Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells.

Learn not only how to recognize high-quality research, but how to improve your own research and apply it to patient care. Plus, find out how to start a journal club, write quality case reports and how to most effectively present your research to others. This book is ideal guide for students at both graduate and undergraduate levels who might be having difficulty with research concepts as well as for practiced clinicians interested in a fresh approach to clinical research. * A jargon-free guide to understanding and conducting research * Uses metaphors, visual images, and examples to simplify complex research concepts * Includes easy-to-do computer exercises to help you understand statistical concepts

Substance Use Disorders: Assessment and Treatment is a summary of everything a therapist should know about substance abuse in one easy-to-read comprehensive book. The book begins with a discussion of the pharmacology of specific drug classes (opioids, hallucinogens, etc.) and the epidemiology of abuse. It then presents psychological theories of substance abuse, the initiation and progression of substance abuse disorders, issues of prevention and early intervention, and screening and assessment for substance abuse (including specific tests for assessment) and discusses in detail the various treatment methodologies available. Two final chapters explore issues relevant to special populations and legal and ethical considerations, regarding issues such as confidentiality and coerced treatment.
Key Features
* A synthesis of the current research and clinical literature
* Includes strengths and weaknesses of commonly used psychometric assessment measures
* Presentation and review of a complete Psychosocial/Substance Use Assessment form
* Discussion of treatment settings and criteria for placement decisions
* Discussion of treatment alternatives and effectiveness of major pharmacological and psychotherapeutic approaches
* Discussion of factors leading to Relapse, and components of Relapse Prevention programs

Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

Recovering Assemblages offers an exciting new insight into the policies and practices of recovery and drug use bridging critical drug studies and the sociology of health and illness. The book investigates lived experiences of young people in Azerbaijan and Germany during their personal recovery from alcohol and other drug use and shows the contingency of 'real' experiences. The sociomaterial and ontological analyses unfold the interrelation of practices, spaces, bodies, and affects in experiencing recovery both within and outside of various treatment facilities. The book will appeal to a range of scholars, postgraduates, and undergraduates engaged in critical, methodological, and empirical studies of recovery, drug use, and policy.

This issue of Sleep Medicine Clinics focuses on Sleep in Older Adults, with topics including: Sleep in Normal Aging; Insomnia in the Older Adult; Sleep Apnea in the Older Adult; Circadian Rhythm Sleep-Wake Disorders in the Older Adult; Restless Legs Syndrome; Periodic Limb Movement Disorder and Other Sleep Related Movement Disorders in the Older Adult; REM Sleep Behavior Disorder and Other Parasomnias in the Older Adult; Neurodegenerative Disorders and Sleep; Medical Conditions and Sleep in the Older Adult; Psychiatric Illness and Sleep in the Older Adult; Sleep and Cognition in the Older Adult; Sleep and Nocturia in the Older Adult; Sleep and Long Term Care; and Sleep in the Hospitalized Older Adult.

This issue of Sleep Medicine Clinics is edited by Drs. Brown and Shahrokh Javaheri and focuses on Advanced PAP Therapies and Non-invasive Ventilation. Article topics include: Current Positive Airway Pressure Device Technology: What's in the "black box?"; Testing the Performance of Positive Airway Pressure Generators: From Bench to Bedside; Treatment of Obstructive Sleep Apnea: Choosing the Best PAP Device; Treatment of Obstructive Sleep Apnea: Choosing the Best Interface; Treatment of Obstructive Sleep Apnea: Achieving Adherence and Dealing with Complications; Treatment of Hyperventilatory Central Sleep Apnea: Idiopathic, CHF, Cerebrovascular Disease, and High Altitude; Disordered Breathing Due to Chronic Opioid Use: Diverse Manifestations and Their Management; Obesity Hypoventilation Syndrome: Choosing the Appropriate Treatment for a Heterogeneous Disorder; Positive Airway Pressure Treatment in the Patient with Ventilatory Failure due to Neuromuscular Disease; Non-invasive Ventilation in Acute Ventilatory Failure; Domiciliary Non-invasive Ventilation for Chronic Ventilatory Failure; The Future of Positive Airway Pressure Technology.

