For students taking courses in phonetics and linguistics. A comprehensive introduction to the art and science of clinical transcription. Clinical Phonetics was written with the belief that the clinical application of phonetics is a specialized branch of the field that requires a particular sensitivity to the challenge of transcribing speech disorders. The three primary strengths of the fourth edition of this text continue to be: authoritative coverage of the phonetics of American English, tested skills teaching in clinical transcription using four hours of audio examples (CDs sold separately), and the discussion of a wealth of clinically-relevant topics throughout the text and numerous appendices. Other notable features of the book are its broad coverage of phonetics, including an overview of the anatomy of speech production; phonetic symbols for consonants, vowels and diphthongs; diacritics for narrow transcription; representing suprasegmentals such as stress pattern; acoustic properties of speech; and dialect. This newly revised edition of Clinical Phonetics preserves the strengths of the earlier editions but offers significant improvements in content and style.

For undergraduates taking introduction courses in communication sciences and disorders. This leading introductory book on communication disorders uses student-friendly content to explore current research, central theories, and the nuts and bolts of clinical therapy. Updated with the most current research and information, the newly revised eighth edition of Human Communication Disorders continues to cover a broad range of topics including speech and language development, genetics, the biology and physics of communication, and an overview of cultural and linguistic diversity. With an emphasis on evidence-based practice, experts in speech-language pathology and audiology place communication processes and communication disorders in perspective, define basic theories of causation, introduce identifying characteristics, and present an overview of procedures for evaluation and treatment - while at the same time focusing on the real people who both have communication disorders and the real people who study them. The new eighth edition has been rewritten with a more contemporary, student-friendly approach and style that makes the content more engaging and easier to process.

In "Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, " expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target. These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. We are convinced that these methods will help researchers from various domains of life sciences, including clinicians, biochemists and virologists. Written in the highly successful "Methods in Molecular Biology"series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols "seeks to aid scientists in the further development of new therapeutic applications implicating RNA molecules or directly targeting harmful RNA."

Nick Charles MBE is a pioneer in treating alcohol dependency. As the founder of both the Chaucer Clinic and the Gainsborough Foundation, he was the first person to be honoured by the Queen 'for services to people with alcohol problems' and his work - over four decades - has helped tens of thousands of people. But Nick's decorated success overlays an extraordinary and unforgettable personal journey, for Nick was once an alcoholic vagrant sleeping rough on the streets of London. In 50 Years of Hard Road, Nick details his time in the abyss of alcohol addiction; a period that despatched relationships, his health, his career, and so much more. Forced to live on the streets for four years, Nick recalls the tough times, the characters he met, and the ever-present call of alcohol, but also how he slowly built up two carrier bags-worth of painstaking research into alcohol and its effects on his fellow man. It was through the documents in these carrier bags that Nick's life was to change forever when, in the mid-1970s, he was taken under the wing of a doctor who cared for those on skid row. This dedicated medic recognised the treasure trove of information Nick had developed. 50 Years of Hard Road is a remarkable, uplifting, and often humorous story of one man's journey from the depths of life-crushing alcohol dependency, to running alcohol clinics and programmes across the country. It describes an incredible life filled with high points, low points, and amazing adventures in-between.

Since the legalisation of off-course cash betting in 1960, and the rise of varying forms of gambling, the British have come to be known as a nation of gamblers. Until this study was published in 1976, barely any evidence existed against which to assess the claim that gambling had become a major social problem. The authors present data drawn from area surveys carried out in Swansea, Sheffield, Wanstead and Woodford, and explore how well previous sociological theories of gambling agree with their findings, particular in connection with certain aspects of work and leisure. Examining different forms of gambling, including betting, bingo and gaming machines, the chapters consider how gambling choices vary between different social groups, and how much time and money is spent on them. With the internet making it easier than ever before to place bets, this title is especially relevant, and provides a systematic basis for an explanation of gambling in relation to social structure.

Inquiry into signed languages has added to what is known about structural variation and language, language learning, and cognitive processing of language. However, comparatively little research has focused on communication disorders in signed language users. For some deaf children, atypicality is viewed as a phase that they will outgrow, and this results in late identification of linguistic or cognitive deficits that might have been addressed earlier. This volume takes a step towards describing different types of atypicality in language communicated in the signed modality such as linguistic impairment caused by deficits in visual processing, difficulties with motor movements, and neurological decline. Chapters within the book also consider communication differences in hearing children acquiring signed and spoken languages.

Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy.
All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy.
The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world.
The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.

Author Mark S. Gold presents the latest medical information on nicotine and tobacco's neurobiological, physiological, and psychological effects. This timely monograph also discusses the latest diagnostic and treatment programs as well as model programs for use by practitioners which were developed by the National Cancer Institute and other eminent organizations. The author also includes a comprehensive history of tobacco use.

