Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

Eating and its Disorders features contributions by international experts in the field of eating disorders which represent an overview of the most current knowledge relating to the assessment, treatment, and future research directions of the study of eating-related disorders. * Presents the newest models and theories for use in the treatment of patients with eating disorders * Written specifically to fulfill the needs of clinical psychologists and therapists * Includes coverage of important service related issues for working with people with eating disorders * Features chapters from a global group of authors which highlight differing methods and perspectives that can be incorporated into clinical practice

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

Eating disorders present diagnostic and treatment challenges to clinicians. While such disorders need both medical and psychological treatment, patients may be too medically ill for a thorough psychiatric evaluation and may be misunderstood by many primary care physicians. In this revised and updated edition of "Eating Disorders," Philip S. Mehler and Arnold E. Andersen provide a user-friendly and comprehensive guide for primary care physicians, mental health professionals, and others who encounter individuals with the problem.

Mehler and Andersen identify common medical complications that people who have eating disorders face and answer questions about how to treat them. They also cover such serious complications as osteoporosis, cardiac arrhythmia, electrolyte abnormalities, immune compromise, and gastrointestinal sequelae. Incorporating case studies, medical background on the complications, suggestions for diagnosis and treatment, and a list of selected references, chapters cover important topics including team treatment and nutritional rehabilitation. The authors also address special areas of concern, such as athletes who have eating disorders and the pharmacologic treatment of obesity.

Mehler and Andersen encourage close medical follow-up for patients who have eating disorders. This book will help primary care and mental health professionals to understand and to more effectively address the complex concerns of patients with eating disorders.

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

Dr. Flavia B. Consens has assembled an expert team of authors on the topic of Sleep in Medical and Neurologic Disorders. Articles include: Sleep and pulmonary disease, Sleep and Pain, Sleep and Neurodegenerative Disorders, Sleep and Stroke, Sleep in the pediatric population, Sleep and cancer, Narcolepsy and excessive daytime sleepiness, Sleep in the hospitalized patient, Sleep and psychiatric disorders, Occupational sleep medicine, and more!

Explore the possibilities for successfully treating incarcerated or community-based substance abusersSubstance Abuse Treatment with Correctional Clients: Practical Implications for Institutional and Community Settings provides key research findings and policy implications for treating alcohol- and drug-addicted correctional clients. This book addresses a range of critical issues associated with delivering treatment in institutional and community settings. The critical thinking questions, tables, extensive bibliographies, and name and subject index will help academics and practitioners in criminal justice, sociology, counseling/psychology, and public policy. Substance Abuse Treatment with Correctional Clients shares the practical knowledge of researchers and practitioners in the fields of drug and alcohol addictions, substance abuse counseling, and criminal justice. The first section provides a review of the theoretical explanations for substance abuse, "best practice" treatment programs for substance abusers, and the use of coerced/mandated treatment. The second section addresses the substance-addicted offender in the institutional setting, the third includes works that describe community-based treatment programs and the problems associated with them, and the fourth looks at special treatment populations, including juveniles and adolescent females. In Substance Abuse Treatment with Correctional Clients, you will find: reviews of various types of treatment programs being used to treat substance-addicted individuals a study of the predictors of success and/or failure in corrections-based substance abuse programming--how to identify and use the predictors to prevent relapse arguments for and against coerced treatment in the correctional environment, and the concept of "motivation" a thorough investigation of the therapeutic community (TC) program for institutional-based substance abusers descriptions of treatment programming designed specifically for substance abusing community corrections clients--drug courts and Pennsylvania's Restrictive Intermediate Punishment treatment programSubstance Abuse Treatment with Correctional Clients guides you through the major policy issues faced by those who provide substance abuse treatment under what can only be described as coercive circumstances. In this important resource, you will discover major treatment modules as well as advice for working with adult, juvenile, and male or female offenders. This book provides you with the techniques that treatment communities need for helping offenders stay clean after they re-enter the community environment.

The strong association between mental health and sleep is examined here in topics that include: Epidemiology of sleep disorders, co-morbidity with mental health disorders and impact on health and quality of life; Neurobiology of sleep; Neurobiology of circadian rhythms; Genetics of sleep disorders; Sleep disturbances in anxiety disorders; Sleep disturbances in mood disorders; Sleep disturbances in schizophrenia; Sleep disturbances in substance abuse disorders; Sleep disturbances and behavioral disturbances in children and adolescents; Sleep disturbances and behavioral disturbances in the elderly; Sleep disturbances and behavioral symptoms in medical patients; Effects of psychotropic medications on sleep continuity and sleep architecture; Circadian rhythm sleep disorders; New developments in sleep medications of relevance to mental health disorders; and Primary sleep disorders: identification and treatment by psychiatrists.

