Principles and Applications of Therapeutic Ultrasound in Healthcare introduces concepts, principles, construction, and applications of therapeutic ultrasound: from bench to bedside. A comprehensive examination of the industry and medical application of ultrasound therapy, this book highlights working principles, research progress, and system structures of therapeutic ultrasound. It describes the principles of therapeutic ultrasound, details the system construction, introduces current and emerging applications, and discusses developing therapeutic ultrasound technologies. Divided into two parts, the book first introduces the fundamentals of biomedical acoustics, discusses ultrasound calibration methods, and the structures of available therapeutic ultrasound systems before moving on to the various applications of ultrasound therapy used in clinics. It includes a variety of extensive clinical trials, outcome photos and illustrating figures, and a critical commentary on the challenges in this field. The author discusses topics that include: The derivation of wave equation The mathematical solution of the wave propagation The phenomena of reflection Refraction and transmission in the acoustic field from different acoustic sources The radiation pattern of the ultrasound transducer The acoustical properties of biological tissues Ultrasound-induced bioeffects Cavitation The design of the ultrasound transducer The characterization method of the produced acoustic field An easy reference offering full coverage of popular ultrasound therapies, Principles and Applications of Therapeutic Ultrasound in Healthcare provides a simple explanation of fundamental acoustics, including wave equation, propagation, nonlinearity, and transducer design. It also discusses other potential applications, and is geared toward academia, industry, and researchers.

It was during the course of the eighteenth and nineteenth centuries that the problem of chronic alcohol dependence in modern society and its consequent medical effects emerged. The topic of drunkenness figures prominently in the thinking and writing of social reformers, politicians, theorists, medical practitioners, and psychiatrists. Eventually, by the mid-nineteenth century, 'alcoholism' was named as the disease of habitual drunkenness. Possibly the most important book to predict this was Trotter's Essay, written in 1804. Through case studies based on wide experience, he detailed the manifestations of alcoholism, ventured therapeutic recommendations, and squarely termed drunkenness a disease - indeed, a mental disease. Originally published in 1988 as part of the Tavistock Classics in the History of Psychiatry series, Roy Porter's Introduction to this facsimile reprint locates Trotter's work within the wider history of the evolution of the idea of alcoholism. It also examines the Essay in the context of Trotter's own life and mind - a mind preoccupied with what he saw as the degenerative tendencies of modern civilization and with the wider issues of drug dependence.

Currently a great deal of public discourse around health is on the assumed relationship between childhood inactivity, young people's diets, and a putative steep rise in obesity. Children and young people are increasingly being identified as a population at 'risk' in relation to these health concerns. Such concerns are driving what might be described as new 'health imperatives' which prescribe the choices young people should make around lifestyle: physical activity, body regulation, dietary habits, and sedentary behaviour. These health imperatives are a powerful force driving major policy initiatives on health and education in a number of countries in the Western world. Schools in particular have been targeted for the implementation of a plethora of initiatives designed to help children and young people lose weight, become more active and change their eating patterns inside and outside school. Addressing these issues requires an innovative theoretical approach. Neither the fields of 'eating disorders' nor 'obesity research' has addressed these issues from a sociological and pedagogical perspective. The contributors to this edited collection draw on a range of social theories, including Michel Foucault and Basil Bernstein to interpret the data collected across three countries (Australia and New Zealand, United Kingdom) and from a range of primary and secondary schools. Each chapter addresses various aspects of the relationship between health imperatives as constituted in government policies, school programs and practices, their recontextualised in school practices and the impact of this on the subjectivities of children and teachers. This book was originally published as a special issue of Discourse: Studies in the Cultural Politics of Education.

This book examines the rehabilitation of language disorders in adults, presenting new research, as well as expert insights and perspectives, into this area. The first chapter presents a study on personalised cueing to enhance word finding. Cynthia K. Thompson and her colleagues contribute a chapter describing The Northwestern Naming Battery and its use in examining for verb and noun deficits in stroke-induced and primary progressive aphasia. Heather Harris-Wright and Gilson J. Capilouto examine a multi-level approach to understanding the maintenance of global coherence in aphasia. Kathryn M. Yorkston and colleagues provide discussion on the training of healthcare professionals, and what speech and language pathology and medical education can learn from one another. Yorkston also presents a systematic review asking whether principles of motor learning can enhance retention and transfer of speech skills. Connie A. Tompkins present a single-participant experiment examining generalization of a novel treatment for coarse coding deficit in right hemisphere damage. Finally, Chris Code returns to the topic of apportioning time for aphasia treatment. This book was originally published as a special issue of Aphasiology.

