This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

This unique volume advances the literature on sleep and health by illuminating the impacts of family dynamics on individuals' quality and quantity of sleep. Its lifespan perspective extends across childhood, adolescence, adulthood and older age considering both phenomena of individual development and family system dynamics, particularly parent-child and marital relationships. It extends, as well, to the broader contexts of social disparities in sleep as a significant health behavior. Emerging concepts and practical innovations include ancestral roots of sleep in family contexts, sleep studies as a lens for understanding family health, and methodologies, particularly the use of actigraphy technology, for studying sleep patterns in individuals and families. This rich area of inquiry holds significant keys to understanding a vital human behavior and its critical role in physical, psychological, and relational health and wellbeing. Among the topics covered: * Sleep and development: familial and sociocultural considerations. * Relationship quality: implications for sleep quality and sleep disorders. * Couple dynamics and sleep quality in an international perspective. * Family influences on sleep: comparative and historical-evolutionary perspectives. * Sociodemographic, psychosocial, and contextual factors in children's sleep. * Dynamic interplay between sleep and family life: review and directions for future research. Family Contexts of Sleep and Health Across the Life Course will advance the work of researchers and students in the fields of population health, family demography and sociology, sleep research and medicine, human development, neuroscience, biobehavioral health, and social welfare, as well as that of policymakers and health and human services practitioners.

Eating and its Disorders features contributions by international experts in the field of eating disorders which represent an overview of the most current knowledge relating to the assessment, treatment, and future research directions of the study of eating-related disorders. * Presents the newest models and theories for use in the treatment of patients with eating disorders * Written specifically to fulfill the needs of clinical psychologists and therapists * Includes coverage of important service related issues for working with people with eating disorders * Features chapters from a global group of authors which highlight differing methods and perspectives that can be incorporated into clinical practice

Originally published in French, this updated and expanded English translation offers a definitive treatment on clays and effects on human health including the long history of clays used as pharmaceutical and therapeutic agents, the origins of clays, their structural properties and modes of action.

Almost one out of every three US children is overweight or obese, with minority youth at highest risk. There are limited efficacious pediatric obesity interventions available for clinicians, and successful weight loss trials for minority youth are rare. Even fewer interventions have been shown to significantly improve clinical health outcomes such as adiposity, blood pressure, and cholesterol level, and maintenance of behavior change over the long-term remains a challenge Translation I research in which "bench" findings are applied to the "bedside" is uncommon in the behavioral arena. Thus, advances in our understanding of fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to our most pressing behavioral health problems. This issue of Pediatric Clinics will focus on promising behavioral treatments "in the pipeline" that have been translated from basic behavioral science and are the process of refinement and proof of concept testing.

This issue of Sleep Medicine Clinics focuses on Novel Therapies for Sleep-Disorderd Breathing. Article topics include: The problems and pitfalls with current approaches to managing sleep disordered breathing; New approaches to diagnosing sleep disordered breathing; Monitoring progress and adherence with PAP therapy for OSA; The future of dental approaches for the treatment of OSA; Pharmacologic approaches for the treatment of OSA; Novel therapies for the treatment of central sleep apnea; Advances and new approaches to managing sleep disordered breathing related to chronic pulmonary disease; The role of big data in the management of sleep disordered breathing; Using genes and biomarkers to assess risk and identify optimal treatments for patients with sleep disordered breathing, and more!

Untold stories of people with substance addictions who have recovered without formal treatment Despite the widely accepted view that formal treatment and twelve-step groups are essential for overcoming dependencies on alcohol and drugs, each year large numbers of former addicts quietly recover on their own, without any formal treatment or participation in self-help groups at all. Coming Clean explores the untold stories of untreated addicts who have recovered from a lifestyle of excessive and compulsive substance use without professional assistance. Based on 46 in-depth interviews with formerly addicted individuals, this controversial volume examines their reasons for avoiding treatment, the strategies they employed to break away from their dependencies, the circumstances that facilitated untreated recovery, and the implications of recovery without treatment for treatment professionals as well as for prevention and drug policy. Because of the pervasive belief that addiction is a disease requiring formal intervention, few training programs for physicians, social workers, psychologists, and other health professionals explore the phenomenon of natural recovery from addiction. Coming Clean offers insights for treatment professionals of how recovery without treatment can work and how candidates for this approach can be identified. A detailed appendix outlines specific strategies which will be of interest to addicted individuals themselves who wish to attempt the process of recovery without treatment.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