Research in Communication Sciences and Disorders: Methods for Systematic Inquiry, Fourth Edition is a comprehensive yet comprehendible text meant for instructors and students of research methods in the field of communication sciences and disorders. This forward-thinking book reflects the movement toward evidence-based practice in speech-language pathology and audiology. The authors ensure that the concepts associated with evidence-based practice are integrated throughout the chapters. Rather than treating empirical research and searching for clinical evidence as separate topics, this text presents both as different applications of a process of scientific inquiry. The order of the chapters reflects the steps a researcher or clinician might complete when conducting an investigation. Also included are features that help students be more active in learning the material. Each chapter has a set of review questions or case scenarios that can be used as homework, as probe questions in class, or as a basis for group activities. In addition, the authors provide lists of supplemental readings from the research literature in the field. As with the previous edition, the fourth edition benefits instructors and students alike with access to a PluralPlus companion website. The website provides convenient lecture slides for each chapter and answers to review questions for instructors. For students, the website lists the key words for each chapter, provides links to supplemental websites and documents, and displays interactive versions of many of the figures within the text. New to the Fourth Edition New author: Jaimie L. Gilbert, PhD for an enhanced audiology perspective New chapter: Writing a Literature Review Reorganized for better flow of information. Various new and updated references to reflect the current state of research Additional illustrations and tables Expanded material on critical appraisal

Dr. Phyllis Zee has put together an expert panel of authors on the topic of the Science of Circadian Rhythms. Articles include: Neurobiology of Circadian Rhythm Regulation, Effect of Light and Melatonin and other Melatonin Receptor Agonists on Human Circadian Physiology, Consequences of Circadian Disruption on Cardiometabolic Health, Consequences Circadian Disruption on Neurologic and Psychiatric Health, Aging and Circadian Rhythms, Circadian and Homeostatic Regulation of Sleep and Performance, Circadian disruption in Psychiatric Disorders, and more!

A comprehensive overview of major 12-step programs, this practical manual also describes the nuances of the various programs that address the same addictive behavior to assist the clinician in assessing and referring clients to any 12-step program. One of the unique features of this book is a description of how 12-step program philosophy aligns with eight major psychotherapy orientations. Another feature is the integration of the client's individual needs and ego structure with the appropriateness and timing of a referral to a 12-step program within the overall therapeutic process.

In this day of managed care, it is essential for clinicians to make informed referrals. This book bridges the gap between the desire to refer and a comprehensive understanding of the intricacies of the various programs. Through the use of detailed description, case vignettes, and clinical examples, this book proves an invaluable resource assisting clinicians to guide their clients through the process of integrating psychotherapy with adjunctive 12-step program involvement. Also included is a description of terms used in 12-step programs that allows the clinicians to join the client in a common language.

Dr. Denise Sharon has put together an expert panel of authors on the topic of Restless Legs Syndrome and Movement Disorders. The comprehensive list of articles includes: Restless Legs Syndrome across the Globe, Neuroimaging in Restless Legs Syndrome, What's in the family of the RLS/WED patient?, Clinical Diagnosis and Diagnostic Criteria, Non-pharmacological management: myths vs. science, Sleep Bruxism, Leg Cramps, Hypnic Jerks, and more!

Cancers of the larynx, while survival outcomes increase, result in massive treatment damage from radiation and surgery. Patients often lose ability to speak and to eat. Preserving the larynx is a fine balance of cancer eradication, life extension, and quality of life. This issueof Otolaryngologic Clinics led by Dr Babak Sadoughi should be of interest to Otolaryngologists, Oncologists, Radiologists, and Speech Therapists. The issue approach reaches all the most important aspects of diagnosing and treating the patient with laryngeal cancer with a focus on preserving the voice in early laryngeal cancer and preserving and restoring function in advanced laryngeal cancer. Topics include: Functional Anatomy and Oncological Barriers of the Larynx; Evaluation of the Dysphonic Patient; Role of Advanced Laryngeal Imaging in Glottic Cancer; Laryngeal Function after Radiation Therapy; Management of Dysphonia after Radiation Therapy; Contemporary Surgical Management of Early Glottic Cancer; Voice Prognosis after Transoral Laser Microsurgery of the Larynx; Voice Rehabilitation after Transoral Laser Microsurgery of the Larynx; Quality of Life after Conservation Surgery for Laryngeal Cancer; Salvage Conservation Surgery of the Larynx; Airway Preservation in Ablative Laryngeal Surgery; Voice Restoration after Total Laryngectomy. A special article for Residents, written by a Resident, emphasizes essential "take home messages" for laryngeal function preservation diagnosis and treatment.

Medical treatment guidelines are written from a clinical perspective, to guide clinical care. The review criteria that will be included in this issue of Physical Medicine & Rehabilitation Clinics are evidence based and are developed by practicing physicians and advisors who work in physical medicine and rehabilitation. Health care providers are expected to be familiar with the guidelines and follow the recommendations. Good medical judgment is important in deciding how to use and interpret this information.