"After decades of research on dysfunctional eating and lack of physical activity, research attention has finally turned to the role of digital technology in eating behaviors and eating disorders. This timely volume offers a thoughtful and wide collection of chapters discussing the possible effects of digital technologies, from those enhancing healthy eating behaviors to those that encourage disordered eating. Highly recommended for both professionals and scholars." Prof. Giuseppe Riva, Universita Cattolica del Sacro Cuore, Milan, Italy. This book examines in depth the multifaceted roles of digital technologies in the eating behaviors and eating disorders. Coverage reflects a broad theoretical and empirical knowledge of current trends in digital technology use in health behaviors, and their risks and benefits affecting wellbeing, with focus on eating behaviors and eating disorders. The authors use both qualitative and quantitative data to focus on the digital lived experiences of people and their eating related behaviors. Among the topics covered: The quality of eating-oriented information online Technology, body image, and disordered eating Eating-oriented online groups Using mobile technology in eating behaviors Usage of digital technology among people with eating disorders What healthcare professionals should know about digital technologies and eating disorders Technology-based prevention and treatment programs for eating disorders A potential source of discussion and debate in various fields across the social sciences, the health sciences, and psychology, Digital Technology, Eating Behaviors, and Eating Disorders will be especially useful to students, academics, researchers, and professionals working in the fields of eating behaviors and eating disorders.

Alcohol use is complex and multifaceted. Our understanding must be also. Alcohol use, both problematic and not, can be understood at many levels - from basic biological systems through to global public health interventions. To provide the multi-level perspective needed to address this complexity, the Handbook of Alcohol Use draws together an eclectic set of authors, including both researchers and practitioners, to examine the causes, processes and effects of alcohol consumption. Specifically, this book approaches the topic from biological, individual cognition, small group/systems, and domestic/global population perspectives. Each examines alcohol use differently and each offers its own ways to combat problematic behavior. While these alternative viewpoints are sometimes construed as incompatible or antagonistic, the current volume also explores how they can be complimentary. In summary, the Handbook of Alcohol Use brings together an international group of experts to explore how alcohol use can be understood from various perspectives and how these conceptualizations relate. In doing so, it allows us to understand alcohol consumption, and our responses to it, more from an account which spans 'from synapse to society'.

This latest addition to the Methods in Molecular Medicine series, Anti- ral Methods and Protocols, is opportune because there is an increasing int- est in discovering compounds that are effective against both chronic and acute viral infections. A number of the methods described in the volume are unp- lished and their inclusion indicates the speed at which this field is moving. This volume is not a review but each chapter contains methods validated by the experts who have spent time in developing the protocols. The hallmark of this series is the comprehensive way in which the me- ods are described, which includes a list of all the reagents needed for each protocol. Of importance is the section on tips and pitfalls that the authors have discovered while developing their protocols. The manual itself is designed to be used by researchers in universities and industry who are familiar with a range of biological techniques but who want to set up quickly a novel assay system. We encourage a dialog between readers and authors, which may also result in useful collaborations.

Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy.
The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined.
The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

It was during a pleasant and warm (both literally and figuratively) two- week period in October, 1991 that a number of researchers, scholars and c1inicians from diverse lands gathered at the beautiful Chateau de Bonas, near Toulouse, France to discuss psychological, neuropsychological and neurolinguistic aspects of reading and writing disorders. The occasion for the serious disputations of theories, research findings and c1inical appli- cations was the Advanced Study Institute (ASI) under the auspices of the Scientific Affairs Division of the North Atlantic Treaty Organization (NATO). There was much sharing of mutual experiences, and considerable debate on some issues. There were also friendly exchanges, 'international' ping-pong, tennis matches, and bicyc1e races, and even some convivial- ity akin to that of a c1ass reunion with members telling their stories of yesterday and visions of tomorrow. All these serious scientific disputations and the friendly exchanges would not have been possible without the major assistance from NATO and other institutions and individuals. We wish to express our deep appre- ciation to Dr. L. v. da Cunha ofNATO Scientific Affairs Division, Dr. Tilo Kester and Mrs. Barbara Kester of the International Transfer of Science and Technology (ITST) for their active support and substantial assistance throughout the Advanced Study Institute; Mr. Charles Stockman and his staff of the Chateau de Bonas for looking after our stay there; Christi Martin and Xi-Wu Feng of Oklahoma State University, and the University of Saskatchewan generally for facilitating our work.

