The Importance of Measuring Alcohol Consumption To date, alcohol studies have attended far more to issues of alco hol dependence and the harmful consequences of drinking than to the level of alcohol consumption itself. This is, perhaps, not surprising since dependence on alcohol is believed to constitute a meaningful and distinct medical syndrome, regardless of the level of alcohol consumption associated with it (Edwards and Gross, 1976). Also, of society is generally more concerned with the adverse consequences drinking (e. g., traffic fatalities, homelessness, health care and legal expenses, and academiclbehavioral problems in young drinkers), than with the quantity of alcohol actually consumed. Nevertheless, accurate assessment of alcohol usage is important in its own right in at least four contexts: 1. Evaluating the effectiveness of alcoholism and alcohol abuse treatment and prevention efforts. Such efforts include both applied evaluations of existing programs and formal, well-controlled efficacy studies on experimental interventions. These investigations require rigorous methodologies to assess outcomes precisely and contrast what may be quite subtle differences between programs and between pre treatment and posttreatment outcomes. Although these studies are usually characterized by the employment of multiple measures of success-including general improvements in social and physical functioning, reduction in degree of dependence, and resolution of problems directly resultant from drinking-it is by their assessment of changes in drinking behavior that they are potentially able to achieve the highest level of objectivity and exactitude."

This text provides a comprehensive overview of psychological approaches to understanding addictions. Without denying the importance of biological factors, emphasis is placed more upon social, psychological and emotional factors as is necessary to a complete understanding of addiction. Within this framework, an addiction is not limited to substance-based behaviours such as drinking alcohol, smoking or drug use. Although these important areas are covered, a wider perspective is taken to include behavioural addictions such as gambling, violence and joy riding. Finally, prevention approaches are discussed with reference to the public health model which encompasses issues relating to the agent, the host and the environment. A list of resources and references is provided for those wishing to obtain further information.;Written in a jargon-free style, "The Psychology of Addiction" is aimed at students at the beginning of their courses. It should also be a valuable resource for professionals: nurses, social workers, police and probation officers and medical students, who often encounter the problems described in the book.

The impetus for the present volume was provided by a European conference held at St. Martens Latem (Belgium) in September 1994 and sponsered by the Directorate General XII (Science, Research and Development) of the European Commission. Preparation of the volume was also financially supported by the Direc- torate General. The editor, the contributors and all the participants in the conference are grateful to the European Commission for the generous help received. vii CONTRIBUTORS Hennann ACKERMANN, Department of Neurology, University of Ttibingen, 3 Hoppe- Seyler-StraBe, 72076 Tiibingen (Gennany). Henny BIJLEVELD, Philologie Germanique, Faculte de Philosophie et Lettres, Universite Libre de Bruxelles, 50 avo F. Roosevelt, 1050 Brussels (Belgium). Veronique CAPPAERT, University Hospital Ghent, 2PI Centrum voor Gehoor- en Spraakrevalidatie, 185 De Pintelaan, 9000 Gent (Belgium). Patrick COPPENS, Speech-Language-Hearing Sciences, Moorhead State University, Moorhead, MN 56563 (USA). Jeanine DELEVAL, Department of Neurology, University Hospital 'Erasme', 808 Route de Lennik, 1070 Brussels (Belgium). Christine EECKHAUT, University Hospital Ghent, 2PI Centrum voor Gehoor- en Spraakrevalidatie, 185 De Pintelaan, 9000 Gent (Belgium). Ingo HERTRICH, Department of Neurology, University of Ttibingen, 3 Hoppe-Seyler- StraBe, 72076 Ttibingen (Gennany). Margaret LEAHY, Clinical Speech and Language Studies, Trinity College, Dublin 2 (Ire- land). Yvan LEBRUN, Neurolinguistics Department, School of Medicine VUB, 103 Laar- beeklaan, 1090 Brussels (Belgium). Nadine MOREAU, Laboratoire de Neuropsycholinguistique Jacques Lordat, Departement des Sciences du Langage, Universite de Toulouse-Le Mirail, 5 allee A. Machado, 31058 Toulouse Cedex (France).

