The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

Originally published in French, this updated and expanded English translation offers a definitive treatment on clays and effects on human health including the long history of clays used as pharmaceutical and therapeutic agents, the origins of clays, their structural properties and modes of action.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

This unique volume advances the literature on sleep and health by illuminating the impacts of family dynamics on individuals' quality and quantity of sleep. Its lifespan perspective extends across childhood, adolescence, adulthood and older age considering both phenomena of individual development and family system dynamics, particularly parent-child and marital relationships. It extends, as well, to the broader contexts of social disparities in sleep as a significant health behavior. Emerging concepts and practical innovations include ancestral roots of sleep in family contexts, sleep studies as a lens for understanding family health, and methodologies, particularly the use of actigraphy technology, for studying sleep patterns in individuals and families. This rich area of inquiry holds significant keys to understanding a vital human behavior and its critical role in physical, psychological, and relational health and wellbeing. Among the topics covered: * Sleep and development: familial and sociocultural considerations. * Relationship quality: implications for sleep quality and sleep disorders. * Couple dynamics and sleep quality in an international perspective. * Family influences on sleep: comparative and historical-evolutionary perspectives. * Sociodemographic, psychosocial, and contextual factors in children's sleep. * Dynamic interplay between sleep and family life: review and directions for future research. Family Contexts of Sleep and Health Across the Life Course will advance the work of researchers and students in the fields of population health, family demography and sociology, sleep research and medicine, human development, neuroscience, biobehavioral health, and social welfare, as well as that of policymakers and health and human services practitioners.

Eating disorders present diagnostic and treatment challenges to clinicians. While such disorders need both medical and psychological treatment, patients may be too medically ill for a thorough psychiatric evaluation and may be misunderstood by many primary care physicians. In this revised and updated edition of "Eating Disorders," Philip S. Mehler and Arnold E. Andersen provide a user-friendly and comprehensive guide for primary care physicians, mental health professionals, and others who encounter individuals with the problem.

Mehler and Andersen identify common medical complications that people who have eating disorders face and answer questions about how to treat them. They also cover such serious complications as osteoporosis, cardiac arrhythmia, electrolyte abnormalities, immune compromise, and gastrointestinal sequelae. Incorporating case studies, medical background on the complications, suggestions for diagnosis and treatment, and a list of selected references, chapters cover important topics including team treatment and nutritional rehabilitation. The authors also address special areas of concern, such as athletes who have eating disorders and the pharmacologic treatment of obesity.

Mehler and Andersen encourage close medical follow-up for patients who have eating disorders. This book will help primary care and mental health professionals to understand and to more effectively address the complex concerns of patients with eating disorders.

This book is a comprehensive guide to the evidence, theories, and practical issues associated with recovery from stuttering in early childhood and into adolescence. It examines evidence that stuttering is associated with a range of biological factors - such as genetics - and psychological factors - such as anxiety - and it critically assesses theoretical accounts that attempt to integrate these findings. Written so that it can be used flexibly to meet the demands of courses about stuttering, the book may be used as a text at the undergraduate or graduate level in psychology or speech-language science.

Untold stories of people with substance addictions who have recovered without formal treatment Despite the widely accepted view that formal treatment and twelve-step groups are essential for overcoming dependencies on alcohol and drugs, each year large numbers of former addicts quietly recover on their own, without any formal treatment or participation in self-help groups at all. Coming Clean explores the untold stories of untreated addicts who have recovered from a lifestyle of excessive and compulsive substance use without professional assistance. Based on 46 in-depth interviews with formerly addicted individuals, this controversial volume examines their reasons for avoiding treatment, the strategies they employed to break away from their dependencies, the circumstances that facilitated untreated recovery, and the implications of recovery without treatment for treatment professionals as well as for prevention and drug policy. Because of the pervasive belief that addiction is a disease requiring formal intervention, few training programs for physicians, social workers, psychologists, and other health professionals explore the phenomenon of natural recovery from addiction. Coming Clean offers insights for treatment professionals of how recovery without treatment can work and how candidates for this approach can be identified. A detailed appendix outlines specific strategies which will be of interest to addicted individuals themselves who wish to attempt the process of recovery without treatment.

Anomia is the inability to access spoken names for objects, most often associated with the elderly or those with brain damage to the left hemisphere. Anomia offers the state-of-the-art review of disorders of naming, written by acknowledged experts from around the world, approached from both clinical and theoretical viewpoints. Goodglass, known around the world for his research in aphasia and speech pathology, edits this first book devoted exclusively to naming and its disorders. Wingfield is known for his classic studies of lexical processing in aphasic and normal speakers. The book includes comprehensive literature reviews, a summary of relevant research data, as well as astudy of recent advances in cognitive analysis and anatomic findings. Anomia is an immensely useful work for all those involved in the study of language, particularly those in cognitive neuroscience, neurology, speech pathology, and linguistics.
Key Features
* Devoted entirely to naming and its disorders
* Includes up-to-date descriptions of advances in cognitive analysis
* Contains approaches from both clinical and theoretical viewpoints
* Brings together the top researchers from the U.S., England, and Italy

Society is becoming increasingly multi-lingual and this presents monolingual professionals, particularly those in special education and speech pathology, with severe problems. Is the language delay in a child from a bilingual environment a result of this background or is there a specific speech problem? Is a child's poor performance in school due to his problems of coping with two languages, or does he need remedial teaching? Originally published in 1984, this book is not concerned with second language learning, but with speech and learning difficulties in bilingual children as they are presented to remedial teachers, psychologists and speech therapists. To this end the first group of specially written articles deals with the patterns of language usage in bilingual communities and the social and psychological factors which shape these patterns; with processes in normal bilingual language acquisition; and with the relationship between cognitive development and growing up with two languages. Management issues and methods involved in helping children with language problems are also tackled: they include taking case histories, family liaison, counselling, bilingual programmes, mother tongue teaching, curriculum development and the training of personnel to work in the bilingual-bicultural field. This book provided a great deal of practical help, in a field that was relatively new at the time of writing, and helped to enlighten readers on the issues involved and assist in crystalising thought and directing future research.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