It was during the course of the eighteenth and nineteenth centuries that the problem of chronic alcohol dependence in modern society and its consequent medical effects emerged. The topic of drunkenness figures prominently in the thinking and writing of social reformers, politicians, theorists, medical practitioners, and psychiatrists. Eventually, by the mid-nineteenth century, 'alcoholism' was named as the disease of habitual drunkenness. Possibly the most important book to predict this was Trotter's Essay, written in 1804. Through case studies based on wide experience, he detailed the manifestations of alcoholism, ventured therapeutic recommendations, and squarely termed drunkenness a disease - indeed, a mental disease. Originally published in 1988 as part of the Tavistock Classics in the History of Psychiatry series, Roy Porter's Introduction to this facsimile reprint locates Trotter's work within the wider history of the evolution of the idea of alcoholism. It also examines the Essay in the context of Trotter's own life and mind - a mind preoccupied with what he saw as the degenerative tendencies of modern civilization and with the wider issues of drug dependence.

This book provides potential students of a chiropractic career path, as well as other health care practitioners, with vital information regarding the training required to enter the chiropractic field and the roles of chiropractors in modern health care. Chiropractic is the second largest physician-level health profession in the United States, with chiropractors providing care to at least 20 million patients annually. As chiropractic health care has been proven to be both effective and cost effective for many musculoskeletal conditions, particularly back pain, the inclusion of Doctors of Chiropractic (DCs) in a variety of health care settings is likely to continue to increase. Surprisingly, there is little readily accessible information on chiropractic as a career path. This book provides concise yet comprehensive information about career paths, training, and professional roles in chiropractic for students considering chiropractic as well as health care practitioners in the field. Written in an easy-to-read style, Careers in Chiropractic Health Care: Exploring a Growing Field serves students, those in non-chiropractic health fields, and general readers considering chiropractic as a career change option. The chapters explain the training and specific licensure requirements for chiropractors in all 50 U.S. states and provide information useful to health care professionals for referrals and management of patients using chiropractic care. Explains the various chiropractic specialization career paths, addresses key considerations when choosing a chiropractic college, and describes what to expect in academic and clinical education when pursuing a chiropractic career Identifies opportunities for additional training and experience for Doctors of Chiropractic (DC) Describes the typical chiropractic practice and details how to set up a successful practice Provides highly useful career guidance information for high school and college students

Why do so many people try dieting, only to fail? What distinguishes those who succeed from those who do not? Are fat people really any different from thin people? What makes us eat, and how do we stop eating? And how can dieting trigger problems with eating normally? Originally published in 1989, Sara Gilbert discusses these questions in Tomorrow I'll Be Slim, and draws on what is known about the psychology of eating, overeating, and weight control to dispel a number of popular myths about dieting. She shows how unsuccessful dieting can lead to new problems with eating and weight control. She points out that long-term success in slimming has more to do with individual factors such as a dieter's expectations, self-confidence, or social and family circumstances than with 'will-power'; and as much to do with how a diet is managed as with the content of a diet sheet. She suggests ways in which people who want to be slimmer can make a realistic assessment of their need to diet. She explains how individuals who seriously need to lose weight or change the way they eat might draw up effective strategies for themselves and prepare for the inevitable difficulties we all face whenever we try to change old habits. Finally, she addresses the problems of taking the emphasis off dieting and examining our attitudes to a slim figure as the key to happiness itself.

Drug Abuse Treatment, together with its companion volume, Alcohol Abuse Treatment, critically examines the many difficult issues and complex strategies associated with the successful treatment of substance abuse today. Because of the high cost in lives, health, and dollars, the need for improved tech-niques and strategies for the treatment and reduction of substance abuse has become a critical national priority. In this volume of Drug & Alcohol Abuse Reviews, Ronald R. Watson and key researchers in the field of drug abuse treatment evaluate both old and new methods, carefully reviewing current data to determine the value of the most important treatment programs in current use. Featured topics include: cocaine and heroin addiction treatment relapse problems and treatment nicotine abuse treatment strategy for drug treatment systems psychological correlates of drug abuse outpatient drug abuse treatment pharmacotherapy for drug abuse Drug Abuse Treatment and its complementary volume on Alcohol Abuse Treatment together offer a thorough review and analysis of drug and alcohol abuse treatment options, providing researchers and clinicians with a valuable framework for understanding, planning, and delivering the effective substance abuse treatment that is so urgently needed now.