Eating disorders present diagnostic and treatment challenges to clinicians. While such disorders need both medical and psychological treatment, patients may be too medically ill for a thorough psychiatric evaluation and may be misunderstood by many primary care physicians. In this revised and updated edition of "Eating Disorders," Philip S. Mehler and Arnold E. Andersen provide a user-friendly and comprehensive guide for primary care physicians, mental health professionals, and others who encounter individuals with the problem.

Mehler and Andersen identify common medical complications that people who have eating disorders face and answer questions about how to treat them. They also cover such serious complications as osteoporosis, cardiac arrhythmia, electrolyte abnormalities, immune compromise, and gastrointestinal sequelae. Incorporating case studies, medical background on the complications, suggestions for diagnosis and treatment, and a list of selected references, chapters cover important topics including team treatment and nutritional rehabilitation. The authors also address special areas of concern, such as athletes who have eating disorders and the pharmacologic treatment of obesity.

Mehler and Andersen encourage close medical follow-up for patients who have eating disorders. This book will help primary care and mental health professionals to understand and to more effectively address the complex concerns of patients with eating disorders.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

This book is a comprehensive guide to the evidence, theories, and practical issues associated with recovery from stuttering in early childhood and into adolescence. It examines evidence that stuttering is associated with a range of biological factors - such as genetics - and psychological factors - such as anxiety - and it critically assesses theoretical accounts that attempt to integrate these findings. Written so that it can be used flexibly to meet the demands of courses about stuttering, the book may be used as a text at the undergraduate or graduate level in psychology or speech-language science.

Dr. Flavia B. Consens has assembled an expert team of authors on the topic of Sleep in Medical and Neurologic Disorders. Articles include: Sleep and pulmonary disease, Sleep and Pain, Sleep and Neurodegenerative Disorders, Sleep and Stroke, Sleep in the pediatric population, Sleep and cancer, Narcolepsy and excessive daytime sleepiness, Sleep in the hospitalized patient, Sleep and psychiatric disorders, Occupational sleep medicine, and more!

Society is becoming increasingly multi-lingual and this presents monolingual professionals, particularly those in special education and speech pathology, with severe problems. Is the language delay in a child from a bilingual environment a result of this background or is there a specific speech problem? Is a child's poor performance in school due to his problems of coping with two languages, or does he need remedial teaching? Originally published in 1984, this book is not concerned with second language learning, but with speech and learning difficulties in bilingual children as they are presented to remedial teachers, psychologists and speech therapists. To this end the first group of specially written articles deals with the patterns of language usage in bilingual communities and the social and psychological factors which shape these patterns; with processes in normal bilingual language acquisition; and with the relationship between cognitive development and growing up with two languages. Management issues and methods involved in helping children with language problems are also tackled: they include taking case histories, family liaison, counselling, bilingual programmes, mother tongue teaching, curriculum development and the training of personnel to work in the bilingual-bicultural field. This book provided a great deal of practical help, in a field that was relatively new at the time of writing, and helped to enlighten readers on the issues involved and assist in crystalising thought and directing future research.