This detailed book presents a comprehensive collection of state-of-the-art protocols on muscular dystrophy therapeutics, covering therapeutics using antisense oligonucleotides, gene replacement, genome editing, small molecules, stem cells, and antibodies. Written by leaders in the field, the volume explores techniques that are currently in use and are starting an exciting therapeutic revolution in muscular dystrophy. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Muscular Dystrophy Therapeutics: Methods and Protocols serves as an ideal resource to inspire readers and provide tips, strategies, and advice to develop new therapeutic technologies for this group of diseases.

Find fresh perspectives on the treatment of addictions and effective methods for helping recovering alcohol and drug abusers in this valuable book Addiction in Human Development provides practical strategies based on theories of human development for working with clients recovering from alcoholism and drug addiction. An understanding of these theories will help therapists and addictions counselors recognize stages of recovery and better select appropriate interventions for every phase of treatment of addicted clients.Addiction in Human Development shows how a developmental perspective is particularly appropriate to the treatment of alcohol and substance abusers and the patterns involved in their addiction. Disruptions in clients'childhood or adolescent development, stemming from their own or a parent 's drug abuse, can influence their present recovery process. This informative book also describes the developmental course of addiction and provides tools designed to interrupt addictive patterns. In addition, stages in the developmental process of recovery are identified to help therapists select appropriate interventions.Some of the topics related to human development and addiction covered in this insightful volume include developmental deficits and developmental arrest in recovering clients, delayed reactions to sexual abuse and other childhood trauma, stages in recovery from alcoholism or drug addiction, developmental issues in the professional 's own life, and multi-problem families with a multigenerational history of substance abuse. Applying these developmental strategies to work with addicted individuals will significantly improve communication and rapport between helping professionals and recovering addicts and lead to more success in alcohol and drug addiction therapy.

This book examines the technologies and processes for the development and commercial production of stem cells according to cGMP guidelines. The initial chapter of the book discusses the therapeutic potentials of stem cells for the treatment of various diseases, including degenerative disorders and genetic diseases. The book then reviews the recent developments in the cultivation of stem cells in bioreactors, including critical cultural parameters, possible bioreactor configuration and integrations of novel technologies in bioprocess developmental stages. The book also introduces microscopic, molecular, and cellular techniques for characterization of stem cells for regulatory approvals. Further, it describes optimal cell transporting conditions to maintain cell viability and properties. Further, it summarizes characterization strategies of clinical grade stem cells for stem cell therapy. This book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

This book provides clinicians and students with insights on the use of psychodynamic therapy to treat drug abuse and addiction, combining theory with clinical case material. The perspectives of analysts such as Abraham, Rado, Zimmel, Tibout, Wurmser, Khanzian, Krystal and McDougall are reviewed alongside original and more recent conceptualizations of drug addiction and recovery based on Kleinian, Winnicottian and Kohutian ideas. The case material deals with clinical phenomena that characterize working with this complex population, such as intense projective identification, countertransference difficulties and relapses. The theoretical analysis covers a range of concepts, such as John Steiner's psychic shelters and Betty Joseph's near-death-addiction, which are yet to be fully explored in the context of addiction. Prevalent topics in the addiction field, such as the reward system, the cycle of change and the 12-step program, are also discussed in relation to psychodynamic theory and practice. Written by an experienced therapist, Psychodynamic Approaches for Treatment of Drug Abuse and Addiction is useful reading for anyone looking to understand how psychodynamic thought is applicable in the treatment of drug abuse and addiction. It may also be of some relevance to those working on treating alcohol use disorders and behavioral addictions.

Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Stem Cell Therapy: Practical Considerations addresses the biological properties of stem cells, mechanisms of action; as well as actual therapeutic decisions such as cell type, source, dose, manipulation, and route of injection. After discussing all this data, the book will illustrate how to travel through the idea from abstract question to laboratory experiment, animal experiment and then on to design a clinical trial throughout all its phases. Written for scientists and postgraduate students in the field of stem cell research and therapy. The authors will cover practical therapeutic issues they have long experienced in the field.

