An excellent survey of and introduction to new methods of biological imaging and sensing, particularly related to biomedical measurements and controls. The main topics discussed include: cell imaging, multiphoton microscopy for biomedical studies, molecular imaging, infrared imaging, biomedical magnetic imaging, and microscopy with laser-trapped particles. The book also deals with nanosurgery with light, the effects of ultrasound on tissue, diagnostics, near- and far-infrared transmission of biomedical information, and cell sensors. This book will be a valuable resource for both medical doctors and biophysicists.

The application of 3D methodology has recently been receiving increasing attention at many PET centres, and this monograph is an attempt to provide a state-of-the-art review of this methodology, covering 3D reconstruction methods, quantitative procedures, current tomography performance, and clinical and research applications. No such review has been available until now to assist PET researchers in understanding and implementing 3D methodology, and in evaluating the performance of the available imaging technology. In all the chapters, the subject matter is treated in sufficient depth to appeal equally to the physicist or engineer who wishes to establish the methodology, and to PET investigators with experience in 2D PET who wish to familiarize themselves with the concepts and advantages of 3D, and to be made aware of the pitfalls.

Optic flow provides all the information necessary to guide a walking human or a mobile robot to its target. Over the past 50 years, a body of research on optic flow spanning the disciplines of neurophysiology, psychophysics, experimental psychology, brain imaging and computational modelling has accumulated. Today, when we survey the field, we find independent lines of research have now converged and many arguments have been resolved; simultaneously the underpinning assumptions of flow theory are being questioned and alternative accounts of the visual guidance of locomotion proposed. At this critical juncture, this volume offers a timely review of what has been learnt and pointers to where the field is going.

At the end of the 20th century, a tremendous progress was made in biotechnology in its widest sense. This progress was largely possible as a result of joint efforts of top academic researchers in both pure fundamental sciences and applied research. The surplus value of such interdisciplinary approaches was clearly highlighted during the 9th European Congress on Biotechnology that was held in Brussels, Belgium (11-15 July, 1999). The present volume in the 'Focus on Biotechnology' series, entiteld 'Physics and Chemistry Basis for Biotechnology' contains selected presentations from this meeting, A collection of experts has made serious efforts to present some of the latest developments in various scientific fields and to unveil prospective evolutions on the threshold of the new millenium. In all contributions the emphasis is on emerging new areas of research in which physicochemical principles form the foundation. In reading the different chapters, it appears that more than ever significant advances in biotechnology very often depend on breakthroughs in the biotechnology itself (e.g.

This book provides a comprehensive reference and practical guide on the application of US to penile diseases and conditions. After introductory chapters on technical requirements and penile anatomy, subsequent chapters offer a systematic overview of the diverse applications of color Doppler US. The topics covered include erectile dysfunction, Peyronie's disease, priapism, trauma, tumors, the postoperative penis, inflammation, and fibrosis. Each topic is introduced by a clinical overview with the purpose of clarifying the problems and elucidating what the urologist may expect from color Doppler US. Thereafter, performance of the US study is explained and the pathological anatomy reviewed. High-quality images obtained with high-end US equipment are included. Each chapter also contains a section on the diagnostic information provided by other imaging modalities, and in particular MRI.

In this book, research and development trends of physics, engineering, mathematics and computer sciences in biomedical engineering are presented. Contributions from industry, clinics, universities and research labs with foci on medical imaging (CT, MRT, US, PET, SPECT etc.), medical image processing (segmentation, registration, visualization etc.), computer-assisted surgery (medical robotics, navigation), biomechanics (motion analysis, accident research, computer in sports, ergonomics etc.), biomedical optics (OCT, soft-tissue optics, optical monitoring etc.) and laser medicine (tissue ablation, gas analytics, topometry etc.) give insight to recent engineering, clinical and mathematical studies.

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century."

Biomedical EPR Part B focuses on applications of EPR techniques and instrumentation, with applications to dynamics. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field that lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR.