Explore the possibilities for successfully treating incarcerated or community-based substance abusersSubstance Abuse Treatment with Correctional Clients: Practical Implications for Institutional and Community Settings provides key research findings and policy implications for treating alcohol- and drug-addicted correctional clients. This book addresses a range of critical issues associated with delivering treatment in institutional and community settings. The critical thinking questions, tables, extensive bibliographies, and name and subject index will help academics and practitioners in criminal justice, sociology, counseling/psychology, and public policy. Substance Abuse Treatment with Correctional Clients shares the practical knowledge of researchers and practitioners in the fields of drug and alcohol addictions, substance abuse counseling, and criminal justice. The first section provides a review of the theoretical explanations for substance abuse, "best practice" treatment programs for substance abusers, and the use of coerced/mandated treatment. The second section addresses the substance-addicted offender in the institutional setting, the third includes works that describe community-based treatment programs and the problems associated with them, and the fourth looks at special treatment populations, including juveniles and adolescent females. In Substance Abuse Treatment with Correctional Clients, you will find: reviews of various types of treatment programs being used to treat substance-addicted individuals a study of the predictors of success and/or failure in corrections-based substance abuse programming--how to identify and use the predictors to prevent relapse arguments for and against coerced treatment in the correctional environment, and the concept of "motivation" a thorough investigation of the therapeutic community (TC) program for institutional-based substance abusers descriptions of treatment programming designed specifically for substance abusing community corrections clients--drug courts and Pennsylvania's Restrictive Intermediate Punishment treatment programSubstance Abuse Treatment with Correctional Clients guides you through the major policy issues faced by those who provide substance abuse treatment under what can only be described as coercive circumstances. In this important resource, you will discover major treatment modules as well as advice for working with adult, juvenile, and male or female offenders. This book provides you with the techniques that treatment communities need for helping offenders stay clean after they re-enter the community environment.

The strong association between mental health and sleep is examined here in topics that include: Epidemiology of sleep disorders, co-morbidity with mental health disorders and impact on health and quality of life; Neurobiology of sleep; Neurobiology of circadian rhythms; Genetics of sleep disorders; Sleep disturbances in anxiety disorders; Sleep disturbances in mood disorders; Sleep disturbances in schizophrenia; Sleep disturbances in substance abuse disorders; Sleep disturbances and behavioral disturbances in children and adolescents; Sleep disturbances and behavioral disturbances in the elderly; Sleep disturbances and behavioral symptoms in medical patients; Effects of psychotropic medications on sleep continuity and sleep architecture; Circadian rhythm sleep disorders; New developments in sleep medications of relevance to mental health disorders; and Primary sleep disorders: identification and treatment by psychiatrists.

Clinical Management of Swallowing Disorders, Fifth Edition is a graduate-level textbook for speech-language pathology programs that examines the diagnosis and treatment of swallowing disorders in children and adults. Thoroughly updated, this popular text emphasizes evidence-based practice, multidisciplinary team management, swallowing safety, nutrition, behavioral treatments, and management following surgical options. Authored by two speech-language pathologists and an otolaryngologist for a multidisciplinary approach, the Fifth Edition continues to be easy-to-understand text for students and also serves as an up-to-date reference for practicing clinicians who treat swallowing disorders in hospitals, rehabilitation centers, nursing homes, and private outpatient clinics. New to the Fifth Edition * New chapter on the aging population! * The Anatomy and Physiology chapter has been thoroughly updated and 15 beautiful, new full color illustrations have been added * More images and enhanced figures, including additional FEES and fluoroscopy video studies of swallowing disorders in head and neck cancer and stroke patients * Many new references, easy-to-read tables, and "treatment hints". * Information on pediatric feeding and swallowing has been updated and expanded * Evidence-based practice methods have been updated * Content has been edited to be more concise, applicable, and reader friendly. The text features numerous pedagogical aids to reinforce student understanding: * Case study inserts in many chapters and 9 extended case studies in the final chapter * 32 videos * Discussion questions and answers for each chapter * Bolded and boxed key terms throughout with an end-of-book glossary * Clinical tips, clinician's roles, areas of emphasis, and key learning points highlighted in boxes throughout the chapters * 8 appendices featuring helpful tests and tools for clinicians * NEW full clinical swallowing examination record form included in appendix * Access to ancillary materials on a PluralPlus companion website, including instructor lecture slides, downloadable versions of the appendices, and PowerPoint flashcards

Dr. Phyllis Zee has put together an expert panel of authors on the topic of the Science of Circadian Rhythms. Articles include: Neurobiology of Circadian Rhythm Regulation, Effect of Light and Melatonin and other Melatonin Receptor Agonists on Human Circadian Physiology, Consequences of Circadian Disruption on Cardiometabolic Health, Consequences Circadian Disruption on Neurologic and Psychiatric Health, Aging and Circadian Rhythms, Circadian and Homeostatic Regulation of Sleep and Performance, Circadian disruption in Psychiatric Disorders, and more!