Obstructive Sleep Apnea (OSA) is the most prevalent sleep disordered breathing disorder. It has become apparent that in more than half the patients with OSA, the frequency and duration of apneas are influenced by body position. To treat patients with Position Dependent OSA (POSA), positional therapy can be considered for preventing patients from sleeping in the worst sleeping position. Treatment of POSA has advanced dramatically recently with the introduction of a new generation of positional therapy. Positional Therapy in Obstructive Sleep Apnea presents improved OSA diagnostic methods and the tools needed to implement positional therapy in clinical practice. This includes patient work-up, positional therapy with or without other treatments, consequences of guidelines and future developments. Clinicians, students and researchers will find this comprehensive guide to be an invaluable resource for evaluating and treating sleep breathing disorders.

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Linguistic Morphology is a unique collection of cutting-edge research in the psycholinguistics of morphology, offering a comprehensive overview of this interdisciplinary field. This book brings together world-leading experts from linguisics, experimental psychology and cognitive neuroscience to examine morphology research from different disciplines. It provides an overview of how the brain deals with complex words; examining how they are easier to read, how they affect our brain dynamics and eye movements, how they mould the acquisition of language and literacy, and how they inform computational models of the linguistic brain. Chapters discuss topics ranging from subconscious visual identification to the high-level processing of sentences, how children make their first steps with complex words through to how proficient adults make lexical identification in less than 40 milliseconds. As a state-of-the-art resource in morphology research, this book will be highly relevant reading for students and researchers of linguistics, psychology and cognitive neuroscience. It will also act as a one-stop shop for experts in the field.

When first published in 2003, this indispensable handbook fulfilled a critical need for information about the various causes of insomnia. Updated and expanded, this new edition of the Clinical Handbook of Insomnia offers healthcare providers the latest diagnostic and treatment strategies, as well as research developments, in the field of insomnia. With contributions from an expanded team of leading researchers from 5 different countries, this important resource includes new chapters on insomnia in special populations such as children, in adolescents, in the geriatric population, in menopausal women, and during pregnancy. The first edition chapter on insomnia in other sleep disorders has been divided and expanded into three comprehensive chapters addressing insomnia in sleep-related breathing disorders, in circadian rhythm disorders, and in sleep-related movement disorders and other parasomnias. The chapter on insomnia in neurological and medical disorders has also been split into two; an expanded one on neurological illness and another on medical disorders. There is also a new chapter on the association between insomnia and pain disorders, and, crucially, a practical how-to' chapter aimed at mid-level clinicians. The Clinical Handbook of Insomnia 2nd edition also includes state-of-the-art discussion of important developments made in recent years. Along with an overview of significant advances in the treatment of insomnia, including four new medications granted FDA approval and a number of others in the pipeline, the text offers a wealth of of new data regarding the pathophysiology of insomnia. Complete with a host of case studies, charts, and graphs to illustrate the material, the Clinical Handbook of Insomnia 2nd edition continues to fill an important niche in the literature by addressing the issue in its multiple forms and by presenting the information to clinicians in an easily accessible format

Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health." --Jimmy Moore, author, Keto Clarity and Cholesterol Clarity Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones--in everyone--and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss. In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight--for good.

In the early 1980s the transtheoretical model of change was still in its infancy. Seminal publications were just appearing, but the model already seemed to hold such promise that we made it the organizing theme for the Third International Conference on Treatment of Addictive Behaviors (ICTAB-3), which convened in Scotland in 1984. That meeting gave rise to the first edition of this volume (Miller & Heather, 1986), which focused on processes involved in moving people from one stage to the next. With the volume still in print more than a decade later, we were approached by Plenum Press with the idea of preparing this second edition. We were, obvi ously, persuaded that there was merit to the idea. Since 1986 the work of Pro chaska and DiClemente has grown exponentially in popularity and influence. In Britain and the Americas, it is now unusual to find an addiction professional who has not at least heard about the stages of change, and more sophisticated applica tions of the transtheoretical model are spreading through health care systems and well beyond. The model has influenced professional training, health care delivery, and the design of many studies including a number of large clinical trials."

Now in its second edition, Speech and Language Therapy: the decision-making process when working with children reveals how recent research and changes in health and education services have affected the decision-making process in the assessment and management of children with speech and language problems.

With individual chapters written by experts in their field, this book:

• Illustrates how the decisions made by practitioners may vary within different work settings
• Shows how these decisions may need to be adapted when working with specific client groups
• Explores how such decisions are part of effective evidence-based practice
• Offers an overview of the skills required by the developing professional
• Provides insight into working as a newly qualified therapist in the current job market.

Rigorously underpinned with current research and revised legislation, this is an important textbook for speech and language therapy students, potential students and specialist teachers in training. Speech and Language Therapy: the decision-making process when working with children will also be relevant to newly qualified therapists, therapists returning to the profession, specialist teachers and Special Educational Needs Coordinators.

