This volume, is developed from a collaborative study sponsored by the World Health Organization over a period of five years, the result of the combined effort of over 30 experts working in 19 different countries. The book presents a comprehensive survey of the development, policy, and procedures of methadone maintenance in countries with experience in this treatment. In addition to presenting a general overview of methadone's role in treating opioid addiction, the volume also focuses on specific questions of current interest, particularly the critical issue of methadone maintenance in the prevention of AIDS. Public health specialists and policymakers will find this book an invaluable source of information about what can be expected from methadone maintenance programs and why such programs have achieved some success in the rehabilitation of opiate users, while so many other attempts in this area have failed.

Following an introductory chapter, the contributors look at the impact of AIDS epidemiology on methadone policy. The role of methadone in addressing intravenous drug abuse and unsafe sex practices in drug dependent persons is explored in an attempt to assess the ability of methadone maintenance programs to stem the spread of AIDS. Subsequent chapters review the world literature on methadone in treating opioid dependency, explore national policies and practices regarding methadone maintenance, present an international survey of methadone's role, and analyze the present state of research on methadone. A bibliography and index complete the volume.

Cancers of the larynx, while survival outcomes increase, result in massive treatment damage from radiation and surgery. Patients often lose ability to speak and to eat. Preserving the larynx is a fine balance of cancer eradication, life extension, and quality of life. This issueof Otolaryngologic Clinics led by Dr Babak Sadoughi should be of interest to Otolaryngologists, Oncologists, Radiologists, and Speech Therapists. The issue approach reaches all the most important aspects of diagnosing and treating the patient with laryngeal cancer with a focus on preserving the voice in early laryngeal cancer and preserving and restoring function in advanced laryngeal cancer. Topics include: Functional Anatomy and Oncological Barriers of the Larynx; Evaluation of the Dysphonic Patient; Role of Advanced Laryngeal Imaging in Glottic Cancer; Laryngeal Function after Radiation Therapy; Management of Dysphonia after Radiation Therapy; Contemporary Surgical Management of Early Glottic Cancer; Voice Prognosis after Transoral Laser Microsurgery of the Larynx; Voice Rehabilitation after Transoral Laser Microsurgery of the Larynx; Quality of Life after Conservation Surgery for Laryngeal Cancer; Salvage Conservation Surgery of the Larynx; Airway Preservation in Ablative Laryngeal Surgery; Voice Restoration after Total Laryngectomy. A special article for Residents, written by a Resident, emphasizes essential "take home messages" for laryngeal function preservation diagnosis and treatment.

Medical treatment guidelines are written from a clinical perspective, to guide clinical care. The review criteria that will be included in this issue of Physical Medicine & Rehabilitation Clinics are evidence based and are developed by practicing physicians and advisors who work in physical medicine and rehabilitation. Health care providers are expected to be familiar with the guidelines and follow the recommendations. Good medical judgment is important in deciding how to use and interpret this information.

Food Allergy and Gluten-Free Weight Loss gives definitive answers to the question, "Why is it so hard to lose weight?" It is because we have missed or ignored the most important pieces in the puzzle of how our bodies determine whether to store or burn fat. Those puzzle pieces are hormones such as insulin, cortisol, leptin, and others. Individuals with food allergies or gluten intolerance face additional weight-loss challenges such as inflammation due to allergies or a diet too high in rice. This book explains how to put your body chemistry and hormones to work for you rather than against you, reduce inflammation which inhibits the action of your master weight control hormone, leptin, and flip your fat switch from "store" to "burn." It includes a flexible healthy eating plan that eliminates hunger, promotes the burning of fat, and reduces inflammation and tells how to customize the plan so it fits you, your allergies or intolerances, and your need for pleasure in what you eat. Information about cooking for special diets, 175 recipes, a list of sources for special foods, and extensive appendix and reference sections are also included.

Drs. John Herman and Max Hirshkowitz have assembled an expert panel of authors in the topic of Sleep and Psychiatry in Adults. Articles include: Sleep Deprivation and Circadian Disruption; Sleep Disturbances in Depression; Interventions for Sleep Disturbance in Bipolar Disorder; Sleep and Mood During Pregnancy and the Postpartum Period,Sleep Disturbances and Suicide Risk; Insomnia and Anxiety, Interconnectedness of Psychological Suymptoms, Personality Traits, and Sleep Disruption; Sleep in Schizophrenia; Post-traumatic Stress Disorder and Sleep; Benzodiazepine and Benzodiazepine Receptor Agonists for Insomnia and Anxiety; Non-benzodiazpine GABA A1 Receptor Agonists for Insonmia; CBT for Insomnia and Depression; Hypnosis for Insomnia in Patients with Depression and Anxiety; and Bright Light Therapy for Seasonal Affective Disorders.

