molecules, pathways and dynamics. The book highlights the advantages and disadvantages of the techniques, and gives state-of-the-art examples of applications using microscopes currently available on the market. It covers key techniques such as stimulated emission depletion (STED), structured illumination microscopy (SSIM), photoactivated localization microscopy (PALM), and stochastic optical reconstruction microscopy (STORM). It will be a useful reference for biomedical researchers who want to work with super-resolution imaging, learn the proper technique for their application, and simultaneously obtain a solid footing in other techniques.

The Migraine Brain, edited by David Borsook, Arne May, Peter J. Goadsby, and Richard Hargreaves, makes a major contribution to the field, addressing the increasingly sophisticated neuroimaging techniques that have allowed researchers to begin to define functional and anatomical characteristics of migraine and other less-common types of headache. Of particular focus is how imaging is changing the way we understand migraine. This includes changes in function, structure and chemistry of the migraine brain. Included are sections that focus on particular aspects of migraine, for example the migraine aura: those symptoms that cause visual sensitivity (blinding white light), sensory difficulty (loud noises, painful touch, and hot/cold spells), slurred language, and motor dysfunction.
Extensively illustrated throughout, The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
A collation of the top thinkers in the field and the only book of its kind, The Migraine Brain is necessary reading for neurologists and neuroscientists.

This issue of Neuroimaging Clinics of North America focuses on The Pediatric Cerebellum, and is edited by Drs. Huisman and Andrea Poretti. Articles will include: The role of the pediatric cerebellum in motor functions, neurocognition and behavior: a clinical perspective; Normal development of the cerebellum: from the fetus to the adolescent; Cerebellar malformations; Cerebellar disruptions; Metabolic disorders with cerebellar involvement; Neurocutaenous syndromes with cerebellar involvement; Vascular disorders of the cerebellum; Tumors of the cerebellum; Infectious and inflammatory diseases of the cerebellum; Cerebro-cerebellar network, and more!

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Radiology Lecture Notes is a succinct yet thorough introduction to the essential imaging techniques used in various clinical situations. This fully revised and updated new edition presents the fundamental core knowledge of film interpretation, specialised radiological investigations, and procedures for imaging specific problems. The book explores common diseases and disorders complemented by good quality radiology images and full-colour illustrations. Concise chapters, organised by body systems cover investigations of the respiratory and gastrointestinal tracts, the cardiovascular and musculoskeletal systems, the liver and pancreas, and many others. Now in its fourth edition, this market-leading guide has been updated to reflect current practices and technologies in the field, featuring new up-to-date content on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This practical guide: Provides a basic foundation in the principles and techniques of radiology Offers new content, including up-to-date CT, MRI and nuclear medicine images Features bulleted lists, 'Key Points' boxes, and 'Radiological Investigations' sections throughout the text Radiology Lecture Notes is an ideal study and revision guide for medical students and junior doctors, and will be a useful aid for specialist nurses, radiographers, and radiology department staff.

The 11 chapters in this book have been selected from the contents of the Interventional Radiology section in Grainger & Allison's Diagnostic Radiology 6e. These chapters provide a succinct up-to-date overview of current imaging techniques and their clinical applications in daily practice and it is hoped that with this concise format the user will quickly grasp the fundamentals they need to know. Throughout these chapters, the relative merits of different procedures and techniques are described, variations are discussed and recent imaging advances are detailed.

This issue of PET Clinics focuses on PET/MRI: Advances in Instrumentation and Quantitative Procedures. Articles will include: Advances in clinical PET/MRI instrumentation; Magnetic resonance imaging-guided attenuation correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided partial volume correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided derivation of the input function for PET kinetic modeling; Innovations in small-animal PET/MRI instrumentation; Dual-modal PET/MRI molecular imaging probes; Magnetic resonance imaging-guided motion compensation of positron emission tomography data in PET/MRI; Attenuation correction for MR coils in combined PET/MR imaging; and more!

This book describes the technical problems and solutions for automatically recognizing and parsing a medical image into multiple objects, structures, or anatomies. It gives all the key methods, including state-of- the-art approaches based on machine learning, for recognizing or detecting, parsing or segmenting, a cohort of anatomical structures from a medical image. Written by top experts in Medical Imaging, this book is ideal for university researchers and industry practitioners in medical imaging who want a complete reference on key methods, algorithms and applications in medical image recognition, segmentation and parsing of multiple objects. Learn: Research challenges and problems in medical image recognition, segmentation and parsing of multiple objects Methods and theories for medical image recognition, segmentation and parsing of multiple objects Efficient and effective machine learning solutions based on big datasets Selected applications of medical image parsing using proven algorithms

This issue of Radiologic Clinics of North America focuses on Topics in Transplantation Imaging. Articles will include: Surgical and imaging workup of the liver pre-transplantation donor and recipient; Surgical techniques and imaging complications of liver transplantation; Surgical and imaging workup of the renal pre-transplantation donor and recipient; Imaging complications of renal transplantation; Surgical and imaging workup of the pancreas pre-transplantation donor and recipient; Interventional and surgical techniques in solid organ transplantation; Complications of immunosuppresive therapy in solid organ transplantation; Pediatric thoracic organ transplantation: current indications, techniques, and imaging findings; Pediatric abdominal organ transplantation: update on current practical imaging assessment; Surgical issues of lung transplantation; Imaging complications of lung transplantation; Current indications, techniques, and imaging findings of stem cell treatment and bone marrow transplant; and more!