A comprehensive overview of major 12-step programs, this practical manual also describes the nuances of the various programs that address the same addictive behavior to assist the clinician in assessing and referring clients to any 12-step program. One of the unique features of this book is a description of how 12-step program philosophy aligns with eight major psychotherapy orientations. Another feature is the integration of the client's individual needs and ego structure with the appropriateness and timing of a referral to a 12-step program within the overall therapeutic process.

In this day of managed care, it is essential for clinicians to make informed referrals. This book bridges the gap between the desire to refer and a comprehensive understanding of the intricacies of the various programs. Through the use of detailed description, case vignettes, and clinical examples, this book proves an invaluable resource assisting clinicians to guide their clients through the process of integrating psychotherapy with adjunctive 12-step program involvement. Also included is a description of terms used in 12-step programs that allows the clinicians to join the client in a common language.

Childhood obesity has become a central concern in many countries and a range of policies have been proposed or implemented to address it. This co-authored book is the first to focus on the complex set of ethical and policy issues that childhood obesity raises. Throughout the book, authors Kristin Voigt, Stuart G. Nicholls, and Garrath Williams emphasize that childhood obesity is a multi-faceted phenomenon, and just one of many issues that parents, schools and societies face. They argue that it is important to acknowledge the resulting complexities and not to think in terms "single-issue" policies. After first reviewing some of the factual uncertainties about childhood obesity, the authors explore central ethical questions. What priority should be given to preventing obesity? To what extent are parents responsible? How should we think about questions of stigma and inequality? In the second part of the book, the authors consider key policy issues, including the concept of the aobesogenic environment,a debates about taxation and marketing, and the role that schools can play in obesity prevention. The authors argue that political debate is needed to decide the importance given to childhood obesity and how to divide responsibilities for action. These debates have no simple answers. Nonetheless, the authors argue that there are reasons for hope. There are a wide range of opportunities for action. Many of these options also promise wider social benefits. "This book provides a welcome re-appraisal of commonly-held beliefs about child obesity and misconceptions about what needs to be done. The authors expose the futility of holding parents responsible for children's unhealthy behaviour, they challenge the assumption that education and family support will solve the problem, and they condemn the prejudice and stigma which surround the narrative of blame. The book shows convincingly how the causes of obesity - and the range of associated diseases - lie in the fabric of the modern market economy: in the food supply which shapes our diets, the social and physical environment which encourages sedentary behaviour, and in the media which promote ever greater consumption. Obesity is not the problem: it is the symptom of a more complex social and economic malaise encouraging poor health. The case for interventions by governments to promote health and wellbeing above crude economic growth is comprehensively proven." - Dr. Tim Lobstein, Director of Policy and Programmes, The International Association for the Study of Obesity and The International Obesity Task Force A well-researched, highly critical, but carefully balanced examination of everyday assumptions about childhood obesity and its prevention from an intensely moral perspective. Although the authors demonstrate that no intervention is without ethical complications or effective entirely on its own, they call for immediate actions to reduce the stigma of childhood obesity, support parents, and create food environments healthier for children, adults, and the environment.- Marion Nestle, Paulette Goddard Professor of Nutrition, Food Studies, and Public Health, NYU Steinhardt School of Culture, Education, and Human Development

'Raw. Vulnerable. Open. Truthful . . . This is a book that will open up the floor for even more honest conversations about the side of yoga we don't often see.' - Angie Tiwari @tiwariyoga How did an ancient spiritual practice become the preserve of the privileged? Nadia Gilani has been practising yoga for twenty-five years. She has also worked as a yoga teacher. Yoga has saved her life and seen her through many highs and lows; it has been a faith, a discipline, and a friend, and she believes wholeheartedly in its radical potential. However, over her years in the wellness industry, Nadia has noticed not only yoga's rising popularity, but also how its modern incarnation no longer serves people of colour, working class people, or many other groups who originally pioneered its creation. Combining her own memories of how the practice has helped her with an account of its history and transformation in the modern west, Nadia creates a love letter to yoga and a passionate critique of the billion-dollar industry whose cost and inaccessibility has shut out many of those it should be helping. By turns poignant, funny, and shocking, The Yoga Manifesto excavates where the industry has gone wrong, and what can be done to save the practice from its own success.