This issue describes in detail the most current thinking on the way genes affect and determine sleep patterns, behaviors, disorders and needs. ? Sleep researchers continue to study genetic markers that may someday lead to a personalized approach to treatment of sleep disorders. The genetics of restless legs syndrome, narcolepsy, circadian rhythm disorders, obstructive sleep apnea, parasomnias, and insomnia are discussed. A solid understanding of the role genetics and molecular biology play in sleep will aid clinicians in diagnosing and treating these disorders, as well as advising their patients.

Substance use disorders occur in 10% to 20% of patients presenting to the primary care physician, and rates are increasing. Primary care physicians are therefore in an excellent position to screen, provide early intervention, or refer patients to specialty care. This issue covers several types of substance abuse-including alcohol, prescription drugs, and recreational drugs-and gives detailed information on screening for and treating these problems.

This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.

Individuals with disabilities that impede their range of motion often have difficulty accessing technologies. With the use of computer-based assistive technology; devices, tools, and services can be used to maintain and improve the functional capabilities of motor disabilities. Assistive Technologies and Computer Access for Motor Disabilities investigates solutions to the difficulties of impaired technology access by highlighting the principles, methods, and advanced technological solutions for those with motor impairments. This reference source is beneficial to academia, industry, and various professionals in disciplines such as rehabilitation science, occupational therapy, human-computer interface development, ergonomics, and teaching in inclusive and special education. This publication is integrated with its pair book Disability Informatics and Web Accessibility for Motor Limitations.

A study of the history of modern insomnia, this book explores how poets, journalists, and doctors of the Victorian period found themselves in near-universal agreement that modernity and sleep were somehow incompatible. It investigates how psychologists, philosophers and literary artists worked to articulate its causes, and its potential cures.

The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.

This issue comprises two parts.? The first part examines pharmacology of drug classes and effects on the slee--wake processes.? The second part focuses on therapeutics for various sleep disorders.? In the first part, basic neuropharmacology of sleep-wake states is discussed.? Other articles review hypnotics, allergy and cardiovascular drugs, anti-convulsant drugs, anti-depressant and anti-psychotic drugs, and stimulants.? The second part focuses on pharmacology for specific sleep disorders: primary insomnia, co-morbid insomnia, sleep-related breathing disorders, narcolepsy and disorders of daytime sleepiness, movement disroders, parasomnias, and circadian rhythm disorders.

Biological interactions of visible light with photosensitizers have been studied for over a century while controlled clinical applications of light and photosensitizers to treat solid tumors, known as photodynamic therapy, have been evolving since the mid 1970's. In Photodynamic Therapy: Methods and Protocols, leading PDT scientists and clinicians provide the first comprehensive collection of methods and protocols specifically related to relevant mechanistic, dosimetric, preclinical, and clinical procedures used in current PDT research. Reflecting the growing number of studies demonstrating that immunological, tumor microenvironmental, and vascular responses are all contributing to PDT treatment outcomes, the contents of this volume move beyond the more traditional PDT concepts in order to investigate the numerous signal transduction and cell death pathways involved. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Photodynamic Therapy: Methods and Protocols is an ideal guide for new investigators just starting out in PDT research as well as seasoned investigators changing the direction of their research with the intention of exploring this vital field of study."

This volume explores sleep medicine, sleep science, and the sleep disorders that keep one-quarter of the U.S. population from getting this necessary component of normal cognitive functioning and survival.

With an emphasis on diagnostic techniques, particularly imaging, this handbook shines newfound attention on the genetic and clinical aspects of sleep medicine. Advances in basic science are explored, including a better understanding of sleep-wakefulness and new models of rapid eye movement (REM) sleep mechanisms. Advancements in the understanding of sleep-wake-dependent genes, gene products, and the role of sleep duration in mortality and morbidity are also presented, along with fascinating noninvasive neuroimaging studies that demonstrate marked changes in function during different sleep states.