Key Features:
EPR Techniques including Saturation Recovery, ENDOR, ELDOR, and Saturation Transfer

Instrumentation Innovations including Loop Gap Resonators, Rapid Mixing, and Time Locked Sub-Sampling

Motion in Biological Membranes

Applications to Structure Determination in Proteins

Discussion of Trends in EPR Technology and Prognosis for the Future "

Dr. Peter S. Conti is a Professor of Radiology and the Director of the PET Imaging Science Center at the University of Southern California, and is a Fellow of both the American College of Radiology and American College of Nuclear Physicians. He is a pioneer in the development of the clinical applications of PET and more recently PET-CT. He and one of his fellows, Dr. Daniel Cham, have published this groundbreaking PET-CT case-based book, which reveals how PET-CT can be applied in routine clinical scenarios. Leading authorities in the field examine a wealth of heavily-illustrated original PET-CT cases that showcase both common and uncommon cancers, and the latest PET-CT applications for neurological and cardiovascular disorders. Correlative three-dimensional cross-sectional PET and CT images highlight pathological findings. Each of the clinical applications is accompanied by a concise explanation of the patient history and interpretation of the PET-CT study. Insightful discussions and "pearls and pitfalls" are included to assist in a better understanding of pathology, diagnosis, and imaging approaches. Readers also find important coverage of pathophysiology and technical artifacts. This unique book is ideal for nuclear medicine practitioners, radiologists, and residents, as well as referring clinicians interested in learning more about how this new medical imaging technology can be applied in their patient populations.This unique book is ideal for nuclear medicine practitioners, nuclear medicine residents, and clinicians interested in medical imaging for tumor patients.

The study of brain function is one of the most fascinating pursuits of m- ern science. Functional neuroimaging is an important component of much of the current research in cognitive, clinical, and social psychology. The exci- ment of studying the brain is recognized in both the popular press and the scienti?c community. In the pages of mainstream publications, including The New York Times and Wired, readers can learn about cutting-edge research into topics such as understanding how customers react to products and - vertisements ("If your brain has a 'buy button, ' what pushes it?," The New York Times, October19,2004), howviewersrespondtocampaignads("Using M. R. I. 's to see politics on the brain," The New York Times, April 20, 2004; "This is your brain on Hillary: Political neuroscience hits new low," Wired, November 12,2007), howmen and womenreactto sexualstimulation ("Brain scans arouse researchers,"Wired, April 19, 2004), distinguishing lies from the truth ("Duped," The New Yorker, July 2, 2007; "Woman convicted of child abuse hopes fMRI can prove her innocence," Wired, November 5, 2007), and even what separates "cool" people from "nerds" ("If you secretly like Michael Bolton, we'll know," Wired, October 2004). Reports on pathologies such as autism, in which neuroimaging plays a large role, are also common (for - stance, a Time magazine cover story from May 6, 2002, entitled "Inside the world of autism").

Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide variety of biodetection applications, offering the advantages of increased speed and ease of use compared to traditional detection methods. In Biosensors and Biodetection: Methods and Protocols, leading experts describe the major technologies in the field in extensive technical detail, allowing readers both to understand the technology and to construct similar devices. Volume 2: Electrochemical and Mechanical Detectors, Lateral Flow and Ligands for Biosensors focuses on direct measurement sensors, indirect methods, ligands, and related technologies, including methods involving electrochemical detectors, recognition ligands, antibodies, aptamers, and peptides, amongst many other subjects. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include brief introductions to the topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Biosensors and Biodetection: Methods and Protocols is an ideal, user-friendly guide to this vital, versatile technology and a perfect tool for those who wish to further the field.

Since the first edition of this book, sonography of the peripheral nervous system has evolved further. This second, revised edition includes many state-of-the-art high-resolution images, the text has been adapted to reflect the current state of the literature, and information is presented using a more modern layout. This book provides a practical, clinically oriented overview of all aspects of sonographic diagnosis and interventional therapy of the peripheral nervous system.

