Synthetic Biology is already an object of intensive debate. However, to a great extent the discussion to date has been concerned with fundamental ethical, religious and philosophical questions. By contrast, based on an investigation of the field’s scientific and technological character, this book focuses on new functionalities provided by synthetic biology and explores the associated opportunities and risks. Following an introduction to the subject and a discussion of the most central paradigms and methodologies, the book provides an overview of the structure of this field of science and technology. It informs the reader about the current stage of development, as well as topical problems and potential opportunities in important fields of application. But not only the science itself is in focus. In order to investigate its broader impact, ecological as well as ethical implications will be considered, paving the way for a discussion of responsibilities in the context of a field at a transitional crossroads between basic and applied science. In closing, the requirements for a suitable regulatory framework are discussed. The book is intended as a source of information and orientation for researchers, students and practitioners in the natural sciences and technology assessment; for members of scientific and technological, governmental and funding institutions; and for members of the general public interested in essential information on the current status, prospects and implications of synthetic biology.

Accidents in technical installations are random events. Hence they cannot be totally avoided. Only the probability of their occurrence may be reduced and their consequences be mitigated. The book proceeds from hazards caused by materials and process conditions to indicating technical and organizational measures for achieving the objectives of reduction and mitigation. Qualitative methods for identifying weaknesses of design and increasing safety as well as models for assessing accident consequences are presented. The quantitative assessment of the effectiveness of safety measures is explained. The treatment of uncertainties plays a role there. They stem from the random character of the accident and from lacks of knowledge on some of the phenomena to be addressed. The reader is acquainted with the simulation of accidents, safety and risk analyses and learns how to judge the potential and limitations of mathematical modelling. Risk analysis is applied amongst others to “functional safety� and the determination of “appropriate distances� between industry and residential areas (land-use planning). This shows how it can be used as a basis for safety-relevant decisions. Numerous worked-out examples and case studies addressing real plants and situations deepen the understanding of the subjects treated and support self-study. Target groups Chemical and petrochemical industry, licensing authorities, testing and certification bodies, safety engineers, engineering , students of process,  chemical and mechanical engineering as well as of industrial and engineering chemistry.

The book provides readers with a snapshot of recent research and technological trends in the field of condition monitoring of machinery working under a broad range of operating conditions. Each chapter, accepted after a rigorous peer-review process, reports on an original piece of work presented and discussed at the 4th International Conference on Condition Monitoring of Machinery in Non-stationary Operations, CMMNO 2014, held on December 15-16, 2014, in Lyon, France. The contributions have been grouped into three different sections according to the main subfield (signal processing, data mining or condition monitoring techniques) they are related to. The book includes both theoretical developments as well as a number of industrial case studies, in different areas including, but not limited to: noise and vibration; vibro-acoustic diagnosis; signal processing techniques; diagnostic data analysis; instantaneous speed identification; monitoring and diagnostic systems; and dynamic and fault modeling. This book not only provides a valuable resource for both academics and professionals in the field of condition monitoring, it also aims at facilitating communication and collaboration between the two groups.

Serving to unify the existing literature on extended warranties, maintenance service contracts and lease contracts, this book also presents a unique perspective on the topic focussed on cost analysis and decision-making from the perspectives of the parties involved. Using a game theoretic approach together with mathematical modelling, results are presented in an integrated manner with key topics that require further research highlighted in order to serve as a starting point for researchers (engineers and statisticians) who are interested in doing further work in these areas. Designed to assist practitioners (managers, engineers, applied statisticians) who are involved with extended warranties, maintenance service contracts and lease contracts, the book provides them with the models and techniques needed for proper cost analysis and effective decision-making, The book is also suitable for use as a reference text in industrial engineering, applied statistics, operations research and management.

The volume presents the research work in understanding, modeling and quantifying the risks associated with different ways of implementing smart grid technology in power systems in order to plan and operate a modern power system with an acceptable level of reliability. Power systems throughout the world are undergoing significant changes creating new challenges to system planning and operation in order to provide reliable and efficient use of electrical energy. The appropriate use of smart grid technology is an important drive in mitigating these problems and requires considerable research activities, some of which (by researchers from academia and industry) are included in this volume: the reliability appraisal of smart grid technologies and their applications, micro-grids, assessment of plug-in hybrid vehicles and the system effects, smart system protection and reliability evaluation, demand response and smart maintenance of power system equipment.