Clinicians will gain new insights into the diagnosis of sleep disorders and sleep science. In addition, researchers will have an invaluable tool that will form a foundation for new approaches into the ongoing study of sleep medicine.
* A comprehensive resource for the study of sleep science, sleep medicine, and sleep disorders
* Fascinating noninvasive neuroimaging studies that demonstrate marked changes during different sleep states
* A state-of-the-art reference that summarizes the clinical features and management of many of the neurological manifestations of sleep disorders

With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.

This issue of Medical Clinics of North America is guest edited by Dr. Christian Guilleminault, one of the world's leading experts in the field of sleep medicine.? He is attributor of the Christian Guilleminault Award for Research in Sleep Medicine bestowed by the World Association of Sleep Medicine.? He has put together an outstanding issue that provides the most essential information for the internist on diagnosis and treatment.? Topics such as insomnia, excessive sleepiness, REM behavior disorder, restless legs syndrome, obstructive sleep apnea, narcolepsy, pediatric sleep disorders, cognitive behavior therapy, pharmacologic therapy, sleep as it relates to various major medical disorders, and more.

This issue reviews the current status of scientific dream study and offers the most up-to-date reviews on topics such as dream recall (including variables affecting dream recall, and the psychopathology of altered dream recall), dream content (including the assessment of dream content and variables affecting dream content), dreaming and cognitive functions (dreaming and emotional processing, personality and psychopathology, and learning and memory), disordered dreaming (such as nightmares in patients with post-traumatic stress disorder, dreaming epiphenomena of narcolepsy, and parasomnias), medications altering dreaming, and the role of dreams in psychotherapy.? Because sleep and dreams are inextricably linked, it is important for every sleep specialist to have an understanding of the current scientific understanding of normal and disordered dreaming.

This issue reviews the major areas of clinical interest in Dental Sleep: Sleep Bruxism; Oral Evaluation and Screening by the Dentist; the Neurologic Basis of Sleep Breathing Disorders; Sleep and Orofacial Pain; Cone Beam Imaging of the Airway; The Cervical Spine: Considerations and Treatment for Sleep Disordered Breathing; the Role of the Nasal Airway; Myofunctional Tongue Therapy for Speech Therapy; Ambulatory Testing by the Dentist for Oral Appliance Therapy; Exercises to Address Posture, the Cervical Spine and the Airway; Oral Appliance Therapy for Sleep Breathing; Surgical Therapy for Sleep Breathing Disorders; Sleep Disorders and Headache; and Anatomy of the Airway.? Every sleep specialist needs to be aware of how dental concerns can impact sleep behaviors and sleep disorders.

There are more than 80 different sleep disorders including insomnia, sleep apnea, restless leg syndrome, hypersomnia, circadian rhythm disorders, and parasomnia. Good sleep is necessary for optimal health and can affect hormone levels and weight. The use of artificial intelligence (AI) and biomedical signals and images can help in healthcare diagnostics that are related to these and other sleep disorders. Advancing the Investigation and Treatment of Sleep Disorders Using AI presents an overview of sleep disorders based on machine intelligence methods in order to learn and explore the latest advancements, developments, methods, systems, futuristic approaches, and algorithms towards sleep disorders and to address their challenges. This book also discusses recent and future advancements in various feature extraction techniques and machine learning methods. Covering topics such as biomedical signal processing, augmented reality for clinical investigation, and sleep disorder detection, this book is essential for sleep medicine practitioners, clinical psychologists, psychiatrists, medical technologists, doctors, IT specialists, biomedical engineers, researchers, graduate students, and academicians.

Using an innovative translational approach between the work of experimental scientists and clinical practitioners this book addresses the current, modest, understanding of how and why addiction treatment works. Through bridging this gap it provides a critical insight into why people react as they do in the context of addiction treatment.