The purpose of this book is to integrate the most re- butions and support of my colleagues and friends cent advances in the diagnosis and treatment of pedi- at The University of Texas Southwestern Medical atric bone and soft tissue sarcomas. The book is di- School,St. Jude Children's Research Hospital,and the vided into two major sections,the ?rst of which pres- Hospital for Sick Children in Toronto. In particular,I ents salient concepts in epidemiology,the impact of would like to thank Drs. George Buchanan, Charles novel tools in imaging and molecular biology,and the Pratt,William Crist, David Parham, Jim Anderson, underlying principles for continued drug develop- and Larry Kun for their friendship,mentorship,and ment. In the second section,the book embarks on an wisdom. Their teachings will continue to be an e- up-to-date survey of the diagnosis and treatment of less source of passion and inspiration. It is my wish each speci?c disease,with particular emphasis on the that this book will provide answers, guidance and need for an integrative, multidisciplinary approach hope to medical professionals, children, and their to diagnosis and treatment. families. I am indebted to my colleagues and collaborators who have contributed their ideas, time, and kno- edge to this project. I am also grateful for the contri- Alberto Pappo,MD IX Contents 1 Epidemiology of Bone 3 Diagnostic Imaging of Pediatric Bone and Soft Tissue Sarcomas and Soft Tissue Sarcomas Logan G. Spector,Julie A. Ross, Thomas D. Henry,Mary E. McCarville, Rajaram Nagarajan Fredric A.

This volume presents a wide range of medical applications that can utilize mathematical computing. This work grew out of a workshop on optimization which was held during the 2005 CIM Thematic Term on Optimization in Coimbra, Portugal. It provides an overview of the state-of-the-art in optimization in medicine and will serve as an excellent reference for researchers in the medical computing community and for those working in applied mathematics and optimization.

This book is devoted to the study of variational methods in imaging. The presentation is mathematically rigorous and covers a detailed treatment of the approach from an inverse problems point of view. Many numerical examples accompany the theory throughout the text. It is geared towards graduate students and researchers in applied mathematics. Researchers in the area of imaging science will also find this book appealing. It can serve as a main text in courses in image processing or as a supplemental text for courses on regularization and inverse problems at the graduate level.

Since 1968, the International Acoustical Imaging Symposium has provided a unique forum for advanced research, promoting the sharing of technology, developments, methods and theory among all areas of acoustics. Volume 28 of the Proceedings offers an excellent collection of papers presented in six major categories, offering both a broad perspective on the state of the art in the field as well as an in-depth look at its leading edge research.

Neutron Imaging and Applications offers an introduction to the basics of neutron beam production in addition to the wide scope of techniques that enhance imaging application capabilities. An instructional overview of neutron sources, detectors, optics and spin-filters allows readers to delve more deeply into the discussions of radiography, tomography and prospective applications available in neutron holography techniques. A section devoted to current applications describes imaging single grains in polycrystalline materials, neutron imaging of geological materials and other materials science and engineering areas. Coverage of thermal neutron imaging of biological tissues, plant physiology, Homeland Security and contraband detection explore the future prospects of this cutting-edge research.

Written by key experts in the field, researchers and engineers involved with imaging technologies will find Neutron Imaging and Applications a valuable reference.

This comprehensive volume is the current final word on the subject. It contains more than 90 papers, giving a summary of clinical and basic studies on cerebral vasospasm. It includes reviews by leading researchers in the field. Several new subjects are proposed for future research that will not only promote research from neurosurgery and neurology but also from other interconnecting fields of emergency medicine, electrophysiology, molecular biology, and vascular biology.

With the development of neural science, knowledge of the molecules and neurons that comprise the brain has increased exponentially in the past two decades. In this book, leading neuroscientists from Japan and Taiwan describe the latest and most relevant research in brain science, including state-of-the-art brain-imaging technologies. They also discuss learning, memory, emotions, and pain. An entirely new and unique field of study is introduced in the learning and memory section.

Chest sonography is an established procedure in the stepwise imaging diagnosis of pulmonary and pleural disease. It is the method of choice to distinguish between solid and liquid lesions and allows the investigator to make an unequivocal diagnosis without exposing the patient to costly and stressful procedures. This book presents the state of the art in chest investigation by means of ultrasonography. A number of excellent illustrations and the compact text provide concise and easy-to-assimilate information about the diagnostic procedure. Basic elements such as indications, investigation techniques and image artifacts are detailed in separate chapters.