The book presents the development of the Construction Quality Assessment System (CONQUAS), Singapore's de facto quality performance measurement system, explains the application of the Quality Management System (QMS) to manage CONQUAS and identifies 33 critical success factors (CSFs) for achieving high CONQUAS scores. Through CONQUAS, the reader benefits from understanding how the Singapore government developed and implemented the first objective system for measuring what many building professionals have perceived to be elusive quality standards in the construction industry. The book presents both the theoretical concepts as well as the practical aspects to achieving strategic Project Quality Management that is anchored on the CSFs to building best practices. To realistically reflect the practical aspects and challenging issues faced by stakeholders in the construction industry, questionnaire surveys were conducted with building professionals to distinguish the importance level and extent of adoption of the 33 CSFs (identified from a comprehensive review of the extant literature) in influencing and affecting the achievement of high CONQUAS scores. These were further anchored by in-depth interviews with quality experts in the Singapore construction industry to provide a better understanding of issues relating to strategic Project Quality Management. Collectively, the empirical findings collated from the building professionals suggest that while the CSFs identified are known tenets of quality, these were still not being followed in their totality. A further case study was conducted through a formal set of in-depth interviews with the quality assurance team of a construction company who has direct involvement before, during and after their tremendous improvements in the CONQUAS scores attained. The strength of this book therefore represents a true account and reflections of real-life practices and experiences in the construction industry for contractors, quality managers and policy-makers to learn from. Although the context of this book relates to the Singapore experience, the lessons and recommendations are equally relevant and applicable to the global construction industry in both the developing and developed countries whose stakeholders (in both the public and private sectors) wish to understand how CONQUAS works, and how the CSFs identified can likewise be implemented for strategic Project Quality Management to building best practices. The book is therefore of interests to researchers, academia and practitioners in the construction industry as well as in other sectors of the economy (in Singapore and other countries) where learning points may be used for enhancing project quality management for buildings.

This book presents a systematic approach in performing reliability assessment of solder joints using Finite Element (FE) simulation. Essential requirements for FE modelling of an electronic package or a single reflowed solder joint subjected to reliability test conditions are elaborated. These cover assumptions considered for a simplified physical model, FE model geometry development, constitutive models for solder joints and aspects of FE model validation. Fundamentals of the mechanics of solder material are adequately reviewed in relation to FE formulations. Concept of damage is introduced along with deliberation of cohesive zone model and continuum damage model for simulation of solder/IMC interface and bulk solder joint failure, respectively. Applications of the deliberated methodology to selected problems in assessing reliability of solder joints are demonstrated. These industry-defined research-based problems include solder reflow cooling, temperature cycling and mechanical fatigue of a BGA package, JEDEC board-level drop test and mechanisms of solder joint fatigue. Emphasis is placed on accurate quantitative assessment of solder joint reliability through basic understanding of the mechanics of materials as interpreted from results of FE simulations. The FE simulation methodology is readily applicable to numerous other problems in mechanics of materials and structures.

This book reports on the state of the art in the field of multiphysics systems. It consists of accurately reviewed contributions to the MMSSD'2014 conference, which was held from December 17 to 19, 2004 in Hammamet, Tunisia. The different chapters, covering new theories, methods and a number of case studies, provide readers with an up-to-date picture of multiphysics modeling and simulation. They highlight the role played by high-performance computing and newly available software in promoting the study of multiphysics coupling effects, and show how these technologies can be practically implemented to bring about significant improvements in the field of design, control and monitoring of machines. In addition to providing a detailed description of the methods and their applications, the book also identifies new research issues, challenges and opportunities, thus providing researchers and practitioners with both technical information to support their daily work and a new source of inspiration for their future research.

The integrated and advanced science research topic Man-Machine-Environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science and technology in China!� MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, “man� refers to people in the workplace (e.g. operators, decision-makers); “ machine� is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and “environment� describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of Man-Machine-Environment systems are to ensure safety, efficiency and economy. Proceedings of the 13th International Conference on Man-Machine-Environment System Engineering are an academic showcase of the best papers selected from more than 400 submissions, introducing readers to the top research topics and the latest developmental trends in the theory and application of MMESE. These proceedings are interdisciplinary studies on the concepts and methods of physiology, psychology, system engineering, computer science, environment science, management, education, and other related disciplines. Researchers and professionals working in these interdisciplinary fields and researchers on MMESE related topics will benefit from these proceedings.