This book by Corey H. Evans, Russell D. White, and coauthorsis a gem. There was a time when exercise testing was largely limited to cardiologists, but no more. Ex- cise testing, which providesinformationon tness, the risk of coronarydisease, and all around vitality, is now being performed in the of ces of primary care physicians across the United States. Although there is a signi cant risk in some populations, a careful doctor who takes the trouble to become knowledgeable in exercise physiology and the pat- physiologyof coronary artery disease can use exercise testing to improve his ability to give excellent, preventive medicine. Over the years I have read many books on this subject, and even contributed to some, andthis oneratesrightup therewith the best. Likemanymultiauthoredbooks thereissomerepetition, butthisisnotallbad.Acarefulstudyofthevariouschapters willprovideadepthofknowledgethatwillcomeingoodsteadwhenproblemsarise. I can especially recommendthe chapter on exercise physiology.When the reader has mastered the material presented in this chapter, he has acquired a knowledge base so that he can become an expert in exercise testing equal to almost anyone. Over the years I have been privileged to know several of the authors and have followed their publications. Their contributions to our knowledge base in this eld havebeenconsiderable.Acquiringthisbookandbecomingfamiliarwithitscontents will set you apart in the eld of exercise testin

Long-term oxygen therapy (LTOT) usually represents the final step in the management of severe chronic respiratory diseases: a large proportion of patients suffering from these conditions is involved and the corresponding impact for the Health Institutions and the Society is dramatically increasing. Although LTOT is well known and widely used since long ago in most modern countries, it still represents a challenging topic due to the huge amount of variables which can affect both its efficacy and effectiveness. Unfortunately, patients, doctors, care-givers, together with health institutions and political decision makers frequently have different visions on LTOT, thus highly contributing to obtain uneven results and changing outcomes. The focus of this volume is on new insights and novel perspectives of LTOT. Starting from consolidated experiences, it's aim is also to emphasize the strategic value of developing technologies and innovative organizational models uniquely to find out even more opportunities and advantages for the management of chronic respiratory patients needing long-term oxygen treatment.

The Obesity in Critically Ill Patients issue, Guest Edited by Linda Harrington, focuses on: Obesity-related risks and prevention strategies; Pulmonary considerations of the obese patient; cardiovascular effects of obesity; Postoperative coronary artery bypass patients; Nutritional needs of critically ill obese patients; Pain management in critically ill obese; Sedation of critically ill obese; Skin integrity in critically ill obese; Trauma in the obese patient; and Impact of obesity on critical care resource utilization.

The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans. These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic.

Integrative Therapies in Lung Health and Sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders-- emphasizing the scientific bases for these therapies; and their implementation into clinical practice. This volume focuses on complementary and alternative medicine (CAM) treatments, modalities, and practices that are integrated with conventional medical treatment and for which there is some evidence of safety and efficacy. Whole Medical Systems, with a specific focus on Traditional Chinese Medicine, are also addressed. Individual chapters are devoted to specific health conditions or illnesses, addressing the current state of the science in the four organizing CAM domains, including available information regarding benefits, risks, or safety considerations. Unique aspects of this volume are the chapters related to evaluation of the evidence base for integrative therapies; new animal model research with herbal preparations focused on the serious problem of sepsis in the ICU; guidance for counseling patients with chronic lung illnesses who may be desperate for a cure; and palliative and end-of-life care for patients with chronic lung conditions. Clinicians in various health care settings will find Integrative Therapies in Lung Health and Sleep beneficial in their practice, particularly as the use of integrative therapies becomes more widespread.

Now in an exciting second edition, this fun and interactive board game has been designed to develop word-finding and categorisation skills for children and adults. With over 200 photographic cards and a colourful, versatile board, Find the Link can be used to facilitate a number of connecting and categorisation games, encouraging users to draw on their existing knowledge and descriptive skills to develop vocabulary, classification, logical thought and concentration. Collaborative and competitive games can be played individually, or in groups of 2 - 5 players, providing opportunities for social engagement alongside skill development. The game includes: * 200 hexagonal cards with new and updated images, which can also be used alone for sorting and classification * 40 card categories, ranging from basic groups such as animals, food, clothes and transport, to complex groups such as function and place * A colourful versatile board * An instruction booklet, with guidance and instructions for different games Part of the bestselling Colorcards series, this is an essential resource for anybody working with young children, adults with impaired language abilities, children and adults with special educational needs, or those learning English as an additional language.