Hyperuricemia is often associated with life-style related disorders such as diabetes mellitus, hypertension, and dyslipidemia, which, in turn, are major causes of CKD. Improved management of hyperuricemia is thus expected to be beneficial for both the general population and CKD patients. This book presents new information on uric acid in tubular transport, early recognition of renal lesions, genetic predisposition, preeclampsia, metabolic syndrome, diabetes, high blood pressure in the young, and the relationship with vitamin D. Moreover, the relationship between AKI and uric acid, as well as the rejection of renal transplants due to hyperuricemia, are discussed. This publication will be of interest to both general practitioners and researchers working in the field of CKD. It provides new insights into renal damage caused by hyperuricemia and into prevention and treatment possibilities.

This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis of AKI. This is followed by sections on pathophysiology, clinical syndromes and patient management. Authored by leading clinicians, epidemiologists, basic scientists, and clinical trialists, this book captures the latest evidence and best practices for treating patients with AKI.

This book provides a comprehensive and up-to-date overview of all key issues related to kidney and urinary tract disease in full-term and premature newborns. Among the many topics addressed are fluid and electrolyte abnormalities, hydronephrosis, urinary tract infection, obstructive uropathy and renal replacement therapy. The approach throughout is clinically oriented, the aim being to provide the reader with hands-on guidance. Each chapter commences with a clinical case vignette and concludes with a take-home message highlighting key aspects of practical importance. In addition, however, informative reviews of the literature and the basic sciences are included. No other book currently on the market focuses solely on the newborn, and Kidney and Urinary Tract Diseases in the Newborn will be especially valuable to those undergoing fellowship training in neonatology or pediatric nephrology/urology.

The renal failure and hemodialysis dependent population is increasing worldwide. Hemodialysis access is the life-line of these patients. Hemodialysis access related surgical and interventional procedures form a major demand to the healthcare services in many developed and developing countries. As such, the proper clinical decision, planning and performance of these procedures will greatly benefit the hemodialysis patients and reduce unnecessary healthcare costs. This book is a practical guide for clinicians and nurses creating, treating or managing hemodialysis accesses for renal failure patients. Basic principles to manage common or difficult situations of hemodialysis access are discussed and illustrative clinical cases are shown as examples. This book is an essential reading material for healthcare professionals in their early phase of developing the hemodialysis access program, while providing useful tips and tricks to established clinicians that will broaden their armamentarium.

The field of interventional nephrology needs to be viewed as a new road towards improving the diagnostic methods and the dialysis access care provided to chronic kidney disease patients across the world. The above issues remain a weak link in the training of young nephrologists and a major hurdle both in the planning and maintenance phase of renal replacement therapy, as well as in the accuracy and safety of diagnosing renal impairment causation. Traditionally, the procedural aspect of care has been left in many cases to surgeons and/or radiologists. The above facts lead in many cases to patient inconvenience and high health care cost. The aim of this book is not only learning the necessary skills to perform renal medical procedures, but for nephrologists to assume leadership roles in coordinating a team to provide the best possible care. Mostly, this book is focused on details and "secrets" that can make the results better than we expect. Introducing renal physicians to the insertion of tunneled lines, medical insertion of peritoneal catheters and kidney biopsies (native and transplant) from the nephrologist's view is a great need in renal society. The primary focus of this book is to generate interest and awareness of the scope of interventional nephrology. The nephrology community across the world needs to evaluate the available resources to discuss the role of various team members and strive to improve patient care. Editors' and authors experiences are exposed in the book, which tends to help the growth and progress of this subspecialty. The trend is also seen as a recruiting tool to train the nephrology workforce in the future.

This new edition is a comprehensive guide to recent advances in the diagnosis and treatment of renal disorders in children. Beginning with an introduction to anatomy and physiology, the following chapters describe various diagnostic tools. The following sections cover numerous renal disorders and their management. The sixth edition has been fully revised and updated with expanded chapters on fluids and electrolytes, cystic kidneys, tubular disorders, acute kidney injury, chronic kidney disease, and renal transplantation. A new chapter on chronic peritoneal dialysis has also been included. The book is highly illustrated with algorithms, tables and diagrams to enhance learning. Key points Comprehensive guide to recent advances in diagnosis and treatment of paediatric renal disorders Fully revised, new edition with expanded chapters and new topics Covers numerous renal disorders, diagnostic tools and processes, and treatment Previous edition (9789350252437) published in 2011

Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

The renal failure and hemodialysis dependent population is increasing worldwide. Hemodialysis access is the life-line of these patients. Hemodialysis access related surgical and interventional procedures form a major demand to the healthcare services in many developed and developing countries. As such, the proper clinical decision, planning and performance of these procedures will greatly benefit the hemodialysis patients and reduce unnecessary healthcare costs. This book is a practical guide for clinicians and nurses creating, treating or managing hemodialysis accesses for renal failure patients. Basic principles to manage common or difficult situations of hemodialysis access are discussed and illustrative clinical cases are shown as examples. This book is an essential reading material for healthcare professionals in their early phase of developing the hemodialysis access program, while providing useful tips and tricks to established clinicians that will broaden their armamentarium.

While patients with metastatic renal cell carcinoma (mRCC) are now living longer with improved quality of life, the success of novel therapies for mRCC has created challenges for practicing oncologists. Many patients who initially respond to targeted therapies ultimately develop progressive disease due to acquired resistance to these agents. Additionally, some patients do not respond at all to any of the currently approved targeted agents, underscoring the need for continued and concerted efforts to identify other relevant targets and pursue alternative therapeutic strategies. Part of the Oxford American Oncology Library, Renal Cell Carcinoma is a concise handbook that addresses the complex management of patients with mRCC. The book begins with a review of the epidemiology, pathology, and biology of renal cell carcinoma followed by chapters on specific targeted therapies and managing complications. The final chapters discuss supportive and integrative care and emerging therapies.

Kidney failure represents a major health economic burden for all people and all nations. Despite the immense number of factors which can cause the initial injury to the kidneys, common response pathways are triggered which, unless broken, will ultimately lead to irreversible fibrosis within the kidneys. Unfortunately, early injuries to the kidneys can frequently be asymptomatic and chronic kidney disease has often developed before the patient has become aware there is a problem. Once established, chronic kidney disease is associated with a high morbidity and mortality for those affected. There has been a large amount of work in recent years focused on the early diagnosis and management of kidney disease to prevent its progression. The purpose of this book is to review the mechanisms which underlie both acute and chronic kidney injury, discuss their diagnosis, complications and management. The first section of this book covers the causes and complications of chronic kidney disease. Initially we review the mechanisms which underlie the progressive fibrosis by which chronic kidney disease progresses. There are then detailed discussions of the cardiovascular complications of chronic kidney disease. The second section of the book focuses on established end stage renal disease. Reviewing access to renal replacement therapies across ethnicities, the role of home therapies and how their use can be increased and finally we discuss the preparation and maintenance of access for dialysis. The third and final section of the book provides an update for the clinician into the diagnosis and management of acute kidney injury. Specifically the diagnosis and management of renal impairment in patients with plasma cell dyscrasias is reviewed and the prevention of acute kidney injury in the critically ill patient is discussed in detail.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A fast, innovative way to learn the core principles and clinical entities associated with nephrology at the point of careA Doody's Core Title for 2015! Nephrology in 30 Days enables you to quickly and easily attain a complete understanding of the basics of nephrology, allowing you to successfully diagnose and manage kidney disease and its associated complications. Designed to impart this knowledge in just thirty days, this unique self-instructional tool is perfect for medical students, physician assistants, medical residents, andnephrology fellows rotating on the clinical nephrology service elective. Now in full color, Nephrology in 30 Days is the most effective way to gain a solid understanding of acute and chronic kidney diseases, disturbances of fluid and electrolyte balance, and disorders of acid-base and mineral metabolism homeostasis--in the least amount of time possible. Updated to include the latest research and advances, including: New formulas for estimating glomerular filtration rate The role of WNK kinases in distal tubular sodium and potassium handling Revised hyponatremia guidelines The use of vaptans for clinical use Newly reported forms of metabolic acidosis The role FGF-23 and Klotho play in phosphorus homeostasis Concerns about the use of erythropoietic stimulating agents Approaches to and classification of both chronic kidney disease and acute kidney injury Discussion of urinalysis and urine microscopy in the evaluation of kidney disease New forms of tubulointerstitial disease such as immunoglobulin G4 (IgG4)-related disease The pathological classification of systemic lupus nephritis and other glomerular diseases The mechanisms and causes of essential and secondary forms of hypertension

"Fundamentals of Renal Pathology" is a compact and up-to-date resource on the basics of renal pathology that will be of particular value for residents and fellows in training in renal pathology, general pathology, and nephrology, but will also serve as a handy reference for the more experienced. This second, revised and updated edition of the book offers an integrated approach based on contributions from established experts in the field. Key diseases are discussed within the context of clinical presentations, with the emphasis on clinicopathological correlation and differential diagnosis. Topics discussed include glomerular diseases with nephrotic or nephritic syndrome presentations; systemic and vascular diseases affecting the kidney, including diseases affecting the renal transplant; tubulointerstitial diseases; and plasma cell dyscrasias and associated diseases. Well-chosen color illustrations and electron micrographs enhance and complement the text.