As bariatric procedures become more commonplace, the safety and quality of bariatric surgery continues to rise. Risk factors remain inconsistent from hospital to hospital and procedure to procedure, however, highlighting the necessity for comprehensive education on the prevention and management of their resulting complications. In response to this need, Prevention and Management of Complications in Bariatric Surgery is the first book to compile the most up-to-date prevention and management strategies in this field. Edited by leading experts, it provides sound recommendations for collecting, monitoring, and analyzing outcomes, with an emphasis on quality and process improvement. Its scope is tremendously comprehensive, covering everything from common complications, such as leaks, bleeding, wound infections, and venous thromboembolism; to rare-but-deadly complications, such as Wernicke's encephalopathy and rhabdomyolsis as well as the emergency management of various life-threatening complications, including internal hernia, gastric nectrosis from banding, pulmonary embolus, and bleeding. Readers also learn about early-day, late-day, and intraoperative complications, for which the authors provide evidence-based recommendations for swift and accurate diagnosis, preventive strategies, and best practices in medical and surgical management. Comprehensive and accessible, this book is a valuable resource for bariatric surgeons and surgical trainees, physicians, and nurses who participate in the perioperative care of the bariatric patient.

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.

This issue, edited by Dr. Babak Mokhlesi, features comprehensive discussion on the subject of Hypoventilation. Articles include: The History of Hypoventilation Syndromes; Pathophysiology of Hypoventilation During Sleep, Sleep Hypoventilation: Diagnostic Considerations and Technological Limitations; Advances in Positive Airway Pressure Treatment Modalities for Hypoventilation Syndromes; Scoring Abnormal Respiratory Events on Polysomnography During Noninvasive Ventilation; Obesity Hypoventilation Syndrome: Epidemiology and Diagnosis; Outcomes for Obese Patients with Chronic Respiratory Failure: Results from Observational and Randomized Controlled Trials; Non-PAP Treatment Modalities in Obesity-Hypoventilation Syndrome: Role of Exercise, Nonsurgical and Surgical Weight Reduction, Tracheostomy, Respiratory Stimulants, and Oxygen, and more!

This issue by Dr. Judith Owens focuses on sleep behavioral problems with articles covering topics such as Addressing Sleep Problems in Children with Anxiety Disorders, Behavioral Treatment of Insomnia in Children with Attention Deficit Hyperactivity Disorder (ADHD), Application of Cognitive Behavioral Therapy for Insomnia (CBT) in the Pediatric Population, Treatment of Delayed Sleep Phase Disorder (DSPD) in Adolescents, Tricks of the Trade: Practical Techniques for Managing Behavioral Sleep Problems in Young Children ,Quality of Life in Children with Narcolepsy, Myofunctional Therapy in the Treatment of Pediatric Sleep Disordered Breathing, Improving Positive Airway Pressure (PAP) Adherence in Children, Creating the "Child-Friendly" Sleep Lab, Controversies in Treatment of Pediatric Insomnia.

This A-Z encyclopedia provides a broad and evenhanded overview of America's complex relationship with marijuana, examining political, recreational, cultural, medical, and economic aspects of marijuana use both historically and in the present day. Marijuana in America is an accessible and comprehensive exploration of the many changes in medical, legal, and cultural issues surrounding cannabis in the United States. This multidisciplinary volume features contributions from several different fields to explain all facets of marijuana, including its chemical composition, evolving depictions in popular culture, and historical, legal, and social settings in which marijuana use occurs. A mix of coverage provides readers with a full and accurate understanding of the spectrum of issues and controversies swirling around marijuana today, including: the changing legal landscape pertaining to the sale, possession, and use of marijuana, both at the state and federal levels; the factual basis for arguments for and against so-called "medical marijuana"; claims that marijuana is a gateway drug to harder drugs; changing cultural attitudes about marijuana and "potheads"; economic arguments for and against marijuana legalization; and the impact of marijuana on families, communities, the economy, and the criminal justice system. Detailed, authoritative, and evenhanded coverage of all medical, legal, cultural, and economic aspects of legal and illegal marijuana in America. Information sources for further research included in each entry. Timeline of legal, cultural, and social events and trends concerning marijuana and its use in the United States. Contributions from several different fields giving the volume a multidisciplinary focus.