A former drug addict turned behavioural neuroscientist reveals how drugs work in the brain ― and what we can do to fight addiction.

Judith Grisel was a daily drug user when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey.

In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Delving into the science of one of the world’s most pressing health problems, she reveals what is different about the brains of addicts even before they first pick up a drink or drug, and highlights the changes that take place in the brain and behaviour as a result of chronic using.

With compassion and clarity, Grisel describes what drove her to addiction, what helped her recover, and her belief that a ‘cure’ for addiction will not be found in our individual brains but in the way we interact with our communities.

Nick Charles MBE is a pioneer in treating alcohol dependency. As the founder of both the Chaucer Clinic and the Gainsborough Foundation, he was the first person to be honoured by the Queen 'for services to people with alcohol problems' and his work - over four decades - has helped tens of thousands of people. But Nick's decorated success overlays an extraordinary and unforgettable personal journey, for Nick was once an alcoholic vagrant sleeping rough on the streets of London. In 50 Years of Hard Road, Nick details his time in the abyss of alcohol addiction; a period that despatched relationships, his health, his career, and so much more. Forced to live on the streets for four years, Nick recalls the tough times, the characters he met, and the ever-present call of alcohol, but also how he slowly built up two carrier bags-worth of painstaking research into alcohol and its effects on his fellow man. It was through the documents in these carrier bags that Nick's life was to change forever when, in the mid-1970s, he was taken under the wing of a doctor who cared for those on skid row. This dedicated medic recognised the treasure trove of information Nick had developed. 50 Years of Hard Road is a remarkable, uplifting, and often humorous story of one man's journey from the depths of life-crushing alcohol dependency, to running alcohol clinics and programmes across the country. It describes an incredible life filled with high points, low points, and amazing adventures in-between.

Alcoholism: A Review of Its Characteristics, Etiology, Treatment, and Controversies provides an accurate picture of the current state of research and treatment effectiveness in the field of alcoholism. Using compelling evidence, Irving Maltzman describes how the field has been distorted by the behavior therapy approach. A distinguished experimental psychologist at the University of California, Los Angeles, Professor Maltzman has written a comprehensive, important work marked by incisive argument. Alcoholism is an excellent reference for academics as well as professionals working in addictions treatment.

The Addiction Casebook presents 12 patients with DSM-5 addiction diagnoses -- plus one experiencing problematic Internet use -- and illustrates practical and successful strategies for diagnosing and treating these patients. The book's cases are analogous to those that clinicians commonly encounter in their everyday practice and effectively demonstrate the intersection of addiction with other psychiatric diagnoses. The experience and clinical wisdom of three generations of addiction specialists are distilled into a single volume that includes the most salient ideas and treatment suggestions for clinicians.

This informative, practical volume strikes a colloquial, and sometimes humorous, tone. General psychiatrists and psychiatric residents seeking to gain expertise in and an understanding of addiction will find it a delight to read, as will a diverse audience of family practitioners, internists, pediatricians, medical students, allied professionals, and anyone interested in sharpening her or his clinical skills.

The book is the first to cover the diagnosis, assessment, and treatment of substance use disorders and other addictions within the DSM-5(R) framework. Its many valuable and helpful features include - An outline of the progression in thinking about psychiatric diagnoses with the move from DSM-IV-TR(R) to DSM-5(R). - Descriptions of hands-on experience with the current diagnosis and treatment of substance use disorders and other addictions that complement substance abuse textbooks and bring the material to life. - Coverage of such subject areas as alcohol, caffeine, cannabis, hallucinogen, inhalant, opioid, sedative, hypnotic, anxiolytic, stimulant, tobacco, gambling, and Internet addictions. - Key points and multiple-answer questions at the end of each chapter that highlight the chapter's most pertinent takeaways and apply and strengthen readers' knowledge of chapter information.- Extensive use of tables, figures, charts, and other instructive materials to illuminate and clarify addiction concepts.

In their preface, the authors assert their hope that the book "will provide the fundamental tools for working with the substance-using patient in the hospital, the clinic, and the community." The Addiction Casebook exceeds its goal by providing mental health and other medical practitioners with timely, current strategies for addiction diagnosis and treatment in a succinct, engaging, and entertaining volume.