Human reliability, error, and human factors in the area of power generation have been receiving increasing attention in recent years. Each year billions of dollars are spent in the area of power generation to design, construct/manufacture, operate, and maintain various types of power systems around the globe, and such systems often fail due to human error. This book compiles various recent results and data into one volume, and eliminates the need to consult many diverse sources to obtain vital information. It enables potential readers to delve deeper into a specific area, providing the source of most of the material presented in references at the end of each chapter. Examples along with solutions are also provided at appropriate places, and there are numerous problems for testing the reader's comprehension. Chapters cover a broad range of topics, including general methods for performing human reliability and error analysis in power plants, specific human reliability analysis methods for nuclear power plants, human factors in control systems, and human error in power plant maintenance. They are written in such a manner that the potential reader requires no previous knowledge to understand their contents. "Human Reliability, Error, and Human Factors in Power Generation" will prove useful to many individuals, including engineering professionals working in the power generation industry, researchers, instructors, and undergraduate and graduate students in the field of power engineering.

Tokamak Engineering Mechanics offers concise and thorough coverage of engineering mechanics theory and application for tokamaks, and the material is reinforced by numerous examples. Chapter topics include general principles, static mechanics, dynamic mechanics, thermal fluid mechanics and multiphysics structural mechanics of tokamak structure analysis. The theoretical principle of the design and the methods of the analysis for various components and load conditions are presented, while the latest engineering technologies are also introduced. The book will provide readers involved in the study of mechanical/fusion engineering with a general understanding of tokamak engineering mechanics. Yuntao Song is Head of the Tokamak Design Division at the Institute of Plasma Physics, Chinese Academic of Science (ASIPP), China.

This critical volume provides practical insights on sulfuric acid and related plant design and on techniques to improve and enhance substantially the efficiency of an existing plant by means of small modifications. The book provides readers with a better understanding of the state-of-art in sulfuric acid manufacture as well as, importantly, in the manufacture of value-added products based on sulfur that are also associated with the manufacture of sulfuric acid. Overall, engineers and plant managers will be introduced to technologies for making their sulfuric acid enterprises more productive, remunerative, and environmentally friendly. A Practical Guide to the Manufacture of Sulfuric Acid, Oleums, and Sulfonating Agents covers sulfuric acid and derivative chemical plant details from the nuts-and-bolts level to a holistic perspective based on actual field experience. The book is indispensable to anyone involved in implementing a sulfuric acid or related chemical plant.

This comprehensive monograph addresses crucial issues in the protection of railway systems, with the objective of enhancing the understanding of railway infrastructure security. Based on analyses by academics, technology providers and railway operators, it explains how to assess terrorist and criminal threats, design countermeasures, and implement effective security strategies. In so doing, it draws upon a range of experiences from different countries in Europe and beyond. The book is the first to be devoted entirely to this subject. It will serve as a timely reminder of the attractiveness of the railway infrastructure system as a target for criminals and terrorists and, more importantly, as a valuable resource for stakeholders and professionals in the railway security field aiming to develop effective security based on a mix of methodological, technological and organizational tools. Besides researchers and decision makers in the field, the book will appeal to students interested in critical infrastructure protection.

Includes the proceedings from the 7th IAASS Conference, "Space Safety is No Accident," held in Friedrichshafen, Germany, in October 2014. The 7th IAASS Conference, "Space Safety is No Accident" is an invitation to reflect and exchange information on a number of topics in space safety and sustainability of national and international interest. The conference is also a forum to promote mutual understanding, trust and the widest possible international cooperation in such matters. The once exclusive "club" of nations with autonomous sub-orbital and orbital space access capabilities is becoming crowded with fresh and ambitious new entrants. New commercial spaceports are starting operations and others are being built. In the manned spaceflight arena a commercial market is becoming a tangible reality with suborbital spaceflights and government use of commercial services for cargo and crew transportation to orbit. Besides the national ambitions in space, the international cooperation both civil and commercial is also gaining momentum. In the meantime robotic space exploration will accelerate and with it the need to internationally better regulate the usage of nuclear power sources. Space-bound systems and aviation traffic will share more and more a crowded airspace, while aviation will increasingly rely on space-based safety-critical services. Finally, most nations own nowadays space assets, mainly satellites of various kinds and purposes, which are under the constant threat of collision with other spacecraft and with the ever increasing number of space debris. Awareness is increasing internationally (as solemnly declared since decades in space treaties) that space is a mankind asset and that we all have the duty of caring for it. Without proactive and courageous international initiatives to organize space, we risk to negate access and use of space to future generations.