This A-Z encyclopedia provides a broad and evenhanded overview of America's complex relationship with marijuana, examining political, recreational, cultural, medical, and economic aspects of marijuana use both historically and in the present day. Marijuana in America is an accessible and comprehensive exploration of the many changes in medical, legal, and cultural issues surrounding cannabis in the United States. This multidisciplinary volume features contributions from several different fields to explain all facets of marijuana, including its chemical composition, evolving depictions in popular culture, and historical, legal, and social settings in which marijuana use occurs. A mix of coverage provides readers with a full and accurate understanding of the spectrum of issues and controversies swirling around marijuana today, including: the changing legal landscape pertaining to the sale, possession, and use of marijuana, both at the state and federal levels; the factual basis for arguments for and against so-called "medical marijuana"; claims that marijuana is a gateway drug to harder drugs; changing cultural attitudes about marijuana and "potheads"; economic arguments for and against marijuana legalization; and the impact of marijuana on families, communities, the economy, and the criminal justice system. Detailed, authoritative, and evenhanded coverage of all medical, legal, cultural, and economic aspects of legal and illegal marijuana in America. Information sources for further research included in each entry. Timeline of legal, cultural, and social events and trends concerning marijuana and its use in the United States. Contributions from several different fields giving the volume a multidisciplinary focus.

A comprehensive overview of major 12-step programs, this practical manual also describes the nuances of the various programs that address the same addictive behavior to assist the clinician in assessing and referring clients to any 12-step program. One of the unique features of this book is a description of how 12-step program philosophy aligns with eight major psychotherapy orientations. Another feature is the integration of the client's individual needs and ego structure with the appropriateness and timing of a referral to a 12-step program within the overall therapeutic process.

In this day of managed care, it is essential for clinicians to make informed referrals. This book bridges the gap between the desire to refer and a comprehensive understanding of the intricacies of the various programs. Through the use of detailed description, case vignettes, and clinical examples, this book proves an invaluable resource assisting clinicians to guide their clients through the process of integrating psychotherapy with adjunctive 12-step program involvement. Also included is a description of terms used in 12-step programs that allows the clinicians to join the client in a common language.

This volume, is developed from a collaborative study sponsored by the World Health Organization over a period of five years, the result of the combined effort of over 30 experts working in 19 different countries. The book presents a comprehensive survey of the development, policy, and procedures of methadone maintenance in countries with experience in this treatment. In addition to presenting a general overview of methadone's role in treating opioid addiction, the volume also focuses on specific questions of current interest, particularly the critical issue of methadone maintenance in the prevention of AIDS. Public health specialists and policymakers will find this book an invaluable source of information about what can be expected from methadone maintenance programs and why such programs have achieved some success in the rehabilitation of opiate users, while so many other attempts in this area have failed.

Following an introductory chapter, the contributors look at the impact of AIDS epidemiology on methadone policy. The role of methadone in addressing intravenous drug abuse and unsafe sex practices in drug dependent persons is explored in an attempt to assess the ability of methadone maintenance programs to stem the spread of AIDS. Subsequent chapters review the world literature on methadone in treating opioid dependency, explore national policies and practices regarding methadone maintenance, present an international survey of methadone's role, and analyze the present state of research on methadone. A bibliography and index complete the volume.

Food Allergy and Gluten-Free Weight Loss gives definitive answers to the question, "Why is it so hard to lose weight?" It is because we have missed or ignored the most important pieces in the puzzle of how our bodies determine whether to store or burn fat. Those puzzle pieces are hormones such as insulin, cortisol, leptin, and others. Individuals with food allergies or gluten intolerance face additional weight-loss challenges such as inflammation due to allergies or a diet too high in rice. This book explains how to put your body chemistry and hormones to work for you rather than against you, reduce inflammation which inhibits the action of your master weight control hormone, leptin, and flip your fat switch from "store" to "burn." It includes a flexible healthy eating plan that eliminates hunger, promotes the burning of fat, and reduces inflammation and tells how to customize the plan so it fits you, your allergies or intolerances, and your need for pleasure in what you eat. Information about cooking for special diets, 175 recipes, a list of sources for special foods, and extensive appendix and reference sections are also included.

This book focuses on two fundamental aspects of brain-language relations: one concerns the neural organization of language in the healthy brain; the other challenges current approaches to treatment of aphasia and offers a new theory for recovery from aphasia. The essence of the book lies in the phrase neural multifunctionality: the constant and dynamic incorporation of non-linguistic functions into language models of the intact brain. The book makes the claim that language is a construction, created as we use it, and cannot be understood as being supported by neurally based linguistic networks only. Rather, language emerges from the constant and dynamic interaction among neural networks subserving cognitive, affective, and praxic functions with neural networks subserving lexical retrieval (naming), sentence processing (comprehension), and discourse (communication, conversation). In persons with stroke-induced aphasia, neural networks for executive system function, attention, memory, motor system function, visual system function, and emotion interact with neural networks for language to produce the aphasia profile and to influence recovery from aphasia. Consequently, neural multifunctionality in aphasia explains individual differences in the lesion-deficit model and continued recovery over time, redefining the concept of recovery from aphasia and offering new opportunities for treatment.

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.