Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader's knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functional neurological aspects of a given substance, along with a focus on the adverse consequences of addictions.

Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.

Oxygen therapy is a treatment that provides a patient with extra oxygen to breathe in. It is also called supplemental oxygen. It is only available through a prescription from a health care provider. Patients may receive it in hospital, another medical setting, or at home. Some people only need it for a short period of time. Others will need long-term oxygen therapy. There are different types of devices that can provide oxygen. Some use tanks of liquid or gas oxygen. Others use an oxygen concentrator, which pulls oxygen out of the air. The oxygen is administered through a nose tube (cannula), a mask, or a tent. The extra oxygen is breathed in along with normal air. This book is a concise guide to oxygen therapy for clinicians and trainees. Divided into four sections the text begins with an overview of the basic facts of oxygen, describing the different types and their individual uses in clinical therapy. Section two discusses the physiology and monitoring of oxygen therapy, and section three covers different devices and delivery systems, and oxygen toxicity (lung damage from breathing in too much extra oxygen). The final section examines oxygen targets in disease specifics, how the therapy works, and the effects of hypoxia (low oxygen levels in body tissues) and hypoxemia (low oxygen levels in the blood).

Addiction takes many forms and has the potential to impact individuals of all ages, socio-economic statuses, and ethnic backgrounds. Technology addiction has become one of the latest topics of interest among researchers and mental health professionals as individuals become more engrossed in and reliant on digital devices. Psychological and Social Implications Surrounding Internet and Gaming Addiction focuses on the dark side of technology and the ways in which individuals are falling victim to compulsive internet use as well as gaming and gambling addictions. Highlighting socio-cultural, psycho-social, and techno-cultural perspectives on problematic technology use, this critical publication is essential to the research and practical needs of therapists, public administrators, psychologists, students, and researchers interested in compulsive disorders, human behavior, dependency, and other key mental health issues. A pivotal addition to the current mental health research available, this book focuses on topics including, but not limited to, digital addiction, gaming addiction disorder, gambling, gamification, hypermedia seduction theory, MMORPGs, psychotherapy, and related public policy issues.

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions is the latest volume from Progress in Brain Research focusing on new trends and developments in addiction research. This established international series examines major areas of basic and clinical research within neuroscience, as well as popular emerging subfields such as addiction. This volume takes an integrated approach to review and summarize some of the most recent progress from the subfield of addiction research, with particular emphasis on potential applications in a clinical setting.

Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.

We spend a third of our life sleeping, so why not use that time more effectively?

Sleep is a miracle cure that optimizes all of our body's functions. And yet we are not optimizing this incredible tool. With the increasingly hectic pace of our daily lives, compounded by the prevalence of so many gadgets and machines and the sheer amount of time we spend attached to our screens, it's little wonder that so few of us are getting our beauty sleep.

We know we're not getting enough sleep, but we don't know how to fix it. What most of us don't realize is that we all have the capacity for awakened sleep. Awakened sleep slowly trains the sleeper to have optimal energy, superior cognition and brain functioning, more balanced emotions, and longevity - especially when compared to the average seven hours of sleep.

Awakened Sleep bridges the gap between science and ancient wisdom traditions so we can improve our lives. It is the first comprehensive "sleep manual" that guides the reader through the current science of sleep but goes several steps beyond by offering an understanding of the higher states of consciousness that emerge from sleep and dreaming, which in turn, impact our spiritual awareness and the subtler aspects of our overall health. With a Foreword by Deepak Chopra, Awakened Sleep fuses cutting-edge scientific research with age-old Vedic practices for balanced, restorative sleep.

Including a comprehensive sleep hygiene protocol and an assessment to uncover your own unique sleep patterns, Awakened Sleep reveals why a good day-indeed, a good life-always begins the night before.

Addiction is a powerful and destructive condition impacting large portions of the population around the world. Addiction takes many forms and has the potential to impact individuals of all ages, socio-economic statuses, and ethnic backgrounds. Substance Abuse and Addiction: Breakthroughs in Research and Practice is an authoritative resource that comprehensively examines the prevalence, assessment, causes, and impacts of substance abuse and addiction from cultural, legal, psychosocial, theoretical, and medical viewpoints. Highlighting a range of pertinent topics such as technological addictions, drug treatment, and addictive behaviors, this publication is an ideal reference source for psychologists, researchers, mental health professionals, clinicians, academicians, and graduate-level students seeking current research on the prevention, assessment, and rehabilitation of substance abuse and addiction.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on the neuropsychiatric complications of stimulant abuse.