Like many of us, journalist David K. Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep. In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder? This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You ll never look at your pillow the same way again."

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

This volume addresses the particular problems associated with several classes of biotechnology products, and at the same time demonstrates that the principles are the same as in the development of small new chemical entities. The first chapter addresses FDA regulatory expectations for biotech products. The next several chapters discuss general issues common to each class of biotech drug such as proteins, peptides, and nucleic acids. The balance of the chapters deal with specific biotech drugs that have successfully made it into clinical trials. The reviews are written by renowned experts in their fields.

First published in 1992. Part I of the book covers phases of treatment for specific phases of recovery by describing key concepts and focusing on three dominant treatment modalities, inpatient, outpatient, and long-term residential therapeutic communities. Part II covers, in substantial depth, psychoanalytic/psychodynamic approaches. art III of the book examines cognitive-behavioral, self-help, and relapse prevention approaches to the treatment of the chemically dependent. Part VI mentions in all phases of treatment and recovery. Part IV of the book provides an overview of contemporary trends in research, while also discussing implications for treatment. n the therapeutic community. Part V attempts to draw the field of chemical dependency toward recognition of the importance of considering distinct population characteristics and how these characteristics may dictate modifications in treatment design. The book is suitable as a text in a course on substance abuse or as a critical reference for anyone doing clinical work or research in the field of chemical dependency.

This reference provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. It includes preventive medical checklists with summaries of appropriate medical intervention; supplies background information about history, genetics and epidemiology; outlines clinical management strategies; establishes guidelines on how to inform parents of the diagnosis and conveys practical suggestions on the handling and care of the infant; and offers a detailed review of the medical literature. Appendices provide information including growth charts and financial checklists.

- Coverage of deaf people and cognition, neuroscience, bimodal/bilingualism, and education technology - Strong multicultural focus - Case studies from authors' clinical and educational practices - Three deaf and one hearing author-a deaf/hearing bilingual team

Note: This is the bound book only and does not include access to the Enhanced Pearson eText. To order the Enhanced Pearson eText packaged with a bound book, use ISBN 0134412087. Language Development From Theory to Practice provides a survey of key topics in language development, including research methods, theoretical perspectives, and major language milestones from birth to adolescence and beyond, and language diversity and language disorders. Each chapter bridges language development theory and practice by providing students with a theoretical and scientific foundation to the study of language development. The authors emphasize the relevance of the material to students' current and future experiences in clinical, educational, and research settings; emphasize multicultural considerations and how they affect language development; focus on using evidence-based practices for making educational and clinical decisions; show the relevance of a multidisciplinary perspective on the theory and practice of language development; and include a number of outstanding pedagogical features to motivate and engage students. The new edition builds on the strengths of the earlier editions while featuring a chapter reorganization that promotes better understanding, more detailed coverage of topics of particular interest to students, expanded categorization of language-development theories, and a variety of helpful new pedagogical features. The Enhanced Pearson eText features embedded videos and assessments. Improve mastery and retention with the Enhanced Pearson eText* The Enhanced Pearson eText provides a rich, interactive learning environment designed to improve student mastery of content. The Enhanced Pearson eText is: Engaging. The new interactive, multimedia learning features were developed by the authors and other subject-matter experts to deepen and enrich the learning experience. Convenient. Enjoy instant online access from your computer or download the Pearson eText App to read on or offline on your iPad (R) and Android (R) tablet.* Affordable. The Enhanced Pearson eText may be purchased stand-alone for 50-60% less than a print bound book. *The Enhanced eText features are only available in the Pearson eText format. They are not available in third-party eTexts or downloads. *The Pearson eText App is available on Google Play and in the App Store. It requires Android OS 3.1-4, a 7" or 10" tablet, or iPad iOS 5.0 or later.