Maximizing reader insights into the use of thermography, specifically pulsed and pulse phase thermography (PT and PPT), for the identification of kissing defects in adhesive bonds, this thesis focuses on the application of PT and PPT for the identification of a range of defect types in a variety of materials to establish the effect of material properties on identification of defects. Featuring analysis of a numerical model developed to simulate the thermal evolution created during a PT or PPT experiment, after validation through a series of case studies, this model is then used as a predictive tool to relate defect detectability to the thermal property contrast between defect and bulk materials. Demonstrating a means of producing realistic kissing defects in bonded joints where insufficient thermal property contrast exists defects have a limited effect on heat propagation through a component and therefore are not detected using PT or PPT, this thesis discusses the addition of a small load to bonds containing kissing defects which was found to open the defects sufficiently to enable their detection. A low cost infrared detector, Flir Tau320, is compared to the research based photon detector, Flir SC5000, and is shown to be suitable for application in PT, thus enabling a significantly lower cost tool to be developed.

This book presents concepts, methods and techniques to examine symptoms of faults and failures of structures, systems and components and to monitor functional performance and structural integrity. The book is organized in five parts. Part A introduces the scope and application of technical diagnostics and gives a comprehensive overview of the physics of failure. Part B presents all relevant methods and techniques for diagnostics and monitoring: from stress, strain, vibration analysis, nondestructive evaluation, thermography and industrial radiology to computed tomography and subsurface microstructural analysis. Part C cores the principles and concepts of technical failure analysis, illustrates case studies, and outlines machinery diagnostics with an emphasis on tribological systems. Part D describes the application of structural health monitoring and performance control to plants and the technical infrastructure, including buildings, bridges, pipelines, electric power stations, offshore wind structures, and railway systems. And finally, Part E is an excursion on diagnostics in arts and culture. The book integrates knowledge of basic sciences and engineering disciplines with contributions from research institutions, academe, and industry, written by internationally known experts from various parts of the world, including Europe, Canada, India, Japan, and USA.

This is a unique book addressing the integration of risk methodology from various fields. It will stimulate intellectual debate and communication across disciplines, promote better risk management practices and contribute to the development of risk management methodologies. Individual chapters explain fundamental risk models and measurement, and address risk and security issues from diverse areas such as finance and insurance, the health sciences, life sciences, engineering and information science. Integrated Risk Sciences is an emerging discipline that considers risks in different fields, aiming at a common language, and at sharing and improving methods developed in different fields. Readers should have a Bachelor degree and have taken at least one basic university course in statistics and probability. The main goal of the book is to provide basic knowledge on risk and security in a common language; the authors have taken particular care to ensure that all content can readily be understood by doctoral students and researchers across disciplines. Each chapter provides simple case studies and examples, open research questions and discussion points, and a selected bibliography inviting readers to further study.

Geometric tolerances are changing the way we design and manufacture industrial products. Geometric Tolerances covers their impact on the world of design and production, highlighting new perspectives, possibilities, current issues and future challenges. The topics covered are designed to be relevant to readers from a variety of backgrounds, ranging from product designers and manufacturers to quality inspection engineers and quality engineers involved in statistical process monitoring. Areas included are: * selection of appropriate geometric tolerances and how they stack up in assembled products; * inspection of parts subjected to geometric tolerancing from the macro to the micro and sub-micro scales; and * enhancement of efficiency and efficacy of quality monitoring. Geometric Tolerances provides the reader with the most recent scientific research in the field, as well as with a significant amount of real-life industrial case studies, delivering a multidisciplinary, synoptic view of one of the hottest and most strategic topics in industrial production.

Offshore Risk Assessment was the first book to deal with quantified risk assessment (QRA) as applied specifically to offshore installations and operations. Risk assessment techniques have been used for more than three decades in the offshore oil and gas industry, and their use is set to expand increasingly as the industry moves into new areas and faces new challenges in older regions. This updated and expanded third edition has been informed by a major R&D program on offshore risk assessment in Norway and summarizes research from 2006 to the present day. Rooted with a thorough discussion of risk metrics and risk analysis methodology, subsequent chapters are devoted to analytical approaches to escalation, escape, evacuation and rescue analysis of safety and emergency systems. Separate chapters analyze the main hazards of offshore structures: fire, explosion, collision, and falling objects as well as structural and marine hazards. Risk mitigation and control are discussed, as well as an illustration of how the results from quantitative risk assessment studies should be presented. The third second edition has a stronger focus on the use of risk assessment techniques in the operation of offshore installations. Also decommissioning of installations is covered. Not only does Offshore Risk Assessment describe the state of the art of QRA, it also identifies weaknesses and areas that need further development. This new edition also illustrates applications or quantitative risk analysis methodology to offshore petroleum applications. A comprehensive reference for academics and students of marine/offshore risk assessment and management, the book should also be owned by professionals in the industry, contractors, suppliers, consultants and regulatory authorities.

This book presents important concepts in metal fatigue in a straightforward manner, for the benefit of readers who must understand more advanced documents on a wide range of metal fatigue topics. The text shows how metal fatigue problems are solved in engineering practice. The book assumes no prior knowledge of metal fatigue, requiring only a basic understanding of stress analysis and mathematics covered in engineering undergraduate courses.

This work gives an overview of significant research from recent years concerning performance-based design and quality control for concrete durability and its implementation. In engineering practice, performance approaches are often still used in combination with prescriptive requirements. This is largely because, for most durability test methods, sufficient practical experience still has to be gained before engineers and owners are prepared to fully rely on them. This book, compiled by RILEM TC 230-PSC, is intended to assist efforts to successfully build the foundation for the full implementation of performance-based approaches through the exchange of relevant knowledge and experience between researchers and practitioners worldwide.

Integrating development processes, policies, and reliability predictions from the beginning of the product development lifecycle to ensure high levels of product performance and safety, this book helps companies overcome the challenges posed by increasingly complex systems in today's competitive marketplace. Examining both research on and practical aspects of product quality and reliability management with an emphasis on applications, the book features contributions written by active researchers and/or experienced practitioners in the field, so as to effectively bridge the gap between theory and practice and address new research challenges in reliability and quality management in practice. Postgraduates, researchers and practitioners in the areas of reliability engineering and management, amongst others, will find the book to offer a state-of-the-art survey of quality and reliability management and practices.

The aim of this book is to summarize probabilistic safety assessment (PSA) of nuclear power plants with WWER440 reactors and demonstrate that the plants are safe enough for producing energy even in light of the Fukushima accident. The book examines level 1 and 2 full power, low power and shutdown PSA, and summarizes the author's experience gained during the last 35 years in this area. It provides useful examples taken from PSA training courses the author has lectured and organized by the International Atomic Energy Agency. Such training courses were organised in Argonne National Laboratory (Chicago, IL, USA), Abdus Salaam International Centre for Theoretical Physics (Trieste, Italy), Malaysia, Vietnam and Jordan to support experts from developing countries. The role of PSA for the plants is an estimation of the risks in absolute terms and in comparison with other risks of the technical and the natural world. Plant-specific PSAs are being prepared for the plants and being applied for detection of weaknesses, design improvement and backfitting, incident analysis, accident management, emergency preparedness, prioritization of research and development and to support the regulatory activities. There are three levels of PSA, being performed for full power and low power operation and shutdown operating modes of the plants: level 1, 2 and 3 PSA. The nuclear regulatory authorities do not require the level 3 PSA for the plants in the member countries of the European Union. This means that only a limited number of NPPs in Europe have the level 3 PSA available. However, in the light of the Fukushima accident the performance of such analyses is strongly recommended in the future. This book is intended for professionals working in the nuclear industry, researchers and students interested in safety of operational plants.

This brief addresses the contextual definition of resilience, explains the existing resiliency frameworks developed by Federal Agencies, and emphasizes the risk informed approach to applying resiliency concepts to National Fire Protection Association (NFPA) documents. In an effort to assess and further define NFPA's position in the realm of resiliency, this brief identifies those provisions in NFPA codes and standards that embody the concepts of resiliency. Additionally, the brief develops an NFPA-centric definition of resiliency and compiles available information to serve as a technical reference for the codes and standards, identifying key gaps in knowledge. Key topics range from engineered features and the built environment to emergency response and risk-informed approaches to disaster events. The brief also includes a comprehensive literature review on multiple resiliency frameworks. Written for fire protection engineers and professionals who handle disaster risk assessment, this brief provides a thorough overview of resiliency concepts and how NFPA procedures strive to meet recommended standards.

Significantly extended from the first edition and published in response to the new international standard ISO55000, this book on physical asset management (2nd Ed.) presents a systematic approach to the management of physical assets from concept to disposal. It introduces the general principles of physical asset management and covers all stages of the asset management process, including initial business appraisal, identification of fixed asset needs, capability gap analysis, financial evaluation, logistic support analysis, life cycle costing, management of in-service assets, maintenance strategy, outsourcing, cost-benefit analysis, disposal and renewal. Physical asset management is the management of fixed assets such as equipment, plant, buildings and infrastructure. Features include: *Suitable for university courses and builds on first edition to provide further analytical material *Aligned with the international asset management standard ISO55000 *Provides a basis for the establishment of physical asset management as a professional discipline *Presents case studies, analytical techniques and numerical examples with solutions Written for practitioners and students in asset management, this textbook provides an essential foundation to the topic. It is suitable for an advanced undergraduate or postgraduate course in asset management, and also offers an ideal reference text for engineers and managers specializing in asset management, reliability, maintenance, logistics or systems engineering.