This addition to the British Dietetic Association Advanced Nutrition and Dietetics book series is written for clinicians and researchers who work with any aspect of obesity and its comorbid conditions. Featuring contributions from leading researchers and practitioners from around the globe Advanced Nutrition and Dietetics in Obesity offers a uniquely international perspective on what has become a worldwide public health crisis. Chapters cover a full range of new ideas and research on the underlying drivers of obesity in populations including discussions on the genetic and clinical aspects of obesity, along with expert recommendations on how to effectively manage and prevent this chronic and persistent disease. Providing a comprehensive overview of the key literature in this field, Advanced Nutrition and Dietetics in Obesity is an invaluable resource for all those all those whose work should or does embrace any aspect of obesity.

Since the legalisation of off-course cash betting in 1960, and the rise of varying forms of gambling, the British have come to be known as a nation of gamblers. Until this study was published in 1976, barely any evidence existed against which to assess the claim that gambling had become a major social problem. The authors present data drawn from area surveys carried out in Swansea, Sheffield, Wanstead and Woodford, and explore how well previous sociological theories of gambling agree with their findings, particular in connection with certain aspects of work and leisure. Examining different forms of gambling, including betting, bingo and gaming machines, the chapters consider how gambling choices vary between different social groups, and how much time and money is spent on them. With the internet making it easier than ever before to place bets, this title is especially relevant, and provides a systematic basis for an explanation of gambling in relation to social structure.

It was during the course of the eighteenth and nineteenth centuries that the problem of chronic alcohol dependence in modern society and its consequent medical effects emerged. The topic of drunkenness figures prominently in the thinking and writing of social reformers, politicians, theorists, medical practitioners, and psychiatrists. Eventually, by the mid-nineteenth century, 'alcoholism' was named as the disease of habitual drunkenness. Possibly the most important book to predict this was Trotter's Essay, written in 1804. Through case studies based on wide experience, he detailed the manifestations of alcoholism, ventured therapeutic recommendations, and squarely termed drunkenness a disease - indeed, a mental disease. Originally published in 1988 as part of the Tavistock Classics in the History of Psychiatry series, Roy Porter's Introduction to this facsimile reprint locates Trotter's work within the wider history of the evolution of the idea of alcoholism. It also examines the Essay in the context of Trotter's own life and mind - a mind preoccupied with what he saw as the degenerative tendencies of modern civilization and with the wider issues of drug dependence.

Why do so many people try dieting, only to fail? What distinguishes those who succeed from those who do not? Are fat people really any different from thin people? What makes us eat, and how do we stop eating? And how can dieting trigger problems with eating normally? Originally published in 1989, Sara Gilbert discusses these questions in Tomorrow I'll Be Slim, and draws on what is known about the psychology of eating, overeating, and weight control to dispel a number of popular myths about dieting. She shows how unsuccessful dieting can lead to new problems with eating and weight control. She points out that long-term success in slimming has more to do with individual factors such as a dieter's expectations, self-confidence, or social and family circumstances than with 'will-power'; and as much to do with how a diet is managed as with the content of a diet sheet. She suggests ways in which people who want to be slimmer can make a realistic assessment of their need to diet. She explains how individuals who seriously need to lose weight or change the way they eat might draw up effective strategies for themselves and prepare for the inevitable difficulties we all face whenever we try to change old habits. Finally, she addresses the problems of taking the emphasis off dieting and examining our attitudes to a slim figure as the key to happiness itself.

Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy.
All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy.
The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world.
The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.

Nowadays, a plethora of treatment technologies is available to the consumer, each employing a variety of concepts of the body, self, sickness and healing. This volume explores the options, strategies and consequences that are both relevant and necessary for patients and practitioners who are manoeuvring this medical plurality. Although wideranging in scope and covering areas as diverse as India, Ecuador, Ghana and Norway, central to all contributions is the observation that technologies of healing are founded on socially learned and to some extent fluid experiences of body and self.

In "Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, " expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target. These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. We are convinced that these methods will help researchers from various domains of life sciences, including clinicians, biochemists and virologists. Written in the highly successful "Methods in Molecular Biology"series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols "seeks to aid scientists in the further development of new therapeutic applications implicating RNA molecules or directly targeting harmful RNA."

Effective social interaction does not come naturally to many children with learning disabilities and yet is vital for developing and maintaining relationships and for independent living outside the school context. This social skills programme for pupils with mild to moderate learning disabilities, physical and/or medical disabilities and for those with special needs in mainstream education is divided into three units: let's communicate; let's be friends and let's practice. It aims to increase self-esteem and improve listening skills and expressive language abilities. Teacher's notes, photocopiable illustrated pupil worksheets and assessment and evaluation forms are included.

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.