This issue of Otolaryngologic Clinics, guest edited by Dr. Maie St. John, is devoted to Multidisciplinary Approach to Head and Neck Cancer. Articles in this issue include: It Takes a Village - The Import of Multidisciplinary Care; The Role of the Patient: Shared Decision Making; A Story in Black and White: Radiologic Evaluation in the Multi-Disciplinary Setting; Beyond the Glass Slide: Pathology Review in the Multi-Disciplinary Setting; Surgical Innovations; It Takes Two - One Resects, One Reconstructs; Advances in Radiation Oncology: What to Consider; Precision Medicine: Genomic Profiles to Individualize Therapy; The Role of Systemic Treatment Before, During, and After Definitive Treatment; Decision Making for Diagnosis and Management: A Consensus Comes to Life; On Pain; Psychosocial Distress and Screening; First We Eat, Then We Do Everything Else: Nutrition; Functional Assessment and Rehabilitation: How to Maximize Outcomes; Survivorship - Morbidity, Mortality, Malignancy; and Immunotherapy: Who is Eligible?

This issue of Sleep Medicine Clinics is edited by Dr.Ahmed BaHammam and focuses on Hypersomnia. Article topics include: Hypersomnia: neurobiological basis; Narcolepsy Immunogenetics: Where is the Evidence?; Genetic markers of sleepiness; Autonomic function instabilities in Narcolepsy; Epidemiology of Excessive Daytime Sleepiness; Evaluation of the sleepy patient: differential diagnosis; Subjective and objective assessment of hypersomnia; Sleepiness in Narcolepsy; Idiopathic hypersomnia; Sleep disordered breathing and excessive daytime sleepiness; Drug-induced excessive sleepiness; Kleine-Levin syndrome and recurrent hypersomnia; Behaviorally induced insufficient sleep syndrome: an underestimated cause of hypersomnia; Sleepiness in children; Sleepiness in Adolescents; Sleepiness in the elderly; Depression and Hypersomnia: a complex association; Neurodegenerative diseases and excessive sleepiness; Sleepiness and traffic safety; Pharmacological management of excessive daytime sleepiness; Non-pharmacological management of excessive daytime sleepiness.

A timely, relevant work, this encyclopedia provides a comprehensive examination of a full range of topics related to eating disorders and body image. The mortality rate associated with eating disorders is higher than that of any other psychiatric illness. What are the factors that influence abnormal perceptions of body image and trigger the deadly behaviors of food deprivation or uncontrollable gluttony? This indispensable resource thoroughly examines the complex subject of eating disorders, particularly the sociocultural, psychological, and nutritional aspects of eating disorders and body image. Eating Disorders: An Encyclopedia of Causes, Treatment, and Prevention explores the definitions, risk factors, symptoms, and health consequences of such illnesses as anorexia, bulimia, and binge eating. The author discusses the assessment and treatment of these conditions, and imparts health education strategies related to the "Dos and Don'ts" of awareness and prevention efforts. Additionally, she shares tips for recognizing symptoms and discusses where to seek help if a friend or family member is affected. Topics include flight attendants and body weight requirements, the impact of Virtual Reality, and media and sociocultural influences. Case illustrations of eating disorder concerns A timeline of the history of eating disorders Contributions from experts in cross-disciplinary fields Types of prevention programs and ways to promote positive body image