This book provides a holistic evidence-based perspective on conceptual, clinical, assessment, and treatment aspects of key non-substance-based addictive disorders related to: gambling, gaming, social media, smartphone, internet, love, sex, exercise, work, and shopping. Each chapter focuses on a different addictive disorder and is structured in a user-friendly way to enable the reader fast navigation, yet the main aspects of the respective disorders are covered in the necessary depth. All in all, this book offers a timely, self-contained introduction to both key concepts and the latest scientific developments in behavioral addictions. It addresses mental health practitioners, researchers in psychology, neuroscience and communication, and undergraduate and postgraduate students alike.

Dreeben-Irimia's Introduction to Physical Therapy Practice for Physical Therapist Assistants, Fourth Edition introduces students to the role of the physical therapist assistant in physical therapy care.

Co-dependency has finally become recognized in the late 1980s as a legitimate and a key issue in the chemical dependency field. Most of the literature available on the topic is addressed to the consumer--the co-dependent individual. In Co-dependency, leading therapists share some remarkable insights into the characteristics of the alcoholic home, co-dependents'patterns of responding to the alcoholic, and the particular problems that family members experience as a result of the environment, including fear, shame and guilt, anger, denial, and confusion. Clinical case material is used to illustrate the value of helping co-dependents through education, peer support, outpatient treatment and psychotherapy. Creative solutions for working with lesbian and gay men and children of alcoholics are also featured.

While millions of people in this country take moderate to massive doses of vitamins and minerals, only one in a thousand actually requires such a supplement in his or her diet. This book explores how vitamin supplements are a threat to public welfare, and looks intensively at legitimate and beneficial uses of vitamins.

"... well-written, informative and interesting". -- Library Journal

This collection is the first of its kind to examine the impact of the COVID-19 pandemic on the caseloads and clinical practice of speech-language pathologists. The volume synthesises existing data on the wide-ranging effects of COVID-19 on the communication, swallowing, and language skills of individuals with COVID infection. Featuring perspectives of scholars and practitioners from around the globe, the book examines the ways in which clinicians have had to modify their working practices to prioritise patient and clinician safety, including the significant increase in the use of telepractice during the pandemic. The volume also reflects on changes in training and education which have seen educators in the field redesign their clinical practicum in order to best prepare students for professional practice in an age of COVID-19 and beyond, as the field continues to grapple with the long-term effects of the pandemic. Offering a holistic treatment of the impact of COVID-19 on the work of speech-language pathologists, this book will be of interest to students, researchers, and clinicians working in the discipline. Chapters 5, 6, 10, and 13 of this book are freely available as downloadable Open Access PDFs under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license available at http://www.taylorfrancis.com

This sensitive book provides a much-needed compilation and description of OT programs for the care of individuals disabled by traumatic brain injury (TBI). Focusing on the disabled individual, the family, and the societal responses to the injured, this comprehensive book covers the spectrum of available services from intensive care to transitional and community living. Both theoretical approaches to the problems of brain injury as well as practical treatment techniques are explored in Occupational Therapy Approaches to Traumatic Brain Injury. The processes of assessment and intervention are vital to the recovery of brain-injured patients and this thorough book devotes two chapters specifically to assessment and several chapters on intervention and family involvement. This useful volume contains information about rehabilitation from coma to community, 'as well as numerous other approaches.The findings and treatment suggestions presented here are applicable to many helping professionals working with TBI patients. Health care practitioners working with brain injured persons and their families in both institutional and community contexts, physical therapists, physicians, nurses, and psychologists and social workers involved with assessment will find this an invaluable addition to their professional references.

Co-dependency has finally become recognized in the late 1980s as a legitimate and a key issue in the chemical dependency field. Most of the literature available on the topic is addressed to the consumer--the co-dependent individual. In Co-dependency, leading therapists share some remarkable insights into the characteristics of the alcoholic home, co-dependents'patterns of responding to the alcoholic, and the particular problems that family members experience as a result of the environment, including fear, shame and guilt, anger, denial, and confusion. Clinical case material is used to illustrate the value of helping co-dependents through education, peer support, outpatient treatment and psychotherapy. Creative solutions for working with lesbian and gay men and children of alcoholics are also featured.