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. "Neurobiology of Alcohol Dependence "highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence.
Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependenceChapters authored by leaders in the field around the globe the broadest, most expert coverage available"

Dr. Peter Gay has put together a team of expert authors centering on the topic of Central Sleep Apnea. Focus will include articles on CSA due to other Medical Disorders, Cheyne-Stokes Respiration, Central Sleep Apnea and Cardiovascular Disease, Complex Sleep Apnea, Adaptive servo-ventilation Treatment, Drug induced central apneas- Mechanism and Therapies, ICSD-2 and AASM Practice Parameters, Alternative approaches to treatment of Central Sleep Apnea, and Infant central apnea

This book documents the history of ideas about problem gambling and its link to addictive disorders. The book uses a combination of literature review and conceptual and linguistic analysis to explore the way ideas about problem gambling gave changed over time. It examines the religious, socio-cultural, and medical influences on the development of the concept of problem gambling as a disease, along with the ways in which such ideas were influenced by attitudes about substance abuse. The history of mental illness, notably as it pertains to themes such as loss of control over behavior, is also addressed. The book ends with a discussion of the current status and future prospects, with an eye to which ideas about problem gambling and addictions seem most promising and which should perhaps be left behind.

Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. "The Effects of Drug Abuse on the Human Nervous System "presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetics of use and treatment success, and strategies to screen populations and provide appropriate interventions. The book offers meaningful, relevant and timely information for scientists, health-care professionals and treatment providers.
*A comprehensive reference on the effects of drug addiction on the human nervous system
*Focuses on core drug addiction issues from nicotine, cocaine, methamphetamine, alcohol, and other commonly abused drugs
*Includes foundational science chapters on the biology of addiction
*Details challenges in diagnosis and treatment options

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn s disease, diabetes, multiple sclerosis, critical limb ischemia and many others.

MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies "in vitro. "In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable "in vitro "expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress.

The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncologyTargeting epigenetic dysregulation and protein interaction networksVaccines and antibodies in cancer immunotherapyTumor heterogeneity and chemotherapy resistanceTumor associated macrophages in anticancer treatment

Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences

Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviewsseries, which features reviews published in "Cell Press" primary research and "Trends" reviews journals.
Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
Features reviews on basic science advances translated into drug discovery and therapeutic approaches
Includes articles originally published in "Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine," and "Trends in Pharmacological Sciences""

This issue of Sleep Medicine Clinics will be Guest Edited by Jim Barker, MD CPE, FACP, FCCP, FAASM Shirley Fong Jones, MD, FCCP of Scott and White Memorial Hospital and will focus on Obstructive Sleep Apnea. Article topics include Weight loss, Pharmacologic therapy of obstructive sleep apnea, Alternative Therapies, Masks and Interfaces, Outcomes of treatment of hypersomnia for OSA, Effects of therapy on CV outcomes, Complex Sleep Apnea, Oral appliances, Cost of therapy, Medicolegal aspects of treatment, Residual sleepiness, Therapy and Metabolic Outcomes, and Therapies for Children with OSA.

This issue of Nursing Clinics of North America is Guest Edited by Al Rundio, RN, at Drexel University and will focus on Addictions. Article topics will include Office-Based Opioid Treatment, Addictions and Pregnancy, Peer Assistance, Relapse Prevention for Addictions, Adolescents and Addiction, Use of Photo Voice in Addictions, Health Promotion and Prevention Strategies, Maintaining Sobriety and Recovery, and SBIRT (Screening Brief Interventio and Treatment.)

The most important writings on the psychoanalytic understandings and treatments of drug and vice addiction Drug abuse, alcoholism, compulsive gambling, and other destructive addictions plague our society. Theories of addiction locate its cause variously-in factors related to the substance, the addict's personality, or to the addict's environment. Arguments about effective treatment programs are fierce. Essential Papers on Addiction presents the most important writing and the various sides of the debate on the psychoanalytic understanding and treatment of addiction. Daniel Yalisove outlines the history of the treatment of addiction and introduces important psychoanalytic concepts used in understanding addicts. The book includes case studies which illustrate the course of addiction and presents the work of the most influential theorists in the field. Divided into eight sections focusing on historical work on addiction, psychoanalytic theories of addiction, transference and countertransference issues in treating addiction, psychoanalytic treatment for the addictions, psychoanalytic therapy and disease concepts, and psychiatric illness and addiction, this definitive volume includes contributions by the most experienced and renowned experts on the subject. Contributors include S. Freud, E. Glover, S. Rado, R. P. Knight, L. Wurmser, N. E. Zinberg, H. Krystal, D. Jacobs, R. Fine, J. Gustafson, C. L. Brown, M. L. Selzer, V. Davidson, J. Imhof, R. Hirsch, R. E. Terenzi, M. E. Chafetz, A. Silber, R. J. Rosenthal, E. M. Pattison, M. B. Sobell, L. C. Sobell, J. E. Zweben, E. Simmel, B. Brickman, E. J. Khantzian, R. D. Weiss, S. M. Mirin, A. T. McLellan, and H. J. Richards.