Food Allergy and Gluten-Free Weight Loss gives definitive answers to the question, "Why is it so hard to lose weight?" It is because we have missed or ignored the most important pieces in the puzzle of how our bodies determine whether to store or burn fat. Those puzzle pieces are hormones such as insulin, cortisol, leptin, and others. Individuals with food allergies or gluten intolerance face additional weight-loss challenges such as inflammation due to allergies or a diet too high in rice. This book explains how to put your body chemistry and hormones to work for you rather than against you, reduce inflammation which inhibits the action of your master weight control hormone, leptin, and flip your fat switch from "store" to "burn." It includes a flexible healthy eating plan that eliminates hunger, promotes the burning of fat, and reduces inflammation and tells how to customize the plan so it fits you, your allergies or intolerances, and your need for pleasure in what you eat. Information about cooking for special diets, 175 recipes, a list of sources for special foods, and extensive appendix and reference sections are also included.

This volume, is developed from a collaborative study sponsored by the World Health Organization over a period of five years, the result of the combined effort of over 30 experts working in 19 different countries. The book presents a comprehensive survey of the development, policy, and procedures of methadone maintenance in countries with experience in this treatment. In addition to presenting a general overview of methadone's role in treating opioid addiction, the volume also focuses on specific questions of current interest, particularly the critical issue of methadone maintenance in the prevention of AIDS. Public health specialists and policymakers will find this book an invaluable source of information about what can be expected from methadone maintenance programs and why such programs have achieved some success in the rehabilitation of opiate users, while so many other attempts in this area have failed.

Following an introductory chapter, the contributors look at the impact of AIDS epidemiology on methadone policy. The role of methadone in addressing intravenous drug abuse and unsafe sex practices in drug dependent persons is explored in an attempt to assess the ability of methadone maintenance programs to stem the spread of AIDS. Subsequent chapters review the world literature on methadone in treating opioid dependency, explore national policies and practices regarding methadone maintenance, present an international survey of methadone's role, and analyze the present state of research on methadone. A bibliography and index complete the volume.

Childhood obesity has become a central concern in many countries and a range of policies have been proposed or implemented to address it. This co-authored book is the first to focus on the complex set of ethical and policy issues that childhood obesity raises. Throughout the book, authors Kristin Voigt, Stuart G. Nicholls, and Garrath Williams emphasize that childhood obesity is a multi-faceted phenomenon, and just one of many issues that parents, schools and societies face. They argue that it is important to acknowledge the resulting complexities and not to think in terms "single-issue" policies. After first reviewing some of the factual uncertainties about childhood obesity, the authors explore central ethical questions. What priority should be given to preventing obesity? To what extent are parents responsible? How should we think about questions of stigma and inequality? In the second part of the book, the authors consider key policy issues, including the concept of the aobesogenic environment,a debates about taxation and marketing, and the role that schools can play in obesity prevention. The authors argue that political debate is needed to decide the importance given to childhood obesity and how to divide responsibilities for action. These debates have no simple answers. Nonetheless, the authors argue that there are reasons for hope. There are a wide range of opportunities for action. Many of these options also promise wider social benefits. "This book provides a welcome re-appraisal of commonly-held beliefs about child obesity and misconceptions about what needs to be done. The authors expose the futility of holding parents responsible for children's unhealthy behaviour, they challenge the assumption that education and family support will solve the problem, and they condemn the prejudice and stigma which surround the narrative of blame. The book shows convincingly how the causes of obesity - and the range of associated diseases - lie in the fabric of the modern market economy: in the food supply which shapes our diets, the social and physical environment which encourages sedentary behaviour, and in the media which promote ever greater consumption. Obesity is not the problem: it is the symptom of a more complex social and economic malaise encouraging poor health. The case for interventions by governments to promote health and wellbeing above crude economic growth is comprehensively proven." - Dr. Tim Lobstein, Director of Policy and Programmes, The International Association for the Study of Obesity and The International Obesity Task Force A well-researched, highly critical, but carefully balanced examination of everyday assumptions about childhood obesity and its prevention from an intensely moral perspective. Although the authors demonstrate that no intervention is without ethical complications or effective entirely on its own, they call for immediate actions to reduce the stigma of childhood obesity, support parents, and create food environments healthier for children, adults, and the environment.- Marion Nestle, Paulette Goddard Professor of Nutrition, Food Studies, and Public Health, NYU Steinhardt School of Culture, Education, and Human Development

Drs. John Herman and Max Hirshkowitz have assembled an expert panel of authors in the topic of Sleep and Psychiatry in Adults. Articles include: Sleep Deprivation and Circadian Disruption; Sleep Disturbances in Depression; Interventions for Sleep Disturbance in Bipolar Disorder; Sleep and Mood During Pregnancy and the Postpartum Period,Sleep Disturbances and Suicide Risk; Insomnia and Anxiety, Interconnectedness of Psychological Suymptoms, Personality Traits, and Sleep Disruption; Sleep in Schizophrenia; Post-traumatic Stress Disorder and Sleep; Benzodiazepine and Benzodiazepine Receptor Agonists for Insomnia and Anxiety; Non-benzodiazpine GABA A1 Receptor Agonists for Insonmia; CBT for Insomnia and Depression; Hypnosis for Insomnia in Patients with Depression and Anxiety; and Bright Light Therapy for Seasonal Affective Disorders.

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.