Spanish speakers, whether in monolingual or bilingual situations, or in majority or minority contexts, represent a considerable population worldwide. Spanish speakers in the U.S. constitute an illustrative context of the challenges faced by speech-language practitioners to provide realistic services to an increasing and diverse Spanish-speaking caseload. There is still considerable paucity in the amount of literature on Hispanic individuals with clinical relevance in speech-language pathology. Particularly lacking are works that link both empirical and theoretical bases to evidence-based procedures for child and adult Spanish users with communication disorders. Further, because communication skills depend on multiple phenomena beyond strictly linguistic factors, speech-language students and practitioners require multidisciplinary bases to realistically understand Spanish clients' communication performance. This volume attempts to address those gaps. This publication takes a multidisciplinary approach that integrates both theoretical and empirical grounds from Speech-Language Pathology, Neurolinguistics, Neuropsychology, Education, and Clinical Psychology to develop evidence-based clinical procedures for monolingual Spanish and bilingual Spanish-English children and adults with communication disorders.

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

This issue of Otolaryngologic Clinics of North America, devoted to Obstructive Sleep Apnea, is guest edited by Dr. Mark A. D'Agostino. Articles in this outstanding issue include: Pediatric Sleep Apnea; Skeletal Procedures for Obstructive Sleep Apnea; Nasal Obstruction and its Role in Obstructive Sleep Apnea and Nasal procedures; Sleep Testing; Drug-induced Sleep Endoscopy; PAP Therapy for Obstructive Sleep Apnea; Palatal Procedures for Obstructive Sleep Apnea; Oral Appliances for Obstructive Sleep Apnea; Obstructive Sleep Apnea Overview and Economic Impact of Untreated Obstructive Sleep Apnea; Genioglossal Advancement, Hyoid Suspension and Tongue Base Radio Frequency for Obstructive Sleep Apnea, Endoscopic Partial Midline Glossectomy; Robotic Partial Glossectomy for Obstructive Sleep Apnea; Upper Airway Stimulation Therapy.

This issue of Sleep Medicine Clinics focuses on Ambulatory Sleep Medicine. Article topics include: Diagnosis of Obstructive Sleep Apnea; Personalised medicine for Obstructive Sleep Apnea therapies: Are we there yet?, Cardiovascular risk of Obstructive Sleep Apnea; Motor Vehicle Accident risk related to Obstructive Sleep Apnea; Impact of Obstructive Sleep Apnea Syndrome on Neurocognitive function and impact of CPAP; CPAP therapy for Obstructive Sleep Apnea; Maximizing adherence including using novel IT based systems; Mandibular advancement splints; Surgical approaches to Obstructive Sleep Apnea; Consequences of Obstructive Sleep Apnea; and more!

This book brings together selected revised papers representing a multidisciplinary approach to language, music, and gesture, as well as their interaction. Among the number of multidisciplinary and comparative studies of the structure and organization of language and music, the presented book broadens the scope with the inclusion of gesture problems in the analyzed spectrum. A unique feature of the presented collection is that the papers, compiled in one volume, allow readers to see similarities and differences in gesture as an element of non-verbal communication and gesture as the main element of dance. In addition to enhancing the analysis, the data on the perception and comprehension of speech, music, and dance in regard to both their functioning in a natural situation and their reflection in various forms of performing arts makes this collection extremely useful for those who are interested in human cognitive abilities and performing skills. The book begins with a philosophical overview of recent neurophysiological studies reflecting the complexity of higher cognitive functions, which references the idea of the baroque style in art being neither linear nor stable. The following papers are allocated into 5 sections. The papers of the section "Language-Music-Gesture As Semiotic Systems" discuss the issues of symbolic and semiotic aspects of language, music, and gesture, including from the perspective of their notation. This is followed by the issues of "Language-Music-Gesture Onstage" and interaction within the idea of the "World as a Text." The papers of "Teaching Language and Music" present new teaching methods that take into account the interaction of all the cognitive systems examined. The papers of the last two sections focus on issues related primarily to language: The section "Verbalization Of Music And Gesture" considers the problem of describing musical text and non-verbal behavior with language, and papers in the final section "Emotions In Linguistics And Ai-Communication Systems" analyze the ways of expressing emotions in speech and the problems of organizing emotional communication with computer agents.

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.