1. Introduction: The Brain-Immune Axis: Role of Opiates and Other Substances of Abuse, the Hypothalmic-Pituitary-Adrenal Axis and Behavior.- 2. Detection of ?-Opioid Receptor mRNA in Immature T Cells.- 3. Identification of Opioid Receptors in the Immune System Using a Novel Combination of Selective Opioid Ligands and Indirect Phycoerythrin Immunofluorescence.- 4. Kappa Opioid Receptors on Three Related Thymoma Cell Lines: Differences in Receptor-Effector Coupling.- 5. Delta Opioid Agonists Inhibit Proliferation of Highly Purified Murine CD4+ and CD8+ T-Cells.- 6. Mitogenic Activation of Human T Lymphocytes Induces a High Affinity Morphine Binding Site.- 7. Morphine-Induced Suppression of Thymocyte Proliferation Is Mediated by Inhibition of I1-2 Synthesis.- 8. Active ?-Endorphin Metabolites Generated by T-Cell Ectopeptidases.- 9. The Cellular Basis for Opioid-Induced Immunosuppression.- 10. Endogenous Opioid Peptides Suppress Cytokine-Mediated Upregulation of HIV-1 Expression in the Chronically Infected Promonocyte Clone U1.- 11. Relevance of Opioid Bimodality to Tolerance/Dependence Formation: From Transmitter Release to Second Messenger Formation.- 12. Agonist Induced Constitutive Receptor Activation As a Novel Regulatory Mechanism: ? Receptor Regulation.- 13. Expression of Cannabinoid Receptor mRNA in Murine and Human Leukocytes.- 14. Cannabinoid Stimulation of Arachidonate Metabolism in Human Peripheral Blood Mononuclear Leukocytes.- 15. Marijuana, Receptors and Immunomodulation.- 16. Mouse Strain Differences in in vivo and in vitro Immunosuppressive Effects of Opioids.- 17. The Clastogenicity of Morphine Sulfate in vivo.- 18. Cellular Mechanisms Involved in Morphine-Mediated Suppression of CTL Activity.- 19. Evidence for the Involvement of Macrophage-Derived Nitric Oxide in the Immunomodulatory Effect of Morphine and Aversive Pavlovian Conditioning.- 20. Mechanisms Whereby Macrophage-Derived Nitric Oxide Is Involved in the Immunomodulatory Effects of Morphine.- 21. Effects of Central Administration of Morphine on Immune Status in Lewis and Wistar Rats.- 22. Morphine Alteration of Histamine Release in vivo.- 23. Effect of Chronic Morphine Treatment on Immune Responses to Keyhole Limpet Hemocyanin in Swine.- 24. SIV Mutations Detected in Morphine-Treated Macaca mulatta Following SIVmac239 Infection.- 25. Adjuvant Effects on Morphine-Induced Suppression of Immune Responses to MN rgp120/HIV-1 in Mice.- 26. Possible Mechanisms of Immunotoxicity Following in vivo Exposure to the Inhalant, Isobutyl Nitrite.- 27. Role of Immune Processes in Peripheral Opioid Analgesia.- 28. Chronic Treatment with Morphine and Ethanol, but Not Cocaine, Attenuates I1-1? Activation of FOS Expression in the Rat Hypothalamic Paraventricular Nucleus.- 29. Effects of r-Hu-Interferon-?2A in the Brain.- 30. Quantification of Macrophage-Derived Substance P Receptor mRNA Using Competitive Polymerase Chain Reaction.- 31. HIV-1 Heterogeneity and Cytokines: Neuropathogenesis.

* Chapters bring the voices of LGBTQ+ into the spotlight through art and contribute to experiential learning, allowing for more understanding of the lives of LGBTQ+ peoples within the dietetic profession * Includes arts-based research that has the capacity to acknowledges multiple truths within the world and to give voice and representation to LGBTQ+ individuals * Topic cover eating disorders, body image, creative practices in nutrition counseling, weight stigma, and gendered understandings of nutrition. Special attention is paid to experiences of marginalization, homophobia, heteronormativity within dietetics and nutritional healthcare, and the intersections of oppression, poverty, social justice, and politics