In this issue of Physical Medicine and Rehabilitation Clinics, guest editor Dr. Thomas (Quin) Throckmorton brings his considerable expertise to Shoulder Rehabilitation. Top experts in the field cover key topics such as shoulder impingement syndrome; non-operative treatment of rotator cuff tears; post-operative rehabilitation following rotator cuff repair; non-operative treatment of the biceps-labral complex; post-operative rehabilitation after SLAP repair; and more. Contains 12 relevant, practice-oriented topics including post-operative rehabilitation after surgery for shoulder instability; scapular dyskinesis; adhesive capsulitis; post-operative rehabilitation after shoulder arthroplasty; muscular re-training and rehabilitation after tendon transfer surgery in the shoulder; and more. Provides in-depth clinical reviews on shoulder rehabilitation, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Sleep has recently been recognized as a critical determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization. In addition to having an impact on obesity, sleep abnormalities, both quantitative and qualitative, have now been shown to have significant effects on obesity associated comorbidities, including metabolic syndrome, premalignant lesions and cancer. Sleep problems and fatigue also constitute a significant challenge for the ever expanding group of cancer survivors. Moreover, circadian misalignment, such as that experienced by "shift workers" has been shown to be associated with an increased incidence of several malignancies including, breast, colorectal and prostate cancer, consistent with the increasing recognition of the role of clock genes in the metabolic processes. Of increasing concern is the accelerating incidence of sleep disorders in childhood, their association with childhood obesity and associated abnormalities of circulating cytokines, adipokines and metabolic factors, many of which are implicated as etiologic mediators of the connection between obesity and cancer. Extensive studies have now been initiated to investigate the mechanisms by which disturbances in sleep duration, sleep continuity and sleep related breathing affect circadian rhythm, central and peripheral tissue oxygenation and metabolism, quality and quantity of dietary intake and circulating inflammatory cytokines and regulatory hormones. This volume aims to present the latest research on sleep, sleep disturbance and its correlation to obesity and cancer.

Recent studies have provided clear evidence on the role of neural-immune interactions in normal brain function and neuropathological conditions. Neuroimmune factors, which play an essential role in neuroinflammatory response, have been implicated in the regulation of neuronal function and plasticity. Thus, neural-immune interactions provide a new frame work for understanding the role of the neuroimmune system in normal brain function, neurodevelopment, and a variety of neurological disorders. These advances have a far reaching impact on many areas of neuroscience, including alcohol research. Studies using human alcoholic brains, gene knockout mice, and gene expression profiling have established a clear link between alcoholism and an altered neuroimmune profile. This book integrates emerging knowledge on neural-immune interactions with key discoveries in alcohol research and provides a comprehensive overview of neural-immune interactions in brain function and behavior associated with alcohol use disorders. While "Neural Immune Interaction in Brain Function and Alcohol Related Disorders" focuses on neural-immune interactions in areas directly related to alcohol use disorders, it is not intended to be all inclusive. Several areas, including sleep disorders, pain, and cholinergic anti-inflammatory pathways, are not covered as independent chapters but briefly mentioned in the text. The close relevance of these topics to neural-immune interactions and alcohol use disorders warrants future discussion and more research efforts."

Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.

The statistics show that as much as twenty percent of the population suffers from chronic insomnia and one-fourth of those with the condition eventually develop an anxiety disorder. As comorbid conditions, they contribute to any number of physical and social problems. Yet too often insomnia is undiagnosed, or treated as merely a symptom of the patient's anxiety. Insomnia and Anxiety is the first clinician guidebook that considers the evaluation and management of insomnia and related sleep disturbances that occur conjointly with the common anxiety disorders. By exploring the ways that one condition may exacerbate the other, its authors present robust evidence of the limitations of viewing insomnia as secondary to GAD, agoraphobia, PTSD, and others in the anxiety spectrum. The book reviews cognitive and emotional factors common to anxiety and sleep disorders, and models a cognitive-behavioral approach to therapy in which improved sleep is a foundation for improved symptom management. Beginning and veteran practitioners alike will find vital insights into all areas of these challenging cases, including: Diagnostic and assessment guidelines. Cognitive-behavior therapy for insomnia. Behavioral strategies for managing insomnia in the context of anxiety. Cognitive strategies for managing comorbid anxiety and insomnia. Sleep-related cognitive processes. Pharmacological treatment considerations. Insomnia and Anxiety is highly useful to clinical psychologists given the range of treatment strategies it describes and to researchers because of its emphasis on the theoretical and empirical bases for its interventions. In addition, its accessible style makes it an excellent training tool for students of therapy and psychopathology.