The last two years have witnessed a continuation in the breakthrough shift toward pulse tube cryocoolers for long-life, high-reliability cryocooler applications. New this year are papers de scribing the development of very large pulse tube cryocoolers to provide up to 1500 watts of cooling for industrial applications such as cooling the superconducting magnets of Mag-lev trains, coolmg superconducting cables for the power mdustry, and liquefymg natural gas. Pulse tube coolers can be driven by several competing compressor technologies. One class of pulse tube coolers is referred to as "Stirling type" because they are based on the linear Oxford Stirling-cooler type compressor; these generally provide coolmg m the 30 to 100 K temperature range and operate ^t frequencies from 30 to 60 Hz. A second type of pulse tube cooler is the so-called "Gifford-McMahon type. " Pulse tube coolers of this type use a G-M type compressor and lower frequency operation (~1 Hz) to achieve temperatures in the 2 to 10 K temperature range. The third type of pulse tube cooler is driven by a thermoacoustic oscillator, a heat engine that functions well in remote environments where electricity is not readily available. All three types are described, and in total, nearly half of this proceedings covers new developments in the pulse tube arena. Complementing the work on low-temperature pulse tube and Gifford-McMahon cryocoolers is substantial continued progress on rare earth regenerator materials.

Neural activity in the human brain generates coherent synaptic and intracellular currents in cortical columns that create electromagnetic signals which can be measured outside the head using magnetoencephalography (MEG) and electroencephalography (EEG). Electromagnetic brain imaging refers to techniques that reconstruct neural activity from MEG and EEG signals. Electromagnetic brain imaging is unique among functional imaging techniques for its ability to provide spatio-temporal brain activation profiles that reflect not only where the activity occurs in the brain but also when this activity occurs in relation to external and internal cognitive events, as well as to activity in other brain regions. Adaptive spatial filters are powerful algorithms for electromagnetic brain imaging that enable high-fidelity reconstruction of neuronal activity. This book describes the technical advances of adaptive spatial filters for electromagnetic brain imaging by integrating and synthesizing available information and describes various factors that affect its performance. The intended audience include graduate students and researchers interested in the methodological aspects of electromagnetic brain imaging.

Despite the fact that images constitute the main objects in computer vision and image analysis, there is remarkably little concern about their actual definition. In this book a complete account of image structure is proposed in terms of rigorously defined machine concepts, using basic tools from algebra, analysis, and differential geometry. Machine technicalities such as discretisation and quantisation details are de-emphasised, and robustness with respect to noise is manifest. From the foreword by Jan Koenderink: It is my hope that the book will find a wide audience, including physicists - who still are largely unaware of the general importance and power of scale space theory, mathematicians - who will find in it a principled and formally tight exposition of a topic awaiting further development, and computer scientists - who will find here a unified and conceptually well founded framework for many apparently unrelated and largely historically motivated methods they already know and love. The book is suited for self-study and graduate courses, the carefully formulated exercises are designed to get to grips with the subject matter and prepare the reader for original research.'

In this monograph, we shall present a new mathematical formulation of quantum theory, clarify a number of discrepancies within the prior formulation of quantum theory, give new applications to experiments in physics, and extend the realm of application of quantum theory well beyond physics. Here, we motivate this new formulation and sketch how it developed. Since the publication of Dirac's famous book on quantum mechanics [Dirac, 1930] and von Neumann's classic text on the mathematical foundations of quantum mechanics two years later [von Neumann, 1932], there have appeared a number of lines of development, the intent of each being to enrich quantum theory by extra polating or even modifying the original basic structure. These lines of development have seemed to go in different directions, the major directions of which are identified here: First is the introduction of group theoretical methods [Weyl, 1928; Wigner, 1931] with the natural extension to coherent state theory [Klauder and Sudarshan, 1968; Peremolov, 1971]. The call for an axiomatic approach to physics [Hilbert, 1900; Sixth Problem] led to the development of quantum logic [Mackey, 1963; Jauch, 1968; Varadarajan, 1968, 1970; Piron, 1976; Beltrametti & Cassinelli, 1981], to the creation of the operational approach [Ludwig, 1983-85, 1985; Davies, 1976] with its application to quantum communication theory [Helstrom, 1976; Holevo, 1982), and to the development of the C* approach [Emch, 1972]. An approach through stochastic differential equations ("stochastic mechanics") was developed [Nelson, 1964, 1966, 1967].

Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.