This is the story of a boy raised up in a village in Poland during World War II, with his father deported to concentration camps throughout the war. Some years after he graduated from medical school, he serendipitously entered the then developing field of dialysis, and he eventually embarked on a career-long practice in the field, where he contributed to the development of a number of new inventions and therapeutic methods. The book contains 13 chapters covering the author's childhood, education, and his career-long contributions to the field of nephrology. The book includes inspirational stories of his patients; the struggles he faced in the course of getting his numerous inventions patented; his research work in the 1990s; his work of teaching and consulting; and not the least, his travels to interesting places unrelated to business. The book concludes with an epilogue summarizing his life, as well as his predictions regarding treatment of chronic renal failure in the future.

As the dialysis population grows, an expert medical resource on the percutaneous creation and maintenance of vascular access is much needed. This book fulfills exactly that need, engaging interventional radiologists, vascular surgeons, interventional nephrologists, and the medical support personnel serving these patients. Providing a clear understanding of best techniques and practices, the authors present an unbiased discussion of patient preparation, procedures, and new devices and equipment. Logically organized and concluding with a compelling collection of 15 noteworthy cases, the book is the culminating work of leading experts in their specialties. The first truly practical reference dedicated to this topic, Essentials of Percutaneous Dialysis Interventions extends across multiple medical specialties to address a global health problem. Easy to use, reader-friendly, and portable, experienced practitioners and trainees alike will find this book to be of daily value.

Discusses the practical pathologic diagnoses of tumours and tumour-like diseases of the prostate gland, seminal vesicles, penis, and scrotum. The authors follow the tradition of the preceding three editions by emphasising pathologic gross and light microscopic diagnostic features and differential diagnoses. They also discuss relevant clinical features, including concise sections on the clinical presentation and the clinical meaning of the pathologic diagnosis in terms of prognosis and treatment. The immunohistochemical and molecular pathologic studies that are of current value in diagnosis are clearly presented. The high-quality images follow the rich tradition of the previous editions to depict the spectrum of tumour morphology from cases mainly from the files of institutions such as The Johns Hopkins Hospital, Barnes-Jewish Hospital, and Instituto de Patologia e Investigacion. This Atlas will be of great value in the field of pathology of the prostate gland, seminal vesicles, penis, and scrotum for years to come.

This handbook provides the fundamental information required to make good clinical assessments and management decisions in children with renal disorders. It includes topics that range from general pediatric nephrology disorders encountered by primary care physicians to more complex renal disorders managed by pediatric nephrologists. Common pediatric renal conditions including glomerular and tubular disorders, hypertension, and urologic conditions are addressed. Current topics such as neonatal disorders, chronic kidney disease, and transplantation are also covered. In addition, illustrations, algorithms and tables are utilized to highlight teaching points.

Whether You Are A Newly Diagnosed Patient With Chronic Kidney Disease, Or Have A Friend Or Relative Undergoing Kidney Dialysis, This Book Offers Help. 100 Questions & Answers About Kidney Dialysis Gives Authoritative, Practical Answers To Your Questions About Kidney Dialysis, Including Preparation, Nutrition, Complications, And Maintaining A Healthy Lifestyle. Insider Tips And Advice Are Given From Both Physicians And Actual Patients Making This Book Is An Invaluable Resource For The 20 Million Americans Coping With The Physical And Emotional Turmoil Of This Disease.

IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

The described material is very important for the clinical and scientific transplantation, because it shows that the atrophy and functional depression of the transplanted kidney is caused not only by immune rejection, but also by non-specific factors of transplantation(denervation, warm ischemia). By means of evidence based reliable data the book confirms the necessity of an artificial surgical re-innervation and relevant hypothermia support of a transplanted kidney which ensures its full value and long-time function.

More than 400,000 people in the United States undergo kidney dialysis. For many, the prospect of a regular appointment with a dialysis machine seems like the end of life itself. But that reaction couldn't be more wrong.
In Dialysis Without Fear, psychiatrist and dialysis patient Dr. Daniel Offer joins with his wife, Marjorie Kaiz Offer, and daughter, Susan Offer Szafir, to reveal how life can be lived--and lived well--on dialysis. Drawing on his long career as a medical expert and more than seven years of
experience as a patient, Dr. Offer convincingly dispels the misconceptions surrounding this treatment, revealing how most dialysis patients can travel, work, and continue to partake in life's joys and celebrations. But the fears and hardships can be quite real, and Dr. Offer brings his years as a
psychiatrist to bear as he provides practical advice on how patients can overcome them. He walks the reader through each step of dialysis, explains different types of treatment, examines the pros and cons of a transplant, and discusses side effects. Dialysis, he notes, affects the entire family; his
own wife and daughter provide realistic insights into how relatives can cope and thrive together. Along the way, they provide a treasure trove of tips on adapting to the new diet, traveling overseas, and adjusting working hours. The Offers also relate inspiring success stories, sharing the humor,
courage, and triumphs of real families.
Life on dialysis is unquestionably difficult--but the difficulties can be overcome. With this inspiring, practical guide, patients can learn to live without fear, fulfill their hopes, and enjoy every day.

The increasing number of small renal tumours being detected had led to the recent development of nephron-sparing surgery. Cryotherapy has become an important treatment option for renal tumours. The recent advances in cryosurgery have occurred as a result of the recent of the introduction of open-type MRI. This new and important book details research on perutaneous freezing therapy by means of MR image monitoring for hepatic carcinomas, renal carcinomas and uterine fibroids. The therapy allows minimising damage to the tissue around the frozen area.

Acute Renal Failure in Practice, edited by practising renal physicians, is the essential guide to the clinical management of patients with acute renal failure and its complex, life-threatening metabolic sequelae. This book explains the workings of the normal kidney, illustrates the aetiology and pathophysiology of acute renal disease, and provides practical treatment guidelines relevant to the day-to-day needs of the practising clinician. There is a clear emphasis on the underlying pathogenic mechanisms naturally leading to a full understanding of the rationale behind the recommended treatments. Each chapter is illustrated throughout by coloured tables and diagrams, and incorporates unique easy-to-follow "practice points" algorithms which detail, step-by-step, the precise treatment protocols required to succeed in caring for these complex patients. An entire section is dedicated to dealing with patients who develop acute renal failure in specific hospital settings, such as the labour ward or intensive care unit. Doctors working in a wide range of acute medical specialities frequently encounter patients with acute renal failure and will therefore find this an invaluable clinical handbook.

Why do we sleep? How much sleep do we really need? What causes sleep apnea, narcolepsy, and insomnia-and what can be done about these sleep disorders? Why do older people have more trouble sleeping than young people? We have all puzzled over-or been plagued by-the mysteries of sleep. Now a leading researcher on sleep provides an engaging and informative introduction to the subject that answers many of our questions. Peretz Lavie surveys the entire field of sleep research and sleep medicine-from the structure of sleep stages and the brain centers involved in sleep regulation to the reasons for and significance of dreams, the importance of sleep in maintaining good health, and the function of biological rhythms-interweaving facts with fascinating case histories, anecdotes, and personal reflections. We learn, for example, about: *development of sleep patterns from infancy to adulthood and in the aged; *the wide variety of sleep habits in animals; *dreams of Holocaust survivors; *sleep under the threat of Scud missile attacks; *how melatonin influences sleep; *the story of the "Acrobat's Leap" sleep-deprivation experiments in the Israeli army; *how to treat insomnia; *what to do with a baby who refuses to go to sleep; and much more. Originally published in Hebrew to great acclaim, this book will enlighten and entertain everyone interested in how and why we sleep.

Aspects of cancer and cancer therapies; long-term adjustments of renal donors and recipients; community life (including support facilities and home dialysis); medical aspects of End Stage Renal Disease (ESRD); psychiatric disturbances; public policy issues; the role of the doctor, staff, and society, sexuality and loss of sexual function, surgical aspects; and anticipatory grief, acute grief, and bereavement are all discussed in this book for caregivers working with ESRD patients.

Neoplasias (tumors) are uncontrolled and progressive new growths of tissue. Frequently physicians caring for patients with neoplastic diseases are confronted with kidney or fluid and electrolyte complications that occur as a direct consequence of the neoplastic process or its treatments. The nine expert essays in this practical and clinically-oriented volume address the origins and treatment of most of these complications. Includes